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Engineering vascularized organotypic tissues via module assembly

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International Journal of Extreme Manufacturing 2024年第1期6卷 155-175页

作者： zhenzhen Zhou Changru Liu Yuting Guo Yuan Pang Wei sun Biomanufacturing Center Department of Mechanical EngineeringTsinghua UniversityHaidian DistrictBeijing 100084People’s Republic of China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Beijing 100084People’s Republic of China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084People’s Republic of China Department of Mechanical Engineering Drexel UniversityPhiladelphiaPA 19104United States of America

Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult,greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, as well as advanced tissue modeling.

关键词： vascularized organotypic tissue module assembly regenerative medicine tissue engineering

Bionic immunoactivator copresenting autophagy promoting and costimulatory molecules for synergistic cancer immunotherapy

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Nano Research 2024年第3期17卷 1710-1724页

作者： Yiwei Peng Yiliang Yang zhenzhen Yang Datong Gao Jiajia Li Qi sun Yitian Du Meng Lin Xianrong Qi Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Immunotherapy has great promise in improving malignant tumor ***,the efficacy of existing strategies is often limited by the immunosuppressive ***,we demonstrate an in situ bionic immunoactivator,PLT-Bec1/DTA-1,with possessed natural advantages of platelets for tumor recruitment and activation,on which DTA-1(CD357 monoclonal antibody)and Bec1 were tethered as combined immune ***-Bec1/DTA-1,as a self-triggered release repository,can deliver the pre-tethered Bec1 and DTA-1 deeply through the secretion of platelet microparticles(PMPs),thereby cooperate tacitly and exhibit superiority in immune activation of dendritic cells(DCs)and T cells via autophagy inducibility,coupled with glucocorticoid-induced tumor necrosis factor receptor(GITR)-triggered T_(Reg) suppression,remodeled the immunosuppressive network of tumor ***-Bec1/DTA-1 promoted antigen presentation and T cell proliferation,and alleviated the low activity state of bone marrow-derived dendritic cells(BMDCs)in tumor suppressive ***-Bec1/DTA-1 inhibited tumor recurrence(5-and 13-fold lower of control group in tumor volume)and CD8^(+)T/T_(Reg) ratio(6.3-and 8.8-fold *** group)in mouse tumor model after intravenous or subcutaneous ***,PLT-Bec1/DTA-1 prevented tumor colonization in lung through in situ immune activation,and was slightly superior to the combined of Bec1 and *** findings highlight the promise of delivering immunostimulatory payloads via bionic carriers,eliciting automatic in situ activation of effector immune cells in tumor microenvironment for tumor *** these results provide promising prospects into the application of immunoactivator in improving cancer synergistic immunotherapy to overcome the bottlenecks in clinic.

关键词： in situ bionic immunoactivator autophagy glucocorticoid-induced tumor necrosis factor receptor(GITR)agonist platelets and platelet microparticles cancer immunotherapy

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基于盲均衡算法的网络大数据异常节点检测

移动信息 2024年第2期46卷 171-174页

作者：孙真真高洪坤沧州交通学院河北沧州161100

网络大数据具有复杂性、多样性,其在流动期间容易出现异常节点。工作人员需采用智能性能检测的方式,才能减少网络故障问题的发生。相关部门基于网络大数据提出了异常节点的检测方法,采用传感序列采集模型,应用盲均衡算法提取网络环境中... 详细信息

网络大数据具有复杂性、多样性,其在流动期间容易出现异常节点。工作人员需采用智能性能检测的方式,才能减少网络故障问题的发生。相关部门基于网络大数据提出了异常节点的检测方法,采用传感序列采集模型,应用盲均衡算法提取网络环境中的噪声均值,以展现网络大数据异常节点的特征。基于此,文中结合实际,简要分析了盲均衡算法,阐述了基于盲均衡算法的网络大数据异常节点检测方法,以期为相关部门的工作提供支持。

关键词：盲均衡算法网络大数据异常节点检测

Targeted axillary dissection after neoadjuvant chemotherapy for highly selective patients with initial cN1 breast cancer:A single-center prospective trial

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Chinese Medical Journal 2024年第12期137卷 1421-1430页

作者： Xiuchun Chen Zhenduo Lu Chengzheng Wang Minhao Lyu Jianghua Qiao Xianfu sun Lianfang Li Chongjian Zhang zhenzhen Liu Department of Breast Disease The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China

Background:Sentinel lymph node(SLN)biopsy is gradually accepted as the standard of care in breast cancer patients with down-staged axillary disease after neoadjuvant chemotherapy(NAC).However,it is still difficult to precisely define pre-NAC clinical node-positive(cN1)and post-NAC clinical node-negative(ycN0).This prospective single-center trial was designed to evaluate the feasibility and accuracy of standard targeted axillary dissection(TAD)after NAC in highly selective pre-NAC cN1 patients(not considering ultrasound-based axillary ycN staging).Methods:This prospective trial included patients with initial pre-NAC cT1-3N1M0 invasive breast cancer but with a rigorous definition of cN1 from the Affiliated Cancer Hospital of Zhengzhou *** NAC was effective(including complete and partial responses)and preoperative axillary palpation was negative,preoperative ultrasound-based axillary staging was not considered,and all patients underwent TAD followed by axillary lymph node(LN)*** detection rate(DR)and false-negative rate(FNR)of TAD were ***:A total of 82 patients were included,and 77 of them were eligible for data *** DR for TAD was 94.8%(73/77).There were 26 patients with one abnormal LN at the time of diagnosis based on ultrasound,45 patients with two,and 2 patients with *** patient had one TAD LN,four patients had two TAD LNs,and 68 patients had three or more TAD *** axillary palpation yielded negative results for all 73 patients who successfully underwent *** ultrasound-based ycN0 and ycN+conditions were detected for 52 and 21 cases,*** FNR was 7.4%(2/27)for standard TAD(≥3 SLNs),which was lower than that of all successful TAD(≥1 SLN;10.0%,3/30).Conclusions:In rigorously defined pre-NAC cN1 breast cancer patients,standard TAD is feasible for those with negative axillary palpation after NAC,and FNR is also less than 10%.Registration:***,ChiCTR2100049093.

关键词： Breast cancer Sentinel lymph node biopsy Neoadjuvant chemotherapy Targeted axillary dissection Clip-marked lymph node

Study on patterns and chemical features of NO effect on marine phytoplankton growth

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Science China Chemistry 2005年第4期48卷 376-384页

作者： ZHANG Zhengbin LIN Cai LIU Chunying XING Lei WU zhenzhen sun Feng Institute of Marine Chemistry Ocean University of ChinaQingdao 266003China Institute of Marine ChemistryOcean University of ChinaQingdao 266003China Institute of Marine ChemistryOcean University of ChinaQingdao 266003China Institute of Marine ChemistryOcean University of ChinaQingdao 266003China Institute of Marine ChemistryOcean University of ChinaQingdao 266003China Institute of Marine ChemistryOcean University of ChinaQingdao 266003China

This article discusses the patterns of NO effect on marine phytoplankton growth from chemical *** experimental results of four algae,which are Platymonas hal-golandica ***,Platymonas subcordiformis,Skeletonema costatum and Nitzschia closterium farma minutissima,are as follows:(i) In f/2 medium or f/50 medium,the growth of these four algae was obviously promoted or inhibited when nitric oxide of different concentrations was added once or twice each day during the cultivation;(ii) The NO effects on the growth of marine phytoplankton are in normal *** phytoplankton has different optimum NO concentration,which is consistent with the influence of NO on the growth of high plants;(iii) The effect of NO on Platymonas halgolandica ***,which is a food alga,is different from that on the red tide algae Skeletonema costatum and Nitzschia closterium farma *** authors put forward a new opinion that every alga has its own NO threshold *** the above results may provide new clues to understand the formation of red tide.

关键词： nitric oxide (NO), marine phytoplankton (red tide algae and food algae), optimum NO concentration, NO threshold concentration, influencing patterns.

Effect of GnRH analogs in advanced male breast cancer:10-year experience from the Henan Breast Cancer Center and literature review

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Chinese Medical Journal 2024年第13期137卷 1623-1625页

作者： Mengwei Zhang Huimin Lyu Limin Niu zhenzhen Liu Huiai Zeng Shengnan Zhao Jing Wang Huihui sun Min Yan Department of Breast Disease Henan Breast Cancer CenterThe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China

To the Editor:Male breast cancer is relatively rare,accounting for just 1%of all breast cancer cases.[1]The management strategies for male breast cancer are mainly based on a limited number of retrospective studies and speculation based on female breast *** study presents a comprehensive account of a decade-long observation of male metastatic breast cancer(mMBC)in our *** Affiliated Cancer Hospital of Zhengzhou University database had records of 2853 advanced breast cancer cases that were treated from January 1,2010 to December 31,*** of the total number,18 cases were identified as *** analysis encompassed data about the treatment administered,the treatment’s effectiveness,and the patient’s survival *** present investigation entails a retrospective examination of our institution’s 10-year experience with patients diagnosed with mMBC and a comprehensive evaluation of relevant literature.

关键词： breast Cancer cancer

Ball-milling Synthesis of Tetrahydroquinolines via 'One-pot' Three-component Diels-Alder Reaction Catalyzed by Phosphotungstic Acid

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Chemical Research in Chinese Universities 2020年第5期36卷 835-842页

作者： WANG Zeyou SHEN Guodong HUANG Xianqiang GONG Shuwen YANG Bingchuan sun zhenzhen ZHANG Zuhao LIU Wanxing School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252000P.R.China Department of Chemistry Liaocheng Chemical Institute of Industrial ScienceLiaocheng 252000P.R.China

We reported an economic and practical ball-milling method for the synthesis of tetrahvdroquinoline derivatives via a wone-pot"three-component Diels-Alder reaction of anilines,aldehydes and alkenes catalyzed by phos-photungstic acid at room *** this reaction,a simple 'one-pot'ball-milling operation was conducted,readily available starting materials were employed,'one-pot'conditions were applied,and the most important was to use inexpensive and environmentally friendly catalyst phosphotungstic *** tetrahvdroquinolines,which might be potentially applicable in the pharmaceutical and biochemical areas,were conveniently synthesized in moderate to excellent yields.

关键词： Ball-milling Diels-Alder reaction Phosphotungstic acid Tetraliydroquinoline

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山西省水-能源-粮食纽带系统效率研究

华北水利水电大学学报（自然科学版） 2023年第3期44卷 69-80页

作者：孙才志孙贞贞辽宁师范大学海洋经济与可持续发展研究中心辽宁大连116029 辽宁师范大学地理科学学院辽宁大连116029

水、能源和粮食是人类生存和发展最重要的战略基础资源,如何保持水、能源、粮食的协调发展是经济社会可持续发展需要解决的关键问题。基于超效率网络DEA模型构建了水-能源-粮食纽带系统指标体系,对山西省2003—2018年水-能源-粮食纽带... 详细信息

水、能源和粮食是人类生存和发展最重要的战略基础资源,如何保持水、能源、粮食的协调发展是经济社会可持续发展需要解决的关键问题。基于超效率网络DEA模型构建了水-能源-粮食纽带系统指标体系,对山西省2003—2018年水-能源-粮食纽带效率进行了测度,从时空角度分析了其变化特征,并利用社会网络分析模型对山西省各地区水-能源-粮食纽带效率的网络关联结构特征进行了研究。研究发现:①山西省水-能源-粮食各子系统及纽带系统效率处于较低水平并呈波动状态;山西省水-能源-粮食纽带效率值表现出明显的空间差异,水-能源-粮食纽带效率高值区域多集中于省内能源型城市;山西省能源子系统对水-能源-粮食纽带系统发挥着更为重要的作用。②山西省水-能源-粮食纽带效率空间关联呈网络结构形态,各地区均处于网络之中,不存在“孤岛”现象,网络的连通性较好。③“净溢出”板块与“双向溢出”板块主要集中在能源禀赋条件优越的地区,且“净溢出”板块的表现更为明显,其在山西省水-能源-粮食纽带效率空间关联网络中扮演着“发动机”的角色;“净受益”板块主要集中在经济发展水平高的地区;“经纪人”板块的水-能源-粮食纽带效率较低,在网络中处在边缘地位。

关键词：水-能源-粮食纽带系统超效率网络DEA模型社会网络分析山西省

Design and optimization of piperidinesubstituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3110-3124页

作者： Yanying sun zhenzhen Zhou Zhongling Shi Fabao Zhao Minghui Xie Zongji Zhuo Erik De Clercq Christophe Pannecouqueb Dongwei Kang Peng Zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJinan 250012China Rega Institute for Medical Research Laboratory of Virology and ChemotherapyK.U.LeuvenLeuven B-3000Belgium China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Jinan 250012China

HIV-1 reverse transcriptase(RT)has received great attention as an attractive therapeutic target for acquired immune deficiency syndrome(AIDS),but the inevitable drug resistance and side effects have always been major challenges faced by non-nucleoside reverse transcriptase inhibitors(NNRTIs).This work aimed to identify novel chemotypes of anti-HIV-1 agents with improved drugresistance profiles,reduced toxicity,and excellent druggability.A series of diarylpyrimidine(DAPY)derivatives were prepared via structural modifications of the leads K-5a2 and *** them,15a with dimethylphosphine oxide moiety showed the most prominent antiviral potency against all of the tested viral panel,being 1.6-fold(WT,EC_(50) Z 1.75 nmol/L),3.0-fold(L100I,EC_(50) Z 2.84 nmol/L),2.4-fold(K103N,EC_(50) Z 1.27 nmol/L),3.3-fold(Y181C,EC50 Z 5.38 nmol/L),2.9-fold(Y188L,EC_(50) Z 7.96 nmol/L),2.5-fold(E138K,EC_(50) Z 4.28 nmol/L),4.8-fold(F227L/V106A,EC_(50) Z 3.76 nmol/L)and 5.3-fold(RES056,EC_(50) Z 15.8 nmol/L)more effective than that of the marketed drug *** docking results illustrated the detailed interactions formed by compound 15a and WT,F227L/V106A,and RES056 ***,15a-HCl carried outstanding pharmacokinetic(t1/2 Z 1.32 h,F Z 40.8%)and safety profiles(LD_(50)>2000 mg/kg),which demonstrated that 15a HCl is a potential anti-HIV-1 drug candidate.

关键词： HIV-1 NNRTIs NNIBP Structural alert Anti-HIV-1 drug candidate