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KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer

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Acta Pharmaceutica Sinica B 2023年第10期13卷 4217-4233页

作者： Cancan Zheng Xiaomei Yu Taoyang Xu Zhichao Liu Zhili Jiang Jiaojiao Xu Jing Yang Guogeng Zhang Yan He Han Yang xingyuan Shi Zhigang Li Jinbao Liu Wen Wen Xu Key Laboratory of Biological Targeting Diagnosis Therapy and Rehabilitation of Guangdong Higher Education Institutesthe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University.Shanghai 200030China Department of Radiation Oncology the Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Thoracic Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China Guangdong Provincial Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory Diseaseand School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhou 511495China

Increasing evidences suggest the important role of calcium homeostasis in hallmarks of cancer,but its function and regulatory network in metastasis remain unclear.A comprehensive investigation of key regulators in cancer metastasis is urgently *** sequencing(RNA-seq)of primary esophageal squamous cell carcinoma(ESCC)and matched metastatic tissues and a series of gain/loss-of-function experiments identified potassium channel tetramerization domain containing 4(KCTD4)as a driver of cancer ***4 expression was found upregulated in metastatic *** KCTD4 expression is associated with poor prognosis in patients with ESCC and contributes to cancer metastasis in vitro and in ***,KCTD4 binds to CLIC1 and disrupts its dimerization,thus increasing intracellular Ca^(2+)level to enhance NFATc1-dependent fibronectin ***4-induced fibronectin secretion activates fibroblasts in a paracrine manner,which in turn promotes cancer cell invasion via MMP24 signaling as positive ***,a lead compound K279-0738 significantly suppresses cancer metastasis by targeting the KCTD4-CLIC1 interaction,providing a potential therapeutic *** together,our study not only uncovers KCTD4 as a regulator of calcium homeostasis,but also reveals KCTD4/CLIC1-Ca^(2+)-NFATc1-fibronectin signaling as a novel mechanism of cancer *** findings validate KCTD4 as a potential prognostic biomarker and therapeutic target for ESCC.

关键词： Cancermetastasis Calcium homeostasis NFAT signaling Fibroblasts Esophageal cancer

New Discovery of Post-Magmatic Pyrite in Natural Coke at Yangliu Coalmine,Northern China

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Acta Geologica Sinica(English Edition) 2018年第6期92卷 2436-2437页

作者： AN Yanfei CHEN Yixiang ZHANG Shuai LI xingyuan LAI Chunkit School of Resource and Environment Engineering Anhui UniversityHefei 230601China Key Laboratory of Geological Process and Mineral Resource Survey of Guangdong Guangzhou 510275China School of Earth Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China Department of Geology University of ReginaReginaSaskatchewan S4S OA2Canada Faculty of Science Universiti Brunei DarussalamGadong BE1410Brunei Centre for Excellence in Ore Deposits University of TasmaniaHobart 7001Australia

Objective Material exchange between magma and coal has recently received much attention, with published studies dedicated mainly to intrusion-related geochemical anomalies(An et al., 2017). It is found that magmatism not only alters the chemical compositions of coal seams, but also brings new minerals to natural coke. Although some studies have related magmatic water to secondary minerals in the natural coke, the mineral formation

关键词： REE Northern China New Discovery of Post-Magmatic Pyrite in Natural Coke at Yangliu Coalmine

Flexible Zn-ion batteries based on manganese oxides: Progress and prospect

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Carbon Energy 2020年第3期2卷 387-407页

作者： xingyuan Gao Haozhe Zhang Xiaoqing Liu Xihong Lu Department of Chemistry Engineering Technology Development Center of Advanced Materials&Energy Saving and Emission Reduction in Guangdong Colleges and UniversitiesGuangdong University of EducationGuangzhouChina MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry The Key Lab of Low-carbon Chem&Energy Conservation of Guangdong ProvinceSchool of ChemistrySun Yat-Sen UniversityGuangzhouChina

The ever-growing market of wearable electronic devices has greatly stimulated the rapid development of flexible Zn-ion batteries(ZIBs).Manganese oxides are one of the most commonly used hosts for zinc ion accommodation and thus receive particular research interest for high-performance flexible ZIB *** this review,a comprehensive summary of the recent development of flexible ZIBs with manganese oxides as cathode materials is *** from the brief introduction of flexible electronic devices and ZIBs,the charge storage mechanisms and crystal structures of various manganese oxides are *** of the cathode materials in terms of morphology,conductivity,structures,and flexibilities are illustrated in detail,together with the demonstration of structure-performance relationships and applications in flexible ***,limitations to be overcome are indicated and the future work directions are proposed.

关键词： cathodes flexible devices manganese oxides MnO2 Zn-ion batteries

Polymeric Complex Nanoparticles Enable the Fabrication of Mechanically Superstrong and Recyclable Poly(aryl ether sulfone)-based Polymer Composites

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CCS Chemistry 2020年第1期2卷 524-532页

作者： xingyuan Lu Yuchao Luo Yixuan Li Chunyang Bao Xiaohan Wang Ni An Guibin Wang Junqi sun State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012(China) Key Laboratory of High Performance Plastics Ministry of EducationCollege of ChemistryJilin UniversityChangchun 130012(China)

It is a long-term pursuit,and also,a challenge to significantly improve the mechanical strength of thermoplastic polymers using readily dispersed polymers as *** this study,we demonstrated that in situ formed carboxylic acid-functionalized poly(aryl ether sulfone)(PAES-COOH)/polyvinylpyrrolidone(PVPON)complex nanoparticles can significantly enhance the mechanical strength of PAES-COOH by mixing PAES-COOH with a small fraction of *** PAES-COOH/PVPON10%composite,which contained∼10 wt%PVPON,exhibited a tensile strength of∼104.8 MPa and Young’s modulus of∼932.2 MPa,which were∼2.0 and∼1.7 times higher than those of the PAES-COOH,*** PAES-COOH/PVPON nanoparticles which were uniformly dispersed in PAES-COOH matrices and had strong hydrogen-bonding interactions with PAES-COOH,served as nanofillers to reinforce the mechanical strength of the *** PAES-COOH/PVPON_(10%)composites possessed excellent solvent-assisted healability,and the fractured composites could be healed to restore their original mechanical ***,the PAES-COOH/PVPON_(10%)composites could be recycled multiple times,and yet retained their shape integration and their original mechanical strength.

关键词： polymer complexes supramolecular chemistry materials science high-strength materials recyclable materials

赞比亚索卢韦齐地区新元古代石英二长岩的成因:年代学、地球化学和Sr-Nd-Hf同位素约束

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西北地质 2023年第5期56卷 20-34页

作者：许康康孙凯吴兴源中国地质调查局天津地质调查中心(华北地质科技创新中心) 天津300170 中国地质调查局南部非洲矿业研究所天津300170

研究卢菲利安弧地区新元古代与裂谷作用有关的基性–中酸性岩浆作用,对了解区域地壳生长和演化具有重要意义。研究表明,卢菲利安弧地区发育有大量新元古代与裂谷作用有关的基性岩类,但相关的中酸性岩岩浆作用却鲜有报道。笔者首次在赞... 详细信息

研究卢菲利安弧地区新元古代与裂谷作用有关的基性–中酸性岩浆作用,对了解区域地壳生长和演化具有重要意义。研究表明,卢菲利安弧地区发育有大量新元古代与裂谷作用有关的基性岩类,但相关的中酸性岩岩浆作用却鲜有报道。笔者首次在赞比亚索卢韦齐地区发现有新元古代的石英二长岩体,锆石U–Pb年龄为(707.1±3.0)Ma。地球化学特征显示该岩体具有较低的MgO(0.46%~0.76%)、CaO(1.63%~1.76%)、K2O(0.49%~0.56%)、Mg#值(8~13)和Sr/Y值(1.14~2.50),较高的Al_(2)O_(3)(15.61%~16.02%)。岩体富集轻稀土和高场强元素HFSEs(Nb、Ta、Hf),(La/Yb)N值为6.64~7.86,亏损P、Ti、Zr和大离子亲石元素LILEs(Rb、Ba、Sr、K)。此外,石英二长岩具有低的初始87Sr/86Sr值(0.7058~0.7060),正的εNd(t)值(1.89~2.03)和锆石εHf(t)值(1.30~5.67),该特征与索卢韦齐地区新元古代早期辉长岩相似,推测石英二长岩可能为新生的镁铁质下地壳在中–低压条件下部分熔融形成的。综合地质年代学和岩石成因研究,笔者认为卢菲利安弧地区在新元古代经历了多阶段的地壳生长作用,后期侵位的地幔岩浆加热早期就位于下地壳的镁铁质岩石并导致其部分熔融,从而达到对地壳的改造作用。

关键词：石英二长岩新元古代岩石成因 Lufilian弧赞比亚

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可逆交联聚合物材料：修复、循环利用与降解

中国材料进展 2022年第1期41卷 39-51+66-67页

作者：李懿轩李天奇陆星远孙俊奇吉林大学化学学院超分子结构与材料国家重点实验室

传统聚合物材料在给人类社会创造便利的同时，也引起了严重的资源浪费和环境污染问题。大力发展可修复、可循环利用及可降解的聚合物材料，能够有效缓解资源浪费及环境污染问题，对构建可持续发展社会具有重要意义。系统总结了基于非共... 详细信息

传统聚合物材料在给人类社会创造便利的同时，也引起了严重的资源浪费和环境污染问题。大力发展可修复、可循环利用及可降解的聚合物材料，能够有效缓解资源浪费及环境污染问题，对构建可持续发展社会具有重要意义。系统总结了基于非共价相互作用及动态共价键的可逆交联聚合物体系制备可修复、可循环利用及可降解聚合物材料方面的进展。基于作者研究组的工作，着重阐述了如何利用多重可逆作用力及微结构的协同制备具有高强度、高韧性及优异抗撕裂性能的可修复与可循环利用聚合物材料，以及具有良好环境稳定性的、可降解的超分子塑料。设计制备基于非共价相互作用与动态共价键的可逆交联聚合物体系，是发展可修复、可循环利用及可降解的聚合物材料的有效思路。

关键词：可逆交联聚合物超分子化学聚合物复合物自修复材料循环利用材料可降解材料

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复杂水下环境中的Dual-HFM速度谱优化

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系统工程与电子技术 2023年第10期45卷 2999-3007页

作者：扶钰斌马晓川李璇孙博昊陈筱月裴兴园中国科学院声学研究所水下航行器实验室北京100190 中国科学院大学北京100049

在理想环境下,双双曲调频(dual hyperbolic frequency modulation,Dual-HFM)速度谱估计方法可得到高分辨率的连续多普勒估计结果。然而由多径、双目标环境引起的旁瓣干扰,削弱了速度谱方法抑制噪声的能力,影响目标参数估计。针对该方法... 详细信息

在理想环境下,双双曲调频(dual hyperbolic frequency modulation,Dual-HFM)速度谱估计方法可得到高分辨率的连续多普勒估计结果。然而由多径、双目标环境引起的旁瓣干扰,削弱了速度谱方法抑制噪声的能力,影响目标参数估计。针对该方法在多径、双目标等各种复杂水声环境中的应用,进行了深入的讨论,推导了多径、双目标造成的速度谱旁瓣位置,并提出了基于多帧信号的速度谱旁瓣抑制方法,利用另一维度信号空间中目标回波信息与多径杂波旁瓣的差异性,抑制了复杂水下环境中的速度谱旁瓣,并保留了速度谱计算量低的优点。通过数值仿真验证了所提方法的适用性,为低信噪比、多径、双目标环境下的多普勒估计提供了理论依据。

关键词：双双曲调频信号多普勒估计多径效应多帧信号旁瓣抑制

A new artificial photosynthetic system coupling photovoltaic electrocatalysis with solar heating catalysis

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National Science Open 2023年第6期2卷 17-28页

作者： Yaguang Li Fanqi Meng Xianhua Bai Dachao Yuan xingyuan San Shufang Wang Lin Gu Qingbo Meng Research Center for Solar Driven Carbon Neutrality Hebei Key Lab of Optic-electronic Information and MaterialsThe College of Physics Science and TechnologyInstitute of Life Science and Green DevelopmentHebei UniversityBaoding 071002China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China College of Mechanical and Electrical Engineering Hebei Agricultural UniversityBaoding 071001China

In this work,we present a novel artificial photosynthetic paradigm with square meter(m^(2))level scalable production by integrating photovoltaic electrolytic water splitting device and solar heating CO_(2)hydrogenation device,successfully achieving the synergy of 1 sun driven 19.4%solar to chemical energy efficiency(STC)for CO production(2.7 times higher than that of large-sized artificial photosynthetic systems)with a low cost(equivalent to 1/7 of reported artificial photosynthetic systems).Furthermore,the outdoor artificial photosynthetic demonstration with 1.268 m^(2)of scale exhibits the CO generation amount of 258.4 L per day,the STC of~15.5%for CO production in winter,which could recover the cost within 833 sunny days of operation by selling CO.

关键词： artificial photosynthetic photovoltaic electrocatalysis solar heating catalysis CO_(2)hydrogenation low cost

降雨诱发堆积体滑坡水土响应与稳定性时空演化试验研究

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水文地质工程地质 2023年第1期50卷 104-112页

作者：孟生勇江兴元杨义孙乾征史文兵贵州大学资源与环境工程学院贵州贵阳550025 贵州大学喀斯特地质资源与环境教育部重点实验室贵州贵阳550025 贵州省地质矿产勘查开发局一〇四地质大队贵州都匀558000

降雨在松散堆积土中入渗引起内部水土力学的变化是影响稳定性的关键。目前研究多侧重考虑颗粒粒径、含量等因素对斜坡破坏的影响,但是针对斜坡体内部水土响应及稳定性时空演化方面的研究存在不足。基于野外滑坡案例,通过室内降雨滑坡模... 详细信息

降雨在松散堆积土中入渗引起内部水土力学的变化是影响稳定性的关键。目前研究多侧重考虑颗粒粒径、含量等因素对斜坡破坏的影响,但是针对斜坡体内部水土响应及稳定性时空演化方面的研究存在不足。基于野外滑坡案例,通过室内降雨滑坡模型试验、土力学试验和理论分析手段,研究了降雨触发松散堆积体斜坡变形破坏过程及模式,采用Van Genuchten模型(VG模型)重构了土体的土-水特征曲线,重点探究了斜坡内部水土力学变化以及稳定性时空演化规律。结果表明:(1)堆积体斜坡破坏经历了微裂隙发育-局部破坏-整体破坏3个阶段,呈现出“初期拉裂-坡面坍塌-塑性滑动”的破坏模式;(2)入渗过程斜坡体积含水率以及孔隙水压力急速增加,而土颗粒之间基质吸力下降甚至消散,促进了斜坡破坏发展;(3)土体力学强度随体积含水率升高呈指数下降,体积含水率为36.3%时,有效黏聚力和有效内摩擦角仅为0.27 kPa、3.39°;(4)基于极限平衡理论和斜坡土水特征监测数据,构建了斜坡稳定性时空演化图谱,与模型试验破坏特征有较好的一致性。研究结果对降雨作用下的堆积层斜坡监测预警与防灾减灾提供理论支撑。

关键词：堆积体斜坡降雨入渗水槽试验稳定性分析水文响应