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Ubiquitin-specific protease 1 facilitates tumor immune escape from natural killer cells and predicts the prognosis in small cell lung cancer

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Oncology research 2025年第1期33卷 213-224页

作者： Shiqin Jiang Yichun Tang Feng Ma Yuchun Niu Lei sun Department of Clinical Pharmacy Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine Shenzhen 518104 China. Department of Pathology Zhujiang Hospital Southern Medical University Guangzhou 510280 China. Department of Radiation Oncology The First People's Hospital of Foshan Foshan 528000 China. Department of Oncology The First Affiliated Hospital of Jinan University Jinan University Guangzhou 510630 China. Department of Oncology The First Dongguan Affiliated Hospital Guangdong Medical University Dongguan 523721 China.

Objective:Small cell lung cancer (SCLC) is commonly recognized as the most fatal lung cancer type. Despite substantial advances in immune checkpoint blockade therapies for treating solid cancers, their benefits are limited to a minority of patients with SCLC. In the present study, novel indicators for predicting the outcomes and molecular targets for SCLC treatment were elucidated.Methods:We conducted bioinformatics analysis to identify the key genes associated with tumor-infiltrating lymphocytes in SCLC. The functional role of the key gene identified in SCLC was determined both and .Results:A significant correlation was observed between patient survival and CD56dim natural killer (NK) cell proportion. Furthermore, we noted that the hub gene ubiquitin-specific protease 1 (USP1) is closely correlated with both CD56dim NK cells and overall survival in SCLC. Bioinformatics analysis revealed that USP1 is upregulated in SCLC. In addition, gene set enrichment analysis revealed that USP1 overexpression hinders NK cell-mediated immune responses. By co-cultivating NK-92 cells with SCLC cells, we demonstrated that NK cell cytotoxicity against SCLC could be improved either via USP1 knock-down or pharmacological inhibition. Furthermore, using a nude-mice xenograft tumor model, we noted that USP1 inhibition effectively suppressed tumor proliferation and increased the expression of NK cell-associated markers.Conclusions:Our study findings highlight the importance of NK cells in regulating SCLC. USP1 overexpression can inhibit NK cell-mediated immunity; therefore, USP1 may serve not only as a prognostic biomarker but also as a potential molecular target of SCLC therapy.

关键词： Immune escape Natural killer (NK) cell Prognosis Small cell lung cancer (SCLC) Ubiquitin-specific protease 1 (USP1)

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi sun Shiqian Shen Robert J.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Sporadic E responds to the 2022 Tonga volcano eruptions recorded by the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 20-28页

作者： YangYi sun Tao Yu Jin Wang Chi Long School of Geophysics and Geomatics China University of Geosciences(Wuhan)Wuhan 430047China School of Physics and Electronic Science Guizhou Normal UniversityGuizhou 550001China

In this study,ionosonde observations over Fuke(19.5°N,109.1°E),Wuhan(30.5°N,114.4°E),and Mohe(53.5°N,122.3°E)were analyzed to demonstrate the responses of the sporadic E()to the severe atmospheric disturbances caused by the Tonga volcanic eruptions on January 15,*** most prominent signature was the disappearance of the layer after~10:00 UT over Wuhan and Fuke,which was attributed to the vertical drift caused by the *** occurred intermittently after 13:00 UT following the arrival of the tropospheric Lamb *** examine the causal mechanism for the intermittence,we also included data of horizontal winds in the mesosphere and lower thermosphere region recorded by the meteor radars at Wuhan and Mohe in this *** wind disturbances with periods of~20 hours contributed to the formation of the layer in the nighttime on January 15.

关键词： sporadic E Tonga eruptions neutral wind disturbances

Cascaded DNA circuits-programmed self-assembly of spherical nucleic acids for high signal amplification

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Science China Chemistry 2020年第1期63卷 92-98页

作者： xiang Li Dongbao Yao Junxiang Zhou xiang Zhou Xianbao sun Bing Wei Chengxu Li Bin Zheng Haojun liang Key Laboratory of Soft Matter Chemistry Chinese Academy of SciencesCollaborative Innovation Center of Chemistry for Energy MaterialsDepartment of Polymer Science and EngineeringHefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of China School of Chemistry and Chemical Engineering Hefei Normal University

Signal amplification is an important issue in DNA nanotechnology and molecular *** this work,we report a strategy for the catalytic self-assembly of spherical nucleic acids(SNAs)programmed by two-layer cascaded DNA circuits through integrating an entropy-driven catalytic network,a catalytic hairpin assembly circuit,and a facile SNA assembly-based reporter *** integrated system could implement^100,000-fold signal amplification in the presence of 1 pM of input *** powerful amplification ability of nucleic acid signal,our strategy should be of great potential in fabricating more robust dynamic networks to be applied for signal transduction,DNA computing,and nucleic acid-based diagnostics.

关键词： catalytic self-assembly DNA circuit signal amplification spherical nucleic acids

Identity for the Exponential-Type Molecule Potentials and the Supersymmetry Shape Invariance

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Communications in Theoretical Physics 2001年第12期36卷 641-646页

作者： JIA Chun-Sheng ZHANG Ying ZENG xiang-Lin sun liang-Tian State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum Institute. Nanchong 637001 Sichuan Province China Department of Computer Science Sichuan Teacher''s College Nanchong 637002 Sichuan Province China Graduate School Southwest Petroleum Institute Nanchong 637001 Sichuan Province China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum Institute. Nanchong 637001 Sichuan Province China

The identity and the supersymmetry shape invariance for a class of exponential-type molecule potentials are studied by introducing a deformed five-parameter exponential-type potential (DFPEP) and via the multi-parameter deformations. It has been shown that the DFPEP is a shape-invariant potential with a translation of parameters. By making use of the shape invariance approach, the exact energy levels are determined for the bound states with zero angular momentum. A class of molecule potentials and their exact energy spectra for the zero angular momentum states are reduced from the DFPEP and a general energy spectrum formula, respectively. The interrelations for some molecule potentials are also discussed.

关键词： deformed five-parameter exponential-type potential, shape invariance, multi-parameter deforma tion, energy eigenvalue

Saturated Adaptive Output-Constrained Control of Cooperative Spacecraft Rendezvous and Docking

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IEEE/CAA Journal of Automatica Sinica 2019年第6期6卷 1462-1470页

作者： liang sun IEEE the Key Laboratory of Knowledge Automation for Industrial Processes Ministry of Education School of Automation and Electrical Engineering and also with the Institute of Artificial Intelligence University of Science and Technology Beijing

This paper investigates the robust relative pose control for spacecraft rendezvous and docking with constrained relative pose and saturated control inputs.A barrier Lyapunov function is used to ensure the constraints of states,so that the computational singularity of the inverse matrix in control command can be avoided,while a linear auxiliary system is introduced to handle with the adverse effect of actuator *** tuning rules for designing parameters in control command and auxiliary system are derived based on the stability analysis of the closed-loop *** is proved that all closed-loop signals always keep bounded,the prescribed constraints of relative pose tracking errors are never violated,and the pose tracking errors ultimately converge to small neighborhoods of *** experiments validate the performance of the proposed robust saturated control strategy.

关键词： Output-constrained control pose tracking control rendezvous and docking saturated control singularity-free control spacecraft control

Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He Lingzi Shi Ran sun Lianfei Ding Mukun He Jiaming Li Hua Guo Tiande Gao Panbo Liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption

Effect and mechanism of nano-Ca_(10)(PO_(4))_(6)(OH)_(2)additive on compressive strength of calcium aluminate cement at high temperature

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Journal of Iron and Steel Research International 2022年第7期29卷 1063-1072页

作者： Qian sun En-hui Wang Xin-mei Hou Zhi-jun He Tong-xiang liang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Material and Metallurgy University of Science and Technology LiaoningAnshan 114501LiaoningChina School of Materials Science and Engineering Jiangxi University of Science and TechnologyGanzhou 341000JiangxiChina

Calcium aluminate cement(CAC)is widely used as a binder for refractory materials,and thus the improvement in compressive strength is of vital importance for CAC applied at high *** this purpose,nano-Ca_(10)(PO_(4))_(6)(OH)_(2)additive with a ratio of 0.5–1.5 mass%was added with the water-cement ratio to be 0.4.X-ray diffraction and isothermal calorimetry analysis demonstrate that nano-Ca_(10)(PO_(4))_(6)(OH)_(2)additive can shorten the hydration process and promote the formation of main hydrates of CaAl2O4·10H2O(CAH10)and Ca2Al2O5·8H2O(C2AH8).In addition,scanning electron microscopy results suggest that nano-Ca_(10)(PO_(4))_(6)(OH)_(2)can protect CAH10 and C2AH8 from being destroyed during the calcination,guaranteeing that these thin lamellar crystals are intertwined to form the denser *** from above effects,nano-Ca_(10)(PO_(4))_(6)(OH)_(2)can obviously improve the compressive strength of the CAC mortar samples cured for 7 d after calcination at 1100°C,while the improving effect is dependent upon its ***,compared with the one without the additive,the compressive strength of the sample with 1.0%nano-Ca_(10)(PO_(4))_(6)(OH)_(2)is increased by 14%.

关键词： Nano-Ca_(10)(PO_(4))_(6)(OH)_(2) Cement Calcination Microstructure Compressive strength

A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye Xie Runxue Zhou Jin Deng Weihong Nie Shuwei sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel