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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Lei Xu tong Lu Zhongbo Chen Hangtian Ni Daquan sun Yufeng Tian Key Laboratory of Road and Traffic Engineering of Ministry of Education， tongji University School of Highway， Chang'an University

Polyurethane (PU) as an alternative for petroleum asphalt binder in pavement engineering can not only prolong the service life of the pavement， but also enable the pavement to perform multiple functions such as drainage， noise reduction， snow melting， and ice melting， and flame retardancy， providing with economic， social and environmental benefits. PU is a kind of "wear-resistant rubber" with high strength and good wear resistance obtained by pre-polymerization of isocyanate and polyol. In this review， the design and preparation of PU and aggregates， i.e. PU mixture， were summarized， followed by the discussion of the strength， stiffness and durability of PU mixture. Numerous creative concepts of structure and mixture design of PU pavements were summarized， and PU dosage， the curing time， temperature， and compaction times were clarified in detail. Particularly， some successful applications including PoroElastic Road Surface (PERS)， PU porous mixture (PPM)， PU rubber particle mixture (PRPM)， and permeable PU stabilized recycled aggregate (PPSRA) were discussed. Special attention was given to the economic and environmental benefits of PU pavement. Overall， the PU pavement can achieve the much-needed functions of modern urban roads or highways， and prolong the service life of the pavement. However， more researches are needed to explore the design methods of PU mixture and improved its road performance. In addition， reducing the price of PU to reduce the construction cost of PU mixture was also a problem that needed to be solved.

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壳聚糖改性磁性碳基吸附剂的制备及其对水中Cr(Ⅲ)-EDTA的吸附机理

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无机化学学报 2020年第7期36卷 1249-1258页

作者：王家宏陈瑶刘宁孙彤彤 Atif Saleem 陕西科技大学环境科学与工程学院西安710021 陕西省无机材料绿色制备与功能化重点实验室西安710021

利用二茂铁制备磁性碳基材料(Fe3O4@C),通过壳聚糖(CS)功能化,制备CS改性Fe3O4@C复合吸附材料(Fe3O4@C-CS)。利用红外光谱(FTIR)、X射线衍射(XRD)、振动样品磁强计(VSM)、热重分析(TGA)和X射线光电子能谱(XPS)等对Fe3O4@C-CS表征分析,... 详细信息

利用二茂铁制备磁性碳基材料(Fe3O4@C),通过壳聚糖(CS)功能化,制备CS改性Fe3O4@C复合吸附材料(Fe3O4@C-CS)。利用红外光谱(FTIR)、X射线衍射(XRD)、振动样品磁强计(VSM)、热重分析(TGA)和X射线光电子能谱(XPS)等对Fe3O4@C-CS表征分析,并通过改变浓度、温度、时间、pH和阳离子等条件系统研究对水中已配位的三价铬(Cr(Ⅲ)-EDTA)的吸附性能。结果表明Fe3O4@C已经成功被CS功能化,在pH=4.0、反应温度25℃、投加量0.4 g·L^-1时,吸附等温线符合Langmuir模型,理论最大吸附量为12.63 mg·g^-1,吸附动力学符合拟二级动力学模型,吸附行为是自发进行的吸热过程。结合吸附实验结果和XPS表征分析,静电吸附和配位作用是Fe3O4@C-CS吸附剂去除水中Cr(Ⅲ)-EDTA的主要机制。4次吸附-脱附循环后,Fe3O4@C-CS对水中Cr(Ⅲ)-EDTA仍具有较高的吸附效率。

关键词：壳聚糖磁性碳基吸附剂 Cr(Ⅲ)-EDTA 吸附阳离子动力学

Effect of Sonic hedgehog gene-modified bone marrow mesenchymal stem cells on graft-induced retinal gliosis and retinal ganglion cells survival in diabetic mice

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 34-41页

作者： tong Wang Hai-Chun Li Jin Ma Xi-Ling Yu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina

AIM:To investigate the effects of Sonic hedgehog(Shh)gene-modified bone marrow mesenchymal stem cells(MSCs)on graft-induced retinal gliosis and retinal ganglion cells(RGCs)survival in diabetic ***:Bone marrow-derived MSCs were genetically modified with the Shh gene to generate a stably transfected cell line of Shh-modified MSCs(MSC-Shh).Intravitreal injections of MSC-Shh and green fluorescent protein-modified MSCs(MSC-Gfp;control)were administered in diabetic *** 4wk,the effects of MSC-Shh on retinal gliosis were evaluated using fundus photography,and markers of gliosis were examined by immunofluorescence and Western *** neurotrophic factors expression and RGCs survival in the host retina were evaluated using Western blotting and *** mechanisms underlying the effects of MSC-Shh was ***:A significant reduction of proliferative vitreoretinopathy(PVR)was observed after intravitreal injection of MSC-Shh compared to *** downregulation of glial fibrillary acidic protein(GFAP)was demonstrated in the host retina after MSC-Shh administration compared to *** extracellular signal-regulated kinase 1/2(ERK1/2),protein kinase B(AKT)and phosphatidylin-ositol-3-kinase(PI3K)pathways were significantly downregulated after MSC-Shh administration compared to ***-derived neurotrophic factor(BDNF)and ciliary neurotrophic factor(CNTF)levels were significantly increased in the host retina,and RGCs loss was significantly prevented after MSC-Shh ***:MSC-Shh administration reduces graft-induced reactive gliosis following intravitreal injection in diabetic *** ERK1/2,AKT and PI3K pathways are involved in this ***-Shh also increases the levels of neurotrophic factors in the host retina and promoted RGCs survival in diabetic mice.

关键词： mesenchymal stem cells Sonic hedgehog signaling reactive gliosis diabetic retinopathy retinal ganglion cells

A highly sensitive multiple-mode optical thermometer designed in Eu^(2+/3+)and Li^(+)co-doped polymorphism compound LaSc_(3)(BO_(3))_(4)

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Journal of Advanced Ceramics 2024年第6期13卷 821-833页

作者： Nan Yang Zhuo Li Tingxia Zhou Ziwang Zhang Wen Shi Yexiang tong Jianxin Shi School of Chemistry IGCMESun Yat-sen UniversityGuangzhou 510006China MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry IGCMEThe Key Lab of Low-Carbon Chemistry&Energy Conservation of Guangdong ProvinceSun Yat-sen UniversityGuangzhou 510006China

Noncontact optical thermometers have attracted widespread attention,but existing problems such as single-mode and low-sensitivity thermometers still urgently need to be ***,a novel multiple-mode thermometer was designed for the polymorphism LaSc_(3)(BO_(3))_(4):Eu^(2+/3+),Li^(+).X-ray diffraction(XRD)patterns revealed a slight transition betweenα-andβ-phases with the concentrations of the dopants,which is further proved by structure refinements and first-principles *** coexistence of Eu^(2+)and Eu^(3+)in the phosphors and their relative percentages were confirmed by X-ray absorption near-edge structure(XANES)*** from appropriate emissions from Eu^(2+)and Eu^(3+)without obvious energy transfer and their opposite changing trends with temperatures under 307 nm excitation,a triple-mode optical thermometer is obtained for this material within the temperature range of 150–450 *** highest sensitivities of 27.65,14.05,and 7.68%·K^(−1)are achieved based on two fluorescence intensity ratio(FIR)modes of Eu^(2+)and Eu^(3+)(5d–4f/^(5)D_(0)–^(7)F_(2,4))and the fluorescence lifetime(FL)mode of Eu^(2+),*** the best of our knowledge,the former is almost the highest in Eu^(2+)and Eu^(3+)co-doped *** results indicate that this material may be used as an excellent multiple-mode optical thermometer.

关键词： phase transition europium(Eu)ions multiple-mode optical thermometer thermal quenching properties fluorescence intensity ratio(FIR) fluorescence lifetime(FL)

Work-function-induced interfacial electron redistribution of MoO_(2)/WO_(2) heterostructures for high-efficiency electrocatalytic hydrogen evolution reaction

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Rare Metals 2024年第2期43卷 489-499页

作者： tong-Fei Li Jing Li Lu-Ping Zhang Jia-Wei Ke Meng-Xing Fan Li-Fang Zhang Cheng-Wei Deng Yi sun Tao Qian Cheng-Lin Yan School of Chemistry and Chemical Engineering Nantong UniversityNantong226019China Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023China Aerospace Hydrogen Energy Technology(Shanghai)Co.Ltd. Shanghai201800China Key Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical Industry College of EnergySoochow UniversitySuzhou215006China Light Industry Institute of Electrochemical Power Sources Suzhou215006China

The engineering of the electronic configurations of active sites,together with the production of more accessible active sites through heterostructure design,has been established as a forceful methodology for boosting water electrolysis ***,a facile approach is developed to fabricate well-dispersed MoO_(2) and WO_(2) nanoparticles with abundant heterointerfaces entrapped in N,P-doped carbon nanofibers(referred to as MoO_(2)/WO_(2)@N,P-CNFs hereafter)as hydrogen evolution reaction(HER)electrocatalysts in alkaline and acidic *** spectroscopic analyses and theoretical findings manifest that the heterointerface formed by the work function modulation of MoO_(2)/WO_(2) triggers the spontaneous electron redistribution from MoO_(2)to WO_(2) and a built-in electric field,which is essential to promote water adsorption,optimize the H-intermediate adsorption energy,result in the enhanced charge transfer efficiency,and ultimately increase the intrinsic HER ***,the intimate confinement of MoO_(2)/WO_(2) heterostructures in the porous carbon substrate can restrain the active sites from unfavorable coarsening and detachment,thus ensuring facilitated HER kinetics and outstanding structural *** a result,MoO_(2)/WO_(2)@N,P-CNFs exhibit superior catalytic HER performance in acidic and basic solutions,requiring 118 and 95 mV overpotentials to achieve 10 mA·cm^(−2),respectively,surpassing a number of reported non-noble metal-based *** work provides guidelines for the rational design and construction of special metallic heterocomponents with optimized interfacial electronic structure for various electrochemical technologies.

关键词： Electrospinning MoO_(2)/WO_(2) heterostructure Work function Hydrogen evolution reaction

The role of primary cilia in mechanical transmission of osteocyte based on a 3D finite element model

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Medicine in Novel Technology and Devices 2024年第1期21卷 31-38页

作者： Zhuang Han Dong Ding Yu-bo Fan Xin-tong Wu Xiao Yang Lian-wen sun Key Laboratory of Biomechanics and Mechanobiology(Beihang University)Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The primary cilium,as a mechanical receptor of osteocytes,participates in the regulation of osteocyte ***,how the length of osteocyte primary cilia changes with fluid shear stress(FSS)are unclear,and how the mechanical transmission within osteocytes altered by primary cilia is not well understood ***,the ciliary length changes of osteocyte under 15dyn/cm2 of FSS were experimentally detected,and then 3D finite element models of osteocyte primary cilia containing the basal body and axoneme were *** results showed that(1)The ciliary length of the CON group,FSS 1h,and FSS 6h were 3.71±1.34μm,3.79±1.04μm,and 1.24±0.73μm respectively,indicating the different durations of FSS might lead to the adaptive changes of cilium *** calculations showed(2)when the ciliary length became shorter with the ciliary angle stayed the same,the deformation and stress of the cell membrane and membrane skeleton was ***,the deformation and stress of the cilia membrane,basal body,the rotation angles of basal body were decreased,and those of cytoplasm,cytoskeleton,actin cortex and nucleus were also decreased;(3)With the decrease of the ciliary angle,the deformation and stress of the cilia membrane,basal body,as well as the rotation angles of basal body were *** of the cytoplasm,cytoskeleton,actin cortex,and nucleus were also increased except the cell membrane and membrane *** calculation results suggested the length and angle of the primary cilia,the deformation and stress of intracellular structures in osteocyte were altered with ciliary basal body,indicated the connection between the basal body and cytoskeleton may be a key factor that affected the mechanical transport in osteocytes across the cell *** finally promoted the adaptive change of ciliary length under FSS.

关键词： Primary cilia Osteocyte model Finite element analysis Mechanotransduction

外源水杨酸（SA）、油菜素内酯（BR）浸种对Ca（NO3）2胁迫下黄瓜幼苗光合特性及叶片解剖结构的影响

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江苏农业学报 2019年第5期35卷 1184-1190页

作者：孙彤彤武春成宋士清河北科技师范学院

为了探索外源水杨酸(Salicylic acid,SA)、油菜素内酯(Brassinosteroids,BR)对黄瓜幼苗Ca(NO 3)2胁迫的诱抗作用,以绿岛7号为试材,采用基质培养的方法,研究了外源SA浸种、BR浸种、SA+BR复配浸种对60 mmol/L Ca(NO 3)2胁迫下黄瓜幼苗生... 详细信息

为了探索外源水杨酸(Salicylic acid,SA)、油菜素内酯(Brassinosteroids,BR)对黄瓜幼苗Ca(NO 3)2胁迫的诱抗作用,以绿岛7号为试材,采用基质培养的方法,研究了外源SA浸种、BR浸种、SA+BR复配浸种对60 mmol/L Ca(NO 3)2胁迫下黄瓜幼苗生长、光合特性和叶片解剖结构的影响。结果表明:外源SA浸种、BR浸种、SA+BR复配浸种均增加了黄瓜幼苗光合色素含量,提高了光合速率,促进了气孔开放,提升了栅栏组织厚度/海绵组织厚度比值。说明SA和BR浸种都能诱导黄瓜幼苗产生耐盐性,缓解Ca(NO 3)2胁迫对黄瓜幼苗生长的抑制作用,其中以SA浸种处理作用效果最明显。

关键词：黄瓜水杨酸油菜素内酯 Ca(NO 3)2胁迫光合特性叶片解剖结构

Suppressing Wnt signaling of the blood-tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2716-2731页

作者： Yang tong Pei An Puxian Tang Rui Mu Yuteng Zeng Hang sun Mei Zhao Ziyan Lv Pan Wang Wanjun Han Chunshan Gui Xuechu Zhen Liang Han Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid *** inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood-tumor barrier(BTB).BTB activates its Wnt signaling to maintain barrier properties,e.g.,Mfsd2a-mediated BTB low ***,we reported VCAM-1-targeting nano-wogonin(W@V-NPs)as an adjuvant of nano-orlistat(O@V-NPs)to intensify drug delivery and inhibit lipogenesis of brain metastases.W@V-NPs were proven to be able to inactivate BTB Wnt signaling,downregulate BTB Mfsd2a,accelerate BTB vesicular transport,and enhance tumor accumulation of O@*** the ability to specifically kill cancer cells in a lipid-deprived environment with IC_(50) at 48 ng/mL,W@V-NPs plus O@V-NPs inhibited the progression of brain metastases with prolonged survival of model *** combination did not induce brain edema,cognitive impairment,and systemic toxicity in healthy *** Wnt signaling could safely modulate the BTB to improve drug delivery and metabolic therapy against brain metastases.

关键词： Lipogenesis Brain metastases Blood-tumor barrier Wnt signaling Drug delivery Fatty acid synthase Nanoparticles Combination therapy

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纳米尺度水薄膜液-气相变分子动力学模拟

大连理工大学学报 2016年第3期56卷 230-235页

作者：黄正兴孙童童李倩倩大连理工大学电子科学与技术学院辽宁大连116024

采用分子动力学模拟,研究了纳米尺度水薄膜厚度和系统温度对液-气相变蒸发率的影响.模拟了水薄膜厚度为2nm时,温度（375～425K）对相变蒸发率的影响;同时模拟了温度400K条件下,水薄膜厚度（2、3、4nm）对相变蒸发率的影响.结果表明：相... 详细信息

采用分子动力学模拟,研究了纳米尺度水薄膜厚度和系统温度对液-气相变蒸发率的影响.模拟了水薄膜厚度为2nm时,温度（375～425K）对相变蒸发率的影响;同时模拟了温度400K条件下,水薄膜厚度（2、3、4nm）对相变蒸发率的影响.结果表明：相同水薄膜厚度下蒸发率随着温度的升高而增大,相同温度下蒸发率随水薄膜厚度的增大而增大,蒸发率随时间呈指数形式递减.相关结果可为微热管及其他依靠内部液体相变传热的散热器件设计提供参考.

关键词：液膜厚度液-气相变分子动力学模拟

Application value of indocyanine green fluorescence imaging in guiding sentinel lymph node biopsy diagnosis of gastric cancer: Meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1883-1893页

作者： Qi-Jia Zhang Zhi-Cheng Cao Qin Zhu Yu sun Rong-Da Li Jin-Long tong Qin Zheng Department of Oncology The Second Hospital of NanjingAffiliated to Nanjing University of Chinese MedicineNanjing 210003Jiangsu ProvinceChina Department of Gastrointestinal Surgery Qilu Hospital of Shandong UniversityJinan 250063Shandong ProvinceChina

BACKGROUND Gastric cancer is a common malignant tumor of the digestive system worldwide,and its early diagnosis is crucial to improve the survival rate of *** green fluorescence imaging(ICG-FI),as a new imaging technology,has shown potential application prospects in oncology *** meta-analysis to study the application value of ICG-FI in the diagnosis of gastric cancer sentinel lymph node biopsy is helpful to comprehensively evaluate the clinical effect of this technology and provide more reliable guidance for clinical *** To assess the diagnostic efficacy of optical imaging in conjunction with indocya-nine green(ICG)-guided sentinel lymph node(SLN)biopsy for gastric *** Electronic databases such as PubMed,Embase,Medline,Web of Science,and the Cochrane Library were searched for prospective diagnostic tests of optical imaging combined with ICG-guided SLN *** 12.0 software was used for analysis by combining the"bivariable mixed effect model"with the"midas"*** true positive value,false positive value,false negative value,true negative value,and other information from the included literature were extracted.A literature quality assessment map was drawn to describe the overall quality of the included literature.A forest plot was used for heterogeneity analysis,and P50%),meta-regression analysis and subgroup analysis were *** were *** Optical imaging involves two methods:Near-infrared(NIR)imaging and fluorescence imaging.A combination of optical imaging and ICG-guided SLN biopsy was useful for *** positive likelihood ratio was

关键词： Gastric neoplasms Sentinel lymph nodes Near infrared imaging Fluorescence imaging Indocyanine green Meta-analysis