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Protein neddylation and its role in health and diseases

Signal Transduction and Targeted Therapy 2024年第5期9卷 1869-1904页

作者： Shizhen Zhang qing Yu Zhijian Li Yongchao Zhao Yi sun Department of Breast Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Institute of Translational Medicine Zhejiang University School of MedicineHangzhou 310029China Department of Thyroid Surgery Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Key Laboratory of Head&Neck Cancer Translational Research of Zhejiang Province Hangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery Zhejiang University School of MedicineHangzhou 310029China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Zhejiang University Cancer Center Hangzhou 310029China Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang Hangzhou 310024China Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

NEDD8(Neural precursor cell expressed developmentally downregulated protein 8)is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation,catalyzed by the enzyme cascade,namely NEDD8 activating enzyme(E1),NEDD8 conjugating enzyme(E2),and NEDD8 ligase(E3).The substrates of neddylation are categorized into cullins and non-cullin *** of cullins activates CRLs(cullin RING ligases),the largest family of E3 ligases,whereas neddylation of non-cullin substrates alters their stability and activity,as well as subcellular ***,the neddylation pathway and/or many neddylation substrates are abnormally activated or over-expressed in various human diseases,such as metabolic disorders,liver dysfunction,neurodegenerative disorders,and cancers,among ***,targeting neddylation becomes an attractive strategy for the treatment of these *** this review,we first provide a general introduction on the neddylation cascade,its biochemical process and regulation,and the crystal structures of neddylation enzymes in complex with cullin substrates;then discuss how neddylation governs various key biological processes via the modification of cullins and non-cullin *** further review the literature data on dysregulated neddylation in several human diseases,particularly cancer,followed by an outline of current efforts in the discovery of small molecule inhibitors of neddylation as a promising therapeutic ***,few perspectives were proposed for extensive future investigations.

关键词： NEDD8 attached attractive

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Crystal Structure and Fluorescent Property of a 2D Coordination Polymer:[Eu(PCPA)_3(H_2O)]_n

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Chinese Journal of Structural Chemistry 2006年第7期25卷 844-848页

作者： sun rui-qing ZHANG Han-Hui CAO Yan-Ning CHEN Yi-Ping WANG Zhen YANG Qi-Yu Department of Chemistry Fuzhou University＇ Fuzhou Fujian 350002 China

The title coordination polymer [Eu（PCPA）3（H2O）]n （PCPA = p-chlorophenoxyacetate） has been synthesized under hydrothermal condition, determined by single-crystal X-ray diffraction and characterized by FT-IR, UV-VIS and fluorescent spectra. The crystal belongs to triclinic system, space group PI^- with a = 7.8036（1）, b = 12.7458（4）, c = 14.0208（3） A, α = 81.610（8）, β = 79.406（8）, γ = 77.567（7）°, V = 1330.40（5） A^3, C24H20Cl3EuO10, Mr = 726.71, Z = 2, F（000） = 716, Dc= 1.814 g/cm^3, λ（MoKa） = 0.71073 A, μ（MoKα） = 2.713 mm^-1, the final R = 0.0284 and wR = 0.0678 for 5529 observed reflections with I 〉 2σ（I）. The europium ions are located in a nine-coordinate environment. PCPA ions with two different coordination modes connect the metal ions to form 1D zigzag chains which are arranged to generate 2D supramolecular layers by intermolecular hydrogen bonds. The luminescence properties of the rare-earth ions are studied in this paper.

关键词： crystal structure europium p-ehiorophenoxyaeetate fluorescent property

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Visual Semantic Segmentation Based on Few/Zero-Shot Learning:An Overview

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1106-1126页

作者： Wenqi Ren Yang Tang Qiyu sun Chaoqiang Zhao qing-Long Han Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China National Key Laboratory of Air-Based Information Perception and Fusion Aviation Industry Corporation of ChinaLuoyang 471000China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia

Visual semantic segmentation aims at separating a visual sample into diverse blocks with specific semantic attributes and identifying the category for each block,and it plays a crucial role in environmental *** learning-based visual semantic segmentation approaches count heavily on largescale training data with dense annotations and consistently fail to estimate accurate semantic labels for unseen *** obstruction spurs a craze for studying visual semantic segmentation with the assistance of few/zero-shot *** emergence and rapid progress of few/zero-shot visual semantic segmentation make it possible to learn unseen categories from a few labeled or even zero-labeled samples,which advances the extension to practical ***,this paper focuses on the recently published few/zero-shot visual semantic segmentation methods varying from 2D to 3D space and explores the commonalities and discrepancies of technical settlements under different segmentation ***,the preliminaries on few/zeroshot visual semantic segmentation,including the problem definitions,typical datasets,and technical remedies,are briefly reviewed and ***,three typical instantiations are involved to uncover the interactions of few/zero-shot learning with visual semantic segmentation,including image semantic segmentation,video object segmentation,and 3D ***,the future challenges of few/zero-shot visual semantic segmentation are discussed.

关键词： Visual segmentation separating

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A study of novel real-time power balance strategy with virtual asynchronous machine control for regional integrated electric-thermal energy systems

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Science China(Technological Sciences) 2024年第7期67卷 2074-2086页

作者： WANG rui LI Ming-Jia WANG YiBo sun QiuYe ZHANG PinJia College of Information Science and Engineering Northeastern UniversityShenyang 110819China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China

The development of regional integrated electric-thermal energy systems(RIETES) is considered a promising direction for modern energy supply systems. These systems provide a significant potential to enhance the comprehensive utilization and efficient management of energy resources. Therein, the real-time power balance between supply and demand has emerged as one pressing concern for system stability operation. However, current methods focus more on minute-level and hour-level power optimal scheduling methods applied in RIETES. To achieve real-time power balance, this paper proposes one virtual asynchronous machine(VAM) control using heat with large inertia and electricity with fast response speed. First, the coupling timescale model is developed that considers the dynamic response time scales of both electric and thermal energy systems. Second, a real-time power balance strategy based on VAM control can be adopted to the load power variation and enhance the dynamic frequency response. Then, an adaptive inertia control method based on temperature variation is proposed, and the unified expression is further established. In addition, the small-signal stability of the proposed control strategy is validated. Finally, the effectiveness of this control strategy is confirmed through MATLAB/Simulink and HIL(Hardware-in-the-Loop) experiments.

关键词： regional integrated electric-thermal energy systems real-time power balance virtual asynchronous machine adaptive inertia small-signal stability

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Role of adaptation measures in addressing heatwave exposure in China

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Advances in Climate Change Research 2024年第1期15卷 148-157页

作者： Qin-Mei HAN qing-Chen CHAO Shao sun Pei-Jun SHI National Climate Centre China Meteorological AdministrationBeijing 100081China State Key Laboratoryof Severe Weather Chinese Academy of Meteorological Sciences Beijing 0o08lChina Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China

Heatwave exposure has increased dramatically because of climate warming and population growth,along with their interactive ***,effective adaptation measures can reduce these ***,the dynamic changes,regional inequality in adaptive capacity and their potential contributions to reducing exposure in the future remain *** study quantifies the impact of adaptive capacity and underscores regional variations in heatwave magnitudes,population exposure and adaptation levels in *** projected the future adaptive capacity using air-conditioner penetration,factoring in climate cooling requirements and individuals'purchasing *** population and gross domestic product(GDP)data from four Shared Socioeconomic Pathways(SSP1,SSP2,SSP3 and SSP5)and daily temperature data from four SSP-based emission scenarios(SSP1-2.6,SSP2-4.5,SSP3-7.0 and SSP5-8.5),we estimated heatwave duration,population exposure and avoided impacts through adaptation across China and its *** show a substantial increase in heatwave duration in Southwest and Southern China,especially under the SSP5-8.5 scenario,with a projection of 163.2±36.7 d during *** the SSP3|SSP3-7.0 scenario,total exposure reaches 156.4±76.8 billion person d per year,which is the highest among all scenarios and 23 times greater than that in 1986-2005 without *** considering adaptation measures,a noteworthy reduction in population exposure is observed,especially in the SSP3|SSP3-7.0 and SSP5JSSP5-8.5 scenarios,with reductions of(62.6±3.9)%and(65.8±5.1)%,respectively,compared with the scenario without adaptation during *** regional disparities in avoided impacts are also evident,with variations of up to 50%across different *** implementation of effective and environmentally friendly adaptation measures can notably address climate change,thereby alleviating the profound threats posed to human well-being.

关键词： Heatwaves Population exposure Adaptation Future projection China

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Research on a TOPSIS energy efficiency evaluation system for crude oil gathering and transportation systems based on a GA-BP neural network

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Petroleum Science 2024年第1期21卷 621-640页

作者： Xue-Qiang Zhang qing-Lin Cheng Wei sun Yi Zhao Zhi-Min Li Key Lab of Ministry of Education for Enhancing the Oil and Gas Recovery Ratio Northeast Petroleum UniversityDaqing163318HeilongjiangChina China Petroleum Pipeline Material and Equipment Co. LtdLangfang065000HebeiChina Research Institute of Petroleum Engineering and Technology Sinopec Northwest Oilfield CompanyUrumqi830011XinjiangChina

As the main link of ground engineering,crude oil gathering and transportation systems require huge energy consumption and complex *** is necessary to establish an energy efficiency evaluation system for crude oil gathering and transportation systems and identify the energy efficiency *** this paper,the energy efficiency evaluation system of the crude oil gathering and transportation system in an oilfield in western China is *** with the big data analysis method,the GA-BP neural network is used to establish the energy efficiency index prediction model for crude oil gathering and transportation *** comprehensive energy consumption,gas consumption,power consumption,energy utilization rate,heat utilization rate,and power utilization rate of crude oil gathering and transportation systems are *** the efficiency and unit consumption index of the crude oil gathering and transportation system,the energy efficiency evaluation system of the crude oil gathering and transportation system is established based on a game theory combined weighting method and TOPSIS evaluation method,and the subjective weight is determined by the triangular fuzzy analytic hierarchy *** entropy weight method determines the objective weight,and the combined weight of game theory combines subjectivity with objectivity to comprehensively evaluate the comprehensive energy efficiency of crude oil gathering and transportation systems and their ***,the weak links in energy utilization are identified,and energy conservation and consumption reduction are *** above research provides technical support for the green,efficient and intelligent development of crude oil gathering and transportation systems.

关键词： Crude oil gathering and transportation system GA-BP neural network Energy efficiency evaluation TOPSIS evaluation method Energy saving and consumption reduction

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HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-κB pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 344-352页

作者： qing-Zhi Hu Zhen-rui Cao Wei-Xiong Zheng Min-Jie Zhao Jun-Hua Gong Cong Chen Zhong-Jun Wu rui Tao Department of Hepatobiliary Surgery Bishan Hospital of Chongqing Medical UniversityChongqing 402760China Department of Cardiothoracic Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China c Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Hepatobiliary Surgery the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Background:Ischemia-reperfusion injury(IRI)poses a significant challenge to liver transplantation(LT).The underlying mechanism primarily involves overactivation of the immune *** shock protein 110(HSP110)functions as a molecular chaperone that helps stabilize protein ***:An IRI model was established by performing LT on Sprague-Dawley rats,and HSP110 was silenced using ***-eosin staining,TUNEL,immunohistochemistry,ELISA and liver enzyme analysis were performed to assess IRI following *** blotting and quantitative reverse transcription-polymerase chain reaction were conducted to investigate the pertinent molecular ***:Our findings revealed a significant increase in the expression of HSP110 at both the mRNA and protein levels in the rat liver following LT(P<0.05).However,when rats were injected with siRNAHSP110,IRI subsequent to LT was notably reduced(P<0.05).Additionally,the levels of liver enzymes and inflammatory chemokines in rat serum were significantly reduced(P<0.05).Silencing HSP110 with siRNA resulted in a marked decrease in M1-type polarization of Kupffer cells in the liver and downregulated the NF-κB pathway in the liver(P<0.05).Conclusions:HSP110 in the liver promotes IRI after LT in rats by activating the NF-κB pathway and inducing M1-type polarization of Kupffer *** HSP110 to prevent IRI after LT may represent a promising new approach for the treatment of LT-associated IRI.

关键词： Ischemia-reperfusion injury Liver transplantation Inflammation HSP110 Heat shock proteins NF-κB

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Subcellular distribution of prohibitin 1 in rat liver during liver regeneration and its cellular implication

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World Journal of Hepatology 2024年第1期16卷 65-74页

作者： qing-Ju sun Tao Liu Department of Clinical Laboratory Navy No.971 HospitalQingdao 266072Shandong ProvinceChina Department of Infectious Diseases Navy No.971 HospitalQingdao 266071Shandong ProvinceChina

BACKGROUND The function of prohibitin 1(Phb1)during liver regeneration(LR)remains relatively *** previous research identified downregulation of Phb1 in rat liver mitochondria 24 h after 70%partial hepatectomy(PHx),as determined by subcellular proteomic *** To investigate the potential role of Phb1 during *** We examined changes in Phb1 mRNA and protein levels,subcellular distribution,and abundance in rat liver during LR following 70%*** also evaluated mitochondrial changes and apoptosis using electron microscopy and flow ***-interference-mediated knockdown of Phb1(PHBi)was performed in BRL-3A *** Compared with sham-operation control groups,Phb1 mRNA and protein levels in 70%PHx test groups were downregulated at 24 h,then upregulated at 72 and 168 ***1 was mainly located in mitochondria,showed a reduced abundance at 24 h,significantly increased at 72 h,and almost recovered to normal at 168 ***1 was also present in nuclei,with continuous increase in abundance observed 72 and 168 h after 70%*** altered ultrastructure and reduced mass of mitochondria during LR had almost completely recovered to normal at 168 *** in BRL-3A cells resulted in increased S-phase entry,a higher number of apoptotic cells,and disruption of mitochondrial membrane *** Phb1 may contribute to maintaining mitochondrial stability and could play a role in regulating cell proliferation and apoptosis of rat liver cells during LR.

关键词： Prohibitin 1 Liver regeneration Subcellular proteomic analysis Mitochondrial stability Cell proliferation

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Significantly Enhanced Melt Memory Effect of Metallocene-made Isotactic Polypropylene Containing Talc

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Chinese Journal of Polymer Science 2024年第2期42卷 213-222,I0008页

作者： Hong-Wen sun Fu-Shan Wang Yan Gao Fu-qing Wei Jia-Chun Feng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China Lanzhou Petrochemical Corporation of PetroChina Lanzhou730060China Lanzhou Petrochemical Research Center Petrochemical Research Institute of PetroChinaLanzhou730060China

The melt memory effect is a widely observed phenomenon in semi-crystalline polymers. In practical applications, various additives are usually introduced into polymers, which may affect their melt memory behavior. In this work, the effect of talc on the melt memory effect of metallocene-made isotactic polypropylene(M-PP) was investigated in detail by using the differential scanning calorimetry. The results indicated that the introduction of talc significantly strengthened the melt memory effect of M-PP. Specifically, the upper limit temperature of Domain II increased from 161 ℃ to 174 ℃, resulting in a substantial widening of the temperature range of Domain IIa from 1 ℃ to 14 ℃. Analysis of the crystal orientation of the M-PP containing talc cooled from various Ts suggested that the remarkably enhanced melt memory effect could be ascribed to the stabilization of oriented nuclei facilitated by talc. This stabilizing effect was likely attributable to the prefreezing effect or the sorption interaction between talc and the M-PP chains.

关键词： Metallocene-made isotactic polypropylene Talc Melt memory effect Crystal orientation

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Rational design of practical layered transition metal oxide cathode materials for sodium-ion batteries

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 121-140页

作者： Yan Wang Ning Ding rui Zhang Guanhua Jin Dan sun Yougen Tang Haiyan Wang Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China College of Energy and Chemical Engineering Xinjiang Institute of TechnologyAksu Prefecture 843100China

Sodium-ion batteries (SIBs), which serve as alternatives or supplements to lithium-ion batteries, have been developed rapidly in recent years. Designing advanced high-performance layered NaxTMO_(2) cathode materials is beneficial for accelerating the commercialization of SIBs. Herein, the recent research progress on scalable synthesis methods, challenges on the path to commercialization and practical material design strategies for layered NaxTMO_(2) cathode materials is summarized. Co-precipitation method and solid-phase method are commonly used to synthesize NaxTMO_(2) on mass production and show their own advantages and disadvantages in terms of manufacturing cost, operative difficulty, sample quality and so on. To overcome drawbacks of layered NaxTMO_(2) cathode materials and meet the requirements for practical application, a detailed and deep understanding of development trends of layered NaxTMO_(2) cathode materials is also provided, including high specific energy materials, high-entropy oxides, single crystal materials, wide operation temperature materials and high air stability materials. This work can provide useful guidance in developing practical layered NaxTMO_(2) cathode materials for commercial SIBs.

关键词： sodium-ion batteries layered oxide industrialization development prospect

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