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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

Research 2024年第2期2023卷 373-387页

作者： Di Wu yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

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Buchstaber Invariants of Universal Complexes

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Chinese Annals of Mathematics,Series B 2017年第6期38卷 1335-1344页

作者： yi sun School of Mathematical Sciences Fudan UniversityShanghai 200433China.

Davis and Januszkiewicz introduced(real and complex) universal complexes to give an equivalent definition of characteristic maps of simple polytopes, which now can be seen as "colorings". The author derives an equivalent definition of Buchstaber invariants of a simplicial complex K, then interprets the difference of the real and complex Buchstaber invariants of K as the obstruction to liftings of nondegenerate simplicial maps from K to the real universal complex or the complex universal complex. It was proved by Ayzenberg that real universal complexes can not be nondegenerately mapped into complex universal complexes when dimension is 3. This paper presents that there is a nondegenerate map from 3-dimensional real universal complex to 4-dimensional complex universal complex.

关键词： Buchstaber invariant Universal complex Lifting problem

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Improved Twin Support Vector Machine Algorithm and Applications in Classification Problems

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China Communications 2024年第5期21卷 261-279页

作者： sun yi Wang Zhouyang Beijing University of Posts and Telecommunications School of Computer Science(National Pilot Software Engineering School) Beijing University of Posts and Telecommunications International School

The distribution of data has a significant impact on the results of *** the distribution of one class is insignificant compared to the distribution of another class,data imbalance *** will result in rising outlier values and ***,the speed and performance of classification could be greatly *** the above problems,this paper starts with the motivation and mathematical representing of classification,puts forward a new classification method based on the relationship between different classification *** with the vector characteristics of the actual problem and the choice of matrix characteristics,we firstly analyze the orderly regression to introduce slack variables to solve the constraint problem of the lone *** we introduce the fuzzy factors to solve the problem of the gap between the isolated points on the basis of the support vector *** introduce the cost control to solve the problem of sample ***,based on the bi-boundary support vector machine,a twostep weight setting twin classifier is *** can help to identify multitasks with feature-selected patterns without the need for additional optimizers,which solves the problem of large-scale classification that can’t deal effectively with the very low category distribution gap.

关键词： fuzzy ordered regression(OR) relaxing variables twin support vector machine

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Thermodynamics and kinetics of extracting zinc from zinc oxide ore by the ammonium sulfate roasting method

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International Journal of Minerals,Metallurgy and Materials 2015年第5期22卷 467-475页

作者： yi sun Xiao-yi Shen Yu-chun Zhai School of Materials and Metallurgy Northeastern University

Thermodynamic analyses and kinetic studies were performed on zinc oxide ore treatment by （NH4）2SO4 roasting technology. The results show that it is theoretically feasible to realize a roasting reaction between the zinc oxide ore and （NH4）2SO4 in a temperature range of 573-723 K. The effects of reaction temperature and particle size on the extraction rate of zinc were also examined. It is found that a surface chemical reaction is the rate-controlling step in roasting kinetics. The calculated activation energy of this process is about 45.57 kJ/mol, and the kinetic model can be expressed as follows： 1 - （1 - α）1/3 = 30.85 exp（-45.57/RT）·t. An extraction ratio of zinc as high as 92% could be achieved under the optimum conditions.

关键词： zinc metallurgy extraction ammonium sulfate ore roasting thermodynamics kinetics

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Dyslipidemia and H pylori in gastric xanthomatosis

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World Journal of Gastroenterology 2007年第34期13卷 4598-4601页

作者： sun Young yi Department of Internal Medicine School of Medicine Ewha Womans University Seoul 158-710 South Korea

AIM： To investigate the relationship among gastric xanthomatosis （GX）, Hpylori, dyslipidemia, and gastritis in Korea, a well-known Hpylori endemic area.METHODS： A total of 771 patients who had undergone gastroduodenoscopy by one endoscopist were included in this study. Among them, 54 patients with GX were assessed for Hpylori infection and their endoscopic characteristics and serum lipid profiles. The findings were compared with 54 age- and sex-matched control subjects without GX.RESULTS： The prevalence of GX was 7% （54/771） with no sex difference. GX was mainly single （64.8%） and located in the antrum （53.7%）. The mean diameter was 7 ± 3 mm. Mean body mass index （BMI） of patients with GX was 23.1 ± 2.8 and no one was above 30. Compared with the controls, lipid profiles of GX group showed significantly lower HDL-cholesterol （48.8 ± 12.3 vs 62.9 ± 40.5, P = 0.028） and higher LDL-cholesterol （112.9 ± 29.9 vs 95.9 ± 22.4, P = 0.032）. The level of total serum cholesterol, triglyceride and the existence of dyslipoproteinemia were not related to the presence of GX. However, GX showed a close relationship with endoscopically determined atrophic gastritis and histologic severity （24/53, 44.4% vs 8/54, 14.8%, P = 0.0082）. H pylori infection and bile reflux gastritis were not significantly related with GX.CONCLUSION： The prevalence of GX is 7% and it may be an increasing entity in Korea. Moreover, dyslipidemia and atrophic gastritis are found to be related to GX, but lip, H pylori infection is not.

关键词： Xanthomatosis Dyslipidemia H pylori Gastritis

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Dark Energy Accretion onto a Black Hole in an Expanding Universe

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Communications in Theoretical Physics 2009年第9期52卷 441-444页

作者： sun Cheng-yi Institute of Modern Physics Northwest University Xi＇an 710069 China

By using the solution describing a black hole embedded in the FLRW universe,we obtain the evolvingequation of the black hole mass expressed in terms of the cosmological *** evolving equation indicates thatin the phant... 详细信息

关键词： black hole dark energy accretion FRW universe

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DRRS-BC:Decentralized Routing Registration System Based on Blockchain

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IEEE/CAA Journal of Automatica Sinica 2021年第12期8卷 1868-1876页

作者： Huimin Lu Yu Tang yi sun College of Computer Science and Technology Qingdao UniversityQingdao 266071China School of Engineering Kyushu Institute of TechnologyKitakyushu 804-8550Japan School of Computer Science(National Pilot Software Engineering School) Beijing University of Posts and TelecommunicationsBeijing 100876China

The border gateway protocol(BGP)has become the indispensible infrastructure of the Internet as a typical inter-domain routing ***,it is vulnerable to misconfigurations and malicious attacks since BGP does not provide enough authentication mechanism to the route *** a result,it has brought about many security incidents with huge economic *** solutions to the routing security problem such as S-BGP,So-BGP,Ps-BGP,and RPKI,are based on the Public Key Infrastructure and face a high security risk from the centralized *** this paper,we propose the decentralized blockchain-based route registration framework-decentralized route registration system based on blockchain(DRRS-BC).In DRRS-BC,we produce a global transaction ledge by the information of address prefixes and autonomous system numbers between multiple organizations and ASs,which is maintained by all blockchain nodes and further used for *** applying blockchain,DRRS-BC perfectly solves the problems of identity authentication,behavior authentication as well as the promotion and deployment problem rather than depending on the authentication ***,it resists to prefix and subprefix hijacking attacks and meets the performance and security requirements of route registration.

关键词： Blockchain decentralized routing protocol routing registration

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QUASICONTINUUM SIMULATION OF NANOINDENTATION OF NICKEL FILM

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Acta Mechanica Solida Sinica 2006年第4期19卷 283-288页

作者： Zeng Fanlin sun yi Department of Astronautic Science and Mechanics Harbin Institute of Technology Harbin 150001 China

A large-scale atom simulation of nanoindentation into a thin nickel film using the quasicontinuum method was performed. The initial stages of the plasticity deformation of nickel were studied. Several useful results were obtained as follows：（1） The response of the load versus indentation depth on the load versus indentation depth curve, besides the straight parts corresponding to the elastic property of nickel, the sudden drop of the load occurred several times; （2） The phenomena of dislocation nucleation -- the dislocation nucleation took place when the load descended, which makes it clear that dislocation nucleation causes the drop of the load; （3） The mechanism of the dislocation emission - the Peierls-Nabarro dislocation model and a pow- erful criterion were used to analyze the dislocation emission. And the computational value was in good agreement with the predict value; （4） The density of geometrically necessary dislocations. A simple model was used to obtain the density of geometrically necessary dislocations beneath the indenter. Furthermore, the influence of the boundary conditions on the simulation results was discussed.

关键词： quasicontinuum method nanoindentation dislocation nucleation density of geometrically necessary dislocation

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Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase

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Protein & Cell 2013年第2期4卷 103-116页

作者： yi sun Hua Li Division of Radiation and Cancer Biology Department of Radiation OncologyUniversity of Michigan4424B Medical Science-I1301 Catherine StreetAnn ArborMI 48109USA.

SAG(Sensitive to Apoptosis Gene),also known as RBX2(RING box protein 2),ROC2(Regulator of Cullins 2),or RNF7(RING Finger Protein 7),was originally cloned in our laboratory as a redox inducible antioxi-dant protein and later characterized as the second member of the RBX/ROC RING component of the SCF(SKP1-CUL-F-box Proteins)E3 ubiquitin *** acting alone,SAG scavenges oxygen radicals by forming inter-and intra-molecular disulfide bonds,whereas by forming a complex with other components of the SCF E3 ligase,SAG promotes ubiquitination and degradation of a number of protein substrates,includ-ing c-JUN,DEPTOR,HIF-1α,IκBα,NF1,NOXA,p27,and procaspase-3,thus regulating various signaling path-ways and biological ***,SAG pro-tects cells from apoptosis,confers radioresistance,and plays an essential and non-redundant role in mouse embryogenesis and ***,stress-inducible SAG is overexpressed in a number of human cancers and SAG overexpression correlates with poor patient ***,SAG transgenic expression in epidermis causes an early stage inhibi-tion,but later stage promotion,of skin tumorigenesis triggered by DMBA/*** its major role in pro-moting targeted degradation of tumor suppressive proteins,leading to apoptosis suppression and accel-erated tumorigenesis,SAG E3 ligase appears to be an attractive anticancer target.

关键词： antioxidant angiogenesis apoptosis Cullin-RING ligases radiation resistance reactive oxygen species SAG/RBX2/ROC2/RNF7 SCF E3 ligases tumori-genesis ubiquitin ligase vasculogenesis

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NADPH oxidase 4(NOX4)as a biomarker and therapeutic target in neurodegenerative diseases

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Neural Regeneration Research 2024年第9期19卷 1961-1966页

作者： Napissara Boonpraman sun Shin yi BK21 four Program Department of Medical SciencesSoonchunhyang UniversityAsanSouth Korea Department of Biomedical Laboratory Science Soonchunhyang UniversityAsanSouth Korea iConnectome Co.Ltd.CheonanSouth Korea

Diseases like Alzheimer’s and Parkinson’s diseases are defined by inflammation and the damage neurons undergo due to oxidative stress. A primary reactive oxygen species contributor in the central nervous system, NADPH oxidase 4, is viewed as a potential therapeutic touchstone and indicative marker for these ailments. This in-depth review brings to light distinct features of NADPH oxidase 4, responsible for generating superoxide and hydrogen peroxide, emphasizing its pivotal role in activating glial cells, inciting inflammation, and disturbing neuronal functions. Significantly, malfunctioning astrocytes, forming the majority in the central nervous system, play a part in advancing neurodegenerative diseases, due to their reactive oxygen species and inflammatory factor secretion. Our study reveals that aiming at NADPH oxidase 4 within astrocytes could be a viable treatment pathway to reduce oxidative damage and halt neurodegenerative processes. Adjusting NADPH oxidase 4 activity might influence the neuroinflammatory cytokine levels, including myeloperoxidase and osteopontin, offering better prospects for conditions like Alzheimer’s disease and Parkinson’s disease. This review sheds light on the role of NADPH oxidase 4 in neural degeneration, emphasizing its drug target potential, and paving the path for novel treatment approaches to combat these severe conditions.

关键词： Alzheimer’s disease astrocytes mitochondrial dysfunction myeloperoxidase NADPH oxidase 4 NADPH oxidase 4 inhibitors neurodegenerative diseases osteopontin Parkinson’s disease reactive oxygen species

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