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Mantle melting factors and amagmatic crustal accretion of the Gakkel ridge, Arctic Ocean

Acta Oceanologica Sinica 2015年第6期34卷 42-48页

作者： ZHANG Tao GAO Jinyao CHEN Mei YANG Chunguo SHEN Zhongyan ZHOU Zhiyuan WU zhaocai sun Yunfan Key Laboratory of Submarine Geosciences State Oceanic Administration Second Institute of Oceanography State Oceanic Administration East China Construction Engineering Corporation of Zhejiang School of Ocean and Earth Science Tongji University

Spreading rate is a primary factor of mantle melting and tectonic behavior of the global mid-ocean ridges. The spreading rate of the Gakkel ridge decreases gradually from west to east. However, the Gakkel ridge can be divided into four thick-and-thin zones with varying crustal thicknesses along ridge axis. This phenomenon indicates that mantle melting of the Gakkel ridge is not a simple function of spreading rate. Mantle temperature, water content, mantle composition, and other factors are important in crustal accretion processes. Based on gravity-derived crustal thickness and wet melting model, we estimate that the mantle potential temperatures of the four zones are 1 270, 1 220, 1 280, and 1 280℃ （assuming that mantle water content equals to global average value）, with corresponding mantle water contents of 210, 0, 340, and 280 mg/kg （assuming that mantle potential temperature is 1 260℃）, respectivly. The western thinned crust zone is best modeled with low mantle temperature, whereas the other zones are mainly controlled by the enhanced conduction caused by the slower spreading rate. Along the Gakkel ridge, the crustal thickness is consistent with rock samples types. Predominated serpentinized peridotite and basalt are found in the area with crustal thickness 〈1.5 km and 〉2.5 km, respectively. The rock samples are including from basalt to peridotite in the area with crustal thickness between 1.5 and 2.5 km. Based on this consistency, the traditional magmatic accretion zone accounted for only 44% and amagmatic accretion accounted for 29% of the Gakkel ridge. The amagmatic accretion is a significant characteristic of the ultra-slow spreading ridge.

关键词： Gakkel ridge residual mantle bouguer anomaly crustal thickness wet melting amagmatic accretion

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Exploration of the shared gene signatures and molecular mechanisms between periodontitis and inflammatory bowel disease:evidence from transcriptome data

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Gastroenterology Report 2023年第1期11卷 412-423页

作者： Chi Zhan zhaocai Zhou Yaxian Huang Shuheng Huang Zhengmei Lin FengHe Zhi Song Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangzhou First People’s Hospital School of MedicineSouth China University of TechnologyGuangzhouGuangdongP.R.China

Background:Periodontitis disease(PD)is associated with a systemic disorder of inflammatory bowel disease(IBD).The immune response is the common feature of the two conditions,but the more precise mechanisms remain ***:Differential expressed genes(DEGs)analysis and weighted gene co-expression network analysis(WGCNA)were performed on PD and Crohn’s disease(CD)data sets to identify crosstalk genes linking the two *** proportions of infiltrating immune cells were calculated by using Single-sample Gene Set Enrichment *** addition,a data set of isolated neutrophils from the circulation was performed via WGCNA to obtain PD-related key ***,single-cell gene set enrichment scores were computed for the key module and grouped neutrophils according to score order in the IBD scRNA-seq data ***-cell gene enrichment analysis was used to further explore the biological process of the ***:A total of 13 crosstalk genes(IL1B,CSF3,CXCL1,CXCL6,FPR1,FCGR3B,SELE,MMP7,PROK2,SRGN,FCN1,TDO2 and CYP24A1)were identified via DEGs analysis and WGCNA by combining PD and CD data *** enrichment analysis showed that these genes were involved in interleukin-10 signaling and inflammatory *** immune infiltration analysis showed a significant difference in the proportion of neutrophils in PD and CD compared with healthy *** were scored based on the expression of a periodontitis-related gene set in the scRNA-seq data set of *** enrichment analysis demonstrated that inflammatory response,TNFa signaling via NF-jB and interferon-gamma response were upregulated in the high-score group,which expressed more pro-inflammatory cytokines and chemokines compared with the low-score ***:This study reveals a previously unrecognized mechanism linking periodontitis and IBD through crosstalk genes and neutrophils,which provides a theoretical framework for future research.

关键词： periodontitis inflammatory bowel disease neutrophils immune infiltration inflammation bioinformatics

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MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages

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Cellular & Molecular Immunology 2023年第12期20卷 1413-1427页

作者： Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua sun Feng Li Hao Chen zhaocai Zhou Yunfeng Cheng Department of Hematology Zhongshan HospitalFudan UniversityShanghai200032China Center for Tumor Diagnosis&Therapy Jinshan HospitalFudan UniversityShanghai201508China Department of Transfusion Medicine Zhongshan HospitalFudan UniversityShanghai200032China Department of Laboratory Medicine Zhongshan HospitalFudan UniversityShanghai200032China Department of Hematology Zhongshan Hospital Qingpu BranchFudan UniversityShanghai201700China Department of Thoracic Surgery Zhongshan-Xuhui HospitalFudan UniversityShanghai200031China State Key Laboratory of Genetic Engineering Zhongshan HospitalSchool of Life SciencesFudan UniversityShanghai200438China Institute of Clinical Science Zhongshan HospitalFudan UniversityShanghai200032China

Primary immune thrombocytopenia(ITP)is an autoimmune hemorrhagic disorder in which macrophages play a critical *** sterile-20-like kinase 4(MST4),a member of the germinal-center kinase STE20 family,has been demonstrated to be a regulator of *** MST4 participates in the macrophage-dependent inflammation of ITP remains *** expression and function of MST4 in macrophages of ITP patients and THP-1 cells,and of a macrophage-specific Mst4−/−(Mst4ΔM/ΔM)ITP mouse model were *** phagocytic assays,RNA sequencing(RNA-seq)analysis,immunofluorescence analysis,coimmunoprecipitation(co-IP),mass spectrometry(MS),bioinformatics analysis,and phosphoproteomics analysis were performed to reveal the underlying *** expression levels of the MST4 gene were elevated in the expanded M1-like macrophages of ITP patients,and this elevated expression of MST4 was restored to basal levels in patients with remission after high-dose dexamethasone *** expression of the MST4 gene was significantly elevated in THP-1-derived M1 *** of MST4 decreased the expression of M1 macrophage markers and cytokines,and impaired phagocytosis,which could be increased by overexpression of *** a passive ITP mouse model,macrophage-specific depletion of Mst4 reduced the numbers of M1 macrophages in the spleen and peritoneal lavage fluid,attenuated the expression of M1 cytokines,and promoted the predominance of FcγRIIb in splenic macrophages,which resulted in amelioration of *** of MST4 directly inhibited STAT1 phosphorylation,which is essential for M1 polarization of *** study elucidates a critical role for MST4 kinase in the pathology of ITP and identifies MST4 kinase as a potential therapeutic target for refractory ITP.

关键词： Primary immune thrombocytopenia Mammalian sterile-20-like kinase 4(MST4) Macrophages M1 polarization Signal transducer and activator of transcription-1(STAT1)

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Improving hard metal implant and soft tissue integration by modulating the“inflammatory-fibrous complex”response

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Bioactive Materials 2023年第2期20卷 42-52页

作者： Peina Huang Jieyun Xu Lv Xie Guangqi Gao Shoucheng Chen Zhuohong Gong Xiaomei Lao Zhengjie Shan Jiamin Shi zhaocai Zhou Zhuofan Chen Yang Cao Yan Wang Zetao Chen Hospital of Stomatology Guanghua School of StomatologySun Yat-sen University and Guangdong Provincial Key Laboratory of StomatologyNo.56Lingyuan West RoadYuexiu DistrictGuangzhou510055China

Soft tissue integration is one major difficulty in the wide applications of metal materials in soft tissue-related *** inevitable inflammatory response and subsequent fibrous reaction toward the metal implant is one key response for metal implant-soft tissue *** is of great importance to modulate this inflammatory-fibrous response,which is mainly mediated by the multidirectional interaction between fibroblasts and *** this study,macrophages are induced to generate M1 and M2 macrophage immune *** cytokine profiles have been proven to have potentially multi-regulatory effects on *** multi-reparative effects of soft tissue cells(human gingival fibroblasts)cultured on metal material(titanium alloy disks)in M1 and M2 immune microenvironments are then *** in the M1 immune microenvironment tend to aggravate the inflammatory response in a pro-inflammatory positive feedback loop,while M2 immune microenvironment enhances multiple functions of fibroblasts in soft tissue integration,including soft tissue regeneration,cell adhesion on materials,and contraction to immobilize soft *** by the close interaction between macrophages and fibroblasts,we propose the concept of an“inflammatory-fibrous complex”to disclose possible methods of precisely and effectively modulating inflammatory and fibrous responses,thus advancing the development of metal soft tissue materials.

关键词： Inflammation Soft tissue Macrophage Fibroblast Metal material

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基于CNN的消费品缺陷领域词典构建方法研究

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数据分析与知识发现 2020年第11期4卷 112-120页

作者：彭郴吕学强孙宁张乐姜肇财宋黎北京信息科技大学网络文化与数字传播北京市重点实验室北京100101 中国标准化研究院北京100191

【目的】有效地构建消费品缺陷领域词典,有助于了解专业领域动态与领域关键信息。【方法】首先,通过语料中的词频特征挖掘领域相关短语词;其次,使用TF-IDF算法构建领域词库以减少人工标注成本;最后,基于卷积神经网络(CNN)模型融入语义... 详细信息

【目的】有效地构建消费品缺陷领域词典,有助于了解专业领域动态与领域关键信息。【方法】首先,通过语料中的词频特征挖掘领域相关短语词;其次,使用TF-IDF算法构建领域词库以减少人工标注成本;最后,基于卷积神经网络(CNN)模型融入语义、位置信息进一步生成领域词典,提升领域词典的健壮性与泛化能力。【结果】实验结果表明,本文方法与统计学习方法相比,在准确率、召回率和F1值上提升了6%~9%。【局限】仅在消费品缺陷领域文本上构建词典,在其他领域的效果有待验证。【结论】基于CNN的消费品缺陷领域词典构建方法可以提升消费品缺陷领域词典的构建效果。

关键词：领域词典词频特征 TF-IDF 卷积神经网络

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塔里木盆地库车山前超深气井砂垢堵塞成因及靶向解除技术

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天然气工业 2024年第8期44卷 85-94页

作者：曹立虎江同文潘昭才孙涛张宝吴红军易俊中国石油塔里木油田公司中国石油天然气集团有限公司超深层复杂油气藏勘探开发技术研发中心新疆维吾尔自治区超深层复杂油气藏勘探开发工程研究中心新疆超深油气重点实验室中国石油天然气股份有限公司

塔里盆地库车山前超深气田是西气东输主力气源地,具有超高温、超高压、高矿化度、储层裂缝非均质性强等特征,气井生产过程中砂垢堵塞问题突出,据统计最高影响气田产能达800×104 m^(3)/d。为实现超深气井高效解堵,通过气水两相结垢热力... 详细信息

塔里盆地库车山前超深气田是西气东输主力气源地,具有超高温、超高压、高矿化度、储层裂缝非均质性强等特征,气井生产过程中砂垢堵塞问题突出,据统计最高影响气田产能达800×104 m^(3)/d。为实现超深气井高效解堵,通过气水两相结垢热力学预测模型、裂缝性储层岩石力学实验、井筒内气液固流动模拟等研究,揭示了超深气井砂垢复合堵塞成因,并形成了靶向解堵复产关键技术。研究结果表明:①“高温流动压降结垢、裂缝面破裂出砂”是超深气井出砂结垢的内在机理;②结垢固化松散砂桥形成复合堵塞是气井堵塞减产的主要原因,其中靶向除垢是解堵复产的关键所在;③靶向除垢解堵区域为井筒变径处和井周5 m内基质—裂缝系统,气井堵塞率30%~60%为最佳解堵时机;④非酸性除垢解堵液相比常用的酸性解堵液,在同级别溶垢能力的基础上,腐蚀速率降至0.49 g/(m^(2)·h),可同时满足低腐蚀和高效除垢的技术要求。结论认为,形成的超深气井靶向除垢解堵技术在塔里木盆地库车山前超深气田规模应用159井次,有效率达93.3%,累计增产天然气75.08×10^(8)m^(3),已成为西气东输主力气井快速解堵复产的“冬保良方”,可为国内外同类气田解堵复产提供技术借鉴。

关键词：塔里木盆地库车山前超深层高温流动压降结垢裂缝性储层出砂砂垢复合堵塞非酸性靶向除垢解堵

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热辊压对锂离子电池正极极片性能的影响

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储能科学与技术 2024年第5期13卷 1443-1450页

作者：吕兆财王玉西汪智涛孙晓辉李景康杭州南都动力科技有限公司浙江杭州311222

利用磷酸铁锂动力锂离子电池生产产线设备进行正极片制备,辊压工序分别将主辊温度设置为25℃、60℃、80℃、100℃、120℃,在相同主辊压力下将涂布后极片辊压至同一厚度,而后将相应极片制备成扣式电池并综合对比极片的各性能指标。结果... 详细信息

利用磷酸铁锂动力锂离子电池生产产线设备进行正极片制备,辊压工序分别将主辊温度设置为25℃、60℃、80℃、100℃、120℃,在相同主辊压力下将涂布后极片辊压至同一厚度,而后将相应极片制备成扣式电池并综合对比极片的各性能指标。结果表明热辊压对极片延展率无影响,但是会在一定程度上对辊压厚度均一性有所改善;热辊压能够降低极片的电阻,相比于常温辊压极片,100℃时极片电阻约下降2.1%;同时,热辊压可减小极片辊压后的厚度反弹,以60℃和100℃时最优,反弹率约为25℃时的一半;剥离力随辊压温度呈现先上升后下降的趋势,在60℃附近达到最高点。从扣电的性能上看,热辊压可有效降低电芯的欧姆阻抗和电荷传递阻抗,在100℃左右时最佳,这与极片膜片电阻结果一致;同时热辊压后的极片在倍率性能上也表现得更加出色,以100℃左右时最佳,但从100周循环数据上看,热辊压后极片所制扣电与常温辊压极片所制扣电无明显差别。综合各主辊温度下辊压所制极片和扣电在各性能测试中的表现,热辊压对极片和电芯性能有正向的改进作用,效果在100℃左右时达到最优。

关键词：锂离子电池热辊压磷酸铁锂工艺窗口

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中国标院:智慧传播助力召回监管

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中国市场监管研究 2020年第10期 73-75页

作者：宋黎姜肇财孙宁中国标准化研究院

缺陷产品召回是后市场监管的重要手段,在改善产品质量,减少因产品缺陷而带来的安全伤害事故、维护公共安全,保护消费者权益,推动经济高质量发展等方面发挥着至关重要的作用。截至目前,我国累计召回车辆7899万辆、消费品6899万件。庞大... 详细信息

缺陷产品召回是后市场监管的重要手段,在改善产品质量,减少因产品缺陷而带来的安全伤害事故、维护公共安全,保护消费者权益,推动经济高质量发展等方面发挥着至关重要的作用。截至目前,我国累计召回车辆7899万辆、消费品6899万件。庞大的缺陷产品召回数量一方面反映了召回制度实施的积极成效;另一方面也给监管部门带来了新的挑战。如何有效引导消费者及时获取产品召回信息、识别产品安全隐患、规避产品安全风险,成为打通召回制度"最后一公里"需要思考和探索实践的重要课题。

关键词：召回制度市场监管缺陷产品召回产品安全公共安全最后一公里产品质量产品缺陷

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