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Genetic dissection of the grain-filling rate and related traits through linkage analysis and genome-wide association study in bread wheat

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Journal of Integrative Agriculture 2022年第10期21卷 2805-2817页

作者： YU Hai-xia DUAN Xi-xian sun Ai-qing sun xiao-xiao ZHANG Jing-juan sun Hua-qing sun Yan-yan NING Tang-yuan TIAN Ji-chun WANG Dong-xue LI Hao FAN Ke-xin WANG Ai-ping MA Wu-jun CHEN Jian-sheng State Key Laboratory of Crop Biology/Key Laboratory of Crop Water Physiology and Drought-tolerance Germplasm Improvement Minstry of Agriculture and Rural Affairs/Group of Wheat Quality BreedingCollege of AgronomyShandong Agricultural UniversityTai’an 271018P.R.China Dezhou Agricultural Protection and Technological Extension Center Dezhou 253000P.R.China Zhongnong Tiantai Seed Co. Ltd.Pingyi 273300P.R.China School of Veterinary and Life Sciences Murdoch UniversityMurdochWA 6150Australia

Wheat grain yield is generally sink-limited during grain *** grain-filling rate(GFR)plays a vital role but is poorly studied due to the difficulty of phenotype *** study explored the grain-filling traits in a recombinant inbred population and wheat collection using two highly saturated genetic maps for linkage analysis and genome-wide association study(GWAS).Seventeen stable additive quantitative trait loci(QTLs)were identified on chromosomes 1B,4B,and *** linkage interval between IWB19555 and IWB56078 showed pleiotropic effects on GFR_(1),GFR_(max),kernel length(KL),kernel width(KW),kernel thickness(KT),and thousand kernel weight(TKW),with the phenotypic variation explained(PVE)ranging from 13.38%(KW)to 33.69%(TKW).198 significant marker-trait associations(MTAs)were distributed across most chromosomes except for 3D and *** major associated sites for GFR included IWB44469(11.27%),IWB8156(12.56%)and IWB24812(14.46%).Linkage analysis suggested that IWB35850,identified through GWAS,was located in approximately the same region as QGFR_(max)2B.3-11,where two high-confidence candidate genes were *** important grain weight(GW)-related QTLs colocalized with grain-filling *** findings contribute to understanding the genetic architecture of the GFR and provide a basic approach to predict candidate genes for grain yield trait QTLs.

关键词： wheat grain-filling rate linkage analysis genome-wide association study

Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

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Science China Chemistry 2025年第1期68卷 273-287页

作者： Shuguang Yang Lijun Hu Hong xiao Zecong xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-sen University Department of Ultrasound The Fifth Affiliated Hospital Sun Yat-sen University Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen University Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen University

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

关键词： fluorescent molecular probes self-amplifying myeloperoxidase photodynamic therapy

MI_3(M=Bi,Sb,As)弹性和电子性质的第一性原理研究

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人工晶体学报 2019年第1期48卷 110-116页

作者：孙霄霄牡丹江师范学院物理与电子工程学院牡丹江157012

采用基于密度泛函理论的第一性原理平面波赝势计算方法,对比研究了菱方结构MI_3(M=Bi,Sb,As)的弹性和电子性质。结果表明:SbI_3的生成焓最低,较BiI_3、AsI_3更易生成。这三种材料都体现了弹性各向异性特征。SbI_3是偏延性材料,BiI_3和As... 详细信息

采用基于密度泛函理论的第一性原理平面波赝势计算方法,对比研究了菱方结构MI_3(M=Bi,Sb,As)的弹性和电子性质。结果表明:SbI_3的生成焓最低,较BiI_3、AsI_3更易生成。这三种材料都体现了弹性各向异性特征。SbI_3是偏延性材料,BiI_3和AsI_3是脆性材料。高压下AsI_3更容易被压缩。德拜温度的大小关系依次为SbI_3> BiI_3> AsI_3。MI_3(M=Bi,Sb,As)都是间接带隙半导体,电子的局域程度较强。在费米能级附近,I-5p轨道电子和金属M-s轨道电子发生杂化,形成共价键。MI_3(M=Bi,Sb,As)中的化学键是共价键和离子键的混合。

关键词：第一性原理 MI3 弹性性质电子结构

PS-CoT-Adapter: adapting plan-and-solve chain-of-thought for ScienceQA

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Science China(Information Sciences) 2025年第1期68卷 392-393页

作者： Qun LI Haixin sun Fu xiao Yiming WANG Xinping GAO Bir BHANU School of Computer Science Nanjing University of Posts and Telecommunications Purple Mountain Laboratories Department of Electrical and Computer Engineering University of California at Riverside

Large language models (LLMs) have recently shown remarkable performance in a variety of natural language processing (NLP) *** further explore LLMs'reasoning abilities in solving complex problems,recent research [1-3]has investigated chain-of-thought (CoT) reasoning in complex multimodal scenarios,such as science question answering (ScienceQA) tasks [4],by fine-tuning multimodal models through human-annotated CoT ***,collected CoT rationales often miss the necessary rea-soning steps and specific expertise.

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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面阵CMOS光纤光谱仪研制

光子学报 2013年第1期42卷 74-78页

作者：孙小小黄梅珍汪洋上海交通大学物理系光科学与工程研究中心上海200240

研制了一种以非对称交叉Czerny-Turner光路为结构的互补金属氧化物半导体小型光纤光谱仪样机,探讨了以面阵互补金属氧化物半导体图像传感器作为光电探测器的光度测量准确性和线性问题,分析了杂散光对吸光度测量的影响.结论是:通过光强... 详细信息

研制了一种以非对称交叉Czerny-Turner光路为结构的互补金属氧化物半导体小型光纤光谱仪样机,探讨了以面阵互补金属氧化物半导体图像传感器作为光电探测器的光度测量准确性和线性问题,分析了杂散光对吸光度测量的影响.结论是:通过光强定标和非线性修正后,互补金属氧化物半导体小型光纤光谱仪可以满足一般的应用要求,其光谱测量范围为380～800nm,光谱带宽约6nm,积分时间1～500ms,波长准确度±1nm,光度准确度±0.03AU.该光谱仪具有小型化、低成本、速度快等优点.

关键词：互补金属氧化物半导体吸光度光强定标

中国行业间劳动要素配置扭曲及对经济的影响分析

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数理统计与管理 2021年第2期40卷 352-365页

作者：任韬孙潇筱首都经济贸易大学统计学院北京100070

劳动是生产的重要要素,其在行业间配置是否合理,对于经济的效率具有重要影响.本文基于C-D生产函数建立了行业间劳动要素的优化配置模型,以人力资本作为代表性变量对劳动要素在行业间的配置扭曲情况进行了估算与分析,并通过对比配置优化... 详细信息

劳动是生产的重要要素,其在行业间配置是否合理,对于经济的效率具有重要影响.本文基于C-D生产函数建立了行业间劳动要素的优化配置模型,以人力资本作为代表性变量对劳动要素在行业间的配置扭曲情况进行了估算与分析,并通过对比配置优化前后全社会全要素生产率的变化分析了劳动要素配置扭曲对经济的影响.本文研究显示,我国行业间劳动要素配置扭曲情况较为严重,如果能够按照优化原则矫正扭曲,则会提高全社会产出总量和全要素生产率.最后,本文对矫正劳动要素配置扭曲的实现路径提出了建议.

关键词：劳动要素要素配置扭曲全要素生产率人力资本

Innovative dual-mode device integrating capacitive desalination and solar vapor generation for high-efficiency seawater desalination

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Journal of Energy Chemistry 2025年第1期100卷 171-179页

作者： Jiacheng Wang Zhaoyu Chen Ruduan Yuan Jiaxin Luo Ben Zhang Keju Ji Meng Li Juanxiu xiao Kuan sun National Innovation Center for Industry-Education Integration of Energy Storage Technology MOE Key Laboratory of Low-grade Energy Utilization Technologies and SystemsCollege of Energy & Power Engineering Chongqing University Xuefeng Mountain Energy Equipment Safety National Observation and Research Station CQU-NUS Renewable Energy Materials & Devices Joint Laboratory Chongqing University Southwest Technology and Engineering Research Institute Jiangsu Provincial Key Laboratory of Bionic Functional Materials College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University

Solar-driven interface evaporation with high solar-to-steam conversion efficiency has shown great potential in seawater ***,due to the influence of latent heat and condensation efficiency,the water yield from solar-driven interface evaporation remains insufficient,posing a significant challenge that requires *** this work,we designed a dual-mode high-flux seawater desalination device that combines solar-driven interface evaporation and capacitive *** utilizing coupled desalination materials exhibiting both photothermal conversion and capacitance activity,the device demonstrated photothermal evaporation rates of 1.41 and 0.97 kg m-2h-1for condensate water yield under one-sun ***,the device exhibited a salt adsorption capacity of up to48 mg g-1and a salt adsorption rate of 2.1 mg *** addition,the salt adsorption capacity increased by approximately 32% under one-sun ***,photo-enhanced capacitive desalination performance was explored through numerical simulations and theoretical *** calculations and characterizations confirmed that the defect energy levels formed by the introduction of sulfur vacancies can effectively widen the light absorption range,improve photothermal conversion performance,and stimulate more photoelectrons to participate in capacitive ***,the electron distribution state of molybdenum disulfide with sulfur vacancies and surface defect sites contributes to ion/electron transport at the solid-liquid *** work provides a novel pathway for integrating solar vapor generation with other low-energy desalination technologies.

关键词： Desalination

Physics based circuit compatible model for hybrid antiferroelectric random access memory

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Science China(Information Sciences) 2025年第1期68卷 396-397页

作者： Qiuxia WU Yue PENG Wenwu xiao Wenxuan MA Shuo ZHANG Litao sun Chunfu ZHANG xiaohua MA Yue HAO School of Microelectronics Xidian University Xi'an Uni IC Semiconductors

Since the discovery of HfO2-based ferroelectric （FE） materials in 2011,considerable advancements have been made in material preparation,mechanism research,and device realization [1].Consequently,these materials are now regarded as leading candidates for embedded non-volatile memory（eNVM）.Beyond eNVM applications,recent studies have demonstrated that memory devices with antiferroelectric（AFE） films can achieve high response speeds,low latency,and reduced power consumption while maintaining excellent endurance characteristics [2,3].Additionally,the typical double hysteresis loops and multiple non-overlapping polarization current peaks of AFE films offer a novel approach to designing multistate ***,in order to further promote the application of high storage density AFE,an AFRAM electronic design automation （EDA） model must be developed,and it has yet to be proposed.

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