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Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger sik-Yin Foo Pierce Kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： NADH oxidase H2O2 production oxidative phosphorylation

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用于带烧烤功能微波炉的转盘装置

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家电科技 2006年第9期 64-64页

作者： Yang. HoGab Cho. Gyu sik

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Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents

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World Journal of Gastroenterology 2015年第11期21卷 3308-3316页

作者： Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong Kook Lee Dong Wook Lee Sung Kook Kim Tae Oh Kim Jonghun Lee Hyung Wook Kim Sam Ryong Jee Seun Ja Park Hyun Jin Kim Division of Gastroenterology Department of Internal MedicineKeimyung University School of Medicine Division of Gastroenterology Department of Internal MedicinePusan National University School of Medicine Division of Gastroenterology Department of Internal MedicineYeungnam University College of Medicine Division of Gastroenterology Department of Internal MedicineCatholic University of Daegu School of Medicine Division of Gastroenterology Department of Internal MedicineKyungpook National University School of Medicine Division of Gastroenterology Department of Internal MedicineDongguk University School of Medicine Division of Gastroenterology Department of Internal MedicineInje University College of Medicine Division of Gastroenterology Department of Internal MedicineDong-A University Medical Center Division of Gastroenterology Department of Internal MedicineKosin University College of Medicine Division of Gastroenterology Department of Internal MedicineGyeongsang National University School of Medicine

AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF ***:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected *** failed to show response or were intolerant to conventional treatments,including steroids or *** measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were ***:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used *** anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of *** patients(8%)had *** cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF ***(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk ***:Anti-TNFs significantly increase the risk of TB infection in Korean patients with *** considerable burden of TB and marked immunosuppression might be attributed to this risk.

关键词： Tuberculosis Anti-TNF Korea Inflammatory bowel dis

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The Effects of Aroma Acupuncture applied on Chronic Headache Patients

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World Journal of Acupuncture-Moxibustion 2005年第3期15卷 35-35页

作者： In Tae JUNG Su Yong KIM Doo Ik LEE Keon sik KIM Jae Dong LEE Yun Ho LEE Do Young CHOI Research Group of Pain & Neuroscience Vision 2000 Project East-West Medical Research Inst Kyung Hee Uni KoreaResearch Group of Pain & Neuroscience Vision 2000 Project East-West Medical Research Inst Kyung Hee Uni KoreaResearch Group of Pain & Neuroscience Vision 2000 Project East-West Medical Research Inst Kyung Hee Uni KoreaResearch Group of Pain & Neuroscience Vision 2000 Project East-West Medical Research Inst Kyung Hee Uni KoreaResearch Group of Pain & Neuroscience Vision 2000 Project East-West Medical Research Inst Kyung Hee Uni KoreaResearch Group of Pain & Neuroscience Vision 2000 Project East-West Medical Research Inst Kyung Hee Uni KoreaResearch Group of Pain & Neuroscience Vision 2000 Project East-West Medical Research Inst Kyung Hee Uni Korea

Background: Because the cause and etiology of chronic headache is not yet fully explained, the treatment of this symptom is not simple. This study compares the effects of aroma acupuncture and normal acupuncture applied on chronic headache patients, in order to establish a primary data for further studies of new treatments and developments of new practical acupuncture. Methods: 38 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as chronic headache patients. The qualified patients were classified into two groups, aroma acupuncture group (Aroma AT group, n=23) and normal acupuncture group (AT group, n=15).

关键词：中医治疗针刺治疗芳香疗法慢性头痛

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Diagnosis of gastrointestinal bleeding: A practical guide for clinicians

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World Journal of Gastrointestinal Pathophysiology 2014年第4期5卷 467-478页

作者： Bong sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li Department of Gastroenterology Royal North Shore Hospital St Leonards NSW 2065 Sydney Australia Department of Medical Oncology Royal North Shore Hospital St Leonards NSW 2065 Sydney Australia Sydney Medical School University of Sydney Camperdown NSW 2050 Sydney Australia Department of Colorectal Surgery Royal North Shore Hospital St Leonards NSW 2065 Sydney Australia Department of Gastrointestinal Surgery Royal North Shore Hospital St Leonards NSW 2065 Sydney Australia Australian School of Advanced Medicine Macquarie University North Ryde NSW 2109 Sydney Australia

Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians.

关键词： Gastrointestinal hemorrhage Diagnostic techniques Endoscopy Colonoscopy Capsule endoscopy Enteroscopy Computed tomography Angiography

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Successful extracorporeal life support in sudden cardiac arrest due to coronary anomaly

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World Journal of Cardiology 2016年第6期8卷 379-382页

作者： Jung Wan Park Jae Hyuk Lee Ki-sik Kim Duk Won Bang Min-Su Hyon Min-Ho Lee Byoung-Won Park Department of Internal Medicine Division of CardiologySoon Chun Hyang University Hospital

Extracorporeal life support(ECLS) has recently been reported to have a survival benefit in patients with cardiac arrest. It is now used widely as a lifesaving modality. Here, we describe a case of sudden cardiac arrest(SCA) in a young athlete with an anomalous origin of the right coronary artery from the left coronary sinus. Resuscitation was successful using ECLS before curative bypass surgery. We highlight the efficacy of ECLS for a patient with SCA caused by a rare, unexpected aetiology. In conclusion, ECLS was a lifesaving modality for SCA due to an anomalous coronary artery in this young patient.

关键词： Coronary vessels anomalies Extracorporeal circulation Cardiac arrest

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毒性中药白降丹质量标准研究

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中成药 2006年第1期28卷 31-33页

作者：王兆基关锡耀徐树棋丁大伦粟晓黎林瑞超郑秀云冯国培香港特别行政区政府化验所香港中国药品生物制品检定所北京100050 香港中文大学香港

目的:建立毒性中药白降丹的质量标准。方法:采用显微、X-衍射方法进行定性鉴别,以滴定法测定含量。结果:各方法可用于白降丹的鉴定。结论:本文建立的显微、X-衍射、滴定等方法可对其进行定性定量分析。

关键词：白降丹二氯化汞氯化亚汞 X-衍射滴定

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应用蒙特卡罗方法计算能量低于3MeV的光子剂量

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中国医学物理学杂志 1998年第2期15卷 97-101页

作者： Ali BENDAOUD A.FAHLI A.AIT HADDOUUnity of work:A.AIT HADDOU (National Center of Energy Science and Nuclear Technology) in Rabat MoroccoA.FAHLI: Hassan Ⅱ University of Science,Faculty Ben M′sik Casablanca Morocco Ali BENDAOUD:Hassan Ⅱ Unive 阿里.班达乌德清华大学留学生

目的：用电脑计算在每个物体中每点处点源释放出的原始光子和平均能量损失，以获得光子线在水模体中的剂量分布情况。材料：钴６０机器，长方体的水模体（ＰＨＡＮＴＯＭ），圆柱状钴６０源，直径为２．５厘米，高为２．６厘米。野的范... 详细信息

目的：用电脑计算在每个物体中每点处点源释放出的原始光子和平均能量损失，以获得光子线在水模体中的剂量分布情况。材料：钴６０机器，长方体的水模体（ＰＨＡＮＴＯＭ），圆柱状钴６０源，直径为２．５厘米，高为２．６厘米。野的范围可从６ｃｍ２取到３０ｃｍ２。方法：蒙特卡罗方法。结果：有两种形式：①研究剂量随深度的变化；②相对剂量（Ｒｅｌａｔｉｖｅｄｏｓｅ）。与Ｐｒｏｗｅｓｓ３０００Ｖｅｒｓ３．０４治疗计划的相应结果比较，此程序所得曲线与Ｐｒｏｗｅｓｓ中曲线基本吻合。结论：本程序应用蒙特卡罗方法模拟能量低于３ＭｅＶ的光子输运具有重要的价值。

关键词：放射疗法钴60源剂量计算蒙特卡罗方法水模体

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毒性中药狼毒质量标准研究

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中成药 2006年第4期28卷 498-503页

作者：粟晓黎林瑞超王兆基关锡耀徐树棋丁大伦郑秀云冯国培中国药品生物制品检定所北京100050 香港特别行政区政府化验所香港中文大学

目的：建立毒性中药狼毒的质量标准。方法：采用硅微、化学、液相色谱／质谱等方法进行定性鉴别，以液相色谱及液相／质谱法测定含量。结果：狼毒大戟中月腺大戟乙素含量为0．01％w／w，月腺大戟中月腺大戟乙素含量范围为0．01％-0．02... 详细信息

目的：建立毒性中药狼毒的质量标准。方法：采用硅微、化学、液相色谱／质谱等方法进行定性鉴别，以液相色谱及液相／质谱法测定含量。结果：狼毒大戟中月腺大戟乙素含量为0．01％w／w，月腺大戟中月腺大戟乙素含量范围为0．01％-0．02％w／w，均末枪出瑞香内酯、狼毒色原酮和新狼毒素A。瑞香狼毒中瑞香内酯、狼毒色原酮及新狼毒素A等成分含量范围分别为0．57％～2．12％w／w、0．86％-1．6％w／w及0．45％-0．96％w／w，但未检出含月腺大戟乙素成分。结论：各法能用于常规榆测狼毒属植物。

关键词：狼毒狼毒大戟月腺大戟瑞香狼毒 HPLC—UV LC—MS-MS

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比较两种全膝关节置换术胫骨假体旋转对线技术的临床应用效果

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生物技术世界 2013年第11期10卷 45-45页

作者：金东叁 Ho sik Choo 郭建斌孙宏彦北京麦瑞骨科医院北京100012 Department of Orthopedic Surgery Ajou University School of Medicine

目的:探究两种全膝关节置换术胫骨假体旋转对线技术的临床应用效果。方法:A组均采用胫骨结节中内1/3线作为解剖标志,B组根据膝内翻程度,分别选择胫骨结节内侧缘至中内1/3线区间定位和胫骨结节中内1/3线作为解剖标志,观察对比临床应用效... 详细信息

目的:探究两种全膝关节置换术胫骨假体旋转对线技术的临床应用效果。方法:A组均采用胫骨结节中内1/3线作为解剖标志,B组根据膝内翻程度,分别选择胫骨结节内侧缘至中内1/3线区间定位和胫骨结节中内1/3线作为解剖标志,观察对比临床应用效果。结果:术后经卡尺测量聚乙烯半月板垫片的旋转角度,B组0°~19°膝内翻改善效果明显优于A组,组间比较差异具有统计学意义,P0.05。结论:胫骨结节内侧缘至中内1/3线区间定位对轻度和重度膝内翻患者的胫骨旋转定位效果较好,临床可进一步进行深入研究。

关键词：全膝关节置换术胫骨假体旋转对线技术

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