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Drosophila CTP synthase can form distinct substrate-and product-bound filaments

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Journal of Genetics and Genomics 2019年第11期46卷 537-545页

作者： Xian Zhou Chen-Jun Guo Huan-Huan Hu Jiale Zhong qianqian sun Dandan Liu Shuang Zhou Chia Chun Chang Ji-Long Liu School of Life Science and Technology ShanghaiTech UniversityShanghai201210China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China iHuman Institute ShanghaiTech UniversityShanghai201210China

Intracellular compartmentation is a key strategy for the functioning of a *** 2010,several studies revealed that the metabolic enzyme CTP synthase(CTPS)can form filamentous structures termed cytoophidia in prokaryotic and eukaryotic ***,recent structural studies showed that CTPS only forms inactive product-bound filaments in bacteria while forming active substrate-bound filaments in eukaryotic *** this study,using negative staining and cryo-electron microscopy,we demonstrate that Drosophila CTPS,whether in substrate-bound or product-bound form,can form *** results challenge the previous model and indicate that substrate-bound and product-bound filaments can coexist in the same *** speculate that the ability to switch between active and inactive cytoophidia in the same cells provides an additional layer of metabolic regulation.

关键词： CTP synthase Drosophila Cytoophidium Cryo-EM

Flower-like Fe-doped NiSe_(2)/C hybrid spheres fabricated by a glucose-intercalation strategy for enhanced sodium storage proper

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ChemPhysMater 2024年第2期3卷 220-229页

作者： Cheng Liu Yi Wen Gaoya Ren Yaxuan Li qianqian sun Shenghui Shen Zhujun Yao Yefeng Yang School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China Instute of Wenzhou Zhejiang UniversityWenzhou 325036China

Nickel diselenide(NiSe_(2)),which has a high theoretical capacity,has attracted considerable attention as a promis-ing anode material for sodium-ion batteries(SIBs).Nevertheless,the intrinsically low conductivity,large volume variation,and significant aggregation of NiSe_(2)during sodiation/desodiation remain significant obstacles to its ***,we report flower-like Fe-doped NiSe_(2)/C hybrid spheres(denoted as Fe-NiSe_(2)/C)fabricated by a glucose intercalation strategy for efficient sodium *** Fe-NiSe_(2)/C hybrid spheres are composed of thin porous carbon nanosheets decorated with Fe-NiSe_(2)*** situ introduced carbon nanosheets derived from intercalated glucose accompanied by moderate Fe doping in NiSe2 nanoparticles can provide ac-celerated ion/electron transfer kinetics through fast ion channels in the flower-like architecture and intimately contacted interfaces between NiSe_(2)and carbon nanosheets as well as maintain structural integrity by alleviating volume ***,the optimal anode of the Fe-NiSe_(2)/C hybrid spheres delivered a high discharge capacity of 415 mAh g^(-1)at 0.5 A g^(-1),outstanding rate capability(243 mAh g^(-1)at 5 A g^(-1)),and significantly enhanced cycling stability(388 mAh g^(-1)at 1 A g^(-1)over 200 cycles).This work offers an efficient and valu-able strategy for realizing tailored heteroatom doping in transition metal selenides,accompanied by an in situ combination of conductive carbonaceous networks for advanced alkali metal ion batteries.

关键词： Glucose-intercalation Fe-doped NiSe_(2) Carbon nanosheets Sodium-ionbatteries

Changing Characteristics of Urban Heat Island Effect in Weihai City

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Meteorological and Environmental Research 2023年第6期14卷 8-15页

作者： Di WANG qianqian sun Wenpeng XIN Key Laboratory for Meteorological Disaster Prevention and Mitigation of Shandong Jinan 25000China Weihai Meteorological Bureau Weihai 264200China

Based on the local climate zoning theory and the observation data of hourly temperature of 22 automatic weather stations from 2012 to 2021, K-means clustering algorithm was used to analyze the daily, monthly, seasonal, annual and spatial variation characteristics of urban heat island effect in Weihai City in the past 10 years. The results showed that in recent 10 years, the average urban heat island intensity was 1.24 ℃, showing a gradual weakening trend of -0.169 3 ℃/10 a;the summer average heat island intensity was 0.86 ℃, showing a gradual weakening trend of -0.047 5 ℃/10 a. The heat island intensity had obvious diurnal variation characteristics, that is, "it was weak in the day and strong at night". In terms of seasonal variation, heat island effect was the weakest in summer, stronger in spring and autumn, and the strongest in winter. The diurnal, seasonal and annual changes of heat island intensity showed a reverse trend to those of temperature. The high-value area of urban heat island was highly consistent with human residential activity areas and industrial and commercial intensive areas, and the extension trend of heat island intensity was the same as the direction of urban development and construction. The "cold island phenomenon" in some offshore areas was related to the geographical location, terrain and the southeast monsoon trend in summer. The adverse effects of urban heat island effect can be reduced by optimizing the types and distribution of vegetation communities, rationally planning and constructing urban water body, promoting green building materials and adjusting shape design, etc.

关键词： Urban heat island effect Local climate zoning K-means clustering algorithm Automatic weather station

Natural biomaterial sarcosine as an interfacial layer enables inverted organic solar cells exhibiting over 16.4% efficiency

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Natural biomaterial sarcosine as an interfacial layer enable...

Optimizing vertical phase separation via an upside down placed method for highly efficient polymer solar cells

第八届新型太阳能材料科学与技术学术研讨会

作者： Yujie Xu qianqian sun School of Physics and Electronic Sciences Shandong Normal University

The natural biomaterial sarcosine as the electron transport layer(ETL) to modify ITO or ITO/ZnO was successfully introduced into the inverted OSCs with PM6:BTP-BO-4 Cl as the active layers. The introduction of sarcosine on the surface of ITO or ITO/ZnO can result in lower work function(WF) and higher surface energy. The active layers processed on the surfaces of ITO or ITO/ZnO have more optimized morphology and more ordered molecular arrangement after modifying with sarcosine. The introduction of sarcosine as ETL can promote charge transport and collection in the OSCs. Therefore, the PCE of OSCs is increased to 13.53% from 3.86% by modifying ITO with sarcosine. The PCE of OSCs with ZnO as ETLs is improved to 16.45% from 14.85% by modifying ZnO with sarcosine. The improved PCEs are benefited from the simultaneously improved short-circuit current density(J), fill factor(FF), and open-circuit voltage(V). This work demonstrates that sarcosine has great potential as an ETL to improve the performance of OSCs.

关键词： Organic solar cells Interface modification Sarcosine

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Optimizing vertical phase separation via an upside down plac...

Analysis on Extreme Temperature Indexes in Rongcheng Station from 1981 to 2010

中国化学会第30届学术年会-第二十二分会：有机光伏的机遇和挑战

作者： qianqian sun Fujun Zhang Key Laboratory of Luminescence and Optical Information Ministry of EducationBeijing Jiaotong University

Morphology optimization of the active layer is an essential way to improve the power conversion efficiency(PCE)of polymer solar cells(PSCs).The key factors for the active layer morphology are the lateral phase separated morphology and the vertical phase *** this work,upside down placed method was carried to optimize the vertical phase separation of active *** PCE of PSCs based on PTB7-Th:PCBM as active layer was

关键词： Vertical phase separation upside down placed Polymer solar cells

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Meteorological and Environmental Research 2015年第5期6卷 5-8页

作者： Chen Xiaojing sun qianqian Teng Zhishan Rongcheng Meteorological Administration Weihai Meteorological Administration

A Based on daily maximum and minimum temperature from Rongcheng station during 1981 -2010, the changing trends of extreme temperature indexes were analyzed. The results show that for the relative indexes, number of warm days （nights） in Rongcheng station showed an increasing trend, while the number of cold days （nights） showed a decreasing trend from 1981 to 2010, but the decreasing trend of number of cold days was small. For the extreme indexes, the extreme maximum temperature, the maximum of extreme minimum temperature and extreme mini- mum temperature increased, while the minimum of extreme maximum temperature decreased from 1981 to 2010. For the absolute indexes, the numbers of frozen days and frost days reduced, and frozen days were less than frost days for all year.

关键词： Rongcheng Extreme temperature indexes Climate change China

Synthesis and biological evaluation of N-Alkylamide derivatives as anti-tumor agents

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Journal of Traditional Chinese Medical Sciences 2020年第4期7卷 393-403页

作者： Kunxiu Jiang Yantao Xing Qinghua Quan qianqian sun Jingyun Tian Cen Liu Xingzhuo Song Xirui Wang Yonggang Liu School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China

Background:N-Alkylamides(NAAs),derived from Anacyclus pyrethrum(L.)DC,have potential anti-tumor *** explore the molecular mechanism and chemo-preventive capacity of NAAs,we synthesized an NAA(H-10)and evaluated whether it could inhibit the proliferation of B16,HepG2,HeLa,and HCT116 cancer cells in 2D ***:To evaluate the antiproliferative activity of H-10 in 2D and 3D culture of BD,HepG2,HeLa,and HCT116 cells,multicellular tumor spheroids were constructed to more accurately reflect the cell tumor *** visualize nuclear changes related to apoptosis,Hoechst 33258 staining and propidium iodide-Annexin V double staining were ***:Compound H-10 strongly inhibited the growth of all tested cell *** 33258 staining and propidium iodide-Annexin V double staining revealed that H-10 did not cause morphological alterations in the nuclei and moderately induced late apoptosis only when treated at 180 *** strongest inhibitory effect was observed in HCT116 *** cytometry analysis indicated that treatment of HCT116 cells with compound H-10 resulted in robust cell growth arrest in G2 phase in 2D and 3D cell culture;in 3D-cultured HCT116 cells,growth arrest occurred in G1 *** with compound H-10 also significantly suppressed angiogenesis of chick chorioallantoic membrane in ***:Treatment with compound H-10 strongly affected clonogenic survival(in the long-term)and migration of HCT116 ***,H-10,a compound of NAAs may be useful for treating cancer because of its anti-neoplastic effect and easy synthesis.

关键词： N-AlkylamideThree-dimensional cell culture HCT116 Anti-tumor agent

The efficiency of inverted organic solar cells with methionine as cathode modification layer exceeds 15%

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The efficiency of inverted organic solar cells with methioni...

β-catenin activation in hair follicle dermal stem cells in duces ectopic hair outgrowth and skin fibrosis

第九届新型太阳能材料科学与技术学术研讨会

作者： Yujie Xu Hang Zhou qianqian sun Shandong Normal University No.1 University of Science and Technology Park

Interfacial modification is an important way to improve the performance of organic solar cells. In this work, we demonstrate an environmentally friendly interfacial modifier, methionine, which is inserted between the ZnO and photoactive layers of inverted organic solar cells. Due to the high open-circuit voltage, short-circuit current and fill factor of the devices using ZnO/methionine as the electron transport layer(ETL),the power conversion efficiency(PCE) of PM6:BTP-ec9 bulk heterojunction solar cells was increased to 15.34%. Atomic force microscopy(AFM) and hydrolytic haptic measurements showed that methionine modified the ZnO/methionine surface, resulting in a reduction in roughness. Suitable work functions and fewer surface defects were observed in the ZnO/methionine ETL. In addition, the optimized ETL improved the carrier transport efficiency and reduced charge complexation. This work offers good prospects for using environmentally friendly materials as interfacial layers to enrich our understanding of the interfacial properties of reversed-phase OSCs.

关键词： Organic solar cells interface modification biomolecules

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Journal of Molecular Cell Biology 2019年第1期11卷 26-38页

作者： Yixin Tao Qingchun Yang Lei Wang Jie Zhang Xuming Zhu qianqian sun Yunbin Han Qian Luo Yushu Wang Xizhi Guo Ji Wu Baojie Li Xiao Yang Lin He Gang Ma Bio-X-Renji Hospital Research Center Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education) Bio-X InstitutesShanghai Jiao Tong UniversityShanghai 200240China School of Life Science and Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Proteomics Genetic Laboratory of Development and DiseasesInstitute of BiotechnologyBeijing 100071China

Hair follicle dermal sheath(DS)harbors hair follicle dermal stem cells(hfDSCs),which can be recruited to replenish DS and dermal papilla(DP).Cultured DS cells can differentiate into various cell lineages in ***,it is unclear how its plasticity is modulated in ***/β-catenin signaling plays an important role in maintaining stem cells of various lineages and is required for HF development and *** we report that activation ofβ-catenin in DS generates ectopic HF outgrowth(EF)by reprogramming HF epidermal cells and DS cells themselves,and endows DS cells with hair inducing *** homeostasis of pre-existing HFs is ***,cell-autonomous progressive skin fibrosis is prominent in dermis,where the excessive fibroblasts largely originate from *** expression analysis of purified DS cells with activatedβ-catenin revealed significantly increased expression of Bmp,Fgf,and Notch ligands and administration of Bmp,Fgf,or Notch signaling inhibitor attenuates EF *** summary,our findings advance the current knowledge of high plasticity of DS cells and provide an insight into understanding how Wnt/β-catenin signaling controls DS cell behaviors.

关键词： Wnt/β-catenin fibrosis hair follicle skin cell differentiation