检索结果-南通市图书馆

First experimental constraints on WIMP couplings in the effective field theory framework from CDEX

在线全文

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2021年第8期64卷 15-22页

作者： Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li renMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao Jifang Zhou ZuYing Zhou JingJun Zhu Key Laboratory of Particle and Radiation Imaging(Ministry of Education) Department of Engineering PhysicsTsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China College of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China Sino-French institute of Nuclear and Technology Sun Yet-sen UniversityZhuhai 519082China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Department of Physics Banaras Hindu UniversityVaranasi 221005India Department of Physics Beijing Normal UniversityBeijing 100875China School of Physics Nankai UniversityTianjin 300071China

We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the china Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)2. region.

关键词： WIMP EFT CDEX dark matter annual modulation

在线全文

学校读者我要写书评

暂无评论

财务欺诈风险特征筛选框架的建立和应用

中国管理科学 2022年第3期30卷 43-54页

作者：袁先智周云鹏严诚幸刘海洋钱国骐王帆韦立坚李志勇李波李祥林曾途成都大学商学院四川成都610106 中山大学管理学院广东广州510275 成都数联铭品科技有限公司(BBD) 四川成都610000 墨尔本大学数学与统计学院澳大利亚墨尔本VIC3010 西南财经大学金融学院四川成都611137 重庆理工大学理学院重庆400054 上海高级金融学院上海200030

本文从金融科技大数据出发,以人工智能的吉布斯随机搜索(Gibbs Sampling)算法为工具,在大数据框架下建立了针对公司财务欺诈风险的特征因子筛选的一般处理方法与特征提取推断原理,并结合上市公司的财务报表数据进行实证分析,结合从2.17... 详细信息

本文从金融科技大数据出发,以人工智能的吉布斯随机搜索(Gibbs Sampling)算法为工具,在大数据框架下建立了针对公司财务欺诈风险的特征因子筛选的一般处理方法与特征提取推断原理,并结合上市公司的财务报表数据进行实证分析,结合从2.17年1月到2.18年12.证监会对上市公司财务报表信息披露违规的数据样本,筛选出刻画财务欺诈的特征因子并进行了验证测试,支持财务欺诈的识别。本文提出的框架和模型方法可以加强和提升对上市公司财务欺诈风险的识别能力,并实现对公司财务在欺诈方面的探测与预测(Detecting and Predicting)功能。

关键词：大数据吉布斯随机搜索(Gibbs Sampling)抽样随机搜索算法 SAS99 财务欺诈风险舞弊三角理论特征提取推断原理

因地而异的气候变化健康影响需要因地而异的应对措施

在线全文

学校读者我要写书评

暂无评论

科学通报 2021年第31期66卷 3925-3931页

作者：蔡闻佳张弛孙凯平艾思奇白玉琪鲍俊哲陈彬程亮亮崔学勤戴瀚程底骞董文轩窦德景范维澄范星高仝耿阳关大博郭亚菲胡艺馨华峻翊黄存瑞黄弘黄建斌蒋婷婷焦珂笛 Gregor Kiesewetter Zbigniew Klimont Pete Lampard 李传玺李奇玮李湉湉李瑞奇林波荣林华亮刘欢刘起勇刘小波刘昱甫刘钊刘志东刘竹楼书含鲁晨曦罗勇马伟 Alice McGushin 牛彦麟任超任浙豪阮增良 Wolfgang Schöpp 苏婧屠滢王杰王琼王雅琪王宇 Nick Watts 肖淙曦谢杨熊辉徐名芳徐冰许磊杨军杨廉平俞乐岳玉娟张少辉张仲宸赵继尧赵亮赵梦真赵哲周景博宫鹏清华大学地球系统科学系地球系统数值模拟教育部重点实验室北京100084 清华大学中国新型城镇化研究院健康城市研究中心北京100084 清华大学中国城市研究院北京100084 北京理工大学管理与经济学院北京100081 北京大学亚太经合组织健康科学研究院北京100871 中山大学公共卫生学院广州510080 郑州大学公共卫生学院郑州450001 北京师范大学环境学院北京100875 北京大学环境科学与工程学院北京100871 清华大学万科公共卫生学院北京100084 清华大学公共安全研究所北京100084 清华大学工程物理系北京100084 百度研究院北京100091 山东师范大学环境与生态研究院济南250013 山东师范大学商学院济南250013 清华大学建筑学院北京100084 Bartlett School of Construction and Project Management University College LondonLondon WC1H 0ALUK 中国疾病预防控制中心传染病预防控制所北京102206 南方科技大学统计与数据科学系深圳518055 香港大学建筑学院香港山东大学齐鲁医院公共卫生学院流行病学系济南250002 Air Quality and Greenhouse Gases Programme International Institute for Applied Systems Analysis(IIASA)Vienna 1-A-2361Austria Department of Health Sciences University of YorkYork YO105DDCanada 清华大学环境学院北京100084 中国疾病预防控制中心环境与人群健康重点实验室中国疾病预防控制中心环境与健康相关产品安全所北京100021 institute for Global Health University College LondonLondon WC1H 0ALUK 清华大学人文学院北京100084 中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室北京100029 清华大学五道口金融学院北京100084 中国科技大学计算机科学与技术学院合肥230027 北京航空航天大学经济与管理学院北京100083 Rutgers Business School the State University of New JerseyNew Brunswick NJ 07102USA 暨南大学环境与气候研究所广州510632 香港大学香港

气候变化的趋势正在对全球的人群健康造成巨大的威胁,迫切需要各国密切协作,积极应对气候变化,为此《柳叶刀》(The Lancet)杂志成立了"柳叶刀健康与气候变化委员会"(以下简称柳叶刀委员会),评估气候变化对人群健康的影响,并寻找保障人... 详细信息

气候变化的趋势正在对全球的人群健康造成巨大的威胁,迫切需要各国密切协作,积极应对气候变化,为此《柳叶刀》(The Lancet)杂志成立了"柳叶刀健康与气候变化委员会"(以下简称柳叶刀委员会),评估气候变化对人群健康的影响,并寻找保障人群健康的应对气候变化措施.柳叶刀委员会在2.15年报告基础上,启动了"柳叶刀倒计时:追踪健康与气候变化进展"项目(以下简称柳叶刀倒计时)[1],每年在《柳叶刀》上发表全球应对气候变化和保护人群健康的最新进展.

关键词：气候变化人群健康柳叶刀倒计时应对措施

在线全文

学校读者我要写书评

暂无评论

二维材料最新研究进展

物理化学学报 2021年第12期37卷 1-151页

作者：常诚陈伟陈也陈永华陈雨丁峰樊春海范红金范战西龚成宫勇吉何其远洪勋胡晟胡伟达黄维黄元季威李德慧李连忠李强林立凌崇益刘鸣华刘楠刘庄 Kian Ping Loh 马建民缪峰彭海琳邵明飞宋礼苏邵孙硕谭超良唐智勇王定胜王欢王金兰王欣王欣然 Andrew T.S.Wee 魏钟鸣吴宇恩吴忠帅熊杰熊启华徐伟高尹鹏曾海波曾志远翟天佑张晗张辉张其春张铁锐张翔赵立东赵美廷赵伟杰赵运宣周凯歌周兴周喻朱宏伟张华刘忠范 institute of Science and Technology Austria Am Campus 13400 KlosterneuburgAustria Department of Chemistry National University of Singapore3 Science Drive 3117543Singapore Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong KongChina Key Laboratory of Flexible Electronics and institute of Advanced Materials Nanjing Tech UniversityNanjing 211816China School of Life Sciences Shanghai UniversityShanghai 200444China Centre for Multidimensional Carbon Materials Institute for Basic ScienceUlsan 44919Korea School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Department of Chemistry City University of Hong KongKowloonHong KongChina Department of Electrical and Computer Engineering and Quantum Technology Center University of MarylandCollege ParkMaryland 20742USA School of Materials Science and Engineering Beihang UniversityBeijing 100191China Department of Materials Science and Engineering City University of Hong KongKowloonHong KongChina Center of Advanced Nanocatalysis(CAN) Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China College of Chemistry and Chemical Engineering State Key Laboratory of Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy Materials(iChEM)Xiamen UniversityXiamen361005Fujian ProvinceChina State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Advanced Research institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-Nano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China School of Optical and Electronic Information Wuhan National Laboratory

Research on two-dimensional(2.) materials has been explosively increasing in last seventeen years in varying subjects including condensed matter physics, electronic engineering, materials science, and chemistry since the mechanical exfoliation of graphene in 2.04. Starting from graphene, 2. materials now have become a big family with numerous members and diverse categories. The unique structural features and physicochemical properties of 2. materials make them one class of the most appealing candidates for a wide range of potential applications. In particular, we have seen some major breakthroughs made in the field of 2. materials in last five years not only in developing novel synthetic methods and exploring new structures/properties but also in identifying innovative applications and pushing forward commercialisation. In this review, we provide a critical summary on the recent progress made in the field of 2. materials with a particular focus on last five years. After a brief backgroundintroduction, we first discuss the major synthetic methods for 2. materials, including the mechanical exfoliation, liquid exfoliation, vapor phase deposition, and wet-chemical synthesis as well as phase engineering of 2. materials belonging to the field of phase engineering of nanomaterials(PEN). We then introduce the superconducting/optical/magnetic properties and chirality of 2. materials along with newly emerging magic angle 2. superlattices. Following that, the promising applications of 2. materials in electronics, optoelectronics, catalysis, energy storage, solar cells, biomedicine, sensors, environments, etc. are described sequentially. Thereafter, we present the theoretic calculations and simulations of 2. materials. Finally, after concluding the current progress, we provide some personal discussions on the existing challenges and future outlooks in this rapidly developing field.

关键词： Two-dimensional materials Transition metal dichalcogenides Phase engineering of nanomaterials Electronics Optoelectronics Catalysis Energy storage and conversion

中国儿科医务人员对脉搏血氧饱和度监测的知信行现状调查及相关影响因素分析

在线全文

学校读者我要写书评

暂无评论

中华实用儿科临床杂志 2022年第23期37卷 1807-1812页

作者：薛凤霞郑跃杰申阿东刘瀚旻陈星钟礼立农光民孙新卢根丁圣刚方元勋潘家华韩志英孙云陈强姜毅朱晓萍唐素萍王秀芳刘长山任少敏陈志敏赵德育殷勇张蓉芳李明尚云晓穆亚平安淑华益西央宗徐佩茹邢燕徐保平赵京陈实向伟李丽红刘恩梅宋瑜欣杨永弘申昆玲国家儿童医学中心国家呼吸系统疾病临床医学研究中心首都医科大学附属北京儿童医院呼吸一科北京100045 深圳市儿童医院呼吸科深圳518038 国家儿童医学中心国家呼吸系统疾病临床医学研究中心首都医科大学附属北京儿童医院北京市儿科研究所北京100045 四川大学华西第二医院小儿呼吸免疫科成都610041 山东第一医科大学附属省立医院小儿呼吸科济南250021 湖南省人民医院儿童医学中心儿童呼吸病学湖南省重点实验室长沙410005 广西医科大学第一附属医院儿科南宁530021 空军军医大学西京医院儿科西安710032 广州市妇女儿童医疗中心呼吸科广州510623 安徽医科大学第一附属医院儿科合肥230022 安徽黄山首康医院儿科黄山245061 中国科学技术大学附属第一医院儿科合肥230001 山西省儿童医院呼吸科太原030013 银川市妇女儿童保健院普儿科银川750001 江西省儿童医院呼吸内科南昌330006 武汉大学人民医院儿科武汉430060 贵州医科大学附属医院儿科贵阳550004 福建省福州儿童医院变态反应科福州350005 郑州大学第三附属医院小儿呼吸内科郑州450052 天津医科大学第二医院儿科天津300211 内蒙古医科大学附属医院儿科呼和浩特010050 浙江大学医学院附属儿童医院呼吸科杭州310052 南京医科大学附属儿童医院呼吸科南京210008 上海交通大学医学院附属上海儿童医学中心呼吸科上海200127 甘肃省妇幼保健院过敏反应科兰州730050 昆明市儿童医院呼吸内科昆明650034 中国医科大学附属盛京医院小儿呼吸内科沈阳110004 沈阳市儿童医院内科沈阳110032 河北省儿童医院呼吸一科石家庄050031 西藏自治区人民医院儿科拉萨850000 新疆医科大学儿科学院乌鲁木齐830000 北京大学第三医院儿科北京100191 首都儿科研究所附属儿童医院变态反应科北京100020 海南省人民医院海南医学院附属医院儿科海口570102 海南省妇女儿童医学中心海口570312 长春市儿童医院呼吸科长春130051 重庆医科大学附属儿童医院呼吸科重庆400014 哈尔滨市儿童医院变态反应科哈尔滨150010

目的调查中国儿科医务人员对脉搏血氧饱和度监测的知识、态度和行为(简称知信行),并分析其影响因素。方法采用自行设计的问卷,在2.2.年3月11日至14日对来自中国31个省、自治区、直辖市的11849例儿科医务人员进行线上调查。采用Logistic... 详细信息

目的调查中国儿科医务人员对脉搏血氧饱和度监测的知识、态度和行为(简称知信行),并分析其影响因素。方法采用自行设计的问卷,在2.2.年3月11日至14日对来自中国31个省、自治区、直辖市的11849例儿科医务人员进行线上调查。采用Logistic回归分析儿科医务人员脉搏血氧饱和度监测知信行的主要影响因素。结果儿科医务人员脉搏血氧饱和度监测知识、态度、行为总得分分别为(5.57±0.96)分、(11.2.±1.2.)分和(11.19±4.54)分,得分率分别为69.61%、74.95%和55.99%。Logistic回归分析显示,儿科医务人员的年龄、从业年限、所在地区和所在单位是否配置脉搏血氧仪是知识水平的主要影响因素(均P<0.05);知识水平、性别、学历、从业年限、所在地区、所在医院级别和所在单位是否配置脉搏血氧仪是态度水平的主要影响因素(均P<0.05);知识水平、性别、年龄和所在单位是否配置脉搏血氧仪是行为水平的主要影响因素(均P<0.05)。结论中国儿科医务人员对脉搏血氧饱和度监测的知识和态度水平有待进一步提高,脉搏血氧仪的使用存在明显不足。亟须制定相关政策/指南,加强教育培训,提高知信度,增加脉搏血氧仪的配置,普及推广脉搏血氧饱和度监测在临床实践中的应用。

关键词：儿科医务人员脉搏血氧饱和度监测脉搏血氧仪知信行

Search for Steady Emission of 10—TeV Gamma Rays from the Crab Nebula,Cygnus X—3,and Hercules X—1 Using the Tibet Air Shower Array

在线全文

学校读者我要写书评

暂无评论

西藏大学学报(社会科学版) 1993年第4期8卷 71-75页

作者： M.Amenomori Z.Cao.L.K.Ding Z.Y.Feng K.Hibino N.Hotta Q.Huang A.X.Huo H.Y.Jia G.Z.Jiang S.Q.Jiao F.Kajino K.Kasahara Labaciren D.M.Mei L.Meng X.R.Meng Mimaeiren K.Mizutani J.Mu H.Nanjo M.Nishizawa Nusang A.Oguro M.Ohnishi I.Ohta J.R.ren To.saito M.Sakata Z.Z.Shi M.Shibata T.shirai H.sugimoto X.X.sun A.Tai K.Taira Y.H.Tan N.Tateyama S.Torii H.Wang C.Z.Wen Y.Yamamoto X.Y.Yao G.C.Yu P.Yuan T.Yuda J.G.Zeng C.S.Zhang H.M.Zhang L.Zhang Zhasang Zhaxlclren W.D.Zhou Department of Physics Hirosaki UniuersityHirosakiJapan institute of High Energy Physics Academia SinicaBeijingChina Department of Physics South West Jiaotong UniuersityChengduChina institute for Cosmic Ray Research Uniuersity of TokyoTanashiJapan Faculty of Education Utsunomiya UniuersityUtsunomiyaJapan Departmem of Physics Konan UniuersityDepartmem of PhysicsKonan UniuersityKobeJapan Faculty of Engireering Kanagawa UniversityYokohamaJapan Department of Mathematics and Physics Tibet UniuersityLhasaChina Department of Physics Saitama UniuersityUrawaJapan Department of Physics Yunnan UniuersityKunmingChina Faculty of Education Yokohama National UniuersityYokohamaJapan Shonan institute of Technology FujisawaJapan

寻找到高能和超高能的Gamma射线点源,在宇宙射线源方面有着极为重要的意义,本文就西藏羊八井观测到的空气簇射阵列及共它资料,对寻找稳定的10-TeV Gamma射线进行了分析论述。

关键词：西藏空气簇射 Gamma射线点源大气厚度 10TeV

Observation of the Crab Nebula with LHAASO-KM2.−a performance study

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2021年第2期45卷 518-530页

作者： F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi H.Cai J.T.Cai Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai D.della Volpe B.D'Ettorre Piazzoli X.J.Dong J.H.fan Y.Z.fan Z.X.fan J.fang K.fang C.F.Feng L.Feng S.H.Feng Y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li F.Li H.B.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli Y.C.Nan B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.sun X.N.sun Z.B.sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.N.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.B.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng B.Zhou H.Zhou J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G.Zhu F.R.Zhu H.Zhu K.J.Zhu X.Zuo Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of Sciences100049 BeijingChina university of Chinese Academy of Sciences 100049 BeijingChina TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Particle Detection and Electronics China university of Science and Technology of china 230026 HefeiAnhuiChina Department of Engineering Physics Tsinghua University100084 BeijingChina National Astronomical Observatories Chinese Academy of Sciences100101 BeijingChina National Space Science Center Chinese Academy of Sciences100190 BeijingChina School of Physics Peking University100871 BeijingChina Center for Astrophysics Guangzhou University510006 GuangzhouGuangdongChina School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen University519000 ZhuhaiGuangdongChina School of Physical Science and Technology Guangxi University530004 NanningGuangxiChina Hebei Normal university 050024 ShijiazhuangHebeiChina School of Physics and Microelectronics Zhengzhou University450001 ZhengzhouHenanChina School of Astronomy and Space Science Nanjing University210023 NanjingJiangsuChina Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences210023 NanjingJiangsuChina institute of Frontier and Interdisciplinary Science Shandong University266237 QingdaoShandongChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of Sciences200030 ShanghaiChina Tsung-Dao Lee institute&School of Physics and Astronomy Shanghai Jiao Tong University200240 ShanghaiChina School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong University610031 ChengduSichuanChina College of Physics Sichuan University610065 ChengduSichuanChina Key Laboratory of Cosmic Rays(Tibet university) Ministry of Education850000 LhasaTibetChina School of Physics and Tec

A sub-array of the Large High Altitude Air Shower Observatory(LHAASO),KM2. is mainly designed to observe a large fraction of the northern sky to hunt for γ-ray sources at energies above 10 *** though the detector construction is still underway,half of the KM2. array has been operating stably since the end of *** this paper,we present the KM2. data analysis pipeline and the first observation of the Crab Nebula,a standard candle in very high energy γ-ray *** detect γ-ray signals from the Crab Nebula in both energy ranges of 10-100 TeV and>100 TeV with high significance,by analyzing the KM2. data of 136 live days between December 2.19 and May *** the observations,we test the detector performance,including angular resolution,pointing accuracy and cosmic-ray background rejection *** energy spectrum of the Crab Nebula in the energy range 10-2.0 TeV fits well with a single power-law function dN/dE=(1.13±0.05stat±0.08sys)×10^(-14).(E/2. TeV)-309±0.06stat±0.02.yscm^(-2. s^(-1) TeV^(-1).It is consistent with previous measurements by other *** opens a new window of γ-ray astronomy above 0.1 PeV through which new ultrahigh-energy γ-ray phenomena,such as cosmic PeVatrons,might be discovered.

关键词： γ-ray Crab Nebula extensive air showers cosmic rays

BRAF V600突变型非小细胞肺癌的治疗进展

在线全文

学校读者我要写书评

暂无评论

中国癌症杂志 2021年第12期31卷 1145-1152页

作者：赵媛媛周建英范云王佳蕾黄鼎智李峻岭史美祺刘基巍姚煜邬麟姚文秀张力中山大学附肿瘤防治中心肿瘤内科广州广东510060 浙江大学医学院附属第一医院呼吸内科浙江杭州310003 中国科学院大学附属肿瘤医院/浙江省肿瘤医院肿瘤内科浙江杭州310022 复旦大学附属肿瘤医院肿瘤内科复旦大学医学院肿瘤学系上海200032 天津市肿瘤医院肺部肿瘤内科天津300181 中国医学科学院肿瘤医院内科北京100021 江苏省肿瘤医院肿瘤内科江苏南京210009 大连医科大学附属第一医院肿瘤科辽宁大连116011 西安交通大学第一附属医院肿瘤内科陕西西安710061 湖南省肿瘤医院胸部内二科湖南长沙410031 四川省肿瘤医院肿瘤内科四川成都610042

肺癌是中国发病率和死亡率均排在第一位的恶性肿瘤,其中非小细胞肺癌(non-small cell lung cancer,NSCLC)约占肺癌的85%。鼠类肉瘤病毒癌基因同源物B1(V-Raf murine sarcoma viral oncogene homolog B1,BRAF)突变在NSCLC中的发生率为1.5%~3.5%,而BRAF V600约占所有BRAF突变的50%,其中V600E突变最为常见。国内外研究显示,NSCLC中的BRAF突变在男女比例和吸烟状态等方面的差异并不一致,而在病理学类型上,BRAF突变(尤其是BRAF V600E突变)的NSCLC患者均以腺癌为主。BRAF V600突变NSCLC患者的预后差,总生存期(overall survival,OS)较短。在此类患者的药物治疗方面,目前化疗和免疫治疗的临床获益并不理想,化疗的无进展生存期(progression-free survival,PFS)仅为1.5~4.2.月;免疫检查点抑制剂治疗BRAF突变NSCLC患者的PFS也只有2.5~5.3个月。而近年来靶向治疗的应用,为肺癌BRAF突变患者带来了新的希望。Ⅱ期临床试验VE-BASKET使用了BRAF抑制剂维莫非尼治疗BRAF V600E突变型NSCLC,最终结果显示,患者中位PFS和OS分别为6.5和15.4个月,初步证明了该药的有效性;但安全性仍需关注,约77%的患者发生了3/4级不良事件(adverse event,AE)。另一种BRAF抑制剂达拉非尼,对于BRAF V600E突变NSCLC患者,在Ⅱ期临床试验BRF11392.的三个队列中,分别证明了该药作为单药治疗经治患者(队列A)、联合丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)激酶(MAPK kinases,MEK)抑制剂曲美替尼治疗经治患者(队列B)以及联合曲美替尼治疗初治患者(队列C)均具有显著疗效,客观缓解率(objective response rate,ORR)分别为33.0%、63.2.和64.0%,PFS分别为5.5、9.7和14.6个月。近期,该研究的5年长期生存随访数据还报告了队列B和C患者的5年OS率分别为19%和2.%。BRF11392.研究表明,无论作为一线治疗还是后线治疗,达拉非尼联合曲美替尼治疗BRAFV600突变NSCLC患者均具有良好的疗效,且优于BRAF单药靶向治疗。在安全性方面,常见AE为发热和消化道不良反应等,且大多为1~2.,而3/4级AE或因AE而中断治疗的发生率相对较低,总体上安全可控。在现有治疗药物的开发基础上,BRAF V600E突变NSCLC仍有许多值得深入探索的方向,如:①将BRAF抑制剂用于辅助/新辅助治疗;②靶向联合免疫治疗或抗血管生成药物;③双靶耐药后,探索耐药机制以开发新靶向药物或新联合治疗模式,或研发新型BRAF抑制剂,或尝试探索双靶耐药后“再挑战”等。近年来的一些病例报告或探索性研究已经提供了这些方向的线索。目前,达拉非尼联合曲美替尼已被美国国家综合癌症网络(National Comprehensive Cancer Network,NCCN)和欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)等多个指南优先推荐为BRAF V600E/V600突变NSCLC患者的优选治疗。将聚焦于BRAF V600突变NSCLC患者,对其临床/病理学特征及治疗进展进行系统阐述。

关键词：非小细胞肺癌鼠类肉瘤滤过性毒菌致癌基因同源体B1 突变抑制剂丝裂原活化蛋白激酶激酶抑制剂

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua fan Lei fan Jian fang Wenxing fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing institute of Spacecraft Environment Engineering BeijingChina Beijing Normal university BeijingChina china institute of Atomic Energy BeijingChina institute of High Energy Physics BeijingChina North china Electric Power university BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua university BeijingChina university of Chinese Academy of Sciences BeijingChina Jilin university ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing university ChongqingChina Dongguan university of Technology DongguanChina Jinan university GuangzhouChina sun Yat-Sen university GuangzhouChina Harbin institute of Technology HarbinChina university of Science and Technology of china HefeiChina The Radiochemistry and Nuclear Chemistry Group in university of South china HengyangChina Wuyi university JiangmenChina Shandong university JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing university NanjingChina Guangxi university NanningChina East china university of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee institute Shanghai Jiao Tong UniversityShanghaiChina institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai university TianjinChina Wuhan university WuhanChina Xi'an Jiaotong university Xi'anChina Xiamen university XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2.,△m_(2.)^(2.,sin^(2.θ_(12.,and sin^(2.θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(2.)^(2. and sin^(2.θ_(12. oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2. parameter will be determined to about 0.2.precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO