检索结果-南通市图书馆

Hi-TOM 2.0:an improved platform for high-throughput mutation detection

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第7期67卷 1532-1534页

作者： Tingting sun qing Liu Xi Chen Fengyue Hu Kejian Wang State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou 310006China Hainan Seed Industry Laboratory Sanya 572025China

Dear Editor,CRISPR/Cas systems,which can create novel mutations by manipulating the genome or transcriptome,have been developed as a powerful molecular tool for gene editing in various organisms(Cheng et al.,2022;Gao,2021).However,identifying mutations in large samples and decoding chimeric mutations are time-consuming,labor-intensive.

关键词： CRISPR/Cas consuming mutation

Microstructure and properties of coarse-grained WC-10Co cemented carbides with different carbon contents during heat treatments

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第4期43卷 1786-1792页

作者： Yuan-Feng Xie Xing-Cheng Xie Zhong-Wu Li rui-Jun Cao Zhong-Kun Lin qing Li Chen-Guang Lin Powder Metallurgy and Special Materials Research Department General Research Institute for Nonferrous MetalsBeijing100088China

The effects of cryogenic treatment(CT)and tempering-cryogenic treatment(TCT)on the microstructure and properties of coarse-grained WC-10Co cemented carbides with different carbon contents were *** binder phase,WC mean grain sizes,W solubility in the binder,relative magnetic s aturation,densities,hardness,wear resistance and second phase precipitation of cemented carbides with different heat treatments were *** results show that there are significant changes of microstructure and properties in the samples with CT and TCT,especially due to the precipitation of metastable nanoparticles W_(x)Co_(y)C_(z) in the binder during the heat treatments of CT and *** the simultaneous combination of microstructure and nanoparticle-reinforced binder,a dramatically improved combination of hardness and wear resistance of the samples after TCT has been achieved.

关键词： Cryogenic treatment Tempering Coarsegrained cemented carbide Carbon content Nanoparticlereinforced binder

The validity of serum ferritin levels in predicting cardiovascular events of metabolic dysfunction-associated steatotic liver disease patients may need more consideration

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2024年第4期13卷 755-756页

作者： Jie Yang qing Liu Jie Li Chao sun Department of Gastroenterology Tianjin Medical University General Hospital Airport HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjinChina Department of Infectious Diseases Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingChina

We read with great interest the informative study by Armandi et al.,which shed light on the potential role of serum ferritin in predicting the long-term prognosis of patients with metabolic dysfunction-associated steatotic liver disease(1).However,there remain certain facets requiring in-depth investigation and *** of all,the study found that integrating stepwise increased ferritin thresholds(215.5 and 272µg/L)into predictive models can improve the performance of fibrosis-4(FIB-4)and Non-Alcoholic Fatty Liver Disease Fibrosis Score(NFS)in the longitudinal risk assessment of liver-related events and overall ***,it has been suggested that metabolic hyperferritinaemia(MHF)appears to exhibit a male predominance(2,3).Since the study primarily comprised male participants(65%),it raises the query of whether the ferritin threshold based on the entire population can accurately predict risks within female ***,a sex-specific analysis is warranted to ensure a more precise evaluation.

关键词： Metabolic dysfunction-associated steatotic liver disease(MASLD) serum ferritin cardiovascular events

Cryptic diversity and rampant hybridization in annual gentians on the qinghai-Tibet Plateau revealed by population genomic analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Diversity 2024年第2期46卷 194-205页

作者： Peng-Cheng Fu Qiao-Qiao Guo Di Chang qing-Bo Gao Shan-Shan sun School of Life Science Luoyang Normal UniversityLuoyang 471934PR China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001PR China

Understanding the evolutionary and ecological processes involved in population differentiation and speciation provides critical insights into biodiversity formation. In this study, we employed 29,865 single nucleotide polymorphisms(SNPs) and complete plastomes to examine genomic divergence and hybridization in Gentiana aristata, which is endemic to the qinghai-Tibet Plateau(QTP) region. Genetic clustering revealed that G. aristata is characterized by geographic genetic structures with five clusters(West, East, Central, South and North). The West cluster has a specific morphological character(i.e., blue corolla) and higher values of FSTcompared to the remaining clusters, likely the result of the geological barrier formed by the Yangtze River. The West cluster diverged from the other clusters in the Early Pliocene;these remaining clusters diverged from one another in the Early Quaternary. Phylogenetic reconstructions based on SNPs and plastid data revealed substantial cyto-nuclear conflicts. Genetic clustering and D-statistics demonstrated rampant hybridization between the Central and North clusters,along the Bayankala Mountains, which form the geological barrier between the Central and North clusters. Species distribution modeling demonstrated the range of G. aristata expanded since the Last Interglacial period. Our findings provide genetic and morphological evidence of cryptic diversity in G. aristata, and identified rampant hybridization between genetic clusters along a geological *** findings suggest that geological barriers and climatic fluctuations have an important role in triggering diversification as well as hybridization, indicating that cryptic diversity and hybridization are essential factors in biodiversity formation within the QTP region.

关键词： Gentiana aristata Hybrid zone qinghai-Tibet Plateau Plastome Nuclear SNPs

Winter extreme precipitation over the Tibetan Plateau influenced by Arctic sea ice on interdecadal timescale

在线全文

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2024年第4期15卷 42-51页

作者： qing-Quan LI Miao BI Song YANG qing-Yuan WU Yi-Hui DING Xin-Yong SHEN Xiao-Ting sun Meng-Chu ZHAO China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China CMA Key Open Laboratory of Transforming Climate Resources to Economy Chongqing Institute of Meteorological SciencesChongqing 401147China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen University Zhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate ***,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are still *** this study,the characteristics and mechisnems of the TP extreme precipitation(TPEP)influenced by Arctic sea ice on interdecadal timescale are studied based on the daily precipitation,monthly sea ice concentration and ERA5 reanalysis data from 1980 to *** found that the dominant mode of the TPEP in winter mostly exhibits a uniform spatial variation on the interdecadal timescale,with an opposite weak variation in the southeastern TP,and the Arctic sea ice concentration(SIC)before 2002 are larger than that after *** interdecadal variation of TPEP is affected by two teleconnection wave trains regulated by the Barents and Kara Sea *** the light ice years,a remarkable positive geopotential height(HGT)anomaly appears over the Barents-Kara Sea and a remarkable negative HGT anomaly is located over the Lake *** wave trains originating over the Barents-Kara Sea can be *** southern branch forms a wave train through the North Atlantic along the subtropical westerly jet stream,showing a‘+-+-+'pattern of HGT anomalies from Arctic to the *** HGT anomaly controls the western TP,which creates dynamic and water vapor conditions for the *** northern branch forms a wave train through the Lake Baikal and the southeast of the TP,showing a‘+-+'HGT anomaly *** HGT anomaly controls the southeastern TP,which is not conducive to precipitation in the *** the SIC in the Barents-Kara Sea increases,the situation is *** above analysis also reveals the reason for the difference in the east-west distribution of the TPEP.

关键词： Arctic sea ice Tibetan Plateau Winter extreme precipitation Rossby wave activity Interdecadal variation

Chalcone derivatives as novel,potent and selective inhibitors against human Notum:Structure–activity relationships and biological evaluations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第3期35卷 321-325页

作者： Jin-Hui Shi Bei Zhao Li-Lin Song Yu-qing Song Meng-Ru sun Tian Tian Hong-Yu Chen Yun-qing Song Jian-Ming sun Guang-Bo Ge Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Dalian Engineering Research Center for Carbohydrate Agricultural Preparations Liaoning Provincial Key Laboratory of CarbohydratesDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 200137China

Human Notum(hNotum)inhibitors could be used for treating Wnt signalling-associated diseases including colorectal ***,two series of chalcone derivatives were designed and synthesized aiming to find selective and potent hNotum ***–activity relationship(SAR)studies showed that 2-methoxyl and 5-bromine substitutions on A-ring significantly enhanced anti-hNotum effect,while 4’-ethoxyl and 3’-alkyl substitutions on B-ring were beneficial for hNotum *** all tested chalcones,B11 displayed the most potent anti-Notum effect(IC_(50)=3.6 nmol/L),good selectivity,excellent chemical stability and suitable metabolic *** investigations showed that B11 acted as a competitive inhibitor of hNotum,while this agent(5μmol/L)significantly weaken the migration abilities of colorectal cancer ***,this study deciphers the SARs of chalcones as hNotum inhibitors and reports a novel and potent hNotum inhibitor with the anti-migration effect on colorectal cancer cells,which offers a promising lead compound to develop novel anti-cancer agents.

关键词： Human notum(hNotum) Chalcone Computer-assisted drug discovery Structure–activity relationship(SAR) Anti-colorectal cancer agent

Temporal Second-order Scheme for a Hidden-memory Variable Order Time Fractional Diffusion Equation with an Initial Singularity

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第4期40卷 1060-1077页

作者： rui-lian DU Zhi-zhong sun School of Big Data Changzhou UniversityChangzhou 213164China Department of Mathematics Shanghai UniversityShanghai 200444China School of Mathematics Southeast UniversityNanjing 210096China

In this work,a novel time-stepping L1 formula is developed for a hidden-memory variable-order Caputo’s fractional derivative with an initial *** formula can obtain second-order accuracy and an error estimate is analyzed *** an application,a fully discrete difference scheme is established for the initial-boundary value problem of a hidden-memory variable-order time fractional diffusion *** experiments are provided to support our theoretical results.

关键词： time fractional diffusion equation hidden-memory variable-order fractional derivative error estimate initial singularity

Biomimetic microchannel network with functional endothelium formed by sacrificial electrospun fibers inside 3D gelatin methacryloyl(GelMA)hydrogel models

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第1期25卷 79-96页

作者： Haoyu sun Haiyang MA Li WANG Yang LIU Tian HOU Wenjie TANG qing YU Meiwen AN Meiling WEN Institute of Biomedical Engineering College of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan030024China

Three-dimensional(3D)hydrogel models play a crucial role in tissue engineering for promoting tissue regeneration.A biomimetic microchannel network system in the 3D hydrogel model is necessary for optimal cellular *** report describes the preparation of a biomimetic hydrogel scaffold with an internal microchannel network,using electrospinning techniques and the sacrificial template method for 3D cell *** and cavities were created within the gelatin methacryloyl(GelMA)hydrogel by sacrificing polyvinyl alcohol(PVA)electrospun fibers(>10µm),resulting in the creation of microvessel-like *** characterizations,swelling properties,and biodegradation analysis were conducted to investigate the feasibility of a biomimetic microchannel network hydrogel scaffold for 3D cell culture *** to pure GelMA hydrogel,the hydrogel with microchannels promoted cell proliferation,adhesion,and endothelial tube ***,the results confirmed that the biomimetic microchannel network scaffold had a major impact on the distribution and arrangement of human umbilical vein endothelial cells(HUVECs)and can enable the formation of artificial microvasculature by the culture of HUVECs and cell media perfusion.

关键词： Biomimetic scaffold Photocrosslinking Microchannel network Tissue engineering Artificial microvascular

Hydrometallurgical recovery of lithium carbonate and iron phosphate from blended cathode materials of spent lithium-ion battery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第3期43卷 1275-1287页

作者： Shao-Le Song Run-qing Liu Miao-Miao sun Ai-Gang Zhen Fan-Zhen Kong Yue Yang School of Minerals Processing and Bioengineering Central South UniversityChangsha410083China Zhejiang Tianneng New Materials Co. Ltd.Huzhou313103China

The recycling of cathode materials from spent lithium-ion battery has attracted extensive attention,but few research have focused on spent blended cathode *** reality,the blended materials of lithium iron phosphate and ternary are widely used in electric vehicles,so it is critical to design an effective recycling *** this study,an efficient method for recovering Li and Fe from the blended cathode materials of spent LiFePO_(4)and LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)batteries is ***,87%A1 was removed by alkali ***,91.65%Li,72.08%Ni,64.6%Co and 71.66%Mn were further separated by selective leaching with H_(2)SO_(4)and H_(2)O_(2).Li,Ni,Co and Mn in solution were recovered in the form of Li_(2)CO_(3)and hydroxide ***,98.38%Fe was leached from the residue by two stage process,and it is recovered as FePO_(4)·2H_(2)O with a purity of 99.5%by *** and P were present in FePO_(4)·2H_(2)O in amounts of 28.34%and 15.98%,***,the drift and control of various components were discussed,and cost-benefit analysis was used to assess the feasibility of potential application.

关键词： Spent lithium-ion battery Blended cathode materials Recovery Lithium carbonate Iron phosphate