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Malignant middle-cerebral artery territory infarction in tuberculous vasculitis

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Neuroimmunology and Neuroinflammation 2014年第1期1卷 95-97页

作者： Salvadeeswaran Meenakshi-sundaram Sundararajan Srinivasan Somalinga Nagendran Karthik Suresh Pandi Alagappan Periyakaruppan Bharathi Sundar Department of Neurosciences Apollo Speciality HospitalsMadurai 625020Tamil NaduIndia Department of Radiology Apollo Speciality HospitalsMadurai 625020Tamil NaduIndia

Intracranial large vessel involvement is an unusual complication of tuberculous *** authors report a 39-year-old female presenting with an episode of seizure,followed by rapid decline in sensorium without prominent systemic *** initial cranial magnetic resonance imaging revealed tuberculomata and patchy *** antituberculous therapy,she progressively worsened.A cranial computed tomography scan done following the worsening revealed a massive middle-cerebral artery(MCA)***,the patient died in spite of decompressive *** MCA territory infarct is a rare and potentially fatal complication of tuberculous meningitis.

关键词： Arteritis malignant middle-cerebral artery territory infarct tuberculous meningitis

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采用模拟乘法器的新型线性热敏电阻温度计

中国检验检测 1991年第2期 33-33,25页

作者： sundaram Natarajan 圆方

1.前言最近,在文献[1]中介绍了采用热敏电阻探头的新型测温电路。在该电路中,作者巧妙的采用了分度型模拟乘法器,而不需知道热敏电阻常数β的实际值。该电路还提供宽的线性范围,在其实验结果中得到证实。然而,在电

关键词：模拟乘法器热敏电阻电压热敏元件参考温度

Reversible posterior leukoencephalopathy syndrome: single photon emission computerized tomography observations

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Neuroimmunology and Neuroinflammation 2017年第2期4卷 28-32页

作者： Salvadeeswaran Meenakshi-sundaram Sathyam Senthilnathan Kaliappan Gurusamy Srinivasan Somalinga Nagendran Karthik Pandi Suresh Somasundaram Palanirajan Department of Neurosciences Apollo Speciality HospitalsMadurai625020Tamil NaduIndia Department of Nuclear Medicine Meenakshi Mission Hospital and Research CentreMadurai625020Tamil NaduIndia KGS Advanced MR and CT Scan Centre Madurai625020Tamil NaduIndia Department of Nephrology Apollo Speciality HospitalsMadurai625020Tamil NaduIndia.

The authors report clinical correlations of single photon emission computerized tomography (SPECT) findings in reversible posterior leukoencephalopathy (RPL). These are observations that have not received wide attention in literature. A 31-year-old hypertensive gentleman, on discontinuing antihypertensive medications, presented with vomiting, headache, focal motor to bilateral tonic-clonic seizures, altered sensorium, right gaze palsy and right hemiparesis. Accelerated hypertension was noted and he improved well with antihypertensive and anticonvulsant therapy. While cranial magnetic resonance imaging (MRI) revealed extensive bilateral lesions, SPECT imaging revealed perfusion defects involving bilateral basal ganglia, left parieto-occipital, right cerebellar and right occipital regions, which corresponded with clinical deficits on examination. While MRI is the standard of care for the evaluation of RPL, this case suggests that SPECT abnormalities may be better localized to the pathogenic lesions. Furthermore, this may begin to explain the pathophysiology of injury in RPL.

关键词： Reversible posterior leukoencephalopathy single photon emission computerized tomography imaging accelerated hypertension crossed cerebellar diaschisis

Efficacy of High Dose Tranexamic Acid in Decreasing Bleeding after Cardiac Surgery for Cyanotic Congenital Heart Disease in Children Less than Ten Kilo Body Weight

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World Journal of Cardiovascular Surgery 2018年第5期8卷 93-102页

作者： Saranya Vishnumathy Sampathkumar Vijayakumar Raju Soundaravalli Balakrishnan Saigopalakrishnan Mandhira Moorthy Anandhi Arul Kalyana sundaram Muthuswamy Muralidharan Srinivasan Division of Cardiac Anesthesia G. Kuppusamy Naidu Memorial Hospital Coimbatore India Pediatric Cardiac Surgery G. Kuppusamy Naidu Memorial Hospital Coimbatore India Pediatric Cardiology G. Kuppusamy Naidu Memorial Hospital Coimbatore India

Background: To determine the effect of high dose tranexamic acid in decreasing immediate postoperative bleeding in children less than ten kilo body weight after complex cardiac surgery and also to evaluate the safety of high dose in small children. Methods: Between January-December 2015, 25 children weighing less than ten kilogram body weight underwent complex cardiac surgery for cyanotic congenital heart disease. All children were given dose of 100 mg/kg tranexamic acid at the time of anaesthetic induction and also 100 mg/kg into the CPB prime. The Median age and weight was 80 days (3 - 365) and 4.69 kg (2.4 - 7.8) respectively. The Median preoperative Hb was 10 g/dl (9.6 - 19.5 g/dl). Cardiac surgery included total intracardiac repair for TOF in 10 pts (40%), TAPVC repair in 6 (24%), arterial switch operation in 6 pts (24%), BD glenn in 1, repair of DORV with VSD in 1 and VSD closure with scimitar vein reimplantation in 1 pt. Median CPB time was 127 minutes (97 - 343) and cross clamp time was 99 (67 - 200) minutes. Moderate to deep hypothermia was maintained in all with median temperature of 24°C (18 - 32). Three children (12%) had elective open chest in view of anticipated bleeding. Results: The Median postoperative drainage was 127 ml, (range 10 - 1250 ml). The median postoperative use of whole blood was 95 ml (range 10 - 275), packed cell was 187 ml (range 50 - 400 ml), frozen plasma was 88 ml (range 30 - 170), platelet concentrate was 57 ml, (range 10 - 100 ml) and cryoprecipitate was median 47.5 ml, (range 30 - 80 ml). No neurological dysfunction and renal dysfunction has been observed in any of the pts. Out of 4 mortalities (16%), only one was attributed to bleeding (4%) due to usage of ECMO. No late neurological or renal dysfunction has been observed in remaining 21 pts on follow up. Conclusion: High dose Tranexamic acid can be safely used in small children during complex cardiac surgery with significant reduction in postoperative bleeding and blood product

关键词： Pediatric Cardiac Surgery Bleeding Antifibrinolytics Tranexamic Acid Renal Dysfunction Neurological Dysfunction

Marker-Assisted Pyramiding of Genes Conferring ResistanceAgainst Bacterial Blight and Blast Diseases into Indian RiceVariety MTU1010

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Rice science 2016年第6期23卷 306-316页

作者： k.arunakumari c.v.durgarani v.satturu k.r.sarikonda p.d.r.chittoor b.vutukuri g.s.laha a.p.k.nelli s.gattu m.jamal a.prasadbabu s.hajira r.m.sundaram Institute of Biotechnology Professor Jayashankar Telangana State Agricultural UniversityRajendranagarHyderabad 500030India Andhra Pradesh Rice Research Institute Acharya N.G.Ranga Agricultural UniversityMaruteruWest Godavari District 534122India Agriculture Research Station Acharya N.G.Ranga Agricultural UniversityNellore 524004India Crop Improvement Section ICAR-Indian Institute of Rice ResearchRajendranagarHyderabad 500030India Urmatt Ltd.Wang Chai Chaingrai 57210Thailand

Two major bacterial blight （BB） resistance genes （Xa21 and xa13） and a major gene for blastresistance （Pi54） were introgressed into an Indian rice variety MTU1010 through marker-assistedbackcross breeding. Improved Samba Mahsuri （possessing Xa21 and xa13） and NLR145 （possessingPi54） were used as donor parents. Marker-assisted backcrossing was continued till BC2 generationwherein PCR based functional markers specific for the resistance genes were used for foregroundselection and a set of parental polymorphic microsatellite markers were used for background selectionat each stage of backcrossing. Selected BC2F1 plants from both crosses, having the highest recoveriesof MTU1010 genome （90% and 92%, respectively）, were intercrossed to obtain intercross F1 （ICF1） plants,which were then selfed to generate 880 ICF2 plants possessing different combinations of the BB andblast resistance genes. Among the ICF2 plants, seven triple homozygous plants （xa13xa13Xa21Xa21Pi54Pi54）with recurrent parent genome recovery ranging from 82% to 92% were identified. All the seven ICF2plants showed high resistance against the bacterial blight disease with a lesion lengths of only 0.53–2.28 cm, 1%–5% disease leaf areas and disease scoring values of ‘1’ or ‘3’. The seven ICF2 plants wereselfed to generate ICF3, which were then screened for blast resistance, and all were observed to behighly resistant to the diseases. Several ICF3 lines possessing high level of resistance against BB andblast, coupled with yield, grain quality and plant type on par with MTU1010 were identified and advanced forfurther selection and evaluation.

关键词： gene pyramiding bacterial blight resistance blast resistance rice marker-assistedbackcross breeding

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Evaluation of safety profile of black shilajit after 91 days repeated administration in rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第3期2卷 210-214页

作者： Velmurugan C Vivek B Wilson E Bharathi T sundaram T Department of Pharmacology Sri Krishna Chaithanya College of Pharmacy Department of Pharmacology Sri K.V College of PharmacyM.G RoadChickballapurKarnataka SRF National Institute of Indian Medical HeritageHyderabad Department of Pharmaceutical Biotechnology Sri Krishna Chaithanya College of Pharmacy Department of Pharmaceutics Sri Krishna Chaithanya College of pharmacy

Objective:To evaluate the safety of shilajit by 91 days repeated administration in different dose levels in ***:In this study the albino rats were divided into four groups. Group Ⅰ received vehicle and group Ⅱ,Ⅲ and Ⅳ received 500,2500 and 5000 mg/kg of shilajit, *** animals were sacrificed and subjected to histopathology and iron was estimated by flame atomic absorption spectroscopy and graphite ***:The result showed that there were no significant changes in iron level of treated groups when compared with control except liver(5000 mg/kg) and histological slides of all organs revealed normal except negligible changes in liver and intestine with the highest dose of *** weight of all organs was normal when compared with ***:The result suggests that black shilajit,an Ayurvedic formulation,is safe for long term use as a dietary supplement for a number of disoniers like iron deficiency anaemia.

关键词： Shilajit Graphite furnace Histopathology Flame atomic absorption spectroscopy

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肾性骨营养不良

国外医学（临床放射学分册） 1991年第1期14卷 21-23页

作者： sundaram M 殷玉明

慢性肾小球功能损害与骨病的关系在100多年以前已确定。1943年,Liu和Chu提出用肾性骨营养不良(renal osteodystrophy)来描述慢性肾衰引起的骨骼改变。在过去45年间,一直用这个名称来描述尿毒性和高氮质血症性骨营养不良。传统上,肾性骨... 详细信息

慢性肾小球功能损害与骨病的关系在100多年以前已确定。1943年,Liu和Chu提出用肾性骨营养不良(renal osteodystrophy)来描述慢性肾衰引起的骨骼改变。在过去45年间,一直用这个名称来描述尿毒性和高氮质血症性骨营养不良。传统上,肾性骨营养不良包括:①甲状旁腺机能亢进,②骨软化,③骨质疏松,④软组织钙化。

关键词：骨营养不良 X线诊断肾病

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Peanuts and Their Nutritional Aspects—A Review

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Food and Nutrition Sciences 2012年第12期3卷 1644-1650页

作者： V. S. Settaluri C. V. K. Kandala N. Puppala J. sundaram National Peanut Research Laboratory United States Department of Agriculture Agricultural Research Service Dawson USA New Mexico State University Las Cruces USA United States Department of Agriculture Agricultural Research Service Athens USA.

Peanut is a legume crop that belongs to the family of Fabaceae, genus Arachis, and botanically named as Arachis hypogaea. Peanuts are consumed in many forms such as boiled peanuts, peanut oil, peanut butter, roasted peanuts, and added peanut meal in snack food, energy bars and candies. Peanuts are considered as a vital source of nutrients. Nutrition plays an important role in growth and energy gain of living organisms. Peanuts are rich in calories and contain many nutrients, minerals, antioxidants, and vitamins that are essential for optimum health. All these biomolecules are essential for pumping vital nutrients into the human body for sustaining normal health. This paper presents an overview of the peanut composition in terms of the constituent biomolecules, and their biological functions. This paper also discusses about the relationship between consumption of peanuts and their effect on human metabolism and physiology. It highlights the usefulness of considering peanuts as an essential component in human diet considering its nutritional values.

关键词： Peanuts Nutrition Biomolecules Vitamins Minerals Plant Protein

Infection of Early and Young Callus Tissues of Indica Rice BPT5204 Enhances Regeneration and Transformation Efficiency

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Rice science 2013年第6期20卷 415-426页

作者： P.MANIMARAN G.RAVI KUMAR M.RAGHURAMI REDDY S.JAIN T.BHASKAR RAO S.K.MANGRAUTHIA R.M.sundaram S.RAVICHANDRAN S.M.BALACHANDRAN Biotechnology Laboratory Crop Improvement SectionDirectorate of Rice ResearchRajendranagarHyderabad 500030India

A rapid and reproducible method to develop transgenic plants with enhanced transformation efficiency using Agrobacterium has been developed for the elite indica rice variety BPT 5204. Different rice calli aged from 3 to 30 d were co-cultivated with pre-incubated Agrobacterium suspension culture （LBA4404： pSB1, pCAMBIA1301） and incubated in dark for 3 d. Based on the transient GUS gene expression analysis, 6-day-old young calli showed high transformation frequency followed by 21-day-old ones. Thus, both 6-and 21-day-old calli were used for assessing the stable transformation efficiency. It was observed that the 6-day-old young transformed calli showed about 2-fold higher regeneration frequency when compared with 21-day-old calli. The transformation efficiency was enhanced for young calli to 5.9% compared with 0.8% of the 21-day-old calli. Molecular and genetic analysis of transgenic plants （To） revealed the presence of 1-2 copies of T-DNA integration in transformants and it follows Mendalian ratio in T1 transgenic plants. From the present study, it was concluded that the development of transgenic rice plants in less duration with high regeneration and transformation efficiency was achieved in BPT 5204 by using 6-day-old young calli as explants.

关键词： Agrobacterium-mediated transformation meihod rice callus transformation transgenicplant indica rice

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