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Preliminary single-arm study of brain effects during transcutaneous auricular vagus nerve stimulation treatment of recurrent depression by resting-state functional magnetic resonance imaging

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Journal of Traditional Chinese Medicine 2022年第5期42卷 818-824页

作者： CHEN Limei sun jifei GUO Chunlei LI Xiaojiao WANG Zhi Hong Yang FANG Jiliang Radiology Department Guang'anmen Hospital of China Academy of Chinese Medical SciencesBeijing 10003China

OBJECTIVE:To examine the brain effects of transcutaneous auricular vagus nerve stimulation(ta VNS)treatment of recurrent depression based on the functional brain network by using resting-state functional magnetic resonance imaging(f MRI).METHODS:Twenty-five patients with recurrent depression were enrolled in a single-arm trial of ta VNS treatment for eight weeks.Clinical results were assessed by 17-item Hamilton Depression Rating Scale(HAMD-17),Hamilton Anxiety Scale(HAMA),Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS),and Ruminative Response Scale(RRS)scales.Resting-state f MRI was conducted to explore the brain effects before and after treatment.For the functional connectivity(FC)analysis,the bilateral nucleus accumbens,globus pallidus,caudate,and putamen were selected as seeds.Finally,the correlations between FC and the clinical scale scores were calculated.RESULTS:After treatment,the patients’scores of HAMD-17,HAMA,SDS,SAS,and RRS were significantly decreased(P<0.05).FC was considerably decreased between the following areas:the left globus pallidus and the right postcentral gyrus,inferior parietal gyrus,the right globus pallidus and the left superior marginal gyrus,postcentral gyrus,superior parietal gyrus,inferior parietal gyrus,precuneus,right postcentral gyrus,superior marginal gyrus,and inferior parietal gyrus,between the right caudate and the right lingual gyrus,calcarine gyrus,and cerebellum.Changes in FC between the right globus pallidus and the left inferior parietal gyrus,between the left globus pallidus and the right postcentral gyrus were negatively correlated with HAMD-17 scores change before and after treatment(before,P=0.003,r=-0.6;after,P=0.009,r=-0.54).The change of FC between the right globus pallidus and the right postcentral gyrus was negatively correlated with the change in SDS(P=0.026,r=-0.474).The difference in FC between the right globus pallidus and the right postcentral gyrus was negatively correlated with the change in SAS(P=0.016,r=-0.513).CONCLUSIONS:Recurrent dep

关键词： recurrence depression magnetic resonance imaging basal ganglia default mode network transcutaneous auricular vagus nerve stimulation

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基于多尺度特征的地基云图分类检测算法

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计算机科学 2024年第S1期51卷 305-310页

作者：孙继飞贾克斌北京工业大学信息学部北京100024 先进信息网络北京实验室北京100024

地基云的自动识别方法和技术为气象分析中的云状识别和云量估计任务提供了重要的手段和依据。然而,对这两种任务的研究往往独立,互不相干,导致地基云图的分类与分割技术无法有效地结合使用。特别是当云图中出现多类云状时,现有技术难以... 详细信息

地基云的自动识别方法和技术为气象分析中的云状识别和云量估计任务提供了重要的手段和依据。然而,对这两种任务的研究往往独立,互不相干,导致地基云图的分类与分割技术无法有效地结合使用。特别是当云图中出现多类云状时,现有技术难以按不同云类分别划分区域并进行云量计算。为了解决这一问题,提出用基于深度学习的语义分割方法实现对地基云图的按类分割。首先,构建了地基云图语义分割数据集GBCSS,该数据集包含3000幅云图,共计11个类别。在此基础上,提出了一种基于U型神经网络的改进方案UNet-PPM作为地基云图语义分割模型。为了增强网络对云的轮廓特征提取能力,引入了金字塔池化模块。该模块提取并聚合了不同尺度的图像特征,提升了网络获取全局信息的能力。最后,将设计的网络在GBCSS上进行了训练以及评估,其在测试集上达到了91.5%的像素准确率。与U-Net相比,UNet-PPM在像素准确率上有5.4%的提升,表明该网络对云的轮廓特征提取的能力更强,以及语义分割应用在地基云图中的可行性。

关键词：地基云图语义分割云图数据集全卷积网络金字塔池化模块

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Development of High Areal Capacity Electrolytic MnO_(2)-Zn Battery via an Iodine Mediator

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Energy & Environmental Materials 2023年第6期6卷 243-250页

作者： Xinhua Zheng Ruihao Luo Touqeer Ahmad jifei sun Shuang Liu Na Chen Mingming Wang Yuan Yuan Mingyan Chuai Yan Xu Taoli Jiang Wei Chen Department of Applied Chemistry School of Chemistry and Materials ScienceHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026 China

The commercialization of electrolytic MnO_(2)-Zn batteries is highly applauded owing to the advantages of cost-effectiveness,high safety,high energy density,and durable working performance.However,due to the low reversibility of the cathode MnO_(2)/Mn^(2+)chemistry at high areal capacities and the severe Zn anode corrosion,the practical application of MnO_(2)-Zn batteries is hampered by inadequate lifespan.Leveraging the full advantage of an iodine redox mediator,here we design a highly rechargeable electrolytic MnO_(2)-Zn battery with a high areal capacity.The MnO_(2)-Zn battery coupled with an iodine mediator in a mild electrolyte shows a high discharge voltage of 1.85 V and a robust areal capacity of 10 mAh cm^(-2)under a substantial discharge current density of 160 mA cm^(-2).The MnO_(2)/I_(2)-Zn battery with an areal capacity of 10 mAh cm^(-2)exhibits prolonged stability of over 950 cycles under a high-capacity retention of~94%.The scaled-up MnO_(2)/I_(2)-Zn battery reveals a stable cycle life under a cell capacity of~600 mAh.Moreover,our constructed MnO_(2)/I_(2)-Zn battery demonstrates a practical energy density of~37 Wh kg^(-1)and a competitive energy cost of<18 US$kWh^(-1)by taking into account the cathode,anode,and electrolyte.The MnO_(2)/I_(2)-Zn battery,with its remarkable reversibility and reasonable energy density,enlightens a new arena of large-scale energy storage devices.

关键词： high areal capacity iodine redox mediator large-scale energy storage MnO2-Zn battery

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Toward dendrite-free and anti-corrosion Zn anodes by regulating a bismuth-based energizer

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eScience 2022年第5期2卷 509-517页

作者： Mingming Wang Yahan Meng Ke Li Touqeer Ahmad Na Chen Yan Xu jifei sun Mingyan Chuai Xinhua Zheng Yuan Yuan Chunyue Shen Ziqi Zhang Wei Chen Department of Applied Chemistry School of Chemistry and Materials ScienceHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefeiAnhui230026China

Aqueous rechargeable zinc metal batteries display high theoretical capacity along with economical effectiveness,environmental benignity and high safety.However,dendritic growth and chemical corrosion at the Zn anodes limit their widespread applications.Here,we construct a Zn/Bi electrode via in-situ growth of a Bi-based energizer upon Zn metal surface using a replacement reaction.Experimental and theoretical calculations reveal that the Bi-based energizer composed of metallic Bi and ZnBi alloy contributes to Zn plating/stripping due to strong adsorption energy and fast ion transport rates.The resultant Zn/Bi electrode not only circumvents Zn dendrite growth but also improves Zn anode anti-corrosion performance.Specifically,the corrosion current of the Zn/Bi electrode is reduced by 90%compared to bare Zn.Impressively,an ultra-low overpotential of 12mV and stable cycling for 4000h are achieved in a Zn/Bi symmetric cell.A Zn–Cu/Bi asymmetric cell displays a cycle life of 1000 cycles,with an average Coulombic efficiency as high as 99.6%.In addition,an assembled Zn/Bi-activated carbon hybrid capacitor exhibits a stable life of more than 50,000 cycles,an energy density of 64Wh kg−1,and a power density of 7kWkg−1.The capacity retention rate of a Zn/Bi–MnO_(2)full cell is improved by over 150%compared to a Zn–MnO_(2)cell without the Bi-based energizer.Our findings open a new arena for the industrialization of Zn metal batteries for large-scale energy storage applications.

关键词： Aqueous Zn anode Anti-corrosion Replacement reaction Dendrite-free Bismuth-based energizer

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Composition,function,and timing:exploring the early‑life gut microbiota in piglets for probiotic interventions

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Journal of Animal Science and Biotechnology 2024年第2期15卷 659-678页

作者： Jianping Quan Cineng Xu Donglin Ruan Yong Ye Yibin Qiu Jie Wu Shenping Zhou Menghao Luan Xiang Zhao Yue Chen Danyang Lin Ying sun jifei Yang Enqin Zheng Gengyuan Cai Zhenfang Wu Jie Yang College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhouGuangdongPeople’s Republic of China Guangdong Provincial Key Laboratory of Agro‑Animal Genomics and Molecular Breeding South China Agricultural UniversityGuangzhouGuangdongChina Yunfu Subcenter of Guangdong Laboratory for Lingnan Modern Agriculture YunfuGuangdongChina National Engineering Research Center for Breeding Swine Industry Wens Foodstuff Group Co.Ltd.YunfuGuangdongPeople’s Republic of China

Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects.However,the optimal timeframe for introducing probiotics to achieve this outcome remains uncertain.Results In the context of this investigation,we conducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time points.Simultaneously,we gathered vaginal and fecal samples from 23 sows.Employing 16S rRNA gene and metagenomic sequencing methodologies,we conducted a comprehensive analysis of the fluctuation patterns in microbial composition,functional capacity,interaction networks,and colonization resistance within the gut microbiota of piglets.As the piglets progressed in age,discernible modifications in intestinal microbial diversity,composition,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal piglets.By D21,the microbial interaction network displayed a more concise and efficient configuration,accompanied by enhanced colonization resistance relative to the other two time points.Moreover,we identified three strains of Ruminococcus sp.at D10 as potential candidates for improving piglets’weight gain during the weaning phase.Conclusions The findings of this study propose that D10 represents the most opportune juncture for the introduction of external probiotic interventions during the early stages of piglet development.This investigation augments our comprehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forthcoming probiotic interventions.

关键词： Colonization resistance Intestinal microbiota Piglet Weaning Weight gain

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High-performance Zn battery with transition metal ions co-regulated electrolytic MnO_(2)

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eScience 2021年第2期1卷 178-185页

作者： Mingyan Chuai Jinlong Yang Mingming Wang Yuan Yuan Zaichun Liu Yan Xu Yichen Yin jifei sun Xinhua Zheng Na Chen Wei Chen Department of Applied Chemistry School of Chemistry and Materials ScienceHefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefeiAnhui230026China College of Materials Science and Engineering Shenzhen UniversityShenzhen518060China

Electrolytic MnO_(2)/Zn batteries have attracted extensive attention for use in large-scale energy storage applications due to their low cost,high output voltage,safety,and environmental friendliness.However,the poor electrical conductivity of MnO_(2)limits its deposition and dissolution at large capacities,which leads to sluggish reaction kinetics and drastic capacity decay.Here,we report a theory-guided design principle for an electrolytic MnO_(2)/Zn battery co-regulated with transition metal ions that has improved electrochemical performance in terms of deposition and stripping chemistries.We start with first-principles calculations to predict the electrolytic effects of regulating transition metal ions in the deposition/stripping chemistry of the MnO_(2)cathode.The results indicate that with the simultaneous incorporation of strongly electronegative Co and Ni,the MnO_(2)cathode tends to possess more active electron states,faster charge-transfer kinetics,and better electrical conductivity than either MnO_(2)regulated with Co or Ni on their own,or pristine MnO_(2);hence,this co-regulation is beneficial for the cathode solid/liquid MnO_(2)/Mn2t reactions.We then fabricate and demonstrate a novel Co2t and Ni2t coregulated MnO_(2)/Zn(Co-Ni-MnO_(2)/Zn)battery that yields significantly better electrochemical performance,finding that the synergistic regulation of Co and Ni on MnO_(2)can significantly increase its intrinsic conductivity and achieve high rates and Coulombic efficiencies at large capacities.The aqueous Co-Ni-MnO_(2)/Zn battery exhibits a high rate(10C,100 mA cm^(-2)),high Coulombic efficiency(91.89%),and excellent cycling stability(600 cycles without decay)at a large areal capacity of 10 mAh cm^(-2).Our proposed strategy of co-regulation with transition metal ions offers a versatile approach for improving the electrochemical performance of aqueous electrolytic MnO_(2)/Zn batteries in large-scale energy storage applications.

关键词： Aqueous battery MnO_(2)cathode Deposition and stripping chemistry Electrolytic effect Large-scale energy storage

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逍遥舒坤汤加味联合阿奇霉素治疗盆腔炎性疾病后遗症临床研究

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新中医 2022年第2期54卷 106-109页

作者：孙吉飞陈芸朱文敏德清县中医院妇产科浙江德清313200 湖州市妇幼保健院妇产科浙江湖州313000

目的:观察逍遥舒坤汤加味联合阿奇霉素治疗盆腔炎性疾病后遗症(SPID)的临床疗效。方法:选取84例SPID患者,按随机数字表法分为观察组和对照组,每组42例。对照组给予阿奇霉素治疗,观察组在对照组基础上给予逍遥舒坤汤加味治疗,2组均治疗1... 详细信息

目的:观察逍遥舒坤汤加味联合阿奇霉素治疗盆腔炎性疾病后遗症(SPID)的临床疗效。方法:选取84例SPID患者,按随机数字表法分为观察组和对照组,每组42例。对照组给予阿奇霉素治疗,观察组在对照组基础上给予逍遥舒坤汤加味治疗,2组均治疗1个月。比较2组临床疗效,观察2组治疗前后盆腔包块直径、T细胞亚群水平、炎症因子水平、红细胞比容(HCT)、红细胞沉降率(ESR)的变化。结果:观察组总有效率为97.62%,高于对照组的83.33%(P<0.05)。治疗后,观察组盆腔包块直径小于对照组(P<0.05),观察组盆腔包块直径治疗前后差值大于对照组(P<0.05)。治疗后,2组血清CD4^(+)、白细胞介素-6 (IL-6)、自然杀伤细胞(NK细胞)水平均较治疗前升高(P<0.05),CD8^(+)、肿瘤坏死因子-α(TNF-α)、HCT、ESR水平均较治疗前降低(P<0.05);观察组CD4^(+)、IL-6、NK细胞水平均高于对照组(P<0.05),CD8^(+)、TNF-α、HCT、ESR水平均低于对照组(P<0.05)。结论:逍遥舒坤汤加味联合阿奇霉素治疗SPID可提高临床疗效,有效缩小盆腔包块,增强机体免疫力,调节炎症因子水平及HCT、ESR。

关键词：盆腔炎性疾病后遗症逍遥舒坤汤盆腔包块直径 T细胞亚群炎症因子红细胞比容红细胞沉降率

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复发性与首发性抑郁症的静息态脑功能MRI低频振幅初步研究

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国际医学放射学杂志 2022年第4期45卷 385-389,395页

作者：孙继飞陈丽梅王智郭春蕾方继良中国中医科学院广安门医院放射科北京100053

目的基于低频振幅(ALFF)方法研究复发性抑郁症(RDE)和首发性抑郁症(FDE)脑功能活动改变特征。方法前瞻性纳入2家医院确诊的20例RDE病人、18例FDE病人,同期纳入性别、年龄相匹配的20例健康志愿者作为对照组(HC组)。3组受试者均行静息态功... 详细信息

目的基于低频振幅(ALFF)方法研究复发性抑郁症(RDE)和首发性抑郁症(FDE)脑功能活动改变特征。方法前瞻性纳入2家医院确诊的20例RDE病人、18例FDE病人,同期纳入性别、年龄相匹配的20例健康志愿者作为对照组(HC组)。3组受试者均行静息态功能MRI(rs-fMRI)检查,并完成汉密顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA-14)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、中文版冗思量表(RRS)评定。采用Matlab平台上的DPARSF 5.0工具包进行rs-fMRI数据预处理,采用单因素方差分析比较3组间ALFF差异,并对结果进行高斯随机场(GRF)校正。提取3组间ALFF有差异脑区的时间序列均值(ALFF值),对ALFF值的事后两两比较采用LSD-t检验,所得结果进行Bonferroni校正(P<0.016)。最后对3组间有统计学差异脑区的ALFF值与临床量表评分进行Pearson相关分析。结果RDE组与FDE组的HAMD-17、HAMA-14、SDS、SAS、RRS评分均高于HC组(均P<0.05),RDE组的SDS、SAS评分高于FDE组(均P<0.05)。与FDE组相比,RDE组左侧杏仁核、右侧海马的ALFF值增高,而右侧额中回、左侧三角部额下回的ALFF值减低(均P<0.016)。与HC组相比,RDE组左侧楔前叶、右侧舌回的ALFF值减低(均P<0.016),FDE组右侧额中回、左侧三角部额下回的ALFF值增高,而FDE组在左侧楔前叶、左侧杏仁核、右侧海马、右侧舌回的ALFF值减低(均P<0.016)。相关性分析显示,RDE组右侧海马ALFF值与HAMA-14量表评分呈负相关(r=-0.53,P=0.014)。结论RDE与FDE病人的ALFF值差异脑区与前额叶-边缘神经环路密切相关,尤其在右侧额中回、左侧三角部额下回、左侧杏仁核、右侧海马表现明显,这有助于区别RDE组和FDE组的神经病理机制差异。

关键词：复发性抑郁症首发性抑郁症静息态功能磁共振成像低频振幅

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经皮耳甲迷走神经刺激对难治性抑郁症的即刻脑效应研究

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中国医学影像学杂志 2022年第8期30卷 757-763页

作者：王智何家恺孙继飞马跃郭春蕾洪洋方继良中国中医科学院广安门医院放射科北京100053 中国中医科学院针灸研究所北京100700

目的观察经皮耳甲迷走神经刺激(ta VNS)治疗难治性抑郁症(TRD)的即刻脑功能调制效应。资料与方法选择2018年9月—2020年1月纳入包括中国中医科学院广安门医院、宣武医院、清华大学玉泉医院就诊的TRD患者(n=34)及同期在网上招募的健康... 详细信息

目的观察经皮耳甲迷走神经刺激(ta VNS)治疗难治性抑郁症(TRD)的即刻脑功能调制效应。资料与方法选择2018年9月—2020年1月纳入包括中国中医科学院广安门医院、宣武医院、清华大学玉泉医院就诊的TRD患者(n=34)及同期在网上招募的健康志愿者(对照组,n=34)进行前瞻性研究。评估每位受试者的汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)、抑郁自评量表(SDS)、焦虑自评量表(SAS)、冗思反应量表(RRS),并于即刻刺激前后(30 min)采集受试者的静息态功能磁共振成像数据。采用度中心度(DC)方法,比较两组治疗前后的DC特征,进一步提取差异脑区的DC值,分析DC差值(刺激后-刺激前)与HAMD-17、HAMA、SDS、SAS、RRS评分的相关性。结果与对照组比较,TRD组在左侧海马旁回/杏仁核/伏隔核、双侧背外侧前额叶(左侧额中回、右侧额中回/额上回)的DC值较高、左侧枕中回/枕上回DC较低,两组刺激前后的差值在前扣带回膝部/眶回内侧部存在差异,以上差异脑区均经高斯随机场校正(体素水平阈值P<0.01,簇水平P<0.05);事后分析显示,刺激前TRD组DC值高于对照组,TRD组刺激后DC值明显低于刺激前(t=2.531、-4.029,P均<0.016);TRD组在前扣带回膝部/眶回内侧部刺激前后的DC差值与RRS、SDS评分呈负相关(r=-0.132,P=0.042;r=-0.389,P=0.023)。结论 TRD除情绪中枢存在功能异常外,还发现与奖赏及认知功能损害有关;ta VNS对情绪为主的相关脑区存在即刻调节作用。

关键词：度中心度难治性抑郁症经皮耳甲迷走神经刺激即刻效应

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非药物疗法治疗轻度认知障碍的临床研究进展

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世界科学技术-中医药现代化 2022年第3期24卷 918-924页

作者：郭春蕾王磊孙继飞何家恺王智张金铃方继良中国中医科学院广安门医院北京100053 中国中医科学院针灸研究所北京100700

当前人口老龄化日益严重,痴呆和轻度认知障碍患者与日俱增,对个人家庭和社会造成沉重的负担。但是,目前药物治疗痴呆和轻度认知障碍的研究进展缓慢。值得注意的是,多种非药物疗法也正探索各自对痴呆和轻度认知障碍的效应,本文将综述认... 详细信息

当前人口老龄化日益严重,痴呆和轻度认知障碍患者与日俱增,对个人家庭和社会造成沉重的负担。但是,目前药物治疗痴呆和轻度认知障碍的研究进展缓慢。值得注意的是,多种非药物疗法也正探索各自对痴呆和轻度认知障碍的效应,本文将综述认知训练、非侵入性脑刺激、针灸和中医特色疗法、以及饮食疗法对轻度认知障碍的研究进展,为临床及科研选择适当方法延缓或控制轻度认知障碍病情提供参考。

关键词：轻度认知障碍非药物疗法进展综述

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