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Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion

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World Journal of Gastroenterology 2021年第32期27卷 5404-5423页

作者： Zi-Yi wang jian-Yu Lin yang-Rong Feng De-Shun Liu xu-Zi Zhao Tong Li Si-Yuan Li jing-Chao sun Shu-Feng Li Wen-Yan Jia hui-Rong jing Emergent Intensive Care Unit The Second Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina Department of Gastrointestinal Surgery Weihai Central HospitalWeihai 264200Shandong ProvinceChina Graduate College Shandong First Medical UniversityJinan 271000Shandong ProvinceChina Department of General Surgery The Second Affiliated Hospital of Dalian Medical UniversityDalian 116027Liaoning ProvinceChina Department of Pharmacology Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100000China Department of General Surgery Qingdao Municipal HospitalQingdao UniversityQingdao 266071Shandong ProvinceChina Physiological Examination Center The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Intestinal barrier breakdown,a frequent complication of intestinal ischemiareperfusion(I/R)including dysfunction and the structure changes of the intestine,is characterized by a loss of tight junction and enhanced permeability of the intestinal barrier and increased *** develop effective and novel therapeutics is important for the improvement of outcome of patients with intestinal barrier *** human angiopoietin-like protein 4(rhANGPTL4)is reported to protect the blood-brain barrier when administered exogenously,and endogenous ANGPTL4 deficiency deteriorates radiationinduced intestinal *** To identify whether rhANGPTL4 may protect intestinal barrier breakdown induced by I/*** Intestinal I/R injury was elicited through clamping the superior mesenteric artery for 60 min followed by 240 min *** epithelial(Caco-2)cells and human umbilical vein endothelial cells were challenged by hypoxia/reoxygenation to mimic I/R in *** Indicators including fluorescein isothiocyanate-conjugated dextran(4 kilodaltons;FD-4)clearance,ratio of phosphorylated myosin light chain/total myosin light chain,myosin light chain kinase and loss of zonula occludens-1,claudin-2 and VE-cadherin were significantly increased after intestinal I/R or cell hypoxia/***4 treatment significantly reversed these indicators,which were associated with inhibiting the inflammatory and oxidative cascade,excessive activation of cellular autophagy and apoptosis and improvement of survival *** results were observed in vitro when cells were challenged by hypoxia/reoxygenation,whereas rhANGPTL4 reversed the indicators close to normal level in Caco-2 cells and human umbilical vein endothelial cells *** rhANGPTL4 can function as a protective agent against intestinal injury induced by intestinal I/R and improve survival via maintenance of intestinal barrier structure and functions.

关键词： Angiopoietin-like protein 4 Intestinal ischemia/reperfusion COVID-19 Myosin light chain kinase Intestinal barrier breakdown

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Effect of Optimized Concentrations of Basic Fibroblast Growth Factor and Epidermal Growth Factor on Proliferation of Fibroblasts and Expression of Collagen： Related to Pelvic Floor Tissue Regeneration

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Chinese Medical Journal 2018年第17期131卷 2089-2096页

作者： Yuan-Yuan Jia jing-Yi Zhou Yue Chang Fang An xiao-Wei Li xiao-Yue xu Xiu-Li sun chun-yang Xiong jian-Liu wang Department of Obstetrics and Gynecology Peking University People's Hospital Beijing 100044 China Beijing Key Laboratory of Female Pelvic Floor Disorders Beijing 100044 China Department of Mechanics and Bioengineering College of Engineering Peking University Beijing 100871 China

Background： Fibroblasts were the main seed cells in the studies of tissue engineering of the pelvic floor ligament. Basic fibroblast growth factor （bFGF） and epidermal growth factor （EGF） were widely studied but at various concentrations. This study aimed to optimize the concentrations of combined bFGF and EGF by evaluating their effects on proliferation and collagen secretion of fibroblasts. Methods： Fibroblasts were differentiated from rat adipose mesenchymal stem cells （ADSCs）. Flow cytometry and immunohistochemistry were used for cell identification. The growth factors were applied at concentrations of 0, 1, 10, and 100 ng/ml as three groups：（1） bFGF alone, （2） EGF alone, and （3） bFGF mixed with EGF. Cell proliferation was evaluated by Cell Counting Kit-8 assays. Expression of Type I and III collagen （Col-I and Col-1II） mRNAs was evaluated by real-time quantitative reverse transcription-polymerase chain reaction. Statistical analysis was performed with SPSS software and GraphPad Prism using one-way analysis of variance and multiple t-test. Results： ADSCs were successfully isolated from rat adipose tissue as identified by expression of typical surface markers CD29, CD44, CD90, and CD45 in flow cytometry. Fibroblasts induced from ADSC, compared with ADSCs, were with higher mRNA expression levels of Col I and Col III （F = 1.29, P = 0.0390）. bFGF, EGF, and the mixture ofbFGF with EGF can enhanced fibroblasts proliferation, and the concentration of 10 ng/ml of the mixture ofbFGF with EGF displayed most effectively （all P 〈 0.05）. The expression levels of Col-I and Col-Ill mRNAs in fibroblasts displayed significant increases in the 10 ng/ml bFGF combined with EGF group （all P 〈 0.05）. Conclusions： The optimal concentration of both bFGF and EGF to promote cell proliferation and collagen expression in fibroblasts was 10 ng/ml at which fibroblasts grew faster and secreted more Type I and III collagens into the extracellular matrix, which might contribute to the stabilit

关键词： Adipose Mesenchymal Stem Cells Basic Fibroblast Growth Factor Epidermal Growth Factor Fibroblasts Tissue Engineering

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Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5919-5930页

作者： Lin wang Jia-Bao Cao bin-bin Xia Yue-Juan Li xuan Zhang Guo-Xin Mo Rui-Juan wang Si-qi Guo Yu-qing Zhang Kun xiao Guang-Fa Zhu Peng-Fei Liu Li-Cheng Song Xi-hui Ma Ping-Chao Xiang jiang wang Yu-Hong Liu Fei Xie xu-Dong Zhang Xiang-Xin Li Wan-Lu sun Yan Cao Kai-Fei wang Wen-hui Zhang Wei-Chao Zhao Peng Yan Ji-Chao Chen Yu-Wei yang Zhong-Kuo Yu jing-Si Tang Li xiao Jie-Min Zhou Li-Xin Xie Jun wang College of Pulmonary&Critical Care Medicine 8th Medical Center of Chinese PLA General HospitalBeijing 100091China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Faculty of Biological Science and Technology Baotou Teacher’s CollegeBaotou 014030China Department of Respiratory Medicine PLA Strategic Support Force Medical CenterBeijing 100101China Department of Respiratory and Critical Care Medicine Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China Respiratory Research Institute Department of Pulmonary&Critical Care MedicineBeijing Key Laboratory of OTIRthe 8th Medical Center of Chinese PLA General HospitalBeijing 100091China Shougang hospital of Peking University Beijing 100144China Department of Respiratory Medicine Beijing Changping HospitalBeijing 102200China Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Pulmonary research institute Senior Department of Respiratory and Critical Care Medicinethe 8th medical center of Chinese PLA general hospitalBeijing 100091China College of Pulmonary&Critical Care Medicine Chinese PLA General HospitalBeijing 100853China China Aerospace Science&Industry Corporation 731 hospital Beijing 100074China Department of Respiratory and Critical Care Medicine Aerospace Center HospitalBeijing 100049China Vision Medicals Center for Infectious Diseases Guangzhou 510700China

The Omicron variant of the severe acute respiratory syndrome coronavirus 2(SARS‑CoV‑2)infected a substantial proportion of Chinese population,and understanding the factors underlying the severity of the disease and fatality is valuable for future prevention and clinical *** recruited 64 patients with invasive ventilation for COVID-19 and performed metatranscriptomic sequencing to profile host transcriptomic profiles,plus viral,bacterial,and fungal content,as well as virulence factors and examined their relationships to 28-day mortality were *** addition,the bronchoalveolar lavage fluid(BALF)samples from invasive ventilated hospital/community-acquired pneumonia patients(HAP/CAP)sampled in 2019 were included for *** analysis revealed that all Omicron strains belong to BA.5 and BF.7 sub-lineages,with no difference in 28-day mortality between *** to HAP/CAP cohort,invasive ventilated COVID-19 patients have distinct host transcriptomic and microbial signatures in the lower respiratory tract;and in the COVID-19 non-survivors,we found significantly lower gene expressions in pathways related viral processes and positive regulation of protein localization to plasma membrane,higher abundance of opportunistic pathogens including bacterial Alloprevotella,Caulobacter,Escherichia-Shigella,Ralstonia and fungal Aspergillus sydowii and Penicillium *** analysis further revealed significant associations between host immune responses and microbial compositions,besides synergy within viral,bacterial,and fungal *** study presents the relationships of lower respiratory tract microbiome and transcriptome in invasive ventilated COVID-19 patients,providing the basis for future clinical treatment and reduction of fatality.

关键词： patients mortality prevention

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Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1845-1855页

作者： huijie Bian Zhao-hui Zheng Ding Wei Aidong Wen Zheng Zhang jian-qi Lian Wen-Zhen Kang chun-qiu Hao jing wang Rong-hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-xuan sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao qing wang Ke wang Jie-Jie Geng bin wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan wang qian He Rui-Rui Yao Ying Shi Xiang-Min yang jian-Sheng Zhou Yi-nan Ma Ya-Tao wang xue Liang Fei huo Zhe wang yang Zhang xu yang Ye Zhang Lu-hua Gao Ling wang xiao-chun Chen Hao Tang Shuang-Shuang Liu qing-Yi wang Zhi-nan Chen Ping Zhu National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'anChina Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'anChina Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi'anChina Center for Infectious Diseases Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Nuclear Medicine Xijing HospitalFourth Military Medical UniversityXi'anChina department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXKanChina College of Military Preventive Medicine Fourth Military Medical UniversityXi'anChina Department of Pharmaceutics Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Pathology Fourth Military Medical UniversityXi'anChina jiangsu Pacific Meinuoke Biopharmaceutical Co.Ltd ChangzhouChina Department of Foreign Languages Fourth Military Medical UniversityXi'anChina

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 *** is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)***,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 *** phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was *** serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic *** obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each *** biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to *** the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent *** meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control *** results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile.

关键词： patients dosage phase

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LSCN:一种用于动作识别的长短时序关注网络

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电子学报 2020年第3期48卷 503-509页

作者：杨珂王敬宇戚琦孙海峰王晶廖建新北京邮电大学网络与交换国家重点实验室北京100876

相较于图像分析,如何分析时序信息是动作识别中的一个主要问题.大多数先前的方法,如3D卷积网络、双流卷积网络,仅使用包含全局时域信息的特征作为视频的表征,忽略了局部时序特征的重要性.考虑到这样的问题,本文提出一种基于时序交互感... 详细信息

相较于图像分析,如何分析时序信息是动作识别中的一个主要问题.大多数先前的方法,如3D卷积网络、双流卷积网络,仅使用包含全局时域信息的特征作为视频的表征,忽略了局部时序特征的重要性.考虑到这样的问题,本文提出一种基于时序交互感知模块的长短时序关注网络——Long and Short Sequence Concerned Networks(LSCN),融合不同的时序信息,利用不同卷积层时序特征的交互加强对不同时序长度的动作实例的表示,兼顾长短动作实例对时序信息的需求.实验结果表明,基于3D ResNext101的LSCN在两个公共数据集(UCF101和HMDB51)上,相较于基础的网络分别有0.4%和2.9%的准确率提升.

关键词：动作识别时序特征特征融合人机交互视频分析深度学习

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Hard X-ray Imager (HXI) onboard the ASO-S mission

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Research in Astronomy and Astrophysics 2019年第11期19卷 49-62页

作者： Zhe Zhang Deng-Yi Chen jian Wu Jin Chang Yi-Ming hu yang Su Yan Zhang jian-Ping wang Yao-Ming Liang Tao Ma jian-hua Guo Ming-Sheng Cai Yong-qiang Zhang Yong-Yi huang xiao-Yan Peng Zong-bin Tang xuan Zhao Hong-He Zhou Lian-Guo wang jing-Xing Song Miao Ma Guang-Zhou xu jian-Feng yang Di Lu Ying-Hong He Jin-You Tao xiao-Long Ma Bao-Gang Lv Yan-Ping Bai Cai-Xia Cao Yu huang Wei-Qun Gan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China National Space Science Center Chinese Academy of SciencesBeijing 100190China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China

Hard X-ray Imager(HXI)is one of the three scientific instruments onboard the Advanced Spacebased Solar Observatory(ASO-S)mission,which is proposed for the 25th solar maximum by the Chinese solar *** is designed to investigate the non-thermal high-energy electrons accelerated in solar flares by providing images of solar flaring regions in the energy range from 30 keV to 200 *** imaging principle of HXI is based on spatially modulated Fourier synthesis and utilizes about 91 sets of bi-grid sub-collimators and corresponding LaBr3 detectors to obtain Fourier components with a spatial resolution of about 3 arcsec and a time resolution better than 0.5 *** engineering prototype has been developed and tested to verify the feasibility of *** this paper,we present background,instrument design and the development and test status of the prototype.

关键词： instrumentation:detectors space vehicles:instruments sun:X-ray techniques:imaging spectroscopy

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The mini-GWAC optical follow-up of gravitational wave alerts – results from the O2 campaign and prospects for the upcoming O3 run

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Research in Astronomy and Astrophysics 2020年第1期20卷 107-123页

作者： Damien Turpin Chao Wu xu-hui Han Li-Ping Xin Sarah Antier Nicolas Leroy Li Cao Hong-Bo Cai Bertrand Cordier Jin-Song Deng Wen-Long Dong qi-Chen Feng Lei huang Lei Jia Alain Klotz Cyril Lachaud hua-Li Li En-Wei Liang Shun-Fang Liu xiao-Meng Lu Xian-Min Meng Yu-Lei qiu hui-Juan wang jing wang Shen wang Xiang-Gao wang jian-Yan Wei Bo-bing Wu Yu-Jie xiao Da-Wei xu yang xu Yuan-Gui yang Pin-Pin Zhang Ruo-Song Zhang Shuang-nan Zhang Ya-Tong ZhengandSi-Cheng Zou Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China LAL Univ.Paris-SudCNRS/IN2P3Universite Paris-SaclayF-91898 OrsayFrance APC Univ Paris DiderotCNRS/IN2P3CEA/lrfuObs de ParisSorbonne Paris CiteFrance CEA Saclay DRF/IRFU/Departement d’astrophysique91191 Gif-sur-YvetteFrance School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Universite de Toulouse IRAP 14 Av.Edouard BelinF-31000 ToulouseFrance Institut de Recherche en Astrophysique et Planetologie(IRAP) UPS-OMPToulouseFrance Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics and Electronic Information Huaibei Normal UniversityHuaibei 235000China

The second(O2)observational campaign of gravitational waves(GWs)organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of GW signals from merger systems involving black holes or neutrons *** O2,14 GW alerts were sent to the astronomical community with sky regions mostly covering over hundreds of square *** them,six were finally confirmed as real astrophysical *** 2013,a new set of ground-based robotic telescopes called Ground-based Wide Angle Camera system(GWAC)project and its pathfinder mini-GWAC has been developed to contribute to the various challenges of multi-messenger and time domain *** GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next *** O2,only the mini-GWAC telescope network was fully *** to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes,they were adept to efficiently cover the sky localization areas of GW event *** this paper,we present the mini-GWAC pipeline we have set up to respond to GW alerts and we report our optical follow-up observations of eight GW alerts detected during the O2 *** observations provided the largest coverage of the GW localization areas with a short latency made by any optical *** found tens of optical transient candidates in our images,but none of those could be securely associated with any confirmed black hole-black hole merger *** on this first experience and the near future technical improvements of our network system,we will be more competitive in detecting the optical counterparts from some GW events that will be identified during the upcoming O3 run,especially those emerging from binary neutron star mergers.

关键词： gravitational waves methods:data analysis methods:observational (stars:)gammaray burst:general

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Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys

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Zoological Research 2020年第1期41卷 3-19页

作者： Pei Zhang Jie-Si Chen qi-Ye Li Long-Xiang Sheng Yi-Xing Gao bing-Zheng Lu Wen-Bo Zhu xiao-Yu Zhan Yuan Li Zhi-bing Yuan Gang xu Bi-Tao qiu Min Yan chun-xue Guo You-qiong wang Yi-Jun huang jing-Xia Zhang Fu-Yu Liu Zhong-Wei Tang Sui-Zhen Lin David NCooper huan-Ming yang jian wang Yu-qi Gao Wei Yin Guo-Jie Zhang Guang-Mei Yan State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China BGI-Shenzhen ShenzhenGuangdong 518083China Section for Ecology and Evolution Department of BiologyUniversity of CopenhagenCopenhagen DK-2100Denmark Department of Pharmacology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Institute of Medicine and Hygienic Equipment for High Altitude Region College of High Altitude Military MedicineThird Military Medical UniversityChongqing 400038China Key Laboratory of High Altitude Medicine of People's Liberation Army Chongqing 400038China Key Laboratory of High Altitude Environmental Medicine Third Military Medical UniversityMinistry of EducationChongqing 400038China School of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510006China Guangzhou Cellprotek Pharmaceutical Co.Ltd. GuangzhouGuangdong 510663China Institute of Medical Genetics School of MedicineCardiff UniversityCardiff CF144XNUK James D.Watson Institute of Genome Sciences HangzhouZhejiang 310058China Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China China National Genebank BGI-ShenzhenShenzhenGuangdong 518120China

Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys (Macaca fascicularis) exposed to acute HH developed human-like HH syndrome involving severe brain injury and abnormal behavior. Transcriptome profiling of white blood cells and brain tissue from monkeys exposed to increasing altitude revealed the central role of the HIF-1 and other novel signaling pathways, such as the vitamin D receptor (VDR) signaling pathway, in co-regulating HH-induced inflammation processes. We also observed profound transcriptomic alterations in brains after exposure to acute HH, including the activation of angiogenesis and impairment of aerobic respiration and protein folding processes, which likely underlie the pathological effects of HH-induced brain injury. Administration of progesterone (PROG) and steroid neuroprotectant 5α-androst-3β,5,6β-triol (TRIOL) significantly attenuated brain injuries and rescued the transcriptomic changes induced by acute HH. Functional investigation of the affected genes suggested that these two neuroprotectants protect the brain by targeting different pathways, with PROG enhancing erythropoiesis and TRIOL suppressing glutamate-induced excitotoxicity. Thus, this study advances our understanding of the pathology induced by acute HH and provides potential compounds for the development of neuroprotectant drugs for therapeutic treatment.

关键词： Acute hypobaric hypoxia Cynomolgus monkeys Brain injury Neuroprotectant Gene regulatory networks

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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： qiang Li Li‑Jiao wang jing‑Yu Tang Xiang‑Biao qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑qing Feng Rong Zhang xiao‑yang sun qi An Hao‑Fan Bai jiang‑Bo Bai Jie Bao Ping Cao qi‑Ping Chen Yong‑Hao Chen Zeng‑qi Cui An‑chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He yang Hong Yi‑Wei hu Han‑Xiong huang Wei jiang Zhi‑Jie jiang Zheng‑Yao Jin Ling Kang Bo Li Gong Li xiao Li yang Li Jie Liu Rong Liu Shu‑bin Liu Yi‑Na Liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Kang sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng wang Peng‑Cheng wang Zhao‑hui wang Zhong‑Wei Wen xiao‑Guang Wu xuan Wu Cong Xia Yong‑Ji Yu Guo‑hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

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The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)

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Research in Astronomy and Astrophysics 2012年第9期12卷 1197-1242页

作者： Xiang-Qun Cui Yong-Heng Zhao Yao-Quan chu Guo-Ping Li qi Li Li-Ping Zhang Hong-Jun Su Zheng-qiu Yao Ya-nan wang xiao-Zheng Xing Xin-nan Li Yong-Tian Zhu Gang wang Bo-Zhong Gu A-Li Luo Xin-qi xu Zhen-Chao Zhang Gen-Rong Liu Hao-Tong Zhang De-hua yang Shu-Yun Cao Hai-Yuan Chen jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru chu Lei Feng xue-Fei Gong Yong-hui Hou Hong-Zhuan hu Ning-Sheng hu Zhong-Wen hu Lei Jia Fang-hua jiang Xiang jiang Zi-Bo jiang Ge Jin Ai-hua Li Yan Li Ye-Ping Li Guan-QunLiu Zhi-Gang Liu huo-Ming Shi Zheng-Hong Tang qing-Sheng Tao Xiang-Yan Yuan Chao Zhai jing Zhang Yan-Xia Zhang Yong Zhang Ming Zhao Fang Zhou Guo-hua Zhou Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China yzhao @ *** nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Tecfinologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects.

关键词： techniques: wide field telescope - active optics - multi fiber - spectroscopy survey - data reduction

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