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Effect of electroacupuncture at Neiguan(PC6)at different time points on myocardial ischemia reperfusion arrhythmia in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 113-121页

作者： sun qianhui CHENG Kai DAI Xingye YANG Zhiwen WU Xiaoling XU Chang QIU Xinghua GAO Xiaofeng LIU Daonan YANG Qirui School of Acupuncture and Tuina Beijing University of Chinese MedicineBeijing 100029China Beijing MedEx Technology Co. Ltd.Beijing 100029China

OBJECTIVE:To observe the effects of electroacupuncture at Neiguan(PC6)at different time points on reperfusion arrhythmia(RA)after myocardial ischemia and reperfusion in rats,and to investigate the correlation of this protective effect with nerve growth factor(NGF),tyrosine kinase A(Trk A),tyrosine hydroxylase(TH),and norepinephrine(NE).METHODS:A total of 72 Sprague-Dawley male rats were randomly divided into six groups(n=12 rats/group):normal group(Norm),sham operation group(Sham),ischemia reperfusion group(I/R),pre-ischemic electroacupuncture group(EAI),pre-reperfusion electroacupuncture group(EAII),post-reperfusion electroacupuncture group(EAIII).The myocardial ischemia-reperfusion injury(MIRI)model was induced by occlusion of left anterior descending coronary artery for 20 min followed by reperfusion for 40 min in *** no intervention in the Norm group and only threading without ligation in the Sham *** pretreatment at 20 min/d for 7 d before ligation in the EAⅠgroup,20 min of electroacupuncture before reperfusion in the EAII group and 20 min of electroacupuncture after reperfusion in the EAIII *** electrocardiogram(ECG)of each group was recorded throughout the whole process,and the success of the MIRI model was determined based on the changs of J-point and T-wave in the *** arrhythmia score was used to record premature ventricular contractions,ventricular tachycardia and ventricular fibrillation during the reperfusion period to assess the reperfusion induced *** expression levels of NGF,Trk A,TH protein were measured by Western ***,the expression levels of plasma and myocardial NE levels were detected by enzyme linked immunosorbent ***:The differences between Norm group and Sham group were not statistically significant in all *** score,myocardial NGF,Trk A,TH,and NE expression were significantly higher in the I/R group compared with the Sham *** score,myocardial NGF,T

关键词： myocardial reperfusion injury reperfusion arrhythmia electroacupuncture point PC6(Neiguan) nerve growth factor protein-tyrosine kinases norepinephrine

Effect of electroacupuncture on inflammatory signal expression in local tissues of rats with chronic pelvic pain syndrome based on purinergic 2X7 receptor/NOD-like receptor pyrin domaincontaining 3 signal pathway

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Journal of Traditional Chinese Medicine 2022年第6期42卷 965-971页

作者： XU Chang LI Na WU Xiaoling DAI Xingye YANG Zhiwen sun qianhui SHI Tianyu CHAI Yemao PANG Dandan CHENG Kai Major in Acupuncture and Tuina school of Acupuncture and TuinaBeijing University of Chinese MedicineBeijing 100029China Experimental science of acupuncture and moxibustion teaching and research section school of Acupuncture and TuinaBeijing University of Chinese MedicineBeijing 100029China Complex laboratory school of Acupuncture and TuinaBeijing University of Chinese MedicineBeijing 100029China Meridians and acupoints teaching and research section school of Acupuncture and TuinaBeijing University of Chinese MedicineBeijing 100029China Academy of Chinese Medical Sciences Beijing 100700China

OBJECTIVES: To study the expression of inflammatory signal in local prostate tissue of chronic pelvic pain syndrome(CPPS) rats by electroacupuncture(EA) of Guanyuan(CV4), Zhongji(CV3), Huiyang(BL35) and Sanyinjiao(SP6), and to explore the possible mechanism of anti-inflammatory and analgesic effects of EA. METHODS : A total of 36 Sprague-Dawley male rats were randomly divided into three groups: control, model and EA(n=12 rats/group). The CPPS model was made by injection of CFA into ventral lobes of the prostate(0.1 m L). Electric acupuncture apparatus was applied to stimulate Guanyuan(CV4), Zhongji(CV3), bilateral Huiyang(BL35) and Sanyinjiao(SP6) acupoints in EA group. The general condition of rats was observed and the prostate index(PI) was calculated. The thermal pain threshold was collected after each therapeutic course. Histopathological changes of the prostate tissue were examined by hematoxylin-eosin staining method. The expression levels of tumor necrosis factor α(TNF-α), interleukin-1β(IL-1β) and prostaglandin E2(PGE2) in prostatic homogenates were measured by enzyme linked immunosorbent assay(ELISA). Moreover, the expression levels of purinergic 2X7 receptor(P2X7R), NOD-like receptor pyrin domain-containing 3(NLRP3), caspase-1 and interleukin-18(IL-18) m RNA were quantified by quantitative real-time polymerase chain reaction. RESULTS: Compared with control group, the PI of rats increased, and the thermal pain threshold decreased significantly in model group. The morphological structure of prostate tissues of rats in model group was severely damaged with a large number of inflammatory cells infiltration. Additionally, the levels of TNF-α, IL-1β and PGE2 were higher, and the expressions of P2X7R, NLRP3, caspase-1 and IL-18 m RNA were higher than those in control group. After EA treatment, the PI was significantly decreased, the thermal pain threshold was significantly increased, and the tissue damage was significantly improved. The expressions of inflammator

关键词： electroacupuncture inflammatory cytokines receptors purinergic P2X7 NLR family pyrin domain-containing 3 protein signal transduction chronic pelvic pain syndrome

Clinical Analysis of Early Noninvasive Mechanical Ventilation in the Treatment of Acute Left Heart Failure Complicated with Respiratory Failure

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国际感染病学（电子版） 2019年第2期8卷 5-7页

作者： Ting sun Tianfu GONG qianhui sun Jian ZHANG Jiaming CAO ICU 98~(th) Hospital CenterChinese people’s Liberation Army

Objective To evaluate the efficacy of early and non-early non-invasive mechanical ventilation(NIV) for acute left heart failure and respiratory failure. Methods 29 cases of patients with acute left heart failure and respiratory failure treated by NIV were selected from our department from August 2016 to March 2019. According to the time of initiation of noninvasive mechanical ventilation, the patients were divided into the early treatment group(group A, treatment with NIV immediately after admission, n=15) and the non-early treatment group(group B, treatment with NIV for 2 h after admission, n=14), the improvement time, mechanical ventilation time, effective rate, intubation rate and fatality rate were compared between the two groups. Results The improvement time of patients in group A was(4.8±2.5) hours, the time of mechanical ventilation was(9.6±3.2) hours, the improvement time of group B was(6.8±2.6) hours, and the time of mechanical ventilation(12.8±4.4) hours. There were significant differences between the two groups(P<0.05). In group A, 13 patients were cured, 2 patients were intubated, 1 patient died, 10 patients in group B were cured, 4 patients were intubated, and 2 patients died. The difference in cure rate, intubation rate and mortality was statistically significant(P<0.05). Conclusion The treatment of acute left heart failure and respiratory failure is effective, and early application can improve the cure rate, reduce intubation and mortality.

关键词： Left ventricular failure Respiratory Failure Mechanical Ventilation

Effects of Continuous Cropping of Panax notoginseng on the Properties of Rhizosphere Soil

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Agricultural Science & Technology 2017年第4期18卷 602-606页

作者： Kaiming LI Meixiang LIU qianhui sun Zilong ZHANG School of Life Science Beijing University of Chinese Medicine Beijing 100102 China School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing 100102 China School of Basic Medical Science Beijing University of Chinese Medicine Beijing 100102 China

[Objective] This experiment aimed to investigate the effects of continuous cropping of Panax notoginseng on the properties of rhizosphere soil. [Method] A total of 12 rhizospheres oil samples were collected in the fields continuously cropped with P. notoginseng for different years and the soil properties including pH value, contents of available N, available K, available P,total N, total K, total P and organic matter were determined. [Result] With the increase in the number of years of continuous cropping, seven soli indices: soil pH value, organic matter content, total N, total P, total K, available P and available K gradually increased, while available N showed a gradual downward trend. The contents of organic matter content, total N, total P, total K,available P, available K and available N after three years of continuous cropping were increased by 74.93%, 65.85%, 123.82%,18.78%, 341.67%, 120.16% and-32.16%, respectively, indicating that continuous cropping of P. notoginseng resulted in nutrient enrichment in rhizosphere soils. The pH value and available N in IBC(soil inside the border check) and UBC(soil under the border check) were higher than that in BBC(soil beside the border check), suggesting that the soil was gradually alkalized due to the continuous cropping of P. notoginseng. [Conclusion] These results suggest that pH change and nutrient imbalance may be the obstacles to the continuous cropping of P. notoginseng.

关键词： Continuous cropping Correlation Nutrient enrichment Panax notoginseng Soil properties

Comparison of Lumbopelvic-Hip Rotation Asymmetry and Pelvic Asymmetry between Individuals with and without Nonspecific Low Back Pain

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Journal of Biosciences and Medicines 2024年第9期12卷 314-328页

作者： qianhui sun Heng-Ju Lee Cheng-Feng Lin Rakhmad Rosadi Department of Physical Education and Sport Sciences National Taiwan Normal University Taipei City Department of Physical Therapy National Cheng Kung University Tainan Department of Physiotherapy Faculty of Health Science University of Muhammadiyah Malang Malang Indonesia

Background: low back pain affects many individuals, with 80% classified as non-specific low back pain (NSLBP) due to mechanical rather than structural issues. The link between pelvic alignment and lumbopelvic-hip rotation movement for NSLBP is controversial. Methods: twenty males with NSLBP and 20 healthy males participated. Data collected included static pelvic asymmetry and active lumbopelvic-hip rotation with motion capture system for kinematic analysis. Results: Unpaired T test was used to compare the difference of kinematic parameters between two groups. NSLBP group showed significantly larger angles between the ASIS-PSIS line and the z-axis (p Conclusion: Evaluations focusing on bone structure alone may be inadequate. A more comprehensive approach including functional assessments like muscle strength and range of motion could be beneficial. Integrating lumbopelvic-hip movement patterns and pelvic symmetry into clinical assessments should be considered, as they may be influenced by physical activity.

关键词： Low Back Pain Biomechanics Pelvic Alignment

局促与丰富——安徽南陵北宋管氏墓的空间研究

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美术研究 2024年第1期 68-73页

作者：孙千惠中央美术学院人文学院 100102

安徽南陵铁拐村出土的“安康郡太君”管氏墓墓葬等级较高,保存较为完整。本文在将其墓葬空间进行细分的基础上,对每一空间单元的内容和观念进行了讨论。从器物组成和摆放位置来看,南陵铁拐管氏墓在试图满足士大夫阶层理想丧仪规范的同时... 详细信息

安徽南陵铁拐村出土的“安康郡太君”管氏墓墓葬等级较高,保存较为完整。本文在将其墓葬空间进行细分的基础上,对每一空间单元的内容和观念进行了讨论。从器物组成和摆放位置来看,南陵铁拐管氏墓在试图满足士大夫阶层理想丧仪规范的同时,运用个性化手段,力求对狭小的墓葬空间进行充分填充,体现了宋代丧葬艺术的世俗化色彩。

关键词：宋墓墓葬空间南陵铁拐宋墓

Design and Realization of Communication Platform "CDream Creating a Dream" for College Students

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Asian Agricultural Research 2019年第2期11卷 114-116页

作者： Xiaoxuan MA Shengzhong DONG Zhuoran XU Nuo MEI qianhui sun Decai SHI Shenyang Normal University

With the increase of employment pressure,college students have aroused strong interest in innovation,entrepreneurship and competition,and they hope to get enough exercise to lay the foundation for future work. But since college students lack relevant experience and project model for reference,the descriptions on project title,format,plan and innovation angle are vague,and its declaration is often unsuccessful,which has frustrated the enthusiasm of college students. We hope to help college students declare " double creation" project via content design of " CDream creating a dream",to realize their dreams.

关键词： Innovation and entrepreneurship CDream creating a dream Project design

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洗钱罪司法适用的困境、反思与对策

法律适用 2023年第10期2023卷 81-90页

作者：栾莉孙芊慧中国人民公安大学法学院中国人民公安大学

洗钱罪在司法实践中存在适用率偏低、定性不准确、没有独立的入罪标准等问题。产生这些问题的原因是多方面的,对上游犯罪范围的限制、主观要素认定的分歧,均削弱了洗钱罪的适用;立法和司法解释加剧了洗钱罪与赃物犯罪的竞合与混乱;重视... 详细信息

洗钱罪在司法实践中存在适用率偏低、定性不准确、没有独立的入罪标准等问题。产生这些问题的原因是多方面的,对上游犯罪范围的限制、主观要素认定的分歧,均削弱了洗钱罪的适用;立法和司法解释加剧了洗钱罪与赃物犯罪的竞合与混乱;重视打击上游犯罪、忽视洗钱罪独立的入罪标准,导致将数额较小的洗钱行为入罪。对此,建议在立法方面取消洗钱罪上游犯罪的范围限制;司法方面,通过具体构成要件严格区分洗钱罪与赃物犯罪的界限,并以实质违法性确立洗钱罪的入罪标准。

关键词：洗钱罪赃物犯罪自洗钱上游犯罪

Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第3期24卷 248-261页

作者： Xuwentai LIU Yue WU Yanyi LI Kaiming LI Siyuan HOU Ming DING Jingmin TAN Zijing ZHU Yingqi TANG Yuming LIU qianhui sun Cong WANG Can ZHANG State Key Laboratory of Natural Medicines/Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases/Center of Advanced Pharmaceuticals and Biomaterials China Pharmaceutical UniversityNanjing 210009China

An effective therapeutic regimen for hepatic fibrosis requires a deep understanding of the pathogenesis *** fibrosis is characterized by activated hepatic stellate cells(aHSCs)with an excessive production of extracellular *** promoted activation of HSCs by M2 macrophages has been demonstrated,the molecular mechanism involved remains ***,we propose that the vitamin D receptor(VDR)involved in macrophage polarization may regulate the communication between macrophages and HSCs by changing the functions of *** confirm that activating the VDR can inhibit the effect of M2 macrophages on HSC *** exosomes derived from M2 macrophages can promote HSC activation,while stimulating VDR alters the protein profiles and reverses their roles in M2 macrophage *** muscle cell-associated protein 5(SMAP-5)was found to be the key effector protein in promoting HSC activation by regulating autophagy *** on these results,we show that a combined treatment of a VDR agonist and a macrophage-targeted exosomal secretion inhibitor achieves an excellent anti-hepatic fibrosis *** this study,we aim to elucidate the association between VDR and macrophages in HSC *** results contribute to our understanding of the pathogenesis mechanism of hepatic fibrosis,and provide potential therapeutic targets for its treatment.

关键词： Hepatic fibrosis Hepatic stellate cell(HSC) Macrophage Exosome Vitamin D receptor(VDR) Smooth muscle cell-associated protein 5(SMAP-5)