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基于数据量化分析的动态视觉景观规划仿真

计算机仿真 2023年第2期40卷 236-239,248页

作者：刘晓青芮潇东南大学成贤学院江苏南京210088

为提升景观规划效用,提出基于数据量化分析的动态视觉景观规划。以数据量化分析作为动态视觉景观规划计算手段,通过人均绿地的面积、绿地率、多样性的指数、优势度指数、均匀度指数、破碎度的指数、分离度指数、分维度指数、连通性指数... 详细信息

为提升景观规划效用,提出基于数据量化分析的动态视觉景观规划。以数据量化分析作为动态视觉景观规划计算手段,通过人均绿地的面积、绿地率、多样性的指数、优势度指数、均匀度指数、破碎度的指数、分离度指数、分维度指数、连通性指数得到景观空间格局指标,再利用城市景观可达性、景观服务效率、人口密度、城市路网、景观绿地形状实现数据量化分析。同时以角二阶矩、相关系数、信息熵以及对比度四种纹理特征描述景观系统图像纹理,采用最大似然法分类完成动态景观整体布局规划。仿真结果证明:所提方法系统性研究相关数据,可精准表达规划设计细节,有效改善地区生态环境,降低空气污染,可作为现实景观规划理论基础。

关键词：数据量化分析动态视觉景观规划最大似然法景观可达性空间格局指标

Expression and significance of factors related to angiogenesis in choroidal melanoma

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International Journal of Ophthalmology(English edition) 2011年第1期4卷 49-54页

作者： Qiang Xu Gui-Qiu Zhao Jie Zhao Hong Lin Ying-Ying Mou qing Wang and Wei-Rong sun Department of Ophthalmology Affiliated Hospital of Qingdao University Medical Collage Qingdao 266003 Shandong Province China

AIM: To investigate expression of factors related to angiogenesis: HIF-1 alpha, iNOS, COX-2 and VEGF in choroidal melanoma and its clinical significance. METHODS: Fifty samples of choroidal melanoma and 15 samples of melanocytic nevi of the eyelid identified by pathology were collected. Immunohistochemistry SP method was used to examine the expression of HIF-1 alpha, iNOS, COX-2 and VEGF in these samples. The comparison among groups was done by SPSS 13.0 software. RESULTS: The positive expression rates of HIF-1 alpha, iNOS, COX-2 and VEGF in choroidal melanoma group were significantly higher than those in eyelid nevi group (chi(2)= 6.5542, 7.7224, 8.5828, 15.1749). The positive expression rate of VEGF was associated with the tumor size (chi(2)= 10.9194), but was not associated with pathological type (chi(2)=2.0712) and the situation of scleral invasion (chi(2)= 5.4289). The positive expression rate of HIF-1 alpha was associated with the tumor size (chi(2)=7.1216) and pathological type (chi(2)=9.0889), but was not associated with the situation of scleral invasion (chi(2)=3.3586). The positive expression rate of iNOS was associated with the tumor size (chi(2)=9.5503), but was not associated with pathological type (chi(2)=1.9450) and the situation of scleral invasion (chi(2)=2.3810). The positive expression rate of COX-2 was associated with the tumor size (chi(2)=7.2970), but was not associated with pathological type (chi(2)=1.8421) and the situation of sclera! invasion (chi(2)= 0.4018). The expression of HIF-1 alpha, iNOS and COX-2 were significantly associated with the expression of VEGF (r = 0.9429, 1, 0.9857). The expression of COX-2 was significantly associated with the expression of iNOS (r=0.9857). The expression of HIF-1 alpha was significantly associated with the expression of COX-2 ( r=0.9857). The expression of HIF-1 alpha was significantly associated with the expression of iNOS (r= 0. 9429). CONCLUSION: The expression of HIF-1 alpha, iNOS and COX-2 protein

关键词： choroidal melanoma immunohistoehemistry hypoxia inducible factor-1a inducible nitric oxide synthase cyclooxygenase-2

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基于谱图小波的多尺度社区搜索方法

计算机工程与科学 2023年第6期45卷 1106-1115页

作者：闫彩瑞马慧芳李青青西北师范大学计算机科学与工程学院甘肃兰州730070

作为可捕获用户个性化信息的网络分析任务,社区搜索旨在挖掘满足内聚性要求的查询节点所在的社区。大多数现有社区搜索方法仅能定位查询节点所在的单尺度社区。据此,设计了一种基于谱图小波的多尺度社区搜索方法,利用谱图小波和局部模... 详细信息

作为可捕获用户个性化信息的网络分析任务,社区搜索旨在挖掘满足内聚性要求的查询节点所在的社区。大多数现有社区搜索方法仅能定位查询节点所在的单尺度社区。据此,设计了一种基于谱图小波的多尺度社区搜索方法,利用谱图小波和局部模块度挖掘查询节点所在的多尺度社区。具体地,首先,构建模块度矩阵和拉普拉斯矩阵并进行矩阵分解得到相关特征向量;其次,结合谱图理论和图小波,设计了基于谱图小波的尺度依赖局部模块度;再次,以归一化拉普拉斯矩阵和局部模块度张成的特征空间为支撑,设计了线性规划问题,以求解在给定尺度下与查询相关的稀疏指示向量;最后,利用社区边界截断策略不断添加节点,使得局部模块度最大。人工网络和真实网络上的实验结果表明了方法的高效率和有效性。

关键词：多尺度社区搜索谱图小波局部模块度

Pretreatment with intestinal trefoil factor alleviates stress-induced gastric mucosal damage via Akt signaling

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World Journal of Gastroenterology 2020年第48期26卷 7619-7632页

作者： Yun Huang Meng-Meng Wang Zhi-Zhou Yang Yi Ren Wei Zhang Zhao-rui sun Shi-Nan Nie Nantong Hospital Affiliated to Nanjing University of Chinese Medicine Nantong 226001Jiangsu ProvinceChina Department of Emergency Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Emergency Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

BACKGROUND Stress-related gastric mucosal damage or ulcer remains an unsolved issue for critically ill *** ulcer prophylaxis has been part of routine intensive care,but uncertainty and controversy still ***-secreted with mucins,intestinal trefoil factor(ITF)is reported to promote restitution and regeneration of intestinal mucosal epithelium,although the mechanism remains *** To elucidate the protective effects of ITF on gastric mucosa and explore the possible *** We used a rat model of gastric mucosal damage induced by water immersion restraint stress and lipopolysaccharide-treated human gastric epithelial cell line to investigate the potential effects of ITF on damaged gastric mucosa both in vivo and in *** ITF promoted the proliferation and migration and inhibited necrosis of gastric mucosal epithelia in *** also preserved the integrity of gastric mucosa by upregulating expressions of occludin and zonula *** the rat model,pretreatment with ITF ameliorated the gastric mucosal epithelial damage and facilitated mucosal *** protective effects of ITF were confirmed to be exerted via activation of Akt signaling,and the specific inhibitor of Akt signaling LY249002 reversed the protective *** ITF might be a promising candidate for prevention and treatment of stressinduced gastric mucosal damage,and further studies should be undertaken to verify its clinical feasibility.

关键词： Intestinal trefoil factor Water immersion restraint stress Gastric mucosa Epithelium integrity Akt signaling pathway

Cloning and characterization of a potato StAN11 gene involved in anthocyanin biosynthesis regulation

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Journal of Integrative Plant Biology 2014年第4期56卷 364-372页

作者： Wang Li Bing Wang Man Wang Min Chen Jing-Ming Yin Ghullam Murtaza Kaleri rui-Jie Zhang Tie-Niu Zuo Xiong You qing Yang College of Life Sciences Nanjing Agricultural University

Anthocyanins are a class of products of plant secondary metabolism and are responsible for tubers color in potato. The biosynthesis of anthocyanins is a complex biological process, in which multiple genes are involved including structural genes and regulatory genes. In this study, StAN11, a WD4o-repeat gene, was cloned from potato cultivar Chieftain （Solanum tuberosum L.）. StAN11 （HQ5995o6） contained no intron and its open reading frame （ORF） was 1,o29 bp long, encoding a putative protein of 342 amino acids. In order to verify its role in anthocyanin biosynthesis, StAN11 was inserted behind the CaMV-35S promoter of pCMBIA1304 and the recombination vector was introduced into the potato cultivar Desiree plants by Agrobacterium-mediated transfor- mation. The color of transgenic tuber skin was significantly deepened, compared to the wild-type control, which was highly consistent with the accumulation of anthocyanin and expression of StAN11 in transgenic lines tuber skin. Further analysis on the expression of Flavonone-3-hydroxylase （F3H）,Dihydroflavonol reductase （DFR）, Anthocyanidin synthase （ANS）, and F1avonoid 3-O-glucosyl transferase （3GT） in transgenic plants revealed that only DFR was upregulated. This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of .StAN11 in the tubers with the genetic background of anthocyanin biosynthesis.

关键词： Anthocyanin biosynthesis cloning genetic transformation potato StAN11

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国际农村人居环境研究知识图谱分析

资源开发与市场 2022年第6期38卷 679-687,738页

作者：张娟孙瑞瑞何艳冰河南理工大学能源经济研究中心河南焦作454000 河南理工大学建筑与艺术设计学院河南焦作454000

借助CiteSpace软件,追踪国际农村人居环境研究进展,识别研究热点,重点解读居住环境、居住空间、居住主体、公共服务设施四大研究主题。结果表明:国际农村人居环境研究热点不断由聚落类型、居住形式等物质空间向健康卫生、乡村性、舒适... 详细信息

借助CiteSpace软件,追踪国际农村人居环境研究进展,识别研究热点,重点解读居住环境、居住空间、居住主体、公共服务设施四大研究主题。结果表明:国际农村人居环境研究热点不断由聚落类型、居住形式等物质空间向健康卫生、乡村性、舒适性等社会空间转移,研究视角不断下沉,研究领域逐步深入多元,学科间交叉融合趋势日益显著。基于国际研究经验,提出未来国内学者应立足不同地域、不同类型农村发展实际,构建适合我国农村人居环境的理论体系,强化城市影响剖析,探讨微观行为主体需求,以服务于国家乡村振兴战略需求。

关键词：农村人居环境研究热点知识图谱

Evaluation of the Factorial Method for Determination of Energy Expenditure in 16 Young Adult Women Living in China

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Biomedical and Environmental Sciences 2011年第4期24卷 357-363页

作者： LIU JianMin PIAO JianHua sun rui TIAN Ying YANG XiaoGuang Key Laboratory of Laboratory Animal Hebei Medical University Shijia Zhuang 050017 Hebei China Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050China

Objective The present study aimed to evaluate the accuracy of the factorial method for estimating energy needs in individuals living in *** Sixteen healthy female adults aged 22.1±1.2 years with a body mass index （kg/m 2） of 20.4±1.7 were selected as *** free-living conditions,energy expenditure （EE） was determined by using the factorial *** the same time,the doubly labeled water method （DLW） was also used to measure energy expenditure of the subjects and served as the criterion *** predicted by the factorial method （EE factorial） was compared with the simultaneous measurement of EE by the validated DLW method （EE DLW）.Results There was excellent agreement between EE factorial （7.46±0.59 MJ/d） and EE DLW （7.64 ± 0.49 MJ/d）,with a difference of-2.6±4.9% （-0.18±0.36 MJ/d）.No significant differences were found between the two *** factorial was highly correlated with EE DLW （r=0.795,P0.001） and a good agreement for individuals was found by using the Bland and Altman *** The factorial method gives satisfactory estimates of EE for both groups and individuals living in China.

关键词： Energy expenditure Chinese adults Factorial method Doubly labeled water

MicroRNAs of bone marrow mesenchymal stem cell-derived exosomes regulate acute myeloid leukemia cell proliferation and apoptosis

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Chinese Medical Journal 2020年第23期133卷 2829-2839页

作者： Yi-Chuan Xu Yan-Si Lin Ling Zhang Ying Lu Yan-Ling sun Zhi-Gang Fang Zi-Yu Li rui-Fang Fan Department of Hematology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of General Practice Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510120China Department of Surgical Intensive Care Unit The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Prevention and Health The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China

Background:Acute myeloid leukemia(AML)is a malignant hematological disease,originating from hematopoiesis stem cell differentiation obstruction and clonal *** reagents or biologicals for the treatment of AML are urgently needed,and exosomes have been identified as candidate biomarkers for disease diagnosis and *** study aimed to investigate the effects of exosomes from bone marrow mesenchymal stem cells(BMSCs)on AML cells as well as the underlying microRNA(miRNA)-mediated ***:Exosomes were isolated using a precipitation method,followed by validation using marker protein expression and nanoparticle tracking *** expressed miRNAs were identified by deep RNA sequencing and confirmed by quantitative real-time polymerase chain reaction(qPCR).Cell proliferation was assessed by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt method,and cell cycle progression and apoptosis were detected by flow *** gene expression was analyzed by qPCR and Western blotting(WB).Significant differences were determined using Student’s t test or analysis of ***:BMSCs-derived exosomes effectively suppressed cell proliferation(both P<0.0001 at 10 and 20μg/mL)and cell cycle progression(P<0.01 at G0-G1 stage),and also significantly enhanced cell apoptosis(P<0.001)in KG-1a *** were 1167 differentially expressed miRNAs obtained from BMSCs-derived exosomes compared with KG-1a cell-derived exosomes(P<0.05).Knockdown of hsa-miR-124-5p in BMSCs abrogated the effects of BMSCs-derived exosomes in regulating KG-1a such as the change in cell proliferation(both P<0.0001 *** KG-1a cell[NC]at 48 and 72 h).KG-1a cells treated with BMSCs-derived exosomes suppressed expression of structural maintenance of chromosomes 4(P<0.001 *** by qPCR and P<0.0001 *** by WB),which is associated with the progression of various *** BMSCs-derived exosomes effect

关键词： Exosomes Mesenchymal stem cell Acute myeloid leukemia hsa-miR-124-5p

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营卫血气之离合:营卫概念的内涵及其发展

中华中医药杂志 2023年第4期38卷 1472-1476页

作者：王锐卿鞠宝兆辽宁中医药大学沈阳110847

文章通过理论研究发现营卫的原始含义是循环之血气,古人为了解释人体气血生化的问题,赋予了“营卫”津液之气,也即血气前身的含义;为了解释人体生理功能和病因病机,古人赋予了“营”以“荣”的意义,从而获得血气的营养功能,又赋予了“... 详细信息

文章通过理论研究发现营卫的原始含义是循环之血气,古人为了解释人体气血生化的问题,赋予了“营卫”津液之气,也即血气前身的含义;为了解释人体生理功能和病因病机,古人赋予了“营”以“荣”的意义,从而获得血气的营养功能,又赋予了“卫”卫外固表之功,从与经脉之营伴行的固定模式和路径中拓展开来,承担了阳气、正气的重任;为了更好地将营卫理论用于临床针刺,古人又赋予了营卫表里深浅的含义。理清营卫概念的内涵及其发展有助于中医理论的发展。

关键词：营卫血气概念发展理论