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Promising dawn in tumor microenvironment therapy:engineering oral bacteria

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International Journal of Oral Science 2024年第2期16卷 208-224页

作者： Zifei Wang Wansu sun Ruixue hua Yuanyin Wang Yang Li Hengguo Zhang Key Laboratory of Oral Diseases Research of Anhui Province College&Hospital of StomatologyAnhui Medical UniversityHefeiChina Department of Stomatology The First Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of Genetics School of Life ScienceAnhui Medical UniversityHefeiChina

Despite decades of research,cancer continues to be a major global health *** human mouth appears to be a multiplicity of local environments communicating with other organs and causing diseases via ***,the role of oral microbes in the development and progression of cancer has received increasing *** the same time,bioengineering technology and nanotechnology is growing rapidly,in which the physiological activities of natural bacteria are modified to improve the therapeutic efficiency of *** engineered bacteria were transformed to achieve directed genetic reprogramming,selective functional reorganization and precise *** contrast to endotoxins produced by typical genetically modified bacteria,oral flora exhibits favorable biosafety *** outline the current cognitions upon oral microbes,engineered microbes and human cancers,related literatures were searched and reviewed based on the PubMed *** focused on a number of oral microbes and related mechanisms associated with the tumor microenvironment,which involve in cancer occurrence and *** engineering oral bacteria can be a possible application of cancer therapy is worth consideration.A deeper understanding of the relationship between engineered oral bacteria and cancer therapy may enhance our knowledge of tumor pathogenesis thus providing new insights and strategies for cancer prevention and treatment.

关键词： prevention organs precise

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仿苏4m绞车改造

煤矿机械 2007年第3期28卷 135-136页

作者：孙清华鹤壁富昌建设工程有限责任公司河南鹤壁458020

仿苏4 m绞车改造项目主要有:由气动平移式制动系统改造为盘形闸制动系统,并对其盘形闸固定剪切力进行计算校核,对提升机电控系统进行技术改造,主回路真空化,转子晶闸管控制,并配有安全可靠的监控装置。绞车改造后,提高了系统的运转可靠... 详细信息

仿苏4 m绞车改造项目主要有:由气动平移式制动系统改造为盘形闸制动系统,并对其盘形闸固定剪切力进行计算校核,对提升机电控系统进行技术改造,主回路真空化,转子晶闸管控制,并配有安全可靠的监控装置。绞车改造后,提高了系统的运转可靠性,并节省了费用,创造了效益。

关键词：仿苏4 m绞车改造效果与效益

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铁路机车司机高血压患病情况及危险因素分析

中国职业医学 2008年第5期35卷 388-390页

作者：孙庆华济南铁路疾病控制所青岛分所济南青岛266012

目的了解某铁路机车司机高血压患病情况及其主要危险因素。方法对1 585名机车司机进行调查,包括病史询问、体格检查(包括血压、身高、体重);40岁以上者,增加总胆固醇、三酰甘油及血糖测定。采用Excel 2003和SPSS 10.0软件进行单因素和... 详细信息

目的了解某铁路机车司机高血压患病情况及其主要危险因素。方法对1 585名机车司机进行调查,包括病史询问、体格检查(包括血压、身高、体重);40岁以上者,增加总胆固醇、三酰甘油及血糖测定。采用Excel 2003和SPSS 10.0软件进行单因素和多因素logistic回归分析。结果高血压患病率为51.86%。单因素分析:与高血压患病可能有关的危险因素有年龄、文化程度、吸烟、饮酒、体重指数(BMI)、总胆固醇、三酰甘油及血糖等;logistic回归分析:机车司机高血压主要影响因素有年龄、饮酒、BMI,其OR值依次为1.501、1.347和1.857;40岁以上人群高胆固醇血症、高三酰甘油血症及空腹血糖异常也是高血压危险因素。结论机车司机高血压患病率较高。降低BMI值和重视血脂、血糖异常的检测干预是预防高血压发病的重要环节。

关键词：高血压患病率危险因素

农村土地流转中的金融服务创新机制研究——基于BPM理论的视角

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中国流通经济 2011年第7期25卷 122-126页

作者：孙清华北京交通大学中国产业安全研究中心北京市100044

本文首先从战略缺口假说角度界定了土地流转的内涵,然后引入内生金融发展模型的重要结论,结合山东省农村中小金融机构为农村土地流转提供金融服务的实践探索,在进行关联性分析的基础之上,提出了土地流转在金融服务方面的制约因素。最后... 详细信息

本文首先从战略缺口假说角度界定了土地流转的内涵,然后引入内生金融发展模型的重要结论,结合山东省农村中小金融机构为农村土地流转提供金融服务的实践探索,在进行关联性分析的基础之上,提出了土地流转在金融服务方面的制约因素。最后,根据业务流程管理理论构建了金融为土地流转提供服务的创新机制,并针对创新机制中的关键环节提出了建议,以期解决土地流转过程中金融服务创新性不足等问题。

关键词：土地流转流程型组织金融服务

Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

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Chinese Journal of Polymer Science 2024年第5期42卷 570-578,I0005页

作者： Xiao-Fei sun Xu Zhang Shu-Ping Song Ya-Qun Yao Yan Zhang Cheng-Liang Wang Jing-Jiang sun qing-Fu Wang Key Laboratory of Rubber-plastics Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao266042China qingdao Research Academy of Environmental Science Qingdao266012China

L-glutamic acid(LA)is a bio-based,non-toxic,environmentally friendly material derived from *** present study reports the application of Passerini three-component polymerization(P-3CP)for the straightforward preparation of LA-based light-responsive polyesters(PLTDs)under mild *** with molar masses up to 8500 g/mol and high yields exceeding 90%are *** chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible(UV-Vis)spectroscopy,size exclusion chromatography(SEC),nuclear magnetic resonance(NMR)spectroscopy,and liquid chromatography mass spectrometry(LC-MS).Meanwhile,monodisperse PLTD-based doxorubicin-loaded nanoparticles(PLTD-DOX-NP)(size=193 nm,PDI=0.018)are formulated by nanoprecipitation *** light-induced depolymerization,the PLTD-DOX-NP undergoes rapid decomposition,resulting in a burst release of 80%cargo within 13 ***,according to biological toxicity tests,the PLTD-NP possesses adequate biosafety,both before and after ***,the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry,significantly simplifying the synthetic pathway of light-responsive polymers.

关键词： L-glutamic acid Passerini three-component polymerization Light-responsive Polyester Nanoparticles

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二矿主井井架改造施工工艺

煤矿机械 2007年第10期28卷 159-160页

作者：孙清华鹤壁富昌建设工程有限责任公司河南鹤壁458020

针对矿井旧井架改造施工工艺，主要介绍了施工改造的总体方案及矿井停产前井架的制作、防腐及安装准备工作，并介绍了矿井停产后提升设施拆除、斜架抬头、立架吊装、立架和斜架的合拢等施工工艺。运用该施工工艺工期可缩短2～3d；运用... 详细信息

针对矿井旧井架改造施工工艺，主要介绍了施工改造的总体方案及矿井停产前井架的制作、防腐及安装准备工作，并介绍了矿井停产后提升设施拆除、斜架抬头、立架吊装、立架和斜架的合拢等施工工艺。运用该施工工艺工期可缩短2～3d；运用大型吊车避免了起立桅杆的繁琐；占用井口时间短。

关键词：矿井旧井架改造施工工艺效果与效益

职业联赛对大连足球发展的影响因素及对策研究

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山东体育学院学报 2009年第8期25卷 23-26,42页

作者：孙华清大连大学体育学院辽宁大连116622

15年职业联赛给大连足球带来了辉煌,也带来了今天的失落;我国的职业联赛还处于发展的初级阶段,不可避免地出现竞赛体制不健全、忽视足球后备人才的培养、俱乐部产权不清、缺乏管理人才、俱乐部过多依附政府、缺乏自身造血功能、俱乐部... 详细信息

15年职业联赛给大连足球带来了辉煌,也带来了今天的失落;我国的职业联赛还处于发展的初级阶段,不可避免地出现竞赛体制不健全、忽视足球后备人才的培养、俱乐部产权不清、缺乏管理人才、俱乐部过多依附政府、缺乏自身造血功能、俱乐部经营不善等现象。针对这些现象,提出对策与建议。

关键词：职业联赛大连足球影响因素对策

Multi-surrogate framework with an adaptive selection mechanism for production optimization

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Petroleum Science 2024年第1期21卷 366-383页

作者： Jia-Lin Wang Li-Ming Zhang Kai Zhang Jian Wang Jian-Ping Zhou Wen-Feng Peng Fa-Liang Yin Chao Zhong Xia Yan Pi-Yang Liu hua-qing Zhang Yong-Fei Yang Hai sun School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina qingdao University of Technology Qingdao266580ShandongChina College of Science China University of PetroleumQingdao266580ShandongChina Zepu Oil and Gas Development Department PetroChina Tarim Oilfield CompanyKorla841000XinjiangChina Hainan Branch of CNOOC Ltd Haikou70311HainanChina

Data-driven surrogate models that assist with efficient evolutionary algorithms to find the optimal development scheme have been widely used to solve reservoir production optimization ***,existing research suggests that the effectiveness of a surrogate model can vary depending on the complexity of the design problem.A surrogate model that has demonstrated success in one scenario may not perform as well in *** the absence of prior knowledge,finding a promising surrogate model that performs well for an unknown reservoir is ***,the optimization process often relies on a single evolutionary algorithm,which can yield varying results across different *** address these limitations,this paper introduces a novel approach called the multi-surrogate framework with an adaptive selection mechanism(MSFASM)to tackle production optimization *** consists of two *** the first stage,a reduced-dimensional broad learning system(BLS)is used to adaptively select the evolutionary algorithm with the best performance during the current optimization *** the second stage,the multi-objective algorithm,non-dominated sorting genetic algorithm II(NSGA-II),is used as an optimizer to find a set of Pareto solutions with good performance on multiple surrogate models.A novel optimal point criterion is utilized in this stage to select the Pareto solutions,thereby obtaining the desired development schemes without increasing the computational load of the numerical *** two stages are combined using sequential transfer *** the two most important perspectives of an evolutionary algorithm and a surrogate model,the proposed method improves adaptability to optimization problems of various reservoir *** verify the effectiveness of the proposed method,four 100-dimensional benchmark functions and two reservoir models are tested,and the results are compared with those obtained by six other surrogate-model-based *** res

关键词： Production optimization Multi-surrogate models Multi-evolutionary algorithms Dimension reduction Broad learning system

Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2024年第10期30卷 1431-1449页

作者： Zheng-Yang Li Yu-qing Mao Qian hua Yong-Hong sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Department of Gastroenterology Jinshan Hospital of Fudan UniversityShanghai 201508China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Gastroenterology Dalian Friendship HospitalDalian 116001Liaoning ProvinceChina Department of Pathology Jinshan Hospital of Fudan UniversityShanghai 201508China

BACKGROUND Serotonin receptor 2B(5-HT2B receptor)plays a critical role in many chronic pain *** possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diarrhea(IBS-D)was investigated in the present *** To investigate the possible involvement of 5-HT2B receptor in the altered gut sensation in rat model and patients with *** Rectosigmoid biopsies were collected from 18 patients with IBS-D and 10 patients with irritable bowel syndrome with constipation who fulfilled the Rome IV criteria and 15 healthy *** expression level of the 5-HT2B receptor in colon tissue was measured using an enzyme-linked immunosorbent assay and correlated with abdominal pain *** IBS-D rat model was induced by intracolonic instillation of acetic acid and wrap *** in visceral sensitivity and 5-HT2B receptor and transient receptor potential vanilloid type 1(TRPV1)expression were examined following 5-HT2B receptor antagonist *** in visceral sensitivity after administration of the TRPV1 antago-INTRODUCTION Irritable bowel syndrome(IBS)is a chronic functional bowel disorder characterized by recurrent abdominal pain with altered bowel habits that affects approximately 15%of the population worldwide[1].IBS significantly impacts the quality of life of *** the pathogenesis of IBS is not completely understood,the role of abnormal visceral sensitivity in IBS has recently emerged[2,3].5-Hydroxytryptamine(5-HT)is known to play a key role in the physiological states of the gastrointestinal *** 5-HT levels in IBS with diarrhea(IBS-D)patients were greater than those in healthy controls[4],suggesting a possible role of 5-HT in the pathogenesis of *** serotonin receptor 2(5-HT2 receptor)family comprises three subtypes:5-HT2A,5-HT2B,and *** 5-HT2 receptors exhibit 46%-50%overall sequence identity,and all of these receptors preferentially bind to Gq/

关键词： Diarrhea-predominant irritable bowel syndrome Serotonin receptor 2B Transient receptor potential vanilloid type-1 Visceral hypersensitivity Abdominal pain