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Potential therapeutic molecular targets for blood-brain barrier disruption after subarachnoid hemorrhage

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Neural Regeneration Research 2019年第7期14卷 1138-1143页

作者： Hideki Kanamaru Hidenori suzuki Department of Neurosurgery Mie University Graduate School of Medicine

Aneurysmal subarachnoid hemorrhage remains serious hemorrhagic stroke with high morbidities and *** rupture causes arterial bleeding-induced mechanical brain tissue injuries and elevated intracranial pressure,followed by global cerebral ***-subarachnoid hemorrhage ischemia,tissue injuries as well as extravasated blood components and the breakdown products activate microglia,astrocytes and Toll-like receptor 4,and disrupt blood-brain barrier associated with the induction of many inflammatory and other *** blood-brain barrier is disrupted,brain tissues are directly exposed to harmful blood contents and immune cells,which aggravate brain injuries ***-brain barrier disruption after subarachnoid hemorrhage may be developed by a variety of mechanisms including endothelial cell apoptosis and disruption of tight junction *** molecules and pathways have been reported to disrupt the blood-brain barrier after subarachnoid hemorrhage,but the exact mechanisms remain *** independent and/or interconnected signaling pathways may be involved in blood-brain barrier disruption after subarachnoid *** review provides recent understandings of the mechanisms and the potential therapeutic targets of blood-brain barrier disruption after subarachnoid hemorrhage.

关键词： blood-brain barrier early brain injury endothelial cell subarachnoid hemorrhage tight junction inflammation matricellular protein Toll-like receptor 4 TLR4

Numerical Investigation on Super-cooled Large Droplet Icing of Fan Rotor Blade in Jet Engine

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Journal of Thermal Science 2014年第5期23卷 432-437页

作者： Keisuke Isobe Masaya suzuki Makoto Yamamoto Graduate School of Mechanical Engineering Tokyo University of Science6-3-1 NiijukuKatsushika-kuTokyo125-8585Japan Aviation Program Group Japan Aerospace Exploration Agency(JAXA)7-44-1 Jindaiji Higashi-machiChofu-shiTokyo182-8522Japan Department of Mechanical Engineering Tokyo University of Science6-3-1 NiijukuKatsushika-kuTokyo125-8585Japan

Icing(or ice accretion) is a phenomenon in which super-cooled water droplets impinge and accrete on a *** is well known that ice accretion on blades and vanes leads to performance degradation and has caused severe *** various anti-icing and deicing systems have been developed,such accidents still ***,it is important to clarify the phenomenon of ice accretion on an aircraft and in a jet ***,flight tests for ice accretion are very expensive,and in the wind tunnel it is difficult to reproduce all climate conditions where ice accretion can ***,it is expected that computational fluid dynamics(CFD),which can estimate ice accretion in various climate conditions,will be a useful way to predict and understand the ice accretion *** the other hand,although the icing caused by super-cooled large droplets(SLD) is very dangerous,the numerical method has not been established *** is why SLD icing is characterized by splash and bounce phenomena of droplets and they are very complex in *** the present study,we develop an ice accretion code considering the splash and bounce phenomena to predict SLD icing,and the code is applied to a fan rotor *** numerical results with and without the SLD icing model are *** this study,the influence of the SLD icing model is numerically clarified.

关键词： Ice Accretion Fan Rotor Blade Super-cooled Large Droplet Multi-physics Simulation

Effects of uniaxial compressive strain on the electronic- transport properties of zigzag carbon nanotubes

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Nano Research 2016年第5期9卷 1267-1275页

作者： Masato Ohnishi Ken suzuki Hideo Miura Fracture and Reliability Research Institute Graduate School of Engineering Tohoku University Sendai 980-8579 Japan

Recently, substantial attention has been paid to the strain sensitivity of the carbon nanotubes＇（CNTs＇） electronic properties. In this study, the relationships between the geometric structures and electronic states of zigzag CNTs under uniaxial compressive strain were investigated. We found that different factors dominate the electronic states of zigzag CNTs depending on the strain regions： the initial stage of the strain loading, which lasts until column-buckling deformation begins, and the strain regions corresponding to column- and shell-buckling deformations. Because shell-buckling deformation significantly increases the re-orbital angle, the angle between the π orbital axis vectors of adjacent atoms, strong localization of the density of states （LDOS） occurs in the buckled area. We also analyzed the current able to pass through deformed CNTs using a tight-binding-based Green＇s function approach and determined that the current can be significantly suppressed by applying uniaxial compressive strain. Our method of predicting the electronic state of a deformed CNT based on the π-orbital angle is expected to be useful for predicting the electronic properties of CNT-based electronic devices and sensors.

关键词： carbon nanotube strain buckling deformation Green's function method electronic-transport property

Numerical Simulation of Sand Erosion Phenomena in Rotor/Stator Interaction of Compressor

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Journal of Thermal Science 2008年第2期17卷 125-133页

作者： Masaya suzuki Kazuaki Inaba Makoto Yamamoto Department of Mechanical Engineering Tokyo University of Science

Sand erosion is a phenomenon where solid particles impinging to a wall cause serious mechanical damages to the wall surface. This phenomenon is a typical gas-particle two-phase turbulent flow and a multi-physics problem where the flow field, particle trajectory and wall deformation interact with each other. On the other hand, aircraft engines operating in a particulate environment are subjected to the performance and lifetime deterioration due to sand erosion. Especially, the compressor of the aircraft engines is severely damaged. The flow fields of the compressor have strongly three dimensional and unsteady natures. In order to estimate the deterioration due to sand erosion, the sand erosion simulation for a compressor is required under the consideration of the rotor-stator interaction. In the present study, we apply our three dimensional sand erosion prediction code to a single stage axial flow compressor. We numerically investigate the change of the flow field, the particle trajectories, and the eroded wall shape in the compressor, to clarify the effects of sand erosion in the compressor.

关键词： sand erosion axial compressor rotor/stator interaction computational fluid dynamics

Toll-like receptor 4 as a possible therapeutic target for delayed brain injuries after aneurysmal subarachnoid hemorrhage

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Neural Regeneration Research 2017年第2期12卷 193-196页

作者： Takeshi Okada Hidenori suzuki Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan

Neuroinflammation is a well-recognized consequence of subarachnoid hemorrhage（SAH）, and Toll-like receptor（TLR） 4 may be an important therapeutic target for post-SAH neuroinflammation. Of the TLR family members, TLR4 is expressed in various cell types in the central nervous system, and is unique in that it can signal through both the myeloid differentiation primary-response protein 88-dependent and the toll receptor associated activator of interferon-dependent cascades to coordinate the maximal inflammatory response. TLR4 can be activated by many endogenous ligands having damage-associated molecular patterns including heme and fibrinogen at the rupture of an intracranial aneurysm, and the resultant inflammatory reaction and thereby tissue damages may furthermore activate TLR4. It is widely accepted that the excreted products of TLR4 signaling alter neuronal functions. Previous studies have focused on the pathway through nuclear factor（NF）-κΒ signaling among TLR4 signaling pathways as to the development of early brain injury（EBI） such as neuronal apoptosis and blood-brain barrier disruption, and cerebral vasospasm. However, many findings suggest that both pathways via NF-κΒ and mitogen-activated protein kinases may be involved in EBI and cerebral vasospasm development. To overcome EBI and cerebral vasospasm is important to improve outcomes after SAH, because both EBI and vasopasm are responsible for delayed brain injuries or delayed cerebral ischemia, the most important preventable cause of poor outcomes after SAH. Increasing evidence has shown that TLR4 signaling plays an important role in SAH-induced brain injuries. Better understanding of the roles of TLR4 signaling in SAH will facilitate development of new treatments.

关键词： cerebral aneurysm cerebral vasospasm early brain injury delayed brain injury delayed cerebral ischemia inflammation subarachnoid hemorrhage Toll-like receptor 4

Lessons from tenascin-C knockout mice and potential clinical application to subarachnoid hemorrhage

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Neural Regeneration Research 2019年第2期14卷 262-264页

作者： Masato Shiba Hidenori suzuki Department of Neurosurgery Mie University Graduate School of Medicine

Subarachnoid hemorrhage by a ruptured cerebral aneurysmremains the most devastating cerebrovascular disorderswith high morbidity and mortality (suzuki et al.,2017), which are mainly caused by early brain injury anddelayed cerebral ischemia. Despite many experimentaland clinical research efforts, the mechanisms of earlybrain injury as well as delayed cerebral ischemia remainunclarified. However, recent works have suggested thattenascin-C, which is a special type of secreted extracellularmatrix proteins, is promising as a novel therapeutictarget against post-subarachnoid hemorrhage early braininjury and delayed cerebral ischemia.

关键词： cerebral clinical ischemia hemorrhage

Implications of periostin in the development of subarachnoid hemorrhage-induced brain injuries

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Neural Regeneration Research 2017年第12期12卷 1982-1984页

作者： Hirofumi Nishikawa Hidenori suzuki Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan

Target of research in subarachnoid hemorrhage（SAH）：The outcome of aneurysmal SAH remains poor despite advances in the diagnosis and *** many factors related to patients,aneurysms,and institutions,as well as physiol... 详细信息

关键词： Implications of periostin the development subarachnoid hemorrhage-induced brain injuries

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巴特罗公寓楼梯与中庭室内设计

城市环境设计 2024年第1期147卷 24-27页

作者： Javier Villar Jaime Fernandez Calvache Gorka Beita Zarandona David Minton Albero Mila Dimitrovska Kimio suzuki(CG) IMAGENSUBLIMINAL

本项目是对高迪在巴特罗公寓中对地中海光线的天才使用的致敬。巴特罗公寓8层通高的中庭能够获取自然光，并将其均匀分布在建筑的各个角落，而在这个项目中，这种光线的垂直传递是在原有应急楼梯的8层封闭空间内进行的，使用一系列悬挂...

本项目是对高迪在巴特罗公寓中对地中海光线的天才使用的致敬。巴特罗公寓8层通高的中庭能够获取自然光，并将其均匀分布在建筑的各个角落，而在这个项目中，这种光线的垂直传递是在原有应急楼梯的8层封闭空间内进行的，使用一系列悬挂式铝板来捕捉光线（在这里是人造光），目的是从明亮的屋顶到地下黑暗深处的旧煤窑创造一系列不断变化的体验。

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Controllable fabrication of carbon aerogels

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Rare Metals 2006年第Z1期25卷 284-288页

作者： TANEMURA Sakae TANEMURA Masaki suzuki Kenzi Department of Environmental Technology & Urban Planning Nagoya Institute of Technology Showa-ku Nagoya 466-8555 Japan EcoTopia Science Institute Nagoya University Chikusa-ku Nagoya Japan

Nano-pore carbon aerogels were prepared by the sol-gel polymerization of resorcinol (1,3-dihydroxybenzene)(C6H4(OH)2) with formaldehyde (HCHO) in a slightly basic aqueous solution, followed by super-critical drying under liquid carbon dioxide as super-critical media and carbonization at 700 ℃ under N2 gas atmosphere. The key of the work is to fabricate carbon aerogels with controllable nano-pore structure, which means extremely high surface area and sharp pore size distribution. Aiming to investigate the effects of preparation conditions on the gelation process, the bulk density, and the physical and chemical structure of the resultant carbon aerogels, the molar ratio of R/C (resorcinol to catalyst) and the amount of distilled water were varied, consequently two different sets of samples, with series of R/C ratio and RF/W (Resorcinol-Formaldehyde to water, or the content of reactant) ratio, were prepared. The result of N2 adsorption/desorption experiment at 77 K shows that the pore sizes decreasing from 11.4 down to 2.2 nm with the increasing of the molar ratio of R/C from 100 to 400, and/or, the pore sizes decreasing from 3.8 down to 1.6 nm with the increasing of reactant content from 0.4 to 0.6.

关键词： resorcinol-formaldehyde aerogels carbon aerogels super-critical drying N2 adsorption/desorption