检索结果-南通市图书馆

Hydrogen sulfide and vascular relaxation

Chinese Medical Journal 2011年第22期124卷 3816-3819页

作者： sun yan tang chao-shu du jun-bao jin hong-fang Department of Pediatrics Peking University First Hospital Beiiing 100034 China

Objective To review the vasorelaxant effects of hydrogen sulfide （H2S） in arterial rings in the cardiovascular system under both physiological and pathophysiological conditions and the possible mechanisms involved. Data sources The data in this review were obtained from Medline and Pubmed sources from 1997 to 2011 using the search terms ＂hydrogen sulfide＂ and ＂vascular relaxation＂. Study selection Articles describing the role of hydrogen sulfide in the regulation of vascular activity and its vasorelaxant effects were selected. Results H2S plays an important role in the regulation of cardiovascular tone. The vasomodulatory effects of H2S depend on factors including concentration, species and tissue type. The H2S donor, sodium hydrosulfide （NariS）, causes vasorelaxation of rat isolated aortic rings in a dose-dependent manner. This effect was more pronounced than that observed in pulmonary arterial rings. The expression of KATp channel proteins and mRNA in the aortic rings was increased compared with pulmonary artery rings. H2S is involved in the pathogenesis of a variety of cardiovascular diseases. Downregulation of the endogenous H2S pathway is an important factor in the pathogenesis of cardiovascular diseases. The vasorelaxant effects of H2S have been shown to be mediated by activation of KATP channels in vascular smooth muscle cells and via the induction of acidification due to activation of the Cr/HCO3 exchanger. It is speculated that the mechanisms underlying the vasoconstrictive function of H2S in the aortic rings involves decreased NO production and inhibition of cAMP accumulation. Conclusion H2S is an important endogenous gasotransmitter in the cardiovascular system and acts as a modulator of vascular tone in the homeostatic regulation of blood pressure.

关键词： hydrogen sulfide, vasorelaxing effects cardiovascular system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

引用

Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian Zhang Lei tang Qi Wu Mu-yan Cai Yuan-fang Li Xiu-Juan Qu hong Qiu Yu-jing Zhang Jie-Er Ying jun Zhang Ling-Yu sun Rong-Bo Lin Chang Wang Hao Liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji yan Xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou jing jin Xiang-Lin Yuan Feng Bi Tian-shu Liu Han Liang yan-Qiao Zhang Guo-Xin Li jun Liang bao-Rui Liu Lin Shen jin Li Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of China,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Body mass index is a promising predictor of response to oral rehydration saline in children with vasovagal syncope

引用

Chinese Medical Journal 2021年第4期134卷 463-468页

作者： Chun-yan Tao Selena Chen Xue-Ying Li chao-shu tang jun-bao du hong-fang jin Department of Pediatrics Peking University First HospitalBeijing 100034China Research Unit of Clinical Diagnosis and Treatment of Pediatric Syncope and Cardiovascular Diseases Chinese Academy of Medical SciencesBeijing 100730China Division of Biological Sciences University of CaliforniaSan DiegoCA 92093USA Department of Medical Statistics Peking University First HospitalBeijing 100034China Department of Physiology and Pathophysiology Peking University Health Science CenterBeijing 100191China

Background:Vasovagal syncope(VVS)greatly impairs quality of *** therapeutic efficacy of oral rehydration saline(ORS)for unselected VVS patients is not satisfactory due to the diverse mechanisms of the *** mass index(BMI)was demonstrated to reflect blood volume to a certain ***,the present study explored the capability of BMI to predict the therapeutic response of children with VVS to ORS ***:Seventy-four children with VVS who visited the Syncope Unit of Pediatrics at Peking University First Hospital from November 2010 to june 2019 receiving ORS treatment were enrolled for this retrospective case-control study.A comparison of demographic,clinical,and hemodynamic characteristics was performed between responders and *** correlation between baseline BMI and response time was *** determine the value of baseline BMI in predicting the therapeutic efficacy of ORS in children with VVS,a receiver operating characteristic curve analysis was ***:Fifty-two children were identified as responders,and the remaining 22 children were identified as *** baseline BMI of the responders was much lower than that of the non-responders(16.4[15.5,17.8]kg/m2vs.20.7±3.6 kg/m2,P<0.001),and baseline BMI was positively correlated with response time in the head-up tilt test after adjusting for sex(r=0.256,95%confidence interval[CI]:0.067-0.439,P=0.029).The area under the receiver operating characteristic curve of baseline BMI was 0.818(95%CI:0.704-0.932,P<0.001),and an optimal cut-off value of 18.9 kg/m2 yielded a sensitivity of 83%and a specificity of 73%to predict the efficacy of ORS in ***:Prior to treatment,baseline BMI is a promising predictor of response to ORS in children with VVS.

关键词： Vasovagal syncope Oral rehydration saline Body mass index Therapeutic response

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predictive role of cerebrospinal fluid hydrogen sulfide in central nervous system leukemia

引用

Chinese Medical Journal 2011年第21期124卷 3450-3454页

作者： du shu-xu XIAO Jiang GUAN Feng sun Li-ming WU Wan-shui tang hong du jun-bao tang chao-shu jin hong-fang Department of Pediatrics Capital Medical College Shijitan Hospital Beijing 100038 China Department of Infectious Disease Capital Medical College Ditan Hospital Beijing 100015 China Department of Neurosurgery Capital Medical College Shijitan Hospital Beijing 100038 China Department of Pediatrics Peking University First Hospital Beijing 100034 China Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100191 China

Background Central nervous system leukemia （CNSL） is an important relapse in children with acute lymphoblastic leukemia （ALL）. We investigated the possible role of endogenous hydrogen sulfide （H2S） of cerebrospinal fluid （CSF） in predicting CNSL. Methods From August 2008 to December 2010, 380 children were enrolled in this study at Shijitan Hospital, China. These children were from 2 to 16 years old, and the median age was 6.5 years. They were divided into a CNSL group （7 cases）, a leukemia group （307 cases）, a non-leukemia group （26 cases） and a healthy group （40 children）. CSF specimens were obtained from conventional lumbar punctured, then centrifuged and supernatants preserved for H2S detection. Leukemic cells precipitates from CSF were found in three cases, the hCSE and hCBS mRNA expression was detected by reverse transcription polymerase chain reaction （RT-PCR）, and H2S levels in serum were also measured. The receiver operating characteristic （ROC） curve and area under curve （AUC） were used to assess the predictive diagnosis role of CSF H2S in children with ALL and CNSL. Results The serum H2S contents of the CNSL and leukemia groups were （96.98±15.77） pmol/L and （93.35±17.16） μmol/L respectively, much higher than those of healthy, （44.29±2.15） pmol/L, and non-leukemia, （46.32±6.54） μmol/L, groups （P 〈0.01）. Compared with the leukemia group, CSF H2S content of the CNSL group was significantly high （P 〈0.01）. Meanwhile, in contrast to the non-leukemia group, CSF H2S contents of the CNSL and leukemia groups were both significantly increased （P 〈0.01）. In addition, leukemic cells from CSF precipitations could express CBS and CSE mRNA. Furthermore, the ROC analysis showed the UAC was 0.929 （95% CI： 0.857-1.000）, and the optimum cut-off value of CSF H2S was 12.08μmol/L, and the sensitivity and specificity were 83.3% and 97.2% respectively. Conclusions CSF H2S contents were significantly increased in children with CNSL. After treatment, H2S contents were decreased su

关键词： child hydrogen sulfide central nervous system leukemia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrogen sulfide induces apoptosis of pulmonary artery smooth muscle cell in rats with pulmonary hypertension induced by high pulmonary blood flow

引用

Chinese Medical Journal 2009年第24期122卷 3032-3038页

作者： LI Wei jin hong-fang LIU Die sun jing-hui JIAN Pei-jun LI Xiao-hui tang chao-shu du jun-bao Department of Pediatrics Peking University First Hospital Beijing 100034 China Department of Pediatrics Jilin University First Hospital Changchun Jilin 130021 China Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100191 China Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing 100191 China

Background Abnormal apoptosis of pulmonary artery smooth muscle cells （PASMCs） is an important pathophysiological process in the pulmonary artery structural remodeling and pulmonary hypertension. We investigated possible effect of endogenous hydrogen sulfide （H2S） on apoptosis of PASMCs during the development of pulmonary hypertension induced by high pulmonary blood flow. Methods Thirty-nine male Sprague-Dawley rats were randomly assigned to 4-week control, 4-week shunt, 4-week shunt＋propargylglycine （PPG）, 11-week control, 11-week shunt and 11-week shunt＋sodium hydrosulfide （NariS） groups. Rats in 4-week shunt, 4-week shunt＋PPG, 11-week shunt and 11-week shunt＋NariS groups underwent an abdominal aorta-inferior vena cava shunt. Rats in 4-week shunt＋PPG group were intraperitoneally injected with PPG, an inhibitor of endogenous H2S production, for 4 weeks. Rats in 11-week shunt＋NariS group were intraperitoneally injected with NariS, a H2S donor, for 11 weeks. Lung tissue H2S was evaluated by sulfide-sensitive electrode. Apoptosis of PASMCs were detected by terminal deoxynucleotidyl transferase mediated duTP nick end labelling （TUNEL）. Expressions of Fas, bcl-2 and caspase-3 in the PASMCs were analyzed with immunochemical staining. Results Four weeks after the shunting operation, the apoptosis of PASMCs and expression of Fas and caspase-3 were significantly decreased （P 〈0.01）, but expression of bcl-2 increased significantly （P 〈0.01）. PPG administration further inhibited the apoptosis of PASMCs, downregulated the expression of Fas and caspase-3 （P 〈0.01）, but increased the expression of bcl-2 （P 〈0.01）. After 11 weeks of shunting operation, the apoptosis of PASMCs and expression of Fas and caspase-3 were significantly decreased （P 〈0.01）, but expression of bcl-2 increased obviously （P 〈0.01）. NariS administration significantly increased the apoptosis of PASMCs, upregulated the expression of Fas and caspase-3, but inhibited the expression of bcl-2. Conclusions H2S indu

关键词： high pulmonary blood flow pulmonary hypertension hydrogen sulfide apoptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Increased Endogenous Sulfur Dioxide Involved in the Pathogenesis of Postural Tachycardia Syndrome in Children： A Case-Control Study

引用

Chinese Medical Journal 2018年第4期131卷 435-439页

作者： hong-Xia Li Xiao-Chun Zheng Si-Yao Chen Ying Liao Zhen-Hui Han Pan Huang Chu-Fan sun Jia Liu jing-Yuan Song chao-shu tang jun-bao du Yong-hong Chen hong-fang jin Department of Pediatrics Peking University First Hospital Beijing 100034 China Department of Cardiac Surgery Guangdong General Hospital Guangzhou Guangdong 510000 China Department of Intensive Care Kaifeng Children's Hospital Kaifeng Henan 475000 China Department of Physiology and Pathophysiology Peking University Health Science Center and Key Laboratory of Molecular Cardiology of Ministry of Education Beijing 100191 China

Background： The pathogenesis of postural tachycardia syndrome （POTS） remains unclear. This study aimed to explore the changes and significance of sulfur dioxide （SO2） in patients with POTS. Methods： The study included 31 children with POTS and 27 healthy children from Peking University First Hospital between December 2013 and October 2015. A detailed medical history, physical examination results, and demographic characteristics were collected. Hemodynamics was recorded and the plasma SO2was determined. Results： The plasma SO2was significantly higher in POTS children compared to healthy children （64.0 ± 20.8 μmol/L vs. 27.2 ± 9.6 μmol/L, respectively, P 〈 0.05）. The symptom scores in POTS were positively correlated with plasma SO2levels （r = 0.398, P 〈 0.05）. In all the study participants, the maximum heart rate （HR） was positively correlated with plasma levels of SO2（r = 0.679, P 〈 0.01）. The change in systolic blood pressure from the supine to upright （ΔSBP） in POTS group was smaller than that in the control group （P 〈 0.05）. The ΔSBP was negatively correlated with baseline plasma SO2levels in all participants （r = ？0.28, P 〈 0.05）. In the control group, ΔSBP was positively correlated with the plasma levels of SO2（r = 0.487, P 〈 0.01）. The change in HR from the supine to upright in POTS was obvious compared to that of the control group. The area under curve was 0.967 （95% confidence interval： 0.928–1.000）, and the cutoff value of plasma SO2level 〉38.17 μmol/L yielded a sensitivity of 90.3% and a specificity of 92.6% for predicting the diagnosis of POTS. Conclusions： Increased endogenous SO2levels might be involved in the pathogenesis of POTS.

关键词： Blood Pressure Children: Pathogenesis Postural Tachycardia Syndrome Sulfur Dioxide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interaction between hydrogen sulfide/cystathionine γ-lyase and carbon monoxide/heme oxygenase pathways in aortic smooth muscle cells

引用

Acta Pharmacologica Sinica 2006年第12期27卷 1561-1566页

作者： hong-fang jin~2 jun-bao du~(2,4)Xiao-hui LI~2 yan-fei WANG~2 Yin-fang LIANG~2 chao-shu tang~3 2 Department of Pediatrics,Peking University First Hospital,Beijing 100034,China 3 Institute of Cardiovascular Research,Peking University First Hospital,Beijing 100034,China Department of Pediatrics Peking University First Hospital Beijing 100034 China.

Aim:To investigate the interaction between hydrogen sulfide（H2S）/cystathion-ine γ-lyase（CSE）and carbon monoxide（CO）/heme oxygenase（HO）pathways inaortic smooth muscle cells（ASMC）.Methods:The ASMCs were divided into thefollowing groups:（1）the control group;（2）the zinc protoporphyrin（ZnPP）20μmol/L group;（3）the propargylglycine（PPG）2 mmol/L,4 mmol/L and 10 mmol/Lgroups;and（4）the sodium hydrosulfide（NariS）1×10-5mol/L,1×10-4mol/L and1×10-3mol/L *** of the groups was further divided into 6h,12h,18hand 24h *** CO level,represented by carboxyhemoglobin（HbCO）content was measured using a spectrophotometric method and H2S content wasdetected by a sensitive electrode *** and HO-1 expressions were de-tected by Western ***:The H2S content in the medium and CSEexpression by ASMC were markedly increased by ZnPP compared with the con-trol *** content in the medium and HO-1 expression by the ASMCstarted strengthening following 24h treatment with PPG at 2 mmol/L,but werefurther strengthened following 18h and 24h treatment with PPG at 4 mmol/Lcompared with the controls（P<0.01）.PPG at 10 mmol/L increased the HbCO levelin the medium following 18h treatment and increased HO-1 expression by theASMC following 12h ***,NariS at 1×10-5mol/L and 1×10-4mol/Ldecreased the HbCO level in the medium and HO-1 expression by the ASMC after6h and 12h treatment,while NariS at 1×10-3mol/L decreased them at all timepoints of the ***:The results suggested that endogenousCO/HO and H2S/CSE pathways inhibited each other in ASMC under physiologi-cal conditions.

关键词： hydrogen sulfide cystathionine γ-lyase carbon monoxide heme oxygenase

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nitric oxide modulates hypoxic pulmonary smooth muscle cell proliferation and apoptosis by regulating carbon monoxide pathway

引用

Acta Pharmacologica Sinica 2007年第1期28卷 28-35页

作者： yan-fei WANG~2 hong TIAN~2 chao-shu tang~(3,4) hong-fang jin~2 jun-bao du~(2,4,5)2 Department of Pediatrics,Peking University First Hospital,Beijing 100034,China 3 Institute of Cardiovascular Diseases,Peking University First Hospital,Beijing 100034,China,4 Key Laboratory of Molecular Cardiovascular Diseases,Ministry of Education,Beijing 100034,China DepartmentofPediatrics PekingUniversityFirstHospitalBeijing100034China InstituteofCardiovascularDiseases PekingUniversityFirstHospitalBeijing100034China KeyLaboratoryofMolecularCardiovascularDiseases MinistryofEduc

Aim:To explore the role of carbon monoxide(CO)in the regulation of hypoxicpulmonary artery smooth muscle cell(PASMC)proliferation and apoptosis bynitric oxide(NO).Methods:PASMC of Wistar rats was cultured in vitro in thepresence of a NO donor,sodium nitroprusside,or an inhibitor of heine oxygenase(HO),zinc protoporphyrin-IX,or under both normoxic and hypoxic *** and carboxyhemoglobin in PASMC medium were detected *** proliferating and apoptotic percentage of PASMC wasmeasured by flow *** expression of HO-1 mRNA in PASMC wasanalyzed by fluorescent real-time quantitative PCR,and the proliferating cell nuclearantigen and caspase-3 were examined by immunocytochemical ***:The results showed that hypoxia suppressed NO generation from PASMC,whichpromoted hypoxic PASMC proliferation and induced ***,hy-poxia induced HO-1 expression in PASMC and promoted CO production fromPASMC,which inhibited PASMC proliferation and regulated PASMC *** upregulated the expression of HO-1 mRNA in hypoxic PASMC;NO also inhib-ited proliferation and promoted apoptosis of hypoxic PASMC,possibly by regu-lating the production of ***:The results indicated that CO couldinhibit proliferation and regulate apoptosis of PASMC,and NO inhibited prolifera-tion and promoted apoptosis of hypoxic PASMC,possibly by regulating the pro-duction of CO.

关键词： hypoxia proliferation apoptosis carbon monoxide nitric oxide

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

CEPC Technical Design Report

引用

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jinR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

二氧化硫对低氧性肺动脉高压大鼠内源性硫化氢体系的调节作用

引用

中华儿科杂志 2011年第12期49卷 890-894页

作者：陈斯瑶金红芳孙燕田悦唐朝枢杜军保北京大学第一医院儿科 100034 北京大学医学部生理与病理生理学系 100083

目的研究二氧化硫（ SO2）对低氧性肺动脉高压大鼠肺动脉内源性硫化氢（H2S）/胱硫醚-γ-裂解酶（ CSE）以及H2S/巯基丙酮酸转硫酶（MPST）体系的调节作用.方法将雄性Wistar大鼠（32只）随机分为对照组、低氧组、低氧＋ SO2组和低氧... 详细信息

目的研究二氧化硫（ SO2）对低氧性肺动脉高压大鼠肺动脉内源性硫化氢（H2S）/胱硫醚-γ-裂解酶（ CSE）以及H2S/巯基丙酮酸转硫酶（MPST）体系的调节作用.方法将雄性Wistar大鼠（32只）随机分为对照组、低氧组、低氧＋ SO2组和低氧＋天冬氨酸异羟肟酸（hydroxamate,HDX）组,每组8只.低氧处理采用常压低氧的方法,氧浓度为10％,每天低氧6h,持续21 d.对照组大鼠在常氧环境中饲养.低氧处理结束后采用右心导管法测定肺动脉平均压,采用硫电极法测定肺组织H2S含量和H2S产率,采用免疫组化法检测各组大鼠肺小动脉内膜及中膜CSE和MPST的蛋白表达.结果低氧组大鼠肺动脉平均压较对照组高[（33.38 ±6.32） mm Hg vs（16.74±3.81） mm Hg,1 mm Hg=0.133 kPa,P＜0.01]；低氧＋SO2组大鼠肺动脉平均压较低氧组低[（29.65±2.53）mm Hg vs（33.38±6.32） mm Hg,P＜0.01],低氧＋HDX组大鼠肺动脉平均压较低氧组高[（39.44±6.26） mm Hg vs（33.38±6.32） mm Hg,P＜0.01].低氧组大鼠肺组织H2S含量[（2.02±0.43） μmol/g vs （3.11±0.42） μmol/g,P＜0.01]及H2S产率[（19.64±3.48） nmol/（g· min）vs（28.20±5.95） nmol/（g·min）,P＜0.05]均较对照组低.给予SO2供体后,低氧＋SO2组肺组织H2S含量[（2.73±0.20）μmol/g vs（2.02±0.43）μmol/g,P＜0.01]及H2S产率[（26.24±1.92） nmol/（g· min）vs（19.64±3.48） nmol/（g· min）,P＜0.01]均较低氧组升高.当给予内源性SO2生成酶抑制剂HDX后,低氧＋HDX组肺组织H2S含量[（1.64±0.23） μmol/g vs （2.02±0.43）μmol/g,P＜0.05]及肺组织H2S产率[（13.94±3.63） nmol/（g·min） vs （19.64±3.48） nmol/（g·min）,P＜0.05]均较低氧组低.低氧组大鼠肺小动脉内膜[（0.31±0.02）vs（0.36±0.01）,P＜0.01]及中膜[（0.27±0.01）vs （0.30±0.01）,P＜0.01]中CSE蛋白表达均较对照组低.低氧＋SO2组大鼠肺小动脉内膜CSE蛋白表达较低氧组高[（0.35±0.02） vs （0.31 ±0.02）,P＜0.01].低氧＋HDX组大鼠肺小动脉内膜CSE蛋白表达较低氧组低[（0.26±0.01） vs （0.31±0.02）,P＜0.01].与对照组相比,低氧组大鼠肺小动脉内膜及中膜MPST的蛋白表达差异没有统计学意义.低氧＋SO2组大鼠肺小动脉中膜MPST的蛋白表达较低氧组高[（0.32±0.02） vs （0.29±0.01）,P＜0.01]；而与低氧组相比,低氧＋ HDX组大鼠肺小动脉内膜及中膜MPST的蛋白表达差异没有统计学意义.结论外源性给予SO2供体可上调低氧性肺动脉高压大鼠肺小动脉内膜H2S生成酶CSE及肺小动脉中膜MPST蛋白表达,促进H2S生成增多,从而间接缓解低氧性肺动脉高压的形成.

关键词：二氧化硫硫化氢高血压,肺性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：