Objective To investigate the therapeutic effect of Xiangshao Granules(XSG)on post-stroke depression(PSD)and explore the underlying *** Forty-three C57BL/6J mice were divided into 3 groups:sham(n=15),PSD+vehicle(n=14),...
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Objective To investigate the therapeutic effect of Xiangshao Granules(XSG)on post-stroke depression(PSD)and explore the underlying *** Forty-three C57BL/6J mice were divided into 3 groups:sham(n=15),PSD+vehicle(n=14),and PSD+XSG(n=14)groups according to a random number *** PSD models were constructed using chronic unpredictable mild stress(CUMS)after middle cerebral artery occlusion(MCAO).The sham group only experienced the same surgical operation,but without MACO and CUMS *** XSG group received XSG(60 mg/kg per day)by gavage for 4 *** mice in the sham and vehicle groups were given the same volume of 0.9%saline at the same *** body weight and behavior tests including open field test,sucrose preference test,tail suspension test,and elevated plus-maze test,were used to validate the PSD mouse ***-time fluorescence quantitative polymerase chain reaction(RT-qPCR),enzyme-linked immunosorbent assay(ELISA),and immunofluorescence staining were used to evaluate the anti-inflammatory effects of *** potential molecular mechanisms were explored and verified through network pharmacology analysis,Nissl staining,Western blot,ELISA,and RT-qPCR,*** The body weight and behavior tests showed that MCAO combined with CUMS successfully established the PSD *** alleviated neuronal damage,reduced the expressions of pro-apoptotic proteins Caspase-3 and B-cell lymphoma-2(BCL-2)-associated X(BAX),and increased the expression of anti-apoptotic protein BCL-2 in PSD mice(P<0.05 or P<0.01).XSG inhibited microglial activation and the expressions of pro-inflammatory cytokines including tumor necrosis factor-α,interleukin(IL)-1β,and IL-6 via the toll-like receptor 4/nuclear factor kappa-B signaling pathway in PSD mice(P<0.05 or P<0.01).Furthermore,XSG decreased the expression of indoleamine 2,3-dioxygenase1(IDO1)and increased the concentration of 5-hydroxytryptamine in PSD mice(P<0.05 or P<0.01).Conclusion XSG could reverse
BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine ***,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)re...
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BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine ***,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)remains relatively *** To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD *** This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December *** on data from previous similar studies,the patients were randomly assigned to either a routine diet(RD)group(n=48)or a personalized nutrition(PN)group(n=48).The RD group received conventional dietary guidance,while the PN group received individualized diet intervention measures based on human *** intervention period lasted for 12 *** mineral density(BMD),body mass index(BMI),muscle mass,mineral content,osteocalcin,25-hydroxyvitamin D,procollagen type I N-terminal propeptide(PINP),beta C-terminal telopeptide of type I collagen(β-CTX),and serum calcium were measured and compared between the two groups before and 12 weeks after the *** No significant differences were observed between groups in terms of age,sex,height,BMI,or other baseline data(P>0.05).In both groups,BMI did not show significant changes after the intervention(P>0.05),whereas muscle mass and mineral content were significantly increased(P-1 compared to the RD group(P<0.05).The mini-mental state examination(MMSE)score was similar in both groups before the ***,12 weeks after the intervention,the MMSE score in the PN group was significantly higher than
In this study,ionosonde observations over Fuke(19.5°N,109.1°E),Wuhan(30.5°N,114.4°E),and Mohe(53.5°N,122.3°E)were analyzed to demonstrate the responses of the sporadic E()to the severe atmospheric disturbances c...
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In this study,ionosonde observations over Fuke(19.5°N,109.1°E),Wuhan(30.5°N,114.4°E),and Mohe(53.5°N,122.3°E)were analyzed to demonstrate the responses of the sporadic E()to the severe atmospheric disturbances caused by the Tonga volcanic eruptions on January 15,*** most prominent signature was the disappearance of the layer after~10:00 UT over Wuhan and Fuke,which was attributed to the vertical drift caused by the *** occurred intermittently after 13:00 UT following the arrival of the tropospheric Lamb *** examine the causal mechanism for the intermittence,we also included data of horizontal winds in the mesosphere and lower thermosphere region recorded by the meteor radars at Wuhan and Mohe in this *** wind disturbances with periods of~20 hours contributed to the formation of the layer in the nighttime on January 15.
Near-eutectic Al-Si alloys are widely used in automotive manufacturing due to their superior wear resistance and high temperature *** of high Si content,the grain refinement of near-eutectic Al-Si alloy has been a pro...
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Near-eutectic Al-Si alloys are widely used in automotive manufacturing due to their superior wear resistance and high temperature *** of high Si content,the grain refinement of near-eutectic Al-Si alloy has been a problem for many *** this study,the effect of deep cryogenic treatment(DCT)on the microstructure and mechanical properties of Al-12Si-4Cu-2Ni-Mg alloy with addition of Al-Ti-C-B master alloy was fully *** show that the average grain size of the alloy is greatly reduced from 0.92 mm to 0.50 mm,and the eutectic Si and Al7Cu4Ni precipitates are spheroidized and refined in Al-12Si-4Cu-2Ni-Mg after DCT for 24 h and aging *** these changes of microstructures result in a significant increment of about 22.5%in elongation and a slight enhancement of about 6.8%in tensile ***,the refinement of microstructure also significantly improves the fatigue life of the alloy.
Autonomous underwater vehicles(AUV) work in a complex marine environment. Its system reliability and autonomous fault diagnosis are particularly important and can provide the basis for underwater vehicles to take corr...
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Autonomous underwater vehicles(AUV) work in a complex marine environment. Its system reliability and autonomous fault diagnosis are particularly important and can provide the basis for underwater vehicles to take corresponding security policy in a failure. Aiming at the characteristics of the underwater vehicle which has uncertain system and modeling difficulty, an improved Elman neural network is introduced which is applied to the underwater vehicle motion modeling. Through designing self-feedback connection with fixed gain in the unit connection as well as increasing the feedback of the output layer node, improved Elman network has faster convergence speed and generalization ability. This method for high-order nonlinear system has stronger identification ability. Firstly, the residual is calculated by comparing the output of the underwater vehicle model(estimation in the motion state) with the actual measured values. Secondly, characteristics of the residual are analyzed on the basis of fault judging criteria. Finally, actuator fault diagnosis of the autonomous underwater vehicle is carried out. The results of the simulation experiment show that the method is effective.
Lithium-sulfur (Li-S) batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish ...
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Lithium-sulfur (Li-S) batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni_(2)P by concurrently introducing B-doped atoms and P vacancies in Ni_(2)P (Vp-B-Ni_(2)P),thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni_(2)P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides (LiPSs) as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni_(2)P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni_(2)P-separators present outstanding rate ability of 777 m A h g^(-1)at 5 C and high areal capacity of 8.03 mA h cm^(-2)under E/S of 5μL mg^(-1)and sulfur loading of 7.20 mg cm^(-2).This work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.
认证数据结构(authenticated data structure,ADS)解决了数据外包存储场景下服务器的不可信问题,用户通过ADS可以验证不可信服务器返回查询结果的正确性与完整性,但数据拥有者的安全性难以保证,攻击者可以篡改数据拥有者存储的ADS,破坏...
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认证数据结构(authenticated data structure,ADS)解决了数据外包存储场景下服务器的不可信问题,用户通过ADS可以验证不可信服务器返回查询结果的正确性与完整性,但数据拥有者的安全性难以保证,攻击者可以篡改数据拥有者存储的ADS,破坏对查询结果的完整性、正确性验证.数据拥有者将ADS存储在区块链上,借助区块链的不可篡改性,可以解决上述问题.但现有ADS实现方案在区块链上维护成本较高并且大部分只支持静态数据的可验证查询,目前缺少一种针对区块链设计的高效ADS.通过分析智能合约的gas消耗机制与基于传统MHT的ADS的gas开销,提出一种新型ADS认证结构SMT,实现对流数据的高效可验证查询,并且在区块链上具备更低的gas消耗.从理论及实验出发,验证了SMT的高效性,通过安全性分析,证明了SMT的安全性.
Sparse rewards pose significant challenges in deep reinforcement learning as agents struggle to learn from experiences with limited reward *** experience replay(HER)addresses this problem by creating“small goals”wit...
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Sparse rewards pose significant challenges in deep reinforcement learning as agents struggle to learn from experiences with limited reward *** experience replay(HER)addresses this problem by creating“small goals”within a hierarchical decision ***,HER does not consider the value of different episodes for agent *** this paper,we propose SPAHER,a framework for prioritizing hindsight experiences based on spatial position *** allows the agent to prioritize more valuable experiences in a manipulation *** achieves this by calculating transition and trajectory spatial position functions to determine the value of each episode for experience *** evaluate SPAHER on eight robot manipulation tasks in the Fetch and Hand environments provided by OpenAI *** results show that our method improves the final mean success rate by an average of 3.63%compared to HER,especially in challenging Hand ***,these improvements are achieved without any increase in computation time.
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