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边缘区淋巴瘤晚期患者R-CVP后利妥昔单抗维持治疗的Ⅱ期研究:一项改善淋巴瘤生存协会(CISL)的研究

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癌症 2020年第3期39卷 118-128页

作者： Sung Yong Oh Won Seog Kim Jin Seok Kim Seok Jin Kim Dok Hyun Yoon Deok‑Hwan Yang Won Sik Lee Hyo Jung Kim Ho‑Young Yhim Seong Hyun Jeong Jong Ho Won Suee Lee Jee Hyun Kong Sung‑Nam lim Jun Ho Ji Kyung A.Kwon Gyeong‑Won Lee Jae Hoon Lee Ho Sup Lee Ho‑Jin Shin Cheolwon Suh Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Division of Hematology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Republic of Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa‑guSeoul 05505Republic of Korea Department of Hematology‑Oncology Chonnam National University Hwasun HospitalHwasun 58128Republic of Korea Department of Hematology Busan Paik HospitalInje University College of MedicineBusan 04511Republic of Korea Department of Internal Medicine Hallym University Sacred Heart HospitalHallym University College of MedicineAnyang 14068Republic of Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907Republic of Korea Department of Hematology‑Oncology Ajou University School of MedicineSuwon 16499Republic of Korea Department of Internal Medicine Soonchunhyang University Seoul HospitalSoonchunhyang University College of MedicineSeoul 04401Republic of Korea Division of Hematology‑Oncology Department of Internal MedicineWonju Severance Christian HospitalYonsei University College of MedicineWonju 26426Republic of Korea Department of Internal Medicine Haeundae Paik HospitalInje University College of MedicineBusan 48108Republic of Korea Division of Hematology and Oncology Department of Internal MedicineSamsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Republic of Korea Division of Hematology‑Oncology Department of Internal MedicineDongnam Institute of Radiological and Medical SciencesBusan 46033Republic of Korea Division of Hematology‑Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Republic of Korea Department of Internal Medicine Gachon University Gil Medical CenterIncheon 21565Republic of

背景与目的利妥昔单抗是一种靶向CD20的单克隆抗体,在治疗边缘区淋巴瘤(marginal zone lymphoma,MZL)中可以单药或联合化疗使用,可提高缓解率和生存率,但治疗后仍可能会复发。因此,仍需探索如何延长MZL患者的缓解期的治疗方案。这项多... 详细信息

背景与目的利妥昔单抗是一种靶向CD20的单克隆抗体,在治疗边缘区淋巴瘤(marginal zone lymphoma,MZL)中可以单药或联合化疗使用,可提高缓解率和生存率,但治疗后仍可能会复发。因此,仍需探索如何延长MZL患者的缓解期的治疗方案。这项多中心、单臂、开放标签的Ⅱ期研究评估了对一线R-CVP(rituximab,cyclophosphamide,vincristine,and prednisolone;利妥昔单抗、环磷酰胺、长春新碱和泼尼松龙)治疗有反应的Ⅲ–Ⅳ期CD20阳性MZL患者进行利妥昔单抗维持治疗2年的生存率。本研究旨在明确R-CVP后利妥昔单抗维持治疗的策略是否有进一步研究的价值。方法在利妥昔单抗维持治疗之前,Ⅲ–Ⅳ期MZL患者应接受6–8周期的R-CVP一线治疗。每个周期为3周,第1 d静脉输注利妥昔单抗(375 mg/m^2)、环磷酰胺(750 mg/m^2)和长春新碱(1.4 mg/m^2;最大2 mg),第1–5 d口服泼尼松龙(100 mg)。对R-CVP治疗达到完全缓解(complete response,CR)、部分缓解(part response,PR)或疾病稳定(stable response,SD)的患者进行利妥昔单抗维持治疗,每8周静脉注射利妥昔单抗375mg/m^2,直到12个周期。主要终点为无进展生存期(progression-free surviva,PFS),次要终点为总生存期(overall survival,OS)和治疗安全性。结果共纳入47例患者,其中45(96%)例接受了利妥昔单抗维持治疗。15(33%)例患者有淋巴结MZL。在进行R-CVP一线治疗后,分别有20(44%)例、22(49%)例和3(7%)例的患者达到了CR、PR和SD。中位随访38.2个月后,患者的3年PFS率为81%。在利妥昔单抗维持治疗期间,R-CVP治疗后有6例PR和1例SD患者获得CR。LDH升高和B症状是PFS的重要预后因素(P=0.003),3年OS率为90%。利妥昔单抗维持治疗的耐受性良好,常见的治疗性不良事件为感觉性神经病(18%)、肌痛(13%)、疲劳(9%)和中性粒细胞减少(9%)。结论一线R-CVP治疗后利妥昔单抗维持治疗在Ⅲ–Ⅳ期MZL患者中不仅表现出较好的PFS,而且药物毒性反应评价良好。

关键词：边缘区淋巴瘤晚期利妥昔单抗环磷酰胺长春新碱维持多中心开放标签生存

广州市5781名中学生睡眠质量现状及影响因素分析

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中国校医 2018年第7期32卷 518-521页

作者：黄若楠林琼芬吕娴佳陈静仪罗敏红广州市健康教育所广东广州510403 广州市中小学卫生健康促进中心

目的了解广州市中学生睡眠质量及其相关因素,为采取有效措施改善中学生的睡眠质量提供客观依据。方法采取分层整群随机抽样方法,对广州市5 781名中学生进行匹兹堡睡眠质量指数问卷(PSQI)调查。结果广州市中学生的PSQI总分为(6.45±2.862... 详细信息

目的了解广州市中学生睡眠质量及其相关因素,为采取有效措施改善中学生的睡眠质量提供客观依据。方法采取分层整群随机抽样方法,对广州市5 781名中学生进行匹兹堡睡眠质量指数问卷(PSQI)调查。结果广州市中学生的PSQI总分为(6.45±2.862)分。睡眠问题的检出率为33.1%,其中,高中生、女生、寄宿生和毕业班学生的睡眠问题分别高于初中生、男生、非寄宿生和非毕业班的学生(P<0.05)。与睡眠问题相关的因素包括性别、学段、寄宿情况等。结论广州市中学生睡眠问题较为严重,应引起足够的重视。应针对重点人群分别采取综合措施,提高中学生身体素质和心理素质,有助于提高他们的睡眠质量。

关键词：青少年学生睡眠中小学生卫生保健服务

Simultaneous whole body ^(18)F-fluorodeoxyglucose positron emission tomography magnetic resonance imaging for evaluation of pediatric cancer: Preliminary experience and comparison with ^(18)F-fluorodeoxyglucose positron emission tomography computed tomogra

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World Journal of Radiology 2016年第3期8卷 322-330页

作者： Brian S Pugmire Alexander R Guimaraes Ruth lim Alison M Friedmann Mary Huang David Ebb Howard Weinstein Onofrio A Catalano Umar Mahmood Ciprian Catana Michael S Gee Department of Radiology Cincinnati Children’s Hospital Medical Center Division of Body Imaging Oregon Health Sciences University Division of Abdominal Imaging Massachusetts General Hospital Martinos Center for Biomedical Imaging Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital Division of Pediatric Imaging Mass General Hospital for Children Division of Pediatric Hematology-Oncology Mass General Hospital for Children

AIM: To describe our preliminary experience with simultaneous whole body ^(18)F-fluorodeoxyglucose(^(18)F-FDG)positron emission tomography and magnetic resonance imaging(PET-MRI) in the evaluation of pediatric oncology ***: This prospective, observational, singlecenter study was Health Insurance Portability and Accountability Act-compliant, and institutional review board approved. To be eligible, a patient was required to:(1) have a known or suspected cancer diagnosis;(2) be under the care of a pediatric hematologist/oncologist; and(3) be scheduled for clinically indicated ^(18)F-FDG PETCT examination at our institution. Patients underwent PET-CT followed by PET-MRI on the same day. PET-CT examinations were performed using standard department protocols. PET-MRI studies were acquired with an integrated 3 Tesla PET-MRI scanner using whole body T1 Dixon, T2 HASTE, EPI diffusion-weighted imaging(DWI) and STIR sequences. No additional radiotracer was given for the PET-MRI examination. Both PET-CT and PETMRI examinations were reviewed by consensus by two study personnel. Test performance characteristics of PETMRI, for the detection of malignant lesions, including FDG maximum standardized uptake value(SUVmax) and minimum apparent diffusion coefficient(ADCmin), were calculated on a per lesion basis using PET-CT as a reference ***: A total of 10 whole body PET-MRI exams were performed in 7 pediatric oncology patients. The mean patient age was 16.1 years(range 12-19 years) including 6 males and 1 female. A total of 20 malignant and 21 benign lesions were identified on PET-CT. PET-MRI SUVmax had excellent correlation with PET-CT SUVmax for both benign and malignant lesions(R = 0.93). PETMRI SUVmax > 2.5 had 100% accuracy for discriminating benign from malignant lesions using PET-computed tomography(CT) reference. Whole body DWI was also evaluated: the mean ADCmin of malignant lesions(780.2 + 326.6) was significantly lower than that of benign lesions(1

关键词： Positron emission tomography Radiology Pediatric imaging Oncology Cancer Magnetic resonance imaging

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深度学习用于胸片上肺转移的检测

国际医学放射学杂志 2022年第1期 108-108页

作者： E.J.Hwang J.S.Lee J.H.Lee W.H.lim J.H.Kim K.S.Choi 李鹏飞

摘要在CT检查受限的情况下，计算机辅助检测(CAD)系统有助于胸部X线摄影对肺转移的监测。目的评估基于深度学习(DL)的CAD系统能否提高肿瘤病人胸部X线片上

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白菜EST-SSR标记的通用性

细胞生物学杂志 2006年第2期28卷 248-252页

作者：忻雅崔海瑞张明龙姚艳玲卢美贞金基强林容杓崔水莲浙江大学原子核农业科学研究所杭州市农业科学研究院生物所杭州310024 忠南大学园艺系

EST-SSR是从表达序列标签(expressedsequencetag,EST)中开发的新型简单序列重复(simplesequencerepeat,SSR)标记。根据白菜EST设计了15对SSR引物,对白菜、油菜、玉米、高粱、水稻和茶树等进行了PCR,研究了白菜的EST-SSR标记在不同物种... 详细信息

EST-SSR是从表达序列标签(expressedsequencetag,EST)中开发的新型简单序列重复(simplesequencerepeat,SSR)标记。根据白菜EST设计了15对SSR引物,对白菜、油菜、玉米、高粱、水稻和茶树等进行了PCR,研究了白菜的EST-SSR标记在不同物种间的通用性。所设计的引物对不同白菜品种、近缘种油菜和远缘种玉米、高粱、水稻和茶树的扩增成功率分别为100%、93.3%、80%、93.3%、93.3%和86.7%。在15对引物中,有11对在远缘种中都有扩增产物,而且一些引物可显示多态性,多态性引物分别占了可扩增引物的33.3%、28.6%、28.6%和61.5%。这些结果表明,白菜EST-SSR引物具有较高的通用性,这对于比较基因组学研究有重要意义。

关键词： SSR标记通用性白菜 SSR引物表达序列标签简单序列重复比较基因组学扩增产物多态性 EST

S-1联合奥沙利铂与卡培他滨联合奥沙利铂治疗转移性结直肠癌的前瞻随机对照的非劣效Ⅲ期临床试验

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消化肿瘤杂志(电子版) 2013年第1期 11-11页

作者： Hong YS Park YS lim HY 张信华马晋平

背景和目的卡培他滨联合奥沙利铂方案（CapeOX）是针对转移性结直肠癌患者的细胞毒化疗备选方案之一。而S-1联合奥沙利铂双药联合方案（SOX）具有很好的发展前景。本试验旨在比较CapeOX方案与SOX方案的有效性和安全性。方法本研究属于... 详细信息

背景和目的卡培他滨联合奥沙利铂方案（CapeOX）是针对转移性结直肠癌患者的细胞毒化疗备选方案之一。而S-1联合奥沙利铂双药联合方案（SOX）具有很好的发展前景。本试验旨在比较CapeOX方案与SOX方案的有效性和安全性。方法本研究属于开放、多中心随机对照的Ⅲ期临床研究,来自韩国11个研究机构参与试验。符合入组标准的患者按照1∶1的比例随机接受CapeOX（第1;4天卡培他滨1 000 mg/m2,每日2次,并且第1天奥沙利铂130 mg/m2）和SOX方案（第1;4天S-1 40 mg/m2,每日2次,并且第1天奥沙利铂130 mg/m2）治疗。两者均为3周方案,包含奥沙利铂的联合化疗共9个疗程,除非在治疗中出现疾病进展、不能耐受的毒性反应和主观拒绝治疗。完成后允许进入卡培他滨或S-1单药治疗的维持期。试验以电脑生成的随机数列进行随机分组（按以下因素进行分层:原发病变部位、既往有无接受辅助或新辅助治疗以及是否存在可测量病灶）。试验的主要终点为SOX方案相对CapeOX方案显示出非劣效无进展生存（PFS）。统计分析来自意向治疗人群。本研究已在***注册,编号为NCT00677443。结果在2008年5月14日至2009年9月23日期间,共有168名患者接受SOX治疗方案,172名患者接受CapeOX方案。两者中位PFS分别为8.5个月（95%CI:7.6-9.3）和6.7个月（6.2;.1,危险比RR=0.79,95%CI:0.60-1.04;非劣效P<0.0001,Log-rank检验P=0.09）。可信区间的上限低于预测值1.43,显示在PFS上,SOX方案劣于CapeOX方案。安全性方面,SOX组记录到3;级粒细胞减少[49（29%）vs.24（15%）]、血小板减少[37（22%）vs.11（71%）]、腹泻[16（10%）vs.7（4%）]的发生率高于CapeOX组。但CapeOX组各级的手-足综合征发生率均高于SOX组[51（31%）vs.23（14%）]。结论 SOX方案有望成为转移性结直肠癌患者可供选择的一线双药联合化疗方案。有必要进一步试验探讨联合靶向药物及其在辅助化疗中的疗效。

关键词：奥沙利铂 S-1 转移性结直肠癌卡培他滨

判断严重主动脉狭窄且左心室功能正常患者的预后:B型利钠肽的作用

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世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 32-32页

作者： lim P. Monin J.L. MonchiM. 高登峰

B-type Natriuretic Peptide(BNP) is activated in patients with severe, symptomatic aortic stenosis(AS), but the prognostic value of BNP in this setting has not been extensively studied. This study aimed to assess the prognostic value of the BNP level in symptomatic and asymptomatic patients with severe AS. Seventy consecutive patients referred to our echocardiography laboratory for severe AS with preserved left ventricular function were prospectively enrolled(40 men, median age 74 years [62-82]; aortic valve area 0.7 cm2[0.6-0.8]; transaortic gradient 48 mmHg[38-60], and left ventricular fractional shortening 38%[32-43]). C-terminal BNP serum level at enrolment was evaluated against baseline functional and echocardiographic parameters as well as clinical outcome. BNP level was elevated in the presence of symptoms and increased with NYHA functional class. BNP serum level >66 pg/ml detected symptomatic patients with a sensitivity, specificity and accuracy of 84%, 82%and 84%, respectively. In symptomatic and asymptomatic patients, BNP level was a strong independent predictor for cardiovascular death by multivariable analysis adjusted to age and NYHA functional class. BNP serum level allows to differentiate symptomatic from asymptomatic patients with severe AS. BNP is an independent predictor of outcome in these patients and may be helpful for risk stratification.

关键词： B型利钠肽主动脉狭窄左心室功能主动脉压力超声检查无症状血清水平阶差活化状态心血管疾病

比较糖尿病患者、不伴糖尿病的高血压患者和健康对照者的脑利钠肽与组织多普勒测定的左心室舒张功能

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世界核心医学期刊文摘（心脏病学分册） 2005年第9期1卷 36-36页

作者： lim H.S. Patel J.V. Nadar S. 王睿 Haemostasis Thromb. Vasc. Biol. U. University Department of Medicine City Hospital Birmingham United Kingdom

In this study, it was found that increased plasma B-type natriuretic peptide(BNP) levels in patients with diabetes may be related to left ventricular(LV) diastolic relaxation, independent of LV mass and atherosclerosis(using common carotid intimamedia thickness as a surrogate index). A “package of care”of glycemic control and cardiovascular risk management was not associated with reduction in BNP levels.

关键词：脑利钠肽左心室舒张功能组织多普勒心血管风险功能减弱内膜中层厚度联合处理替代指标颈总动脉

基于深度学习的胸部X线恶性结节自动检测的开发与验证研究

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国际医学放射学杂志 2019年第2期42卷 233-233页

作者： J.G.Nam S.Park E.J.Hwang J.H.Lee K.N.Jin K.Y.lim 邓江(译) 王玉婷(校) Department of Radiology Seoul National University Hospital and College of Medicine101 Daehak-roJongno-guSeoul 03080 不详

目的开发并验证一种基于深度学习的胸片恶性肺结节自动检测算法(DLAD),并与包括胸部放射医师在内的医师诊断进行比较。材料与方法对本回顾性研究,采用2010—2015年期间共34 676例病人(健康与结节分别为30 784和3 892)的43 292张胸部X线... 详细信息

目的开发并验证一种基于深度学习的胸片恶性肺结节自动检测算法(DLAD),并与包括胸部放射医师在内的医师诊断进行比较。材料与方法对本回顾性研究,采用2010—2015年期间共34 676例病人(健康与结节分别为30 784和3 892)的43 292张胸部X线片(正常胸片与结节胸片分别为34 067和9 225)进行DLAD的开发。

关键词：恶性结节自动检测算法深度学习