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A novel heat-resistant Al–Si–Cu–Ni–Mg base material synergistically strengthened by Ni-rich intermetallics and nano-AlN_p microskeletons

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Journal of Materials Science & Technology 2019年第3期35卷 306-312页

作者： Kaiqi Hu Qingfei Xu Xia Ma qianqian sun Tong Gao Xiangfa Liu Key Laboratory for Liquid–Solid Structural Evolution and Processing of Materials Ministry of Education Shandong University

In this work, nano-AlN particle(nano-AlN_p) microskeletons were introduced into an Al–Si–Cu–Ni–Mg alloy by Al–8 AlN master alloy in which the nano-AlN_p reinforcements connect with each other to form three-dimensional networks. It is found that these nano-AlN_p microskeletons mainly distribute in the binary Al–Si eutectic zones resulting in flaky eutectic Si phases being modified to particulates. Meanwhile,the microskeletons strengthen the matrix synergistically with semi-continuous Ni-rich intermetallics in three dimensions. The tensile mechanical properties, micro-hardness and thermal expansion properties of the alloy at different temperatures are significantly improved. Especially, the ultimate tensile strength(UTS) at 350℃ increases from 85MPa to 106MPa, rising by 24.7%, which is ascribed to nano-AlN_p microskeletons assisting intermetallics with undertaking mechanical loading, and to the modification of eutectic Si phases to reduce the stress concentration at elevated temperatures.

关键词： Al–Si alloy Heat-resistant Al alloy Mechanical properties at high temperatures Nano-AlN_p microskeletons

Structural fl exibility and functional interaction of Mediator Cdk8 module

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Protein & Cell 2013年第12期4卷 911-920页

作者： Xuejuan Wang Jianye Wang Zhenrui Ding Jinhua Ji qianqian sun Gang Cai School of Life Sciences University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale Center for Integrative ImagingHefei 230026China

Mediator is a highly conserved large protein complex(25 proteins,>1000 kD a)and preeminently responsible for eu-karyotic transcription,which contains a dissociable‘Cdk8 module’.Although increasing evidence demonstrates that Cdk8 module plays both positive and negative roles in transcription regulation,the detailed structure,and subu-nit organization,molecular mechanism how it regulates transcription remain *** we used single-particle electron microscopy to characterize the structure and subunit organization of the Cdk8 module and illuminated the substantial mobility of the Med13 subunit results in the structural fl *** Cdk8 module interaction with core Mediator is concurrent with active transcription in *** interaction with the Cdk8 module induces core Mediator into very extended conformation in vitro,which is presumed to be an active functional state of *** together,our results illuminated the detailed archi-tecture of Cdk8 module,and suggested the Cdk8 module could positively regulate transcription by modulating Me-diator conformation.

关键词： Mediator Cdk8 kinase module transcription regulation

Dual-targeted nanoformulation with Janus structure for synergistic enhancement of sonodynamic therapy and chemotherapy

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Chinese Chemical Letters 2023年第7期34卷 454-460页

作者： Zhifang Wang Man Wang Yanrong Qian Yulin Xie qianqian sun Minghong Gao Chunxia Li Institute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China

The accurate delivery of nanoparticles and organic small molecule drugs remains a serious challenge in nanoparticle-based tumor ***-targeted therapy combining tumor cell targeting and organelle targeting is an effective ***,an anticancer nanoformulation accurate delivery system was prepared using hyaluronic acid (HA) targeting CD44 receptors on the surface of tumor cells and IR780iodine (IR780) targeting mitochondrial for *** system is based on an ultra-small Janus structured inorganic sensitizer TiO_(2-x)@NaGdF_(4) nanoparticles (TN NPs) prepared by one-step pyrolysis,further loaded with organic small molecule acoustic sensitizer IR780 and mitochondrial hexokinase Ⅱ inhibitor lonidamine (LND),followed by encapsulation of ***-small size nanoparticles exhibit strong tissue penetration,tumor inhibition and in vivo *** ultrasound radiation,TN NPs and IR780could produce a synergistic effect,effectively increased the efficiency of reactive oxygen species (ROS)***,the released IR780 could smoothly target the mitochondria,and the ROS produced by IR780 can destroy the mitochondrial structure and disrupt the mitochondrial *** could inhibit the energy metabolism of tumor cells by reducing the activity of hexokinase Ⅱ (HK Ⅱ),which further accelerates the process of ***,since the Janus structure allows the integration of multifunctional components into a single system,TN NPs can not only serve as an acoustic sensitizer to generate ROS,but the Gd element contained can also act as the nuclear magnetic resonance (MR)imaging contrast agent,suggesting that the nanoformulation can enable imaging-guided diagnosis and *** conclusion,a new scheme to enhance sonodynamic therapy (SDT) and chemotherapy synergistically is proposed here based on ultra-small dual-targeted nanoformulation with Janus structure in the ultrasound radiation environment.

关键词： Ultra-small Janus structure Mitochondrial targeting CD44 targeting Synergistic therapy MR imaging

Fabrication of oxygen-doped MoSe2 hierarchical nanosheets for highly sensitive and selective detection of trace trimethylamine at room temperature in air

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Nano Research 2020年第6期13卷 1704-1712页

作者： Nannan Hou qianqian sun Jing Yang Su You Yun Cheng Qian Xu Wei Li Shiqi Xing Li Zhang Junfa Zhu Qing Yang Hefei National Laboratory of Physical Sciences at the Microscale(HFNL) Department of ChemistryLaboratory of Nanomaterials for Energy Conversion(LNEC)University of Science and Technology of ChinaHefei230026China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230029China

Nano Research volume 13,pages1704–1712(2020)Cite this article 191 Accesses Metrics details Abstract Intelligent gas sensors based on the layered transition metal dichalcogenides(TMDs)have attracted great interest in the field of gas sensing due to their multiple active sites,fast electron,mass transfer capability and large surface-to-volume ***,conventional TMDs-based sensors typically work at elevated temperature in inert atmosphere,which would largely limit the corresponding practical ***,novel oxygen-doped MoSe2 hierarchical nanostructures composed of ultrathin nanosheets with large specific surface area have been designed and generated typically at 200°C in air for fast and facile gas sensing of trimethylamine(TMA),*** from the gas-accessible hierarchical morphology and high surface area with abundant nanochannels,highly sensitive and selective detection of trace TMA has been achieved under ambient condition,and as detected the theoretical limit of detection(LOD)is 8 ppb,which is the lowest for TMA detection under ambient condition among the reported *** mechanism of oxygen doping on the improved gas-sensing performance has been investigated,revealing that the oxygen doping could greatly optimize the electronic structure,thus regulate the Fermi level of MoSe2 as well as the affinity between TMA molecule and sensor *** is expected that the oxygen doping strategy developed for the highly efficient gas sensors based on TMDs in present work may also be applicable to other types of gas-sensing semiconductors,which could open up a new direction for the rational design of high-performance gas sensors working under ambient condition.

关键词： oxygen-doped MoSe2 nanosheet ambient gas sensing trimethylamine detection highly selective trace detection limit

Teaching Exploration of Green Building Design Practice

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Journal of Landscape Research 2019年第5期11卷 152-154页

作者： sun qianqian School of Architecture and Civil Engineering Xi’ an University of Science and Technology

Green building design is the current development trend of architectural *** architectural colleges are actively seeking a new design method and teaching mode that integrates green building education and undergraduate course teaching *** courses pay attention to the implantation of green building design in teaching reform,which is of great significance to cultivate students to set up green building values,and improve students’ practical ability and ecological building *** the green building design education practice of Xi’an University of Science and Technology as an example,the study aimed to provide effective methods for cultivating green building design professionals through teaching content reform,teaching method innovation,and diversified teaching modes.

关键词： Green buildings Practical application Teaching reform

Design of Prefabricated Old-age Building Based on Modularization:A Case Study of Institutional Elderly Houses Design in Taigou Village,Xi'an City

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Journal of Landscape Research 2018年第5期10卷 84-87页

作者： sun qianqian School of Architectural and Civil Engineering Xi'an University of Science and Technology

Old-age building was designed in Ziwu Town,from the aspects of energy saving,environmental protection,full use of solar energy and characteristics of the local *** order to meet the requirements of energy conservation,environmental protection and climate adaptability of residential buildings,this paper integrates the construction and design in the prefabricated building design,at the same time,with the consideration of the possibility of expansion and removal of the nursing home,the concept of "modular unit" is put *** the climatic adaptability of the base position,the utilization of solar energy and the organization of natural ventilation should be paid attention to,also,the rammed soil construction method is added in this design,which can improve the thermal insulation performance of the building enclosure and create a comfortable indoor thermal environment both in winter and *** order to realize the object of industrial building construction and design,the prefabricated construction method is used,which produces impact on the surrounding environment more environmentally *** building will be easily built,less restricted,and ***'s more,local material and the advantages of all dry work increase the operability of the project.

关键词： Prefabricated assembly Old-age building design Modular units

The Problem analysis of the dairy farming in our country

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Journal of Zhouyi Research 2014年第6期 3-5页

作者： qianqian sun Youchun Tang School of Management Shanghai University of Engineering Science. Shanghai China

Exploration and Research on the Construction of First-class Undergraduate Major of Architecture:A Case Study on Xi'an University of Science and Technology

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Journal of Landscape Research 2022年第4期14卷 57-60页

作者： REN Xiang sun qianqian College of Architecture and Civil Engineering Xi’an University of Science and TechnologyXi’anShaanxi 710054China

With the decision of the Ministry of Education to fully implement the“Six Excellence and One Top-notch”plan 2.0 and launch the“Double Ten-thousand Plan”for the construction of first-class undergraduate majors,colleges and universities across the country have fully launched the construction of first-class undergraduate *** architecture major of Xi’an University of Science and Technology has achieved certain results in deepening the comprehensive reform of the major,strengthening the construction of teaching staff and grass-roots teaching organizations,and enhancing the construction of the professional teaching quality assurance *** quality of graduate training and external evaluation have achieved good results by integrating into the teaching system of special courses,improving the high-level talent training system,taking the construction of“new engineering”as an opportunity,promoting education and teaching reform,relying on the platform of discipline advantages,and building a multi-level practical teaching system.

关键词： First-class undergraduate major Architecture major Innovation and improvement

The Problem analysis of the dairy farming in our country

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International English Education Research 2015年第3期 3-5页

作者： qianqian sun Youchun Tang School of Management Shanghai University of Engineering Science Shanghai. China

After the reform and opening up, especially in recent years. Dairy farming has a rapid development in our country, however, the dairy farming link in our country also is in a small scale, and dairy cows yield at lower levels, based on the present situation of dair farming in our country, This article mainly analysis the problems of dairy farming link, and puts torward the corresponding countermeasures and suggestions to solve these problems.

关键词： Dairy farming Problem Countermeasures