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Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats

World Journal of Gastroenterology 2006年第2期12卷 287-291页

作者： sv rana S Attri K Vaiphei R Pal A Attri K Singh Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh-160012India Department of Palhotogy Postgraduate Institute of Medical Education and ResearchChandigarh-160012India. Department of Surgery Govt. Medical CollegeCha-ndigarh-160012India

AIM, To study the role of N-acetylcysteine （NAC） as a protective agent in rifampicin （RMP）-induced oxidative hepatic injury of young rats. METHODS： Hepatic injury was produced by giving 50mg/kg body weight/day of RMP for 3 wk. A dose of NAC （100mg/kg body weight/day） was given in combination with RMP intraperitoneally. Analysis of lipid peroxidation, thiol levels, cytochrome P4se, superoxide dismutase （SOD）, catalase, glutathione peroxidase, reductase and transferase were estimated in liver along with the body weight, liver weight and histological observations. RESULTS： RMP exposure resulted in no change in body and liver weight while antioxidative enzymes were altered but the non protein thiol （GSH） status was well preserved. Cytochrome P450 system and peroxidation of lipids were induced by RMP exposure. Partial protection was observed with NAC against RMP-induced changes in liver, which was evidenced from the prevention of increase in lipid peroxidation and the reduction in SOD and catalase enzyme levels. CONCLUSION. NAC protects young rats against RMP- induced oxidative hepatic injury.

关键词： Rifampicin N-acetylcysteine Hepatoprotection

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Optimization of Wire-EDM Parameters for Ti-6Al-4V Using Taguchi-MRSN Optimization Approach

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Journal of Harbin Institute of Technology(New series) 2024年

作者： Ipsita Nayak Jaydev rana Department of Mechanical Engineering， Veer Surendra Sai University of Technology

Ti-6Al-4V is a lightweight， extremely strong material with high resistance to corrosion and is widely used in aerospace industries， medical implants and many more. Contour cutting in such material with sharp corner radius， narrow kerf width， and maintaining high dimensional accuracy and surface integrity is a challenge for the modern manufacturing industry. Wire electrical discharge machining （WEDM） is a feasible process to meet the above challenges. However， proper control of process parameters is highly necessary for quality cutting of such material. In order to meet the above challenges， the present work focuses on the optimum selection of different process parameters such as pulse-on time (TON)， pulse-off time (TOFF)， spark gap voltage （sv） and wire feed rate （WF） using Taguchi-based multi response signal to noise ratio （MRSN） technique. This is a very simple multi response optimization technique to simultaneously optimize vital responses like thickness of white layer formed on the machined surfaces， average crack density， surface roughness and dimensional accuracy， without the assistance of any software. Moreover， simple regression models are developed to determine the above responses for any combination of process parameters. Industry personnel will find this study useful in utilizing this expensive non-conventional machining method in a techno-economic manner.

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