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Biomaterial‑based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration

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Military Medical Research 2025年第1期12卷 96-120页

作者： Ying-Ying Li Shuai-Fei Ji Xiao-Bing Fu Yu-Feng Jiang Xiao-yan sun Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department Chinese PLA General Hospital and PLA Medical CollegePLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin InjuryRepair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China 2Department of Tissue Regeneration and Wound RepairChinese PLA General HospitalBeijing 100853China

Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages,ultimately impairing its normal physiological *** evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration,promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic *** field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical ***,a comprehensive understanding of the underlying mechanisms remains somewhat elusive,limiting the broader application of these *** this review,we present two promising biomaterial-based mechanical approaches aimed at bolstering the regenerative capacity of compromised *** first approach involves leveraging biomaterials with specific biophysical properties to create an optimal scarless environment that supports cellular activities essential for *** second approach centers on harnessing mechanical forces exerted by biomaterials to enhance cellular plasticity,facilitating efficient cellular reprogramming and,consequently,promoting the regeneration of skin *** summary,the manipulation of mechanical cues using biomaterial-based strategies holds significant promise as a supplementary approach for achieving scarless wound healing,coupled with the restoration of multiple skin appendage functions.

关键词： Scarless Wound healing Biomaterials Mechanical cues Skin appendages

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Recent Advances in Wide-Range Temperature Metal-CO_(2)Batteries:A Mini Review

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Nano-Micro Letters 2025年第4期17卷 435-453页

作者： Xuejing Zhang Ning Zhao Hanqi Zhang Yiming Fan Feng Jin Chunsheng Li yan sun Jiaqi Wang Ming Chen Xiaofei Hu School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003People’s Republic of China Engineering Research Center of Energy Storage Materials and Devices Ministry of EducationSchool of ChemistryXi’an Jiaotong UniversityXi’an 710049People’s Republic of China State Key Laboratory for Strength and Vibration of Mechanical Structures Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China School of Chemistry and Life SciencesSuzhou University of Science and TechnologySuzhou 215009People’s Republic of China Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002People’s Republic of China

The metal-carbon dioxide batteries,emerging as high-energy-density energy storage devices,enable direct CO_(2)utilization,offering promising prospects for CO_(2)capture and utilization,energy conversion,and ***,the electrochemical performance of M-CO_(2)batteries faces significant challenges,particularly at extreme *** such as high overpotential,poor charge reversibility,and cycling capacity decay arise from complex reaction interfaces,sluggish oxidation kinetics,inefficient catalysts,dendrite growth,and unstable *** significant advancements at room temperature,limited research has focused on the performance of M-CO_(2)batteries across a wide-temperature *** review examines the effects of low and high temperatures on M-CO_(2)battery components and their reaction mechanism,as well as the advancements made in extending operational ranges from room temperature to extremely low and high *** discusses strategies to enhance electrochemical performance at extreme temperatures and outlines opportunities,challenges,and future directions for the development of M-CO_(2)batteries.

关键词： M-CO_(2)batteries Wide-range temperature Electrolytes Interfaces Electrode reactions

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Advancing insights into calcium homeostasis and signaling in plant growth and resilience

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Science Bulletin 2025年第2期70卷 125-127页

作者： Songchong Lu yan sun Lichao Ma Sheng Luan Guofeng yang College of Life Sciences Qingdao Agricultural UniversityQingdao 266109China Key Laboratory of National Forestry and Grassland Administration on Grassland Resources and Ecology in the Yellow River Delta College of Grassland ScienceQingdao Agricultural UniversityQingdao 266109China Department of Plant and Microbial Biology University of CaliforniaBerkeleyCA 94720USA

Calcium is a crucial macronutrient and functions as a widespread signal in eukaryotes,ranging from yeast,plants to *** crucial second messengers,calcium ions(Ca^(2+))play indispensable roles in plant growth and development,response to external stressors,and signal transduction by modulating downstream cellular responses,including gene expression,metabolic activities,and transport functions[1,2].Unlike other nutrients,the levels of Ca^(2+)in the extracellular space and in certain intracellular stores are typically 10,000 times higher than resting cytoplasmic Ca^(2+)([Ca^(2+)]_(cyt))*** substantial gradient poses potential risks of[Ca^(2+)]_(cyt)overload and toxicity,and it can also lead to a rapid and transient increase in[Ca^(2+)]_(cyt),which is a key signaling mechanism for plants to respond to environmental *** mitigate the cytotoxicity of Ca^(2+)and continuously maintain the potential to generate specific Ca^(2+)signals,it is essential to keep the resting[Ca^(2+)]_(cyt)at a low level of approximately 100 nmol/L[3].Calcium homeostasis is fundamental for maintaining cellular function and organismal health in plants.

关键词： homeostasis stores typically

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Potassium ions and cyano group modified g-C_(3)N_(4) for effective generation of H_(2)O_(2) through two-electron oxygen reduction

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Science China Chemistry 2025年第1期68卷 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen Ke Lei Yujie Duan Linjiao Mao Xuhui Zeng Xi Luo Yuntao Zhang Yuqin Dong Jin Zhong Zhang yan sun School of Mechanical Engineering Chengdu UniversityChengdu 610106China Department of Chemistry and Biochemistry University of CaliforniaSanta CruzCA 95064USA

Potassium ions(K^(+))doped graphitic carbon nitride(g-C_(3)N_(4))was prepared by a thermal etching method using potassium hydroxide(KOH)as an ion *** transform infrared spectroscopy(FTIR)and X-ray photoelectron spectroscopy(XPS)results showed that the generation of the cyano group was detected while introducing K^(+).Under simulated sunlight irradiation,the sample with a K^(+)doping amount of 10%showed the highest hydrogen peroxide(H_(2)O_(2))generation rate of2,140.2μmol h^(-1)g^(-1).The apparent quantum yield(AQY)at 400 nm and the solar-to-chemical conversion(SCC)are 4.35%and1.23%,respectively.K^(+)acted as a bridge between g-C_(3)N_(4)layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons(H^(+))and promoted the yield of H_(2)O_(2).The catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals(·O_(2)^(-))were the most important active species in the reaction *** production of H_(2)O_(2)was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H_(2)O_(2)generation.

关键词： photocatalysis hydrogen peroxide oxygen reduction reaction potassium doping cyano group

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Emerging patterns of antimicrobial resistance:Concurrent presence of mcr-1.1 and mcr-8.1 in a ST15 Klebsiella pneumoniae isolated from poultry in China

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Journal of Integrative Agriculture 2025年第1期24卷 403-407页

作者： Dong'an Cui Panpan Liu Ling Wang Jiongjie He Yuzhang yan Mengke Ru Baocheng Hao yan sun Shengyi Wang Key Laboratory of New Animal Drug Project Gansu Province/Key Laboratory of Veterinary Pharmaceutical DevelopmentMinistry of Agriculture and Rural AffairsLanzhou Institute of Husbandry and Pharmaceutical SciencesChinese Academy of Agricultural SciencesLanzhou 730050China College of Animal Science and Technology Guangxi UniversityNanning 530005China China Institute of Veterinary Drug Control Beijing 100081China

Colistin serves as a crucial treatment for multidrugresistant(MDR)Gram-negative bacterial ***,its excessive use has contributed to an increase in colistin-resistant strains within livestock production(Binsker et al.2022).The mobile colistin resistance gene,mcr,which reduces colistin affinity by incorporating phosphoethanolamine(pEtN)into the bacterial lipopolysaccharide,significantly compromises the effectiveness of colistin treatments(Liu et al.2016).

关键词： poultry treatment compromise

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构建中国特色国家实验室体系——动力机制、内涵特征与着力点

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科学学研究 2025年第1期43卷 49-57页

作者：李静孙雁霍竹科技部科技评估中心北京100081

构建中国特色国家实验室体系是打造国家战略科技力量,提升国家创新体系整体效能的重要战略部署,对于科技进步、高质量发展和保障国家安全具有重要意义。目前协同构建中国特色国家实验室体系尚处于起步探索阶段,其动力机制、内涵特征以... 详细信息

构建中国特色国家实验室体系是打造国家战略科技力量,提升国家创新体系整体效能的重要战略部署,对于科技进步、高质量发展和保障国家安全具有重要意义。目前协同构建中国特色国家实验室体系尚处于起步探索阶段,其动力机制、内涵特征以及着力点亟待揭示。基于资源依赖理论和交易成本理论,结合国际局势、国内形势和科技发展趋势外部条件,附加国家实验室、全国重点实验室自身发展和使命实现的内在驱动,揭示了构建中国特色国家实验室体系的动力机制,并在此基础上阐释了其丰富内涵和系统特征。与体系创新主体、创新要素和创新环境构成相对应,统筹体系布局、强化要素保障、优化制度环境几个方面应为构建中国特色国家实验室体系的着力点。

关键词：国家实验室体系资源依赖交易成本国家实验室全国重点实验室

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China(Life Sciences) 2025年第1期68卷 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye yan sun Jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care HospitalDongguan 523000China Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People’s HospitalSouthern University of Science and TechnologyShenzhen 518020China State Key Laboratory for Quality Ensurance andSustainable Use of Dao-di Herbs Artemisinin Research CenterandInstitute of Chinese Materia MedicaChina Academyof Chinese Medical SciencesBeijing 100700China State Key Laboratory of Antiviral Drugs School of PharmacyHenan UniversityKaifeng 475004China Reproductive Medicine Center Foshan Women and Children HospitalFoshan 528000China

Ovarian endometrioma(OE),also known as“chocolate cysts,”is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus,leading to symptoms such as dysmenorrhea,pelvic pain,and ***,the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown,posing challenges for diagnosis and ***,we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell *** identified notable alterations in cell type-specific proportions and molecular signatures associated with ***,the activation of IGFBP5^(+) macrophages with pro-inflammatory properties,NK cell exhaustion,and aberrant proliferation of IQCG^(+) and KLF2^(+) epithelium are key features and may be the potential mechanisms underlying the pathogenesis of ***,our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang yan sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei Wen-Bo Cao Sai-Jun Mo Zhi-yan sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

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