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Deafening-induced rapid changes to spine synaptic connectivity in the adult avian vocal basal ganglia

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Integrative Zoology 2022年第6期17卷 1136-1146页

作者： Xiaojuan ZHOU Yalan CHEN Jikan PENG Mingxue ZUO yingyu sun Beijing Key Laboratory of Gene Resource and Molecular Development College of Life SciencesBejiing Normal UniversityBeijingChina Chinese Institute for Brain Research(CIBR) BeijingChina Technology Center for Protein Sciences Tsinghua UniversityBeijingChina School of Life Sciences Westlake UniversityHangzhouChina

The basal ganglia have been implicated in auditory-dependent vocal learning and plasticity in human and songbirds,but the underlying neural phenotype remains to be clariﬁ***,using confocal imaging and three-dimensional electron microscopy,we investigated striatal structural plasticity in response to hearing loss in Area X,the avian vocal basal ganglia,in adult male zebraﬁnch(Taeniopygia guttata).We observed a rapid elongation of dendritic spines,by approximately 13%,by day 3 after deafening,and a considerable increase in spine synapse density,by approximately 61%,by day 14 after deafening,compared with the controls with an intact ***ﬁnd-ings reveal structural sensitivity of Area X to auditory deprivation and suggest that this striatal plasticity might contribute to deafening-induced changes to learned vocal behavior.

关键词： basal ganglia dendritic spine songbird synapse vocal plasticity

Age effect of deafening on stereotyped song maintenance in adult male bengalese finches Lonchura striata domestica

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Current Zoology 2009年第3期55卷 212-218页

作者： yingyu sun Rui WANG Shuli SHAO Shaoju ZENG Mingxue ZUO College of Life Sciences Beijing Normal University Beijing 100875 China Life Science and Engineering College Qiqihar University Qiqihar 161006 China

Birdsong is a complex learned vocal behavior that relies on auditory experience for development. However, it appears that among different species of close-ended songbirds, there are some variations in the necessity of auditory feedback for maintaining stereotyped adult song. In zebra finches, the deterioration of adult songs following deafness depends on the birds＇ age. It is unknown whether this age effect is a general rule in other avian species as well. Therefore, we chose Bengalese finches, whose songs show more complexity and have much heavier dependency on auditory feedback than that of zebra finches, to compare the degree of song degradation after hearing loss in old （over 18 months old） and young adult birds （5 - 6 months old）. We found that both syllable sequence and syllable phonology were much less severely affected by deafening in old adults than that in young ones. Moreover, young adults almost lost their capability to sing trills over 6 months following deafening, while old birds continued to sing plenty of trills and trilled syllables after the same period of deafening. Our results suggest that age plays an important role in affecting the dependency of adult song maintenance on auditory feedback in Bengalese finches. Furthermore, the age dependency may be a general phenomenon in different species of close-ended songbirds [ Current Zoology 55 （3）： 212 - 218, 2009].

关键词： Auditory feedback Bengalese finch Deafening Age Syllable

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

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Frontiers of Medicine 2023年第2期17卷 240-262页

作者： Jing Feng Zheng Zhao Yanfei Wei Zhaoshi Bao Wei Zhang Fan Wu Guanzhang Li Zhiyan sun Yanli Tan Jiuyi Li Yunqiu Zhang Zejun Duan Xueling Qi Kai Yu Zhengmin Cong Junjie Yang Yaxin Wang yingyu sun Fuchou Tang Xiaodong Su Chuan Fang Tao Jiang Xiaolong Fan Beijing Key Laboratory of Gene Resource and Molecular Development Laboratory of Neuroscience and Brain DevelopmentBeijing Normal UniversityBeijing 100875China Beijing Neurosurgical Institute Beijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Pathology Affiliated Hospital of Hebei UniversityBaoding 071000China Gendya Biotechnology Ltd. Beijing 100176China Center of Growth Metabolism&Aging Key Laboratory of Bio-Resource and Eco-Environment of Ministry of EducationCollege of Life SciencesSichuan UniversityChengdu 610065China Department of Pathology Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China Biodynamic Optical Imaging Center(BIOPIC) School of Life SciencesPeking UniversityBeijing 100871China Department of Neurosurgery Affiliated Hospital of Hebei UniversityBaoding 071000China Hebei Key Laboratory of Precise Diagnosis and Treatment of Glioma Baoding 071000China Chinese Glioma Genome Atlas Network(CGGA) Beijing 100070China College of Life Sciences Sichuan Normal UniversityChengdu 610101China

Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

关键词： glioma progression molecular classification EM PM subtyping intratumor heterogeneity

信托公司为什么“刚性兑付”——基于声誉机制的解释

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财贸经济 2017年第7期38卷 78-90页

作者：蔡英玉孙涛山东大学经济研究院

本文在KMRW声誉模型的基础上,构建了"监管机构—信托公司—投资者"三方多阶段博弈模型来研究信托公司"刚性兑付"问题。分析认为,由于投资者缺乏识别和定价能力,以及监管机构的准入审批和评级机制,使信托公司可以利用监管机构的"信用背... 详细信息

本文在KMRW声誉模型的基础上,构建了"监管机构—信托公司—投资者"三方多阶段博弈模型来研究信托公司"刚性兑付"问题。分析认为,由于投资者缺乏识别和定价能力,以及监管机构的准入审批和评级机制,使信托公司可以利用监管机构的"信用背书",在前期通过"刚性兑付"建立声誉,进而在未来获取超额收益,因此"刚性兑付"成为信托公司的必然选择。利用68家信托公司2010-2015年度数据,实证分析发现当期声誉与下一期收益呈现出显著正相关关系,好声誉能够为信托公司带来更高收益。对此,应当从加强投资者教育、转变监管方式、强化信托公司治理三个方面来打破"刚性兑付"。

关键词： KMRW声誉模型信托公司刚性兑付声誉机制

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SARS冠状病毒的系统发育基因组研究

北京师范大学学报（自然科学版） 2005年第2期41卷 169-171页

作者：孙颖郁张原北京师范大学生命科学学院北京100875

对SARS冠状病毒(SARSCoronavirus,SARS -CoV)进行了系统发育基因组研究.应用CLUSAL- X1. 83程序,将来自GenBank数据库的全部102条SARS -CoV全基因组序列记录做多序列联配,然后采用MEGA3软件包进行系统发育基因组分析,使用邻接法构建系... 详细信息

对SARS冠状病毒(SARSCoronavirus,SARS -CoV)进行了系统发育基因组研究.应用CLUSAL- X1. 83程序,将来自GenBank数据库的全部102条SARS -CoV全基因组序列记录做多序列联配,然后采用MEGA3软件包进行系统发育基因组分析,使用邻接法构建系统发育树.根据该系统树,SARS -CoV全基因组记录可以分为2类.第1类包括2个来源于动物的分离株;第2类则覆盖了所有的人源分离株,并且可进一步分为2组,其中第1组包括5个来自于广东省的分离株,而第2组则覆盖了其他的来自于香港、内地和海外的分离株.这一分支格局代表了SARS- CoV从兽到人、从广东到全球的传播过程,并且基因组的替代变异幅度在传播过程中由大到小,逐渐稳定下来.还详细地给出了区分上述2群和2组的分子标签,为新毒株的鉴定和分型提供了理论依据.

关键词： SARS冠状病毒系统发育基因组研究分子标签

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高职思政课混合式教学模式实践探讨

苏州市职业大学学报 2023年第1期34卷 43-47页

作者：孙颖玉苏州旅游与财经高等职业技术学校商贸系江苏苏州215104

对高职思政课混合式教学模式进行了探讨,认为混合式教学模式是改变传统思政课教学模式的有效形式。在阐述高职思政课混合式教学模式含义与特点的基础上,分析了高职思政课实行混合式教学模式的现实依据,提出了打造线上资源、优化教学设... 详细信息

对高职思政课混合式教学模式进行了探讨,认为混合式教学模式是改变传统思政课教学模式的有效形式。在阐述高职思政课混合式教学模式含义与特点的基础上,分析了高职思政课实行混合式教学模式的现实依据,提出了打造线上资源、优化教学设计、坚持科学评价的高职思政课混合式教学模式的实现路径。

关键词：高职思政课混合式教学模式特点依据实现路径

速激肽1型受体(NK1R)在斑胸草雀脑干鸣唱控制相关核团及部分听觉核团内的分布

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北京师范大学学报（自然科学版） 2014年第4期50卷 390-396页

作者：黄丽徐程张信文孙颖郁海南师范大学生命科学学院海口571158 浙江大学生命科学学院杭州310058 北京师范大学生命科学学院北京100875

采用免疫组织化学的方法研究了速激肽1型受体(NK1R)在斑胸草雀脑干发声控制核团和部分听觉中枢内的分布及阳性标记特征.结果显示,NK1R广泛分布于斑胸草雀发声控制核团和部分听觉中枢内;1)发声控制相关核团:中脑丘间复合体背内侧核(DM)... 详细信息

采用免疫组织化学的方法研究了速激肽1型受体(NK1R)在斑胸草雀脑干发声控制核团和部分听觉中枢内的分布及阳性标记特征.结果显示,NK1R广泛分布于斑胸草雀发声控制核团和部分听觉中枢内;1)发声控制相关核团:中脑丘间复合体背内侧核(DM)有大量的NK1R免疫阳性胞体标记,极少出现纤维;中脑腹侧被盖区(VTA)、黑质致密部(SNc)及周围脑区有大量的NK1R阳性胞体和NK1R免疫阳性纤维分布;2)听觉中枢:中脑背外侧核(MLd)和耳蜗核前庭外侧核(NM)有密集的胞体标记;而耳蜗核层状核(NL)及角核(NA)有少量NK1R阳性胞体分散分布,且角核可见大量密集深染纤维.本实验结果提示NK1R可能在鸣禽的发声控制及听觉中枢内具有重要的生理功能.

关键词：速激肽1型受体鸣唱控制听觉斑胸草雀鸣禽

离子型谷氨酸受体AMPA亚型GluR2在成年斑胸草雀鸣唱系统的分布

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北京师范大学学报（自然科学版） 2015年第2期51卷 148-153页

作者：刘武林孙颖郁张信文海南师范大学生命科学学院海南海口571158 北京师范大学生命科学学院北京100875

主要采用DAB免疫组织化学方法对离子型谷氨酸受体AMPA亚型GluR2在成年雄性斑胸草雀(Taeniopygia guttata)鸣唱系统的分布进行了研究.结果显示:1)端脑高级发声中枢HVC(proper name)中,GluR2表达丰富,并主要分布于胞体部位;在HVC投射至弓... 详细信息

主要采用DAB免疫组织化学方法对离子型谷氨酸受体AMPA亚型GluR2在成年雄性斑胸草雀(Taeniopygia guttata)鸣唱系统的分布进行了研究.结果显示:1)端脑高级发声中枢HVC(proper name)中,GluR2表达丰富,并主要分布于胞体部位;在HVC投射至弓状皮质栎核(robust nucleus of the arcopallium,RA)的路径上,有大量的GluR2阳性细胞分布,并有少量阳性纤维分布;2)RA中,呈密集的GluR2阳性胞体标记;3)前脑基底神经节X区(Area X)中,有少量阳性胞体标记;4)中脑腹侧被盖区(ventral tegmental area,VTA)、黑质致密部(substantia nigra compacta,SNc)存在大量的阳性胞体标记.本实验结果表明GluR2可能参与了鸣唱运动的调控和维持.

关键词： GluR2 斑胸草雀鸣唱控制系统

速激肽1型受体(NK1R)在斑胸草雀端脑发声核团的分布

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北京师范大学学报（自然科学版） 2014年第4期50卷 397-401页

作者：林春黄丽孙颖郁张信文海南师范大学生命科学学院海口571158 北京师范大学生命科学学院北京100875

应用免疫组织化学的方法,对斑胸草雀端脑发声控制核团内速激肽1型受体(NK1R)的表达进行初步研究.结果显示,NK1R在高级发声中枢(HVC,proper name)、巢皮质巨细胞核外侧部(lateral magnocellular nucleus of the anterior nidopallium,LM... 详细信息

应用免疫组织化学的方法,对斑胸草雀端脑发声控制核团内速激肽1型受体(NK1R)的表达进行初步研究.结果显示,NK1R在高级发声中枢(HVC,proper name)、巢皮质巨细胞核外侧部(lateral magnocellular nucleus of the anterior nidopallium,LMAN)和弓状皮质栎核(robust nucleus of the arcopallium,RA)均有大量的免疫阳性标记,但前脑基底神经节X区(Area X)仅有少量的表达,X区内的P物质和NK1R分布密度具有不一致性.结果表明:NK1R广泛分布于斑胸草雀发声控制核团中.提示NK1R可能参与鸣唱学习相关的重要生理过程.

关键词：速激肽1型受体 P物质鸣唱控制核团斑胸草雀