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Gel electrolytes containing several kinds of particles used in quasi-solid-state dye-sensitized solar cells

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Rare Metals 2006年第z1期25卷 201-206页

作者： GENG Yi sun xiaodan CAI Qiang SHI Yantao LI Hengde Laboratory of Advanced Materials Department of Materials Science&EngineeringTsinghua UniversityBeijing 100084China

Composite gel electrolytes containing several kinds of particles used as the quasi-solid-state electrolytes in dye-sensitized solar cells(DSSCs)were *** particles(MCM-41)with unique structures composed of ordered nanochannels were served as a new kind of gelator for quasi-solid-state ***-41,hydrophobic fumed silica Aerosil R972 and TiO_(2)nanopatricles P25 were dispersed into gel electrolytes *** solar energy-to-electricity conversion efficiency of these cells is 4.65%,6.85%and 5.05%respectively under 30 mW·cm^(-2)*** preparation methods and the particles sizes exert an influence on the performance of corresponding solar *** to unique pore structures and high specific BET surface area,mesoporous silica MCM-41 was expected to have the potential to afford conducting nanochannels for redox couple diffusion.

关键词： dye-sensitized solar cells nanocomposite gel electrolyte mesoporous nanoparticle

NRF2 participates in the suppressive tumor immune microenvironment of KRAS/KEAP1 co-mutant non-small cell lung cancer by inhibiting the STING

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Genes & Diseases 2023年第5期10卷 1727-1730页

作者： sun xiaodan Zhao Peiyan Li Hui Liu Yan Cheng Ying Postdoctoral Research Workstation Jilin Cancer HospitalChangchunJilin 130012China Translational Cancer Research Jilin Cancer HospitalChangchunJilin 130012China Department of Medical Thoracic Oncology Jilin Cancer HospitalChangchunJilin 130012China

Kirsten rat sarcoma(KRAS)mutant non-small cell lung cancer(NSCLC)has distinct co-mutational *** 20%of KRAS mutant NSCLC cases underwent loss-of-function mutation of Kelch-like ECH-associated protein 1(KEAP1)gene,namely KRAS-KEAP1 comutation(KK)type,which exhibited a poorer immune checkpoint inhibitor(ICl)response compared with individual KRAS mutation(K)type tumors.i Recent studies suggest that K-type tumors are referred to as"hot tumors"while KK-type tumors are as"cold tumors".Therefore,clarifying the molecular mechanism of the poor IClresponsive phenotype of KK-type tumors is the key to improving the clinical efficacy and breaking through the therapy ***-mutations could regulate the immune contexture to reshape the tumor immune microenvironment(TIME)。

关键词： KRAS inhibiting cancer

Preparation of 3-D porous fibroin scaffolds by freeze drying with treatment of methanol solutions

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Chinese Science Bulletin 2007年第13期52卷 1791-1795页

作者： ZHAN JingLin sun xiaodan CUI FuZhai KONG XiangDong Laboratory of Advanced Materials Department of Materials Science & Engineering Tsinghua University Beijing 100084 China Xinyuan Institute of Medicine and Biotechnology College of Life Science Zhejiang Science and Technology University Hangzhou 310029 China

In this study, silk scaffolds with appropriate porous structures were prepared by adjusting solution concentrations and providing treatment with methanol solutions in the way of freeze drying. The effects of the preparation conditions on the microstructures and properties of the scaffolds were discussed. Fibroin solutions with different concentrations of 4, 6, 8, 10 wt% were used respectively to prepare the scaffolds. The effects of the addition of 20 vol% methanol before or after freeze drying to the 4 wt% fibroin solution were investigated. As demonstrated by Scanning Electron Microscope (SEM), the fib-roin scaffolds prepared without methanol had porous microstructures composed of thin sheets, and the sizes of the pores decreased with the increase of the fibroin solution concentrations, while the scaffolds prepared in the presence of methanol showed porous microstructures formed by fine-particle aggregates. The porosities and mechanical properties of the prepared fibroin scaffolds under different conditions were tested. The crystalline structures and conformations of the fibroin scaffolds were detected by Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD).

关键词：蚕丝蛋白多孔材料冷藏干燥甲醇

Dynamic corner frequency in source spectral model for stochastic synthesis of ground motion

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Earthquake Science 2009年第3期22卷 271-276页

作者： xiaodan sun Xiaxin Tao Guoxin Wang Taojun Liu Department of Civil Engineering Harbin Institute of Technology Harbin 150090 China Institute of Engineering Mechanics China Earthquake Administration Harbin 150080 China Department of Civil and Hydraulic Engineering Dalian University of Technology Dalian 116024 China

The static comer frequency and dynamic comer frequency in stochastic synthesis of ground motion from fi- nite-fault modeling are introduced, and conceptual disadvantages of the two are discussed in this paper. Furthermore, the non-uniform radiation of seismic wave on the fault plane, as well as the trend of the larger rupture area, the lower comer frequency, can be described by the source spectral model developed by the authors. A new dynamic comer frequency can be developed directly from the model. The dependence of ground motion on the size of subfault can be eliminated if this source spectral model is adopted in the synthesis. Finally, the approach presented is validated from the comparison between the synthesized and observed ground motions at six rock stations during the Northridge earthquake in 1994.

关键词： source spectral model dynamic corner frequency stochastic synthesis finite-fault

Continuously released Zn^(2+)in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties

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Bioactive Materials 2023年第6期24卷 361-375页

作者： Chunxu Li Fengbo sun Jingjing Tian Jiahao Li Haidan sun Yong Zhang Shigong Guo Yuanhua Lin xiaodan sun Yu Zhao Department of Orthopedics Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China State Key Laboratory of Advanced Ceramics and Fine Processing School of MaterialsTsinghua UniversityBeijingChina Medical Science Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Core Facility of Instrument Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijingChina The State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijingChina Department of Rehabilitation Medicine Southmead HospitalBristolUK

Long-term nonunion of bone defects has always been a major problem in orthopedic *** bone graft materials such as Poly(lactic-co-glycolic acid)/β-tricalcium phosphate(PLGA/β-TCP)scaffolds are expected to solve this problem due to their suitable degradation rate and good ***,insufficient mechanical properties,lack of osteoinductivity and infections after implanted limit its large-scale clinical ***,we proposed a novel bone repair bioscaffold by adding zinc submicron particles to PLGA/β-TCP using low temperature rapid prototyping 3D printing *** first screened the scaffolds with 1 wt%Zn that had good biocompatibility and could stably release a safe dose of zinc ions within 16 weeks to ensure long-term *** designed,the scaffold had a multi-level porous structure of biomimetic cancellous bone,and the Young’s modulus(63.41±1.89 MPa)and compressive strength(2.887±0.025 MPa)of the scaffold were close to those of cancellous *** addition,after a series of in vitro and in vivo experiments,the scaffolds proved to have no adverse effects on the viability of BMSCs and promoted their adhesion and osteogenic differentiation,as well as exhibiting higher osteogenic and anti-inflammatory properties than PLGA/β-TCP scaffold without zinc *** also found that this osteogenic and anti-inflammatory effect might be related to Wnt/β-catenin,P38 MAPK and NFkB *** study lay a foundation for the follow-up study of bone regeneration mechanism of Zn-containing *** envision that this scaffold may become a new strategy for clinical treatment of bone defects.

关键词： 3D printing Zinc submicron particles Osteoinductivity Anti-inflammatory Bone defect repair

Response of nitrogen fractions in the rhizosphere and bulk soil to organic mulching in an urban forest plantation

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Journal of Forestry Research 2021年第6期32卷 2577-2588页

作者： xiaodan sun Gang Wang Yuqian Ye Qingxu Ma Qingwei Guan Davey L.Jones College of Biology and the Environment Nanjing Forestry UniversityNanjing 210037People’s Republic of China Co-Innovation Center for Sustainable Forestry in Southern China Nanjing 210037People’s Republic of China School of Natural Sciences Bangor UniversityBangor LL572UWGwyneddUK

Nitrogen is an essential component in forest ecosystem nutrient *** fractions,such as dissolved nitrogen,ammonium,nitrate,and microbial biomass nitrogen,are sensitive indicators of soil nitrogen pools which affect soil fertility and nutrient ***,the responses of nitrogen fractions in forest soils to organic mulching are less well *** rhizosphere is an important micro-region that must be considered to better understand element cycling between plants and the soil.A field investigation was carried out on the effect of mulching soil in a 15-year-old Ligustrum lucidum urban *** in total nitrogen and nitrogen fractions in rhizosphere and bulk soil in the topsoil(upper 20 cm)and in the subsoil(20-40 cm)were evaluated following different levels of mulching,in addition to nitrogen contents in fine roots,leaves,and organic *** relationships between nitrogen fractions and other measured variables were *** mulching had no significant effect on most nitrogen fractions except for the rhizosphere microbial biomass nitrogen(MBN),and the thinnest(5 cm)mulching layer showed greater effects than other *** MBN was more sensitive to mulching compared to bulk soil,and was more affected by soil environmental *** and soil depth had more pronounced effects on nitrogen fractions than *** nitrogen and dissolved nitrogen were correlated to soil phosphorus,whereas other nitrogen fractions were strongly affected by soil physical properties(temperature,water content,bulk density).Mulching also decreased leaf nitrogen content,which was more related to soil nitrogen fractions(except for MBN)than nitrogen contents in either fine roots or organic *** applications of small quantities of organic mulch contribute to nitrogen transformation and utilization in urban forests.

关键词： Rhizosphere Nitrogen fraction Organic mulching Soil–plant interaction Urban plantation forest

Stochastic simulation of ground motions based on NGA-West2 strong motion records

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Earthquake Science 2019年第3期32卷 115-124页

作者： Peng Tian xiaodan sun Xin Li Keyu Wan Departement of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China

Stochastic modeling of ground motion is a simple tool to predict ground shaking level for future earthquake and less time consuming than physics-based deterministic *** this paper,a record-based stochastic method that considers the time-and frequency-evolution of ground motion is used to estimate ground motion for scenario earthquakes in tectonic active *** stochastic method employs a time-domain modulation function to describe the temporal nonstationarity and a filter impulse response function that describe the evolution of frequency *** characterizing the modulation function and the filter impulse function,six parameters(Ia,D5-95,tmid,ωmid,ω',ξf)are defined,and 2,571 pairs of ground motion recording in the NGA-west2 database are selected to identify the six *** density function is assigned to each of the parameter by fitting the frequency distribution *** parameters are then transformed into standard normal space where regression analysis is performed by considering each parameter as function of moment magnitude,rupture distance,vS30(The time-averaged shear wave velocity of the top 30 m of soil).The prediction equations are used to generate ground motions for several scenario earthquakes and compared to NGA-West2 GMPEs.

关键词： stochastic modeling nonstationarity scenario earthquake NGA-West2

Neurogenic differentiation of human umbilical cord mesenchymal stem cells on aligned electrospun polypyrrole/ polylactide composite nanofibers with electrical stimulation

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Frontiers of Materials Science 2016年第3期10卷 260-269页

作者： Junfeng ZHOU Liang CHENG xiaodan sun Xiumei WANG ShouhongJIN Junxiang LI Qiong WU Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and Engineering Tsinghua University Beijing 100084 China School of Life Sciences Tsinghua University Beijing 100084 China

Adult central nervous system （CNS） tissue has a limited capacity to recover after trauma or disease. Recent medical cell therapy using polymeric biomaterial- loaded stem cells with the capability of differentiation to specific neural population has directed focuses toward the recovery of CNS. Fibers that can provide topographical, biochemical and electrical cues would be attractive for directing the differentiation of stem cells into electro-responsive cells such as neuronal cells. Here we report on the fabrication of an electrospun polypyrrole/polylactide composite nanofiber film that direct or determine the fate of mesenchymal stem cells （MSCs）, via combination of aligned surface topography, and electrical stimulation （ES）. The surface morphology, mechanical properties and electric properties of the film were characterized. Comparing with that on random surface film, expression of neurofilament-lowest and nestin of human umbilical cord mesenchymal stem cells （huMSCs） cultured on film with aligned surface topography and ES were obviously enhanced. These results suggest that aligned topography combining with ES facilitates the neurogenic differentiation of huMSCs and the aligned conductive film can act as a potential nerve scaffold.

关键词： human umbilical cord mesenchymal stem cells neurogenic differentiation conductive composite film electrospun nanofibers electrical stimulation

Nucleation and growth mechanism of cefodizime sodium at different solvent compositions

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Frontiers of Chemical Science and Engineering 2013年第4期7卷 490-495页

作者： Xinwei ZHANG Shudong ZHANG xiaodan sun Zequn YIN Quanjie LIU Xiwen ZHANG Qiuxiang YIN Fushun Research Institute of Petroleum and Petrochemicals SINOPEC Fushun 113001 China School of Chemical Engineering and Technology State Key Laboratory of Chemical Engineering Tianjin University Tianjin 300072 China

The induction time of cefodizime sodium was measured in ethanol-water at different solvent composi- tions by the laser technology measurement. The results indicate that the solvent composition played an important role in the supersaturation and the nucleation process of cefodizime sodium solution. According to the modified classical nucleation theory, the nucleation and growth mechanism were identified. The correlation results show that heterogeneous nucleation dominated the nucleation process at lower supersaturation, where homogeneous nucleation is the most important mechanism at higher supersaturation. Based on the correlated results, the 2D mediated growth mechanism had the highest correlation coefficients （R2）, so this mechanism was selected as the proper growth mechanism for cefodizime sodium.

关键词： cefodizime sodium induction time primarynucleation growth mechanism