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Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy

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Nano Research 2015年第12期8卷 3982-3991页

作者： qin Liu Chunyang sun Qun He Adnan Khalil Ting xiang Daobin Liu Yu Zhou Jun Wang Li Song National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230029 China Hefei National Laboratory for Physical Science at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027 China

In this study, we present the preparation of stable 1T-WS2 ultrathin nanosheets with NH~ intercalation using a bottom-up hydrothermal method and the potential application of this material in light-induced photothermal cancer therapy. Our results revealed that nanosheets with a size of 150 nm were highly hydrophilic and exhibited strong light absorption and excellent photostability in the broad near-infrared wavelength region. The in vitro experimental results indicated good biocompatibility of the nanosheets. More notably, our in vivo antitumor experiments illustrated that light-induced photothermal ablation originating from irradiation of the 1T-WS2 nanosheets with an 808 nm laser could efficiently kill tumor cells; these effects were obtained not only at the cellular level but also in the living organs of mice. This result may lead to new applications of two-dimensional layered materials in novel photothermal therapies and other photothermal related fields.

关键词： hydrothermal ammoniumion-intercalated 1T-WS2 ultrathin nanosheets biocompatibility photostability photothermal therapy

基于二维浅水方程的胖头泡蓄滞洪区洪水演进数值模拟

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人民珠江 2024年第6期45卷 82-91页

作者：孙振宇周运浩张勤旭秦梦恩张明亮大连海洋大学海洋科技与环境学院辽宁大连116023 辽宁省近海生态环境与灾害防护工程技术创新中心辽宁大连116023

探究蓄滞洪区洪水演进对蓄滞洪区的防洪工作有着重要意义。为在洪水来临时,短时间内对洪水运动进行预测。运用Godunov型有限体积法建立了1个二维浅水水动力数值模型,该模型的的优势在于采用非结构性三角形网格,能够较好地拟合不规则边界... 详细信息

探究蓄滞洪区洪水演进对蓄滞洪区的防洪工作有着重要意义。为在洪水来临时,短时间内对洪水运动进行预测。运用Godunov型有限体积法建立了1个二维浅水水动力数值模型,该模型的的优势在于采用非结构性三角形网格,能够较好地拟合不规则边界,并采用GPU异构并行技术,有效解决了非结构化网计算耗时长的问题,运用限制器减少二阶精度数值的扩散和振荡,引入负水深和干湿边界处理技术,使模型模拟的精确度得到了有效提高。模型应用多个溃坝水流实验算例对模型进行率定,在验证其具有良好的干湿边界计算能力和静水和谐性的基础上,采用嫩江流域1998年洪水数据对嫩江流域的胖头泡蓄滞洪区的洪水演进进行模拟计算。结果显示:模型对胖头泡蓄滞洪区模拟的蓄水量为34.9亿m^(3),与实测值的相对误差为1.7%,洪水淹没面积为1 267.27 km^(2),与实测值的相对误差为9.24%。对研究区域不同的土地类型进行糙率分区的情况下,模型模拟的蓄水量结果更趋近于实测结果。并行化后的程序能使模型计算速度提升33%,因此模型能快速、精准计算复杂地形溃决水流的洪水演进过程。研究结果可以为蓄滞洪区的防洪规划、灾情预警提供相关信息。

关键词：浅水方程有限体积法蓄滞洪区洪水演进

Protective effects of Jiayan Kangtai granules on autoimmune thyroiditis in a rat model by modulating Th17/Treg cell balance

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Journal of Traditional Chinese Medicine 2018年第3期38卷 380-390页

作者： Hou Yi Wang Tieshan Guo Xiangyu sun Wen Guo Xuan Wu Lili qin Lingling Zhang Chengfei Liu Tonghua Key Laboratory of Health Cultivation of the Ministry of Education Beijing University of Chinese Medicine Beijing 100029 China Dongfang Hospital of Beijing University of Chinese Medicine Beijing 100078 China Beijing Research Institute of Chinese Medicine & Beijing University of Chinese Medicine Beijing100029 China Department of Endocrinology Dongfang Hospital of Beijing University of Chinese Medicine Beijing100078 China Beijing Key Laboratory of Health Cultivation Beijing University of Chinese Medicine Beijing 100029China Science and Technology Department Beijing University of Chinese Medicine Beijing 100029 China

OBJECTIVE: To investigate the protective effects of Jiayan Kangtai(JYKT) granules, consisting of 9 Chinese herbs, in a rat model of autoimmune thyroiditis(AIT), and the possible underlying ***: Female Lewis rats(6-8 weeks) were randomly apportioned to 5 groups of 10, including a normal control. AIT was induced in the untreated AIT-model group, and rats treated subsequently with daily low, medium, or high dose JYKT granules. After 12 weeks, plasma levels of thyroid autoantibodies and morphological changes in the thyroid were detected by enzyme-linked immunosorbent assay and histological examination, respectively. The presence of interleukin(IL)-6,IL23 p19, and IL-2 in thyroid tissue was assessed by immunohistochemical staining. The percentages of T helper(Th)17 cells and regulatory T cells(Tregs) in the peripheral blood were analyzed by flow cytometry. Relevant levels of cytokines and proteins were examined via bead-based multiplex flow cytometry and ELISA, respectively. Expressions of genes and proteins regulated by Th17 cells and Tregs were shown by real-time PCR and Western ***: Compared to the control, AIT-model rats had higher plasma concentrations of thyroid autoantibodies. The high-dose JYKT rats showed significantly lower levels of thyroid autoantibodies compared with the AIT model group. Rats in the AIT-JYKT groups also had fewer thyroid lesions and less lymphocytic infiltration, a lower percentage of Th17 cells, and a higher percentage of Tregs, compared with the AIT-model. Rats given high-dose JYKT had a significantly lower Th17/Treg ratio compared with the AIT model. Differences in plasma cytokine concentrations and relevant gene and protein expressions in the spleens of JYKT-treated rats and the AIT group suggested an association between JYKT treatment and lower Th17 cell percentage and higher Treg ***: JYKT treatment appeared to be protective against AIT in rats, possibly via the regulation of the Th17 cell/Treg im

关键词： thyroiditis autoimmune Th17 cells T-Lymphocytes regulatory Herbal medicine Jiay-an Kangtai granules

Alfalfa-containing diets alter luminal microbiota structure and short chain fatty acid sensing in the caecal mucosa of pigs

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Journal of Animal Science and Biotechnology 2018年第2期9卷 361-369页

作者： Jiawei Wang Chunfu qin Ting He Kai Qiu Wenjuan sun Xin Zhang Ning Jiao Weiyun Zhu Jingdong Yin State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health College of Animal Science and Technology Nanjing Agricultural University College of Biotechnology and Food Science Hebei Normal University for Nationalities

Background: Pork produced by outdoor-reared pigs raised mostly on alfalfa pastures attracts increasing population of consumer from most of the world. In China, pigs were raised with alfalfa-containing diets to seek for good quality ***, the influence of dietary alfalfa involving high level of insoluble dietary fiber(IDF) on pig intestinal luminal microbiota composition remains unclear. The objective of this study was to investigate the effects of alfalfa on luminal microbiota and short chain fatty acids(SCFA) production, and gene expressions involved in SCFA sensing, transporting and absorbing in pig caecal ***: Twenty-four growing pigs were randomly allotted to four diets containing 0%, 5%, 10% and 15% alfalfa meal for a 28-d experiment. Ingestion of alfalfa meal-contained diets significantly increased the ratio of body weight gain to feed consumption. Illumina MiS eq sequencing of the V3 region of the 16 S r RNA genes showed that alfalfa-containing diet significantly decreased the relative abundance of genera Turicibacter, Acidiphilium, Paracoccus, Propionibacterium,Corynebacterium, Pseudomonas, Acinetobacter, and Staphylococcus, and increased the relative abundance of genera Lachnospira, Marvinbryantia, and Desulfovibrio in the caecal digesta. Butyrate concentration was significantly increased in the hindgut by the supplementation of alfalfa meal in diets. The m RNA gene expressions of FFAR3, SMCT1, MCT1,PYY, and GCG were significantly increased in the caecal mucosa of pigs fed alfalfa ***: Our results suggested that alfalfa-containing diet has exerted significant impacts on caecal microbiota composition, butyrate concentration and significantly upregulated m RNA expression of host caecal mucosal genes involved in SCFA sensing and absorption as well as regulation of satiety.

关键词： Alfalfa meal Growing pigs Insoluble fiber Microbiota SCFA

Fully-exposed Pt clusters stabilized on Sn-decorated nanodiamond/graphene hybrid support for efficient ethylbenzene direct dehydrogenation

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Nano Research 2022年第12期15卷 10029-10036页

作者： Linlin Wang Xuetao qin Ting sun Xiangbin Cai Mi Peng Zhimin Jia Xiaowen Chen Ning Wang Jiangyong Diao Hongyang Liu Ding Ma Department of Chemistry Northeastern UniversityShenyang110819China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Beijing National Laboratory for Molecular Engineering College of Chemistry and Molecular Engineering and College of EngineeringBIC-ESATPeking UniversityBeijing100871China Department of Physics Hong Kong University of Science and TechnologyKowloonHong Kong999077China School of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China

The pursuit of energy conservation and environmental protection has always been a hot topic in the catalytic fields,which is inseparable from the rational designing of efficient catalysts and an in-depth understanding of the catalytic reaction *** this work,fully-exposed Pt clusters were fabricated on the atomically dispersed Sn decorated nanodiamond/graphene(Sn-ND@G)hybrid support and employed for direct dehydrogenation(DDH)of ethylbenzene(EB)to styrene(ST).The detailed structural characterizations revealed the fully-exposed Pt clusters were stabilized on Sn-ND@G,assisted by the spatial separation of atomically dispersed Sn *** as-prepared Pt/Sn-ND@G catalyst showed enhanced ST yield(136.2 molEB·molpt-1·h-1 EB conversion rate and 99.7%ST selectivity)and robust long-term stability at 500℃for the EB DDH reaction,compared with the traditional ND@G supported Pt nanoparticle catalyst(Pt/ND@G).The ST prefers to desorb from the fully-exposed Pt clusters,resulting in the enhanced DDH catalytic performance of the Pt/Sn-ND@G *** present work paves a new way for designing highly dispersed and stable supported metal catalysts for DDH reactions.

关键词： Pt cluster ethylbenzene dehydrogenation fully-exposed catalyst heterogeneous catalysis

Resolving the sintering conundrum of high-rhenium tungsten alloys

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Journal of Materials Science & Technology 2023年第35期166卷 78-85页

作者： Zhongyou Que Xingyu Li Lin Zhang Xuanhui Qu Zichen Wei Chenguang Guo Haishen sun Mingli qin Gang Chen Peinan Du Yanhao Dong Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of ChinaChengdu 610213China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Tungsten-rhenium(W-Re)alloys with high-Re contents are the preferred refractory metal materials in many applications because of the improved ductility and processability over pure W and low-Re tung-sten ***,the sintering concurrently becomes increasingly more difficult with increasing Re *** we proposed that the sintering conundrum is caused by the lowered crystal symmetry and the wider dihedral angle distribution when body-center-cubic(BCC)W is alloyed with more hexagonal-close-packed(HCP)Re,which results in inefficient pore removal in the final stage *** showed that the conundrum can be resolved by pressureless two-step sintering(TSS)which suppresses acceler-ating final-stage grain growth,and our proposal is supported by the data of the critical densityρc that is required to start the second step for successful TSS at different W-Re *** ultrafine-grained W-Re alloys with∼300 nm average grain size and up to 25 wt%Re were successfully *** work demonstrates the unique opportunities offered by two-step sintering to advance the scientific understanding and technological practices in powder metallurgy and related fields.

关键词： W-Re alloys Two-step sintering Grain growth Ultrafine-grained materials

Rational fabrication of ordered porous solid strong bases by utilizing the inherent reducibility of metal-organic frameworks

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Nano Research 2022年第4期15卷 2905-2912页

作者： Song-Song Peng Xiang-Bin Shao Yu-Xia Li Yao Jiang Chen Gu Manish Kumar Dinker Xiao-qin Liu(✉) Lin-Bing sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech University30 South Puzhu RoadNanjing 211816China

Ordered porous solid strong bases(OPSSBs)have attracted great research interest due to the excellent performance as heterogeneous catalysts in various *** main obstacle for fabricating OPSSBs is the requirement of high temperature to produce strong basicity on ordered porous *** example,the temperatures of 600-650℃ are required for the decomposition of base precursor NaNO_(3)to basic sites on mesoporous silica SBA-15 and zeolite *** high decomposition temperatures are energy-intensive and harmful to the structure of ***,we report the fabrication of OPSSBs by utilizing the redox interaction between base precursor and low-valence metal centers(e.g.,Cr^(3+))in metal-organic frameworks(MOFs).The base precursor NaNO_(3)on MIL-101(Cr)can be converted to basic sites entirely at 300℃,which is quite lower than those of the conventional thermal conversion on SBA-15 and zeolite Y(600-650℃).The exploration on decomposition mechanism reveals that the valence change of Cr^(3+)to Cr^(6+)takes place during the conversion of NaNO_(3)to basic *** this way,MOFs-derived base catalysts have been synthesized successfully by the host-guest redox strategy and exhibit high catalytic activity in typical base-catalyzed reactions.

关键词： metal-organic frameworks ordered porous solid strong bases host–guest redox interaction transesterification reaction Cr centers

Electrically pumped optomechanical beam GaN-LED accelerometer based on the quantum-confined Stark effect

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Photonics Research 2023年第9期11卷 1583-1591页

作者： GANGYI ZHU XIN JI ZHENFU ZHANG XINGCAN YAN YING YANG FEIFEI qin XIN LI JIAGUI WU XIAOJUAN sun JUNBO YANG YONGJIN WANG GaN Optoelectronic Integration International Cooperation Joint Laboratory of Jiangsu Province Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Arts&Science National University of Defense TechnologyChangsha 410003China School of Physical Science and Technology Southwest UniversityChongqing 400715China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

Micro-nano optomechanical accelerometers are widely used in automobile,aerospace,and other industrial ***,we fabricate mechanical sensing components based on an electrically pumped GaN light-emitting diode(LED)with a beam *** relationship between the blueshift of the electroluminescence(EL)spectra and the deformation of the GaN beam structure based on the quantum-confined Stark effect(QCSE)of the InGaN quantum well(QW)structure is studied by introducing an extra mass *** the equivalent acceleration condition,in addition to the elastic deformation of GaN-LED,a direct relationship exists between the LED’s spectral shift and the acceleration’s *** extra mass block(gravitational force:7.55×10^(-11)N)induced blueshift of the EL spectra is obtained and shows driven current dependency.A polymer sphere(PS;gravitational force:3.427×10^(-12)N)is placed at the center of the beam GaN-LED,and a blueshift of 0.061 nm is observed in the EL spectrum under the injection current of 0.5 *** maximum sensitivity of the acceleration is measured to be 0.02 m∕s^(2),and the maximum measurable acceleration is calculated to be 1.8×10^(6)m∕s^(2).It indicates the simultaneous realization of high sensitivity and a broad acceleration measurement *** work is significant for several applications,including light force measurement and inertial navigation systems with high integration ability.

关键词： pumped beam acceleration

Porous-structure engineered spacer for high-throughput and rapidgrowth of high-quality graphene films

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Nano Research 2022年第11期15卷 9741-9746页

作者： Ziteng Ma Heng Chen Xiaofeng Song Buhang Chen qin Li Yanglizhi Li Haiyang Liu Kaicheng Jia Shenghong Huang Luzhao sun Zhongfan Liu Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute Beijing 100095China College of Materials Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China College of Energy Soochow Institute for Energy and Materials InnovationS(SIEMIS)Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China

Chemical vapor deposition(CVD)in conjunction with batch-to-batch manufacturing process is considered as the most promising technical route for mass-production of high-quality graphene *** improve the space utilization of the CVD chamber and increase the throughput per batch,stacking of the Cu foil substrates is efficient,but suffers from the problems of adjacent fusion and the poor ***,we demonstrate an efficient strategy for high-throughput and rapid growth of high-quality graphene by alternate stacking of Cu foils and porous carbon fiber paper(CFP).Relying on the unhindered mass-transfer through the pores of CFPs,full-covered high-quality graphene films on compact-stacked Cu foils were achieved within 2 *** fluid dynamics(CFD)simulation and isotope labeling technique were performed to explore the gas diffusion and graphene growth process in the confined space of the Cu-CFP *** work provides a feasible method for industrial production of graphene films,which may also be used for batch production of other two-dimensional materials.

关键词： graphene chemical vapor deposition fast growth high-throughput batch-to-batch production