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First observation results of Macao Science Satellite-1 on lightning-induced electron precipitation

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Science China Earth Sciences 2025年第1期 1-10页

作者： Yongping WANG yixin sun Qiugang ZONG Gaopeng LU Xudong GU Ze-Jun HU Bin LI Key Laboratory for Polar Science Ministry of Natural Resources Polar Research Institute of China Institute of Space Physics and Applied Technology Peking University State Key Laboratory of Lunar and Planetary Science Macau University of Science and Technology School of Earth and Space Sciences University of Science and Technology of China School of Electronic Information Wuhan University

The Medium-energy Electron Spectrometers(MES) is a space-borne instrument onboard Macao Science Satellite-1(MSS-1) dedicated to monitoring the typical charged particle radiation characteristics in the satellite orbit and the process of their occurrence and development, including short bursts of lightning-induced electron precipitation(LEP).This paper presents the first results of the LEP measurements by the MSS-1.47 LEP events are identified with the routine operation for 3 months since satellite launch, all within the range of 1.5

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Large-scale episodic enhancements of relativistic electron intensities in Jupiter's radiation belt

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Earth and Planetary Physics 2021年第4期5卷 314-326页

作者： ChongJing Yuan YiQiao Zuo Elias Roussos Yong Wei yixin Hao yixin sun Norbert Krupp Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Max Planck Institute for Solar System Research Justus-von-Liebig-Weg 3Göttingen37077Germany Institute of Space Physics and Applied Technology Peking UniversityBeijing 100871China

Previous studies indicate that,in the Jovian magnetosphere,the long-term trend of the radial profile of relativistic electron intensities is primarily shaped by slow radial ***,measurements by the Galileo spacecraft reveal the existence of transient increases in MeV electron intensities well above the ambient *** is unclear how common such transient enhancements are,and to which dynamic processes in Jupiter's magnetosphere their occurrence is *** investigate the radial distributions of >11 MeV and >1 MeV electron intensities from 9R_(J) to 40R_(J)(R_(J)=71492km denotes the Jovian radius),measured by the Galileo spacecraft from 1996 to *** find transient enhancements of MeV electrons during seven Galileo crossings,mostly occurring around~20R_(J).An apparent dawn-dusk asymmetry of their occurrence is resolved,with a majority of events discovered at *** dawn-dusk asymmetry,as well as the average recurrence time scale of a few days,implies a potential relationship between the MeV electron transients and the storm-like dynamics in the middle and outer magnetosphere detected using a variety of Galileo,Juno and remote sensing aurora *** suggest that the observations of some of these transients in the inner magnetosphere may result from a synergy between the convective transport by a large-scale dawn-dusk electric field and the sources provided by injections in the middle magnetosphere.

关键词： radiation belt Jupiter relativistic electrons magnetosphere

Reverberation nulling and echo enhancement at low frequency using waveguide invariance

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Chinese Science Bulletin 2011年第2期56卷 142-150页

作者： GUO GuoQiang YANG yixin sun Chao Institute of Acoustic Engineering Northwestern Polytechnical University Xi' an 710072 China

Based on the fact that the transfer function vector between a source receiver array and the dominant scatterer of boundary reverberation at a range can be obtained from the corresponding reverberations scattered from this range cell,a reverberation nulling concept using time reversal processing has been ***,current reverberation nulling methods have certain limitations when applied into practice,which would null boundary reverberation and target echo *** a solution,a passive reverberation nulling and echo enhancement method at low frequency using waveguide invariance is proposed in this *** this method,the reverberation subspace for the target range cell is not obtained directly from the return signals scattered by the target range cell but from the return signals scattered by a range cell located before the target using waveguide invariance,so as to suppress the reverberation embodied in the target echo by passive reverberation ***,a range-dependent optimal weighting vector rather than conventional projector matrix is deduced to null the reverberation component meanwhile maximizing the target echo,thereby enhancing the echo-to-reverberation ratio *** simulations in typical range-independent shallow water environment demonstrate the efficacy and the improved performance of the proposed method for echo-to-reverberation enhancement.

关键词：低频率混响调零变性波导目标回波回声距离单元

Evolution of electron“zebra stripes”in the South Atlantic Anomaly:Initial observations from Macao Science Satellite-1

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Science China(Technological Sciences) 2024年第11期67卷 3344-3353页

作者： LIU Ying ZONG QiuGang ZOU Hong YE YuGuang sun yixin Institute of Space Physics and Applied Technology Peking UniversityBeijing 100871China State Key Laboratory of Lunar and Planetary Science Macao University of Science and TechnologyMacao 999078China

“Zebra stripes”denote banded structures characterized by periodic peaks and valleys in the spectrograms of energetic electrons in the Earth's inner radiation belt and slot *** contrast to previous investigations primarily grounded in equatorial observations,this study presents two events exhibiting the evolution of electron zebra stripes within the South Atlantic Anomaly,as observed from the Macao Scientific Satellite-1 in low Earth *** findings affirm that the structural and evolutionary features of zebra stripes in both events accord with the drift echo *** start time extrapolated from the electron spectrograms correlates with substorm onsets,consistent with prior ***,the duration of zebra stripe evolution during the event of June 5–6,2023,reaches an impressive 34.7 h,a markedly longer interval than findings from the Van Allen *** discrepancy suggests that the observed lifetime of electron zebra stripes may not inherently reflect natural limitations but could be constrained by instrumental *** results implicate that high-energy-resolution detectors have the potential to significantly enhance our capacity to scrutinize the dynamics of the radiation belt.

关键词： zebra stripe inner radiation belt energetic electron South Atlantic Anomaly Macao Science Satellite large-scale electric field

Highlight Advances in Planetary Physics in the Solar System: In Situ Detection Over the Past 20 Years

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Space(Science & Technology) 2023年第1期3卷 24-53页

作者： yixin sun Jiutong Zhao Chuanpeng Hou Weixin Jiao Center of Planetary and Space Sciences Peking UniversityBeijingChina

Planetary science is the science of studying planets,moons,and planetary *** scale of the research objects ranges from small meteoroids to large gas giant planets,and the research purpose is to determine their composition,dynamics,formation,evolution,mutual relationship,and *** the development of human space technology,planetary exploration has become one of the most important space exploration activities of *** to statistics from the Spacecraft Encyclopedia website,as of December 2021,a total of 252 planetary probes have been launched around the *** missions reveal the deep space to *** this paper,we review some advances in planetary science made by these missions in the past *** topics involve interior structures,geological features,atmospheres,magnetospheres,and so on,not every aspect but as much as *** there are still many extraordinary scientific results that have not been included,we believe that this review can already help people learn about the scientific results of planetary exploration and hopefully inspire the next generation of planetary missions.

关键词： planetary Solar planet

Facile synthesis of Cu-In-Zn-S alloy nanospheres for fast photoelectric detection across the visible spectrum

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Frontiers of Materials Science 2020年第3期14卷 323-331页

作者： Yang Sheng Jie Yang Qiliang Zhu yixin sun Rong Zhang Xiaosheng Tang Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials School of Materials Science and EngineeringChangzhou UniversityChangzhou213164China Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing211800China Key Laboratory of Optoelectronic Technology and Systems(Ministry of Education) College of Optoelectronic EngineeringChongqing UniversityChongqing400044China Jiangsu Chenguang Paint Co. Ltd.Changzhou213154China

Fast and broadband photoelectric detection is a key process to many photoelectronic applications,during which the semiconductor light absorber plays a critical *** this report,we prepared Cu-In-Zn-S(CIZS)nanospheres with different compositions via a facile hydrothermal *** nanospheres were^200 nm in size and comprised of many small nanocrystals.A photodetector responded to the visible spectrum was demonstrated by spraying the solution processed nanospheres onto gold interdigital *** photoelectric characterization of these devices revealed that CIZS nanospheres with low molar ratio of n(Cu)/n(In)exhibited improved photoelectric response compared to those with high n(Cu)/n(In),which was attributed to the reduced *** relatively large switching ratio(Ion/Ioff),fast response and wide spectral coverage of the CIZS-based photodetector render it a promising potential candidate for photoelectronic applications.

关键词： chalcogenides Cu-In-Zn-S nanospheres solvothermal photoelectric detection

Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy:opportunities,challenges, and future development

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1382-1396页

作者： yixin sun Dongyang Zhao Gang Wang Yang Wang Linlin Cao Jin sun Qikun Jiang Zhonggui He Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Guangxi University of Chinese MedicineNanning 530200China Department of Pharmaceutics the Second Hospital of Dalian Medical UniversityDalian 116023China

Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the tumor cells. Oxygen-consumption photodynamic therapy(PDT) suffers from the undesirable impediment of local hypoxia in tumors. Moreover, PDT could further worsen hypoxia. Therefore, developing effective strategies for manipulating hypoxia and improving the effectiveness of PDT has been a focus on antitumor treatment. In this review, the mechanism and relationship of tumor hypoxia and PDT are ***, we highlight recent trends in the field of nanomedicines to modulate hypoxia for enhancing PDT, such as oxygen supply systems, down-regulation of oxygen consumption and hypoxia ***, the opportunities and challenges are put forward to facilitate the development and clinical transformation of PDT.

关键词： medicines Oxygen challenges

Intestinal OCTN2-and MCT1-targeted drug delivery to improve oral bioavailability

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Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 158-172页

作者： Gang Wang Lichun Zhao Qikun jiang yixin sun Dongyang Zhao Mengchi sun Zhonggui He Jin sun Yang Wang Zhuang Yao Medicine Center of Engineering and Technology Guang Xi University of Chinese MedicineNanning 530200China School of Pharmacy Guang Xi University of Chinese MedicineNanning 530200China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs,thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug *** particular,intestinal carnitine/organic cation transporter 2(OCTN2)and mono-carboxylate transporter protein 1(MCT1)possess high transport capacities and complementary ***,we outline recent developments in transporter-targeted oral drug delivery with regard to the OCTN2 and MCT1 proteins in this ***,basic information of the two transporters is reviewed,including their topological structures,characteristics and functions,expression and key features of their ***,progress in transporter-targeting prodrugs and nanoparticles to increase oral drug delivery is discussed,including improvements in the oral absorption of anti-inflammatory drugs,antiepileptic drugs and anticancer ***,the potential of a dual transporter-targeting strategy is discussed.

关键词： Carnitine/organic cation transporter 2(OCTN2) Monocarboxylate transporter protein 1(MCT1) Transporter-targeting Nanoparticle Prodrug

A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 631-639页

作者： yixin sun Dongyang Zhao Gang Wang Qikun Jiang Mengran Guo Qiming Kan Zhonggui He Jin sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Guangxi University of Chinese MedicineNangning 530200China School of Pharmacy Shenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China

Monocarboxylate transporter 1(MCT1)is responsible for oral absorption of short-chain monocarboxylic acids from small intestine,hence,it’s likely to serve as an ideal design target for the development of oral ***,potential application of MCT1 to facilitate the oral delivery is still *** oral absorption,poor permeability and bioavailability greatly limit the oral delivery efficiency of 5-fluorouracil(5-FU).Herein,we design three 5-FU-fatty acid conjugates targeting intestinal MCT1 with different lipophilic ***,due to high MCT1 affinity and good gastrointestinal stability,5-FUoctanedioic acid monoester prodrug exhibited significant improvement in membrane permeability(13.1-fold)and oral bioavailability(4.1-fold)compared to *** surprisingly,stability experiment in intestinal homogenates showed that 5-FU prodrugs could be properly activated to release 5-FU within intestinal cells,which provides an ideal foundation for the improvement of oral *** summary,good gastrointestinal stability,high membrane permeability and appropriate intestinal cell bioactivation are the important factors for high-efficiency 5-FU oral prodrugs,and such work provides a good platform for the development of novel oral prodrugs targeting intestinal transporters.

关键词： 5-Fluorouracil Prodrugs Monocarboxylate transporter 1 Permeability Oral bioavailability