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Biomedical and Environmental Sciences 2023年第2期36卷 206-212页

作者： HONG Shan DING Chun Jie ZHOU Qiang sun yun zhe ZHANG Miao LI Ning DONG Xin Wen GUAN Yi ZHANG Lin TIAN Lin Qiang CAO Jia YAO Wu REN Wen Jie YAO San Qiao School of Public Health Xinxiang Medical UniversityXinxiang 453003HenanChina Department of Nephrology Xinxiang Second People’s HospitalXinxiang 453003HenanChina School of Public Health North China University ofScience and TechnologyTangshan 063210HebeiChina Clinical Medical Research Center for Women and ChildrenDiseases Maternal and Child Health Care Hospital of Shandong ProvinceShandong UniversityJinan 250001ShandongChina Institute of Trauma and Orthopedics Xinxiang Medical UniversityXinxiang 453003HenanChina ToxicologyResearch Institute PLA Army Medical UniversityChongqing 400038China School of Public Health ZhengzhouUniversityZhengzhou 450000HenanChina

Gas explosion injury is a compound injury caused by a shock wave,high-temperature flame,or toxic gas directly or indirectly acting on the human body,resulting in multiple organ damage.As a hyperaerated tissue,the lung is the primary organ that experiences an early injury.The pathological manifestations of gas-explosion-induced acute lung injury(ALI)include pulmonary tissue edema.

关键词： lung Lung acute

Particles attrition of binary mixtures in the coal-fueled chemical looping system based on fluidized bed

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Particuology 2024年第3期86卷 281-290页

作者： Heyu Li zhe sun Yan Cao Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Bejing 100049China CAS Key Laboratory of Renewable Energy Guangzhou 510640China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640China College of Chemistry and Chemical Engineering Anhui UniversityHefei230601China

In this work,a reactive air jet attrition device with auto-recording and collection of elutriated fines was developed.Results established insights into the physiochemical interaction and further correlated attrition behaviors between char and oxygen carriers under various operation modes.The attrition rate increased by over 110% upon the introduced CO_(2),which brought in the significant effect of thermo-chemical stress,similarly in effects of the increased char addition ratio and the decreased sizes of char or hematite in different extents.For the char-hematite co-attrition process,the elutriated carbon loss of char with poor mechanical strength was found to be over 10%,while the reactive iron loss of hematite was found to be 6.3%,and was enriched in elutriated fines.The reaction-derived thermochemical stress and the collision-derived mechanical stress jointly controls the particle attrition during the cyclic transformation of oxygen carrier particles in coal-fueled chemical looping fluidization,especially sig-nificant in its reduction stage.

关键词： Attrition Binary species Chemical looping Oxygen carrier CO_(2)capture

The role of inflammasomes in human diseases and their potential as therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 479-508页

作者： Jing Yao Keenan Sterling zhe Wang yun Zhang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053China Townsend Family Laboratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Key Laboratory of Neurodegenerative Diseases Ministry of EducationBeijingP.R.China zhejiang Clinical Research Center for Mental Disorders Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and The Affiliated Kangning HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325000China Oujiang Laboratory(zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000China

Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response.Each inflammasome complex has three major components:an upstream sensor molecule that is connected to a downstream effector protein such as caspase-1 through the adapter protein ASC.Inflammasome formation typically occurs in response to infectious agents or cellular damage.The active inflammasome then triggers caspase-1 activation,followed by the secretion of pro-inflammatory cytokines and pyroptotic cell death.Aberrant inflammasome activation and activity contribute to the development of diabetes,cancer,and several cardiovascular and neurodegenerative disorders.As a result,recent research has increasingly focused on investigating the mechanisms that regulate inflammasome assembly and activation,as well as the potential of targeting inflammasomes to treat various diseases.Multiple clinical trials are currently underway to evaluate the therapeutic potential of several distinct inflammasome-targeting therapies.Therefore,understanding how different inflammasomes contribute to disease pathology may have significant implications for developing novel therapeutic strategies.In this article,we provide a summary of the biological and pathological roles of inflammasomes in health and disease.We also highlight key evidence that suggests targeting inflammasomes could be a novel strategy for developing new disease-modifying therapies that may be effective in several conditions.

关键词： inflam therapeutic potential

Intraspecific floral colour variation in three Pedicularis species

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Plant Diversity 2024年第2期46卷 274-279页

作者： Qiu-Yu Zhang zhe Chen Hang sun Yang Niu State Key Laboratory of Plant Diversity and Specialty Crops Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina University of Chinese Academy of Sciences Beijing 100049China

Flower constancy describes the phenomenon that pollinators tend to successively visit flowers of a single species during foraging,reducing reproductive interference in natural communities.The extent of flower constancy is largely determined by the floral traits of co-flowering species.Both higher inter-specific and lower intraspecific differences of floral traits should contribute to a higher level of flower constancy.However,previous studies mainly focused on interspecific difference,and the intraspecific variation(consistency)of floral traits received much less attention.We hypothesise that selection may favour lower intraspecific floral trait variation in communities composed of multiple co-flowering congeners.We investigated the floral colour variation of three focal Pedicularis species that share pollinators in 19communities composed of either single or multiple Pedicularis species.Colour was quantified using image-based colour analysis as perceived by pollinators.We found that most of the intrapopulation floral colour variation was below the colour discrimination threshold of bumblebees,implying strongly constrained by the visual selection by pollinators.Contrary to the hypothesis,there is no significant difference in intraspecific floral colour variation between different community contexts.It may be due to the relatively large interspecific floral colour differences of most co-flowering species.The influence of community context on intraspecific variation may be reflected in floral traits other than colours.

关键词： Flower constancy Floral colour variation Plantepollinator interactions Pollinator vision

Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis:Implications for bone health

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World Journal of Stem Cells 2024年第4期16卷 389-409页

作者： Ling-Ling Wang Zhan-Jin Lu Shun-Kui Luo yun Li zhe Yang Hong-yun Lu Department of Gerontology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Endocrinology and Metabolism The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Endocrinology and Metabolism Zhuhai People’s Hospital(Zhuhai Clinical Medical College of Jinan Universitythe First Hospital Affiliated with Medical College of Macao University of Science and Technology)Zhuhai 519000Guangdong ProvinceChina

BACKGROUND Osteoporosis(OP)has become a major public health problem worldwide.Most OP treatments are based on the inhibition of bone resorption,and it is necessary to identify additional treatments aimed at enhancing osteogenesis.In the bone marrow(BM)niche,bone mesenchymal stem cells(BMSCs)are exposed to a hypoxic environment.Recently,a few studies have demonstrated that hypoxiainducible factor 2alpha(HIF-2α)is involved in BMSC osteogenic differentiation,but the molecular mechanism involved has not been determined.AIM To investigate the effect of HIF-2αon the osteogenic and adipogenic differentiation of BMSCs and the hematopoietic function of hematopoietic stem cells(HSCs)in the BM niche on the progression of OP.METHODS Mice with BMSC-specific HIF-2αknockout(Prx1-Cre;Hif-2αfl/fl mice)were used for in vivo experiments.Bone quantification was performed on mice of two genotypes with three interventions:Bilateral ovariectomy,semilethal irradiation,and dexamethasone treatment.Moreover,the hematopoietic function of HSCs in the BM niche was compared between the two mouse genotypes.In vitro,the HIF-2αagonist roxadustat and the HIF-2αinhibitor PT2399 were used to investigate the function of HIF-2αin BMSC osteogenic and adipogenic differentiation.Finally,we investigated the effect of HIF-2αon BMSCs via treatment with the mechanistic target of rapamycin(mTOR)agonist MHY1485 and the mTOR inhibitor rapamycin.RESULTS The quantitative index determined by microcomputed tomography indicated that the femoral bone density of Prx1-Cre;Hif-2αfl/fl mice was lower than that of Hif-2αfl/fl mice under the three intervention conditions.In vitro,Hif-2αfl/fl mouse BMSCs were cultured and treated with the HIF-2αagonist roxadustat,and after 7 d of BMSC adipogenic differentiation,the oil red O staining intensity and mRNA expression levels of adipogenesis-related genes in BMSCs treated with roxadustat were decreased;in addition,after 14 d of osteogenic differentiation,BMSCs treated with roxadustat exhibited increased expression of osteogenesis

关键词： Hypoxia-inducible factor-2α Bone marrow niche Bone mesenchymal stem cells Osteoporosis Osteogenic/adipogenic differentiation Mechanistic target of rapamycin signaling pathway

Tuberous sclerosis complex combined with primary lymphedema:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2642-2648页

作者： Xing-Peng Li Xiao-Li sun Xin Liu zhe Wen Li-Hua Jiang Yan Fu yun-Long Yue Ren-Gui Wang Department of Radiology Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China Department of Lymph Surgery Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China Department of Nuclear Medicine Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China Department of MRI Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China

BACKGROUND Tuberous sclerosis complex(TSC)and primary lymphedema(PLE)are both rare diseases,and it is even rarer for both to occur in the same patient.In this work,we have provided a detailed description of a patient's clinical presentation,imaging findings,and treatment.And a retrospective analysis was conducted on 14 published relevant case reports.CASE SUMMARY A 16-year-old male came to our hospital for treatment due to right lower limb swelling.This swelling is already present from birth.The patient’s memory had been progressively declining.Seizures had occurred 1 year prior at an unknown frequency.The patient was diagnosed with TSC combined with PLE through multimodal imaging examination:Computed tomography,magnetic resonance imaging,and lymphoscintigraphy.The patient underwent liposuction.The swelling of the patient's right lower limb significantly improved after surgery.Epilepsy did not occur.after taking antiepileptic drugs and sirolimus.CONCLUSION TSC with PLE is a rare and systemic disease.Imaging can detect lesions of this disease,which are important for diagnosis and treatment.

关键词： Tuberous sclerosis complex Lymphedema Sirolimus Multimodal imaging examination Case report

The importance of data assimilation components for initial conditions and subsequent error growth

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Science China Earth Sciences 2024年第1期67卷 105-116页

作者： Zhongrui WANG Haohao sun Lili LEI zhe-Min TAN Yi ZHANG Key Laboratory of Mesoscale Severe Weather Ministry of Educationand School of Atmospheric SciencesNanjing UniversityNanjing 210023China Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China

Despite a specific data assimilation method,data assimilation(DA)in general can be decomposed into components of the prior information,observation forward operator that is given by the observation type,observation error covariances,and background error covariances.In a classic Lorenz model,the influences of the DA components on the initial conditions(ICs)and subsequent forecasts are systematically investigated,which could provide a theoretical basis for the design of DA for different scales of interests.The forecast errors undergo three typical stages:a slow growth stage from 0 h to 5 d,a fast growth stage from 5 d to around 15 d with significantly different error growth rates for ensemble and deterministic forecasts,and a saturation stage after 15 d.Assimilation strategies that provide more accurate ICs can improve the predictability.Cycling assimilation is superior to offline assimilation,and a flow-dependent background error covariance matrix(Pf)provides better analyses than a static background error covariance matrix(B)for instantaneous observations and frequent time-averaged observations;but the opposite is true for infrequent time-averaged observations,since cycling simulation cannot construct informative priors when the model lacks predictive skills and the flow-dependent Pf cannot effectively extract information from low-informative observations as the static B.Instantaneous observations contain more information than time-averaged observations,thus the former is preferred,especially for infrequent observing systems.Moreover,ensemble forecasts have advantages over deterministic forecasts,and the advantages are enlarged with less informative observations and lower predictive-skill model priors.

关键词： Data assimilation Atmospheric predictability Background error covariances Ensemble forecasts

A game-theoretic approach for federated learning:A trade-off among privacy,accuracy and energy

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Digital Communications and Networks 2024年第2期10卷 389-403页

作者： Lihua Yin Sixin Lin zhe sun Ran Li Yuanyuan He Zhiqiang Hao Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China School of Cyber Science and Engineering Huazhong University of Science and TechnologyWuhan430074China China Industrial Control Systems Cyber Emergency Response Team Beijing100040China

Benefiting from the development of Federated Learning(FL)and distributed communication systems,large-scale intelligent applications become possible.Distributed devices not only provide adequate training data,but also cause privacy leakage and energy consumption.How to optimize the energy consumption in distributed communication systems,while ensuring the privacy of users and model accuracy,has become an urgent challenge.In this paper,we define the FL as a 3-layer architecture including users,agents and server.In order to find a balance among model training accuracy,privacy-preserving effect,and energy consumption,we design the training process of FL as game models.We use an extensive game tree to analyze the key elements that influence the players’decisions in the single game,and then find the incentive mechanism that meet the social norms through the repeated game.The experimental results show that the Nash equilibrium we obtained satisfies the laws of reality,and the proposed incentive mechanism can also promote users to submit high-quality data in FL.Following the multiple rounds of play,the incentive mechanism can help all players find the optimal strategies for energy,privacy,and accuracy of FL in distributed communication systems.

关键词： Federated learning Privacy preservation Energy optimization Game theory Distributed communication systems

Deciphering the Shared and Specific Drug Resistance Mechanisms of Anaplastic Lymphoma Kinase via Binding Free Energy Computation

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Research 2024年第1期2023卷 663-674页

作者： Yang Yu zhe Wang Lingling Wang Qinghua Wang Rongfan Tang Sutong Xiang Qirui Deng Tingjun Hou Huiyong sun Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 210009JiangsuP.R.China Innovation Institute for Artificial Intelligence in Medicine of zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058ZhejiangP.R.China

Anaplastic lymphoma kinase(ALK),a tyrosine receptor kinase,has been proven to be associated with the occurrence of numerous malignancies.Although there have been already at least 3 generations of ALK inhibitors approved by FDA or in clinical trials,the occurrence of various mutations seriously attenuates the effectiveness of the drugs.Unfortunately,most of the drug resistance mechanisms still remain obscure.Therefore,it is necessary to reveal the bottom reasons of the drug resistance mechanisms caused by the mutations.In this work,on the basis of verifying the accuracy of 2 main kinds of binding free energy calculation methodologies[end-point method of Molecular Mechanics with Poisson-Boltzmann/Generalized Born and Surface Area(MM/PB(GB)SA)and alchemical method of Thermodynamic Integration(TI)],we performed a systematic analysis on the ALK systems to explore the underlying shared and specific drug resistance mechanisms,covering the one-drug-multiple-mutation and multiple-drug-onemutation cases.

关键词： drugs Anaplastic clinical

Electricity Theft Detection Method Based on Ensemble Learning and Prototype Learning

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 213-224页

作者： Xinwu sun Jiaxiang Hu zhenyuan Zhang Di Cao Qi Huang zhe Chen Weihao Hu the School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengduChina Southwest University of Science and TechnologyChengduChina

With the development of advanced metering infrastructure(AMI),large amounts of electricity consumption data can be collected for electricity theft detection.However,the imbalance of electricity consumption data is violent,which makes the training of detection model challenging.In this case,this paper proposes an electricity theft detection method based on ensemble learning and prototype learning,which has great performance on imbalanced dataset and abnormal data with different abnormal level.In this paper,convolutional neural network(CNN)and long short-term memory(LSTM)are employed to obtain abstract feature from electricity consumption data.After calculating the means of the abstract feature,the prototype per class is obtained,which is used to predict the labels of unknown samples.In the meanwhile,through training the network by different balanced subsets of training set,the prototype is representative.Compared with some mainstream methods including CNN,random forest(RF)and so on,the proposed method has been proved to effectively deal with the electricity theft detection when abnormal data only account for 2.5%and 1.25%of normal data.The results show that the proposed method outperforms other state-of-the-art methods.

关键词： Electricity theft detection ensemble learning prototype learning imbalanced dataset deep learning abnormal level