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Spatial Pattern and Development of Protected Areas in the North-south Transitional Zone of China

Chinese Geographical Science 2021年第1期31卷 149-166页

作者： LI Xiang MA Beibei LU Chunxia YANG He sun mengyu School of Geography and Tourism Shaanxi Normal UniversityXi'an 710119China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

The north-south transitional zone in China mainly consists of the Qinling-Daba Mountains. It is the most important West-East geo-ecological space in China, containing protected areas vital for biodiversity conservation and ecological security of China. The protection and rational development of its natural habitat is of great significance to China’s ecological security and integration of protected areas based on mountain forest ecosystems on a global scale. In this study, five important types of protected areas in the transitional zone were selected, and their spatial patterns were analysed. Spatial analysis methods, such as kernel density estimation and accessibility analysis, were employed for both point and areal data, and focused on four aspects: land use scale, shift in the centre of gravity, spatial agglomeration, and accessibility. In addition, policy background and evolution of spatial and temporal characteristics of the protected area system in the transitional zone from 1963 to 2017 were also examined. We analysed the characteristics and geographical significance of the West-east corridor using the spatial pattern of the protected area system from the perspective of ecological and economic spaces. We focused on spatial shape, type intersection, and key areas to analyse the spatial overlap of the protected areas. Protected area establishment was divided into three stages: initial(1956–1980), rapid development(1981–2013), and national park transformation(2014–present). These stages reflected the change in the concept of ‘simple protection—sustainable use—integration and upgrade’ for protected areas of China. The spatial centre of gravity of the protection zone system was located in the west Qinling-Daba Mountains, and its high-density core exhibited a relatively stable N-shaped structure composed of four gathering areas. Affected by factors such as geographic environment and socio-economic development density, the average access time for protected areas was

关键词： North-south Transitional Zone(NSTZ) protected area(PA) spatial-temporal pattern accessibility the West-east corridor spatial overlap

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Specific generation of nitric oxide in mitochondria of cancer cell for selective oncotherapy

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Nano Research 2022年第6期15卷 5273-5278页

作者： mengyu sun Yanjuan Sang Qingqing Deng Zhengwei Liu Jinsong Ren Xiaogang Qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100039China

Nitric oxide(NO)gas therapy,especially,L-arginine(L-Arg)-based NO treatment strategies have attracted extensive attention in the field of ***,current strategies are unable to differentiate well between normal cells and cancer cells,which may lead to unpredictable *** by the fact that mitochondria of cancer cells can express excessive nitric oxide synthetase(NOS),herein,a nanozyme-based NO generator,cerium oxide(CeO_(2))-AT,is fabricated to specifically catalyze the production of NO in cancer cells for selective tumor *** this system,after being endocytosed into cancer cells,the generator can produce a number of NO under the catalysis of NOS in mitochondria of cancer cells,which can disrupt the mitochondrial respiratory chain of tumor cells and further induce cell *** addition,the generator with catalase(CAT)-like activity can catalyze H_(2)O_(2)to produce O_(2),which can promote the generation of NO and improve the performance of NO gas *** is more,our system has no obvious impact on the viability of normal cells owing to the less production of *** work paves a new way for the development of highly selective NO-based treatment particularly useful for the safe and specific cancer therapy.

关键词： nitric oxide nitric oxide synthetase nanozyme mitochondria specific cancer therapy

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Large Active Faults and the Wharton Basin Intraplate Earthquakes in the Eastern Indian Ocean

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Journal of Ocean University of China 2023年第6期22卷 1563-1571页

作者： CHEN Jie GUO Laiyin YANG Xiaodong ZHANG Jinchang ZHANG Zhiwen sun mengyu LIN Jingxue Fourth Institute of Oceanography Ministry of Natural ResourcesBeihai 536007China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China CAS Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyInnovation Academy of South China Sea Ecology and Environmental EngineeringChinese Academy of SciencesGuangzhou 511458China China-Pakistan Joint Research Center on Earth Science CAS-HECIslamabad 45320Pakistan University of Chinese Academy of Sciences Beijing 100049China

In recent years,great earthquakes occurred within the Wharton Basin in the eastern Indian Ocean,and they have been associa-ted with active faulting on the ancient oceanic *** seismogenic faults were thought to be the fault reactivation on the ancient oceanic crust,but these phenomena are still unclear and require *** study used high-quality multibeam bathymetry and multichannel seismic data collected over the northern Ninetyeast Ridge to investigate detailed fault geometry,structure,and *** recognized 12 large linear active faults by integrating bathymetry maps and multichannel seismic reflection *** results showed that these faults have high angles,and they all displaced the basement and propagated to the seafloor with distinct fault *** trended NWW-SEE with a spacing of 10–40km and were parallel to each other and the nearby subfault of the 2012 great intraplate earthquake,suggesting similar stress *** faults are also in agreement with the orientations of magnetic isochrons,implying their formation by seafloor ***,regarding the strike-slip focal mechanism of 2012 earthquakes,we proposed that these faults were created early by a normal spreading process and then evolved into a strike-slip pattern since the ancient oceanic crust ap-proached the subduction zones.

关键词： Ninetyeast Ridge Wharton Basin strike-slip faults great earthquakes seismogenic structure earthquake mechanism

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Understanding the dynamical-microphysical-electrical processes associated with severe thunderstorms over the Beijing metropolitan region

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Science China Earth Sciences 2021年第1期64卷 10-26页

作者： Xiushu QIE Shanfeng YUAN Zhixiong CHEN Dongfeng WANG Dongxia LIU mengyu sun Zhuling sun Abhay SRIVASTAVA Hongbo ZHANG Jingyu LU Hui XIAO Yongheng BI Liang FENG Ye TIAN Yan XU Rubin JIANG Mingyuan LIU Xian XIAO Shu DUAN Debin SU Chengyun sun Wenjing XU Yijun ZHANG Gaopeng LU Da-Lin ZHANG Yan YIN Ye YU Key Laboratory of Middle Atmosphere and Global Environment Observation(LAGEO) Institute of A tmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Cloud-Precipitation Physics and Severe Storms(LACS) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China College of Atmospheric Science Chengdu University of Information TechnologyChengdu 610225China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration Nanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Earth and Planetary Science University of Chinese Academy of ScienceBeijing 100049China Meteorological Observation Centre Beijing Meteorological BureauBeijing 100081China Jiangxi Weather Modification Nanchang 330096China Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Department of Atmospheric and Oceanic Science University of MarylandMaryland 20742USA

The Dynamical-microphysical-electrical Processes in Severe Thunderstorms and Lightning Hazards(STORM973)project conducted coordinated comprehensive field observations of thunderstorms in the Beijing metropolitan region(BMR)during the warm season from 2014 to *** aim of the project was to understand how dynamical,microphysical and electrical processes interact in severe thunderstorms in the BMR,and how to assimilate lightning data in numerical weather prediction models to improve severe thunderstorm *** platforms used in the field campaign included the Beijing Lightning Network(BLNET,consisting of 16 stations),2 X-band dual linear polarimetric Doppler radars,and 4 laser raindrop *** collaboration also made use of the China Meteorological Administration’s mesoscale meteorological observation network in the Beijing-Tianjin-Hebei *** diverse thunderstorm types were documented,it was found that squall lines and multicell storms were the two major categories of severe thunderstorms with frequent lightning activity and extreme rainfall or unexpected local short-duration heavy rainfall resulting in inundations in the central urban area,influenced by the terrain and environmental *** flash density maximums were found in eastern Changping District,central and eastern Shunyi District,and the central urban area of Beijing,suggesting that the urban heat island effect has a crucial role in the intensification of thunderstorms over *** addition,the flash rate associated with super thunderstorms can reach hundreds of flashes per minute in the central city *** super(5%of the total),strong(35%),and weak(60%)thunderstorms contributed about 37%,56%,and 7%to the total flashes in the BMR,*** to the close connection between lightning activity and the thermodynamic and microphysical characteristics of the thunderstorms,the lightning flash rate can be used as an indicator of severe weather events,such as hail

关键词： Lightning 3D location Dual linear polarimetric Doppler radar Severe thunderstorm Lightning data assimilation Hail Short-term heavy precipitation

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Fufang E’jiao Jiang’s effect on immunity,hematopoiesis,and angiogenesis via a systematic“compound-effect-target”analysis

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Food Science and Human Wellness 2024年第5期13卷 2813-2832页

作者： Xiang Li Xiao Xu Ying Dong Shusheng Fan Xueyang Ren Yuan Zheng Jiamu Ma Feng Zhang Qingyue Deng Xianxian Li Yingyu He mengyu sun Wei Liu Mengxia Li Qing Xia Yan Zhang Gaimei She School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Biology Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan 250103China National Engineering Research Center for Gelatin-based Traditional Chinese Medicine Dong-E-E-Jiao Co.Ltd.Liaocheng 252201China

Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s *** find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were *** on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of *** data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by *** bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and *** studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.

关键词： Fufang E’jiao Jiang Zebrafish(Danio rerio) Network pharmacology Transcriptome Bibliometrics

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不同氮肥在石灰性潮土中的转化及ATS对尿素氮转化的调控效应

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农业工程学报 2023年第24期39卷 100-108页

作者：王硕孙梦宇李长青孙志梅河北农业大学资源与环境科学学院保定071000 河北省农田生态环境重点实验室保定071000

根据氮肥施入土壤后的转化特性进行氮肥的高效调控和管理是提高氮肥利用效率、缓解氮肥污染的重要措施。为探究不同氮肥在石灰性潮土中的转化特性差异及硫代硫酸铵(ammonium thiosulfate,ATS)作为氮肥调控剂对尿素氮转化的影响,该研究... 详细信息

根据氮肥施入土壤后的转化特性进行氮肥的高效调控和管理是提高氮肥利用效率、缓解氮肥污染的重要措施。为探究不同氮肥在石灰性潮土中的转化特性差异及硫代硫酸铵(ammonium thiosulfate,ATS)作为氮肥调控剂对尿素氮转化的影响,该研究采用室内土壤培养(土壤水分含量为田间持水量的60%,温度25℃)试验方法,以尿素、硫酸铵、氯化铵和ATS作为供试肥料,比较4种氮肥施入石灰性潮土后的转化特性差异,并以ATS作为氮素调控剂,以单施尿素作为对照,探究尿素配施不同用量ATS对尿素氮转化的影响。结果表明,4种供试氮肥在石灰性潮土中的转化过程明显不同。尿素在石灰性潮土中的水解速率快,硝化作用强度也最高,硫酸铵其次;氯化铵由于Cl^(−)的硝化抑制作用,土壤表观硝化率在7~21 d显著低于尿素和硫酸铵(P<0.05);ATS施入土壤后,NH_(4)^(+)-N转化为NO_(2)^(−)-N的速率最高,而NO_(2)^(−)-N转化为NO_(3)^(−)-N的速率最低,NH_(4)^(+)-N在土壤中的存留时间最长,出现峰值之后也一直保持最高的含量,表观硝化率最低。将ATS作为氮素调控剂与尿素配合施用,当其用量在60 mg/kg(含S量)以上时,既表现出了明显的抑制尿素水解的作用效果,也表现出了显著的硝化抑制作用(P<0.05),且随着ATS用量的增加,抑制效应明显增强。这对于减少氮素损失,提高氮肥利用效率具有积极意义。但供试4种氮肥施入土壤后均出现了亚硝酸盐的累积,其中ATS处理的累积量显著高于尿素、硫酸铵和氯化铵(P<0.05),累积持续时间也最长。ATS作为氮素调控剂调控氮素转化,也出现了类似的结果,且随着ATS用量增加,亚硝酸盐在土壤中存留时间明显延长,含量和峰值明显提高,出现峰值的时间也明显延后。

关键词：土壤氮肥氮素转化脲酶抑制剂硝化抑制剂硫代硫酸铵(ATS)

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基于油中水分含量的变压器绝缘纸寿命评估

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高电压技术 2018年第8期44卷 2541-2547页

作者：李长云孙孟玉张迎春齐鲁工业大学电气工程与自动化学院

水分是影响电力变压器油纸绝缘性能的重要因素,如何通过油中水分含量简单、准确地判断变压器绝缘纸的老化状态成为当今研究的重点。本文首先分析了油纸绝缘系统的水分来源及其危害,然后基于频率因数a的Taylor展开式得出a与绝缘纸中水分... 详细信息

水分是影响电力变压器油纸绝缘性能的重要因素,如何通过油中水分含量简单、准确地判断变压器绝缘纸的老化状态成为当今研究的重点。本文首先分析了油纸绝缘系统的水分来源及其危害,然后基于频率因数a的Taylor展开式得出a与绝缘纸中水分含量间存在正比关系,进而得到了计及水分含量的修正Arrhenius定律。其次,结合化学反应动力学推得绝缘纸中水分含量与聚合度间的量化关系,并根据纤维素老化对Oommen油纸水分平衡的影响,获得了绝缘纸的聚合度（degree of polymerization,DP）与油中水分含量间数量关系的修正表达式;在此基础上推得了绝缘纸特征寿命的预测判据。最后,通过实验数据表明未考虑绝缘纸老化影响时,油纸水分与纸中水分间的表达式的计算误差为20%～50%,基于油中水分含量的DP表达式的计算误差为3.8%～38.4%;而修正表达式可分别将上述误差降低到12.5%以下及23.3%以下。当老化温度为140℃,油中水分的体积分数分别为10^（-6）和13×10^（-6）时,绝缘纸的特征寿命分别为65天和12天。

关键词：电力变压器油纸绝缘系统聚合度水分含量寿命预测判据

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Discovery of active compounds and key targets of Thymus quinquecostatus Celak. based on gastrointestinal metabolism and Gut flora-Compound-Target-Pathway network with TOPSIS method

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Food Science and Human Wellness 2024年

作者： Xueyang Ren Jiamu Ma Ying Dong Yuan Zheng Rufeng Wang Chongjun Zhao Wei Liu Mingxia Li mengyu sun Feng Zhang Yingyu He Xianxian Li Qingyue Deng Gaimei She School of Chinese Materia Medica， Beijing University of Chinese Medicine School of Life Sciences， Beijing University of Chinese Medicine Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica

Thymus quinquecostatus Celak.， a traditional aromatic edible plant from Lamiaceae， is widely used as food additive， food condiment， spice， and herbal teas. Its polyphenol-rich fraction （PRF） has been proven to be effective protective effect for cerebral ischemia reperfusion injury （CIRI） in our previous study. In this study， we developed a novel “Gut flora-Compound-Target-Pathway” （GCTP） network based on network pharmacology coupled with gastrointestinal metabolism for screening bio-active components， key targets and gut floras through the classical technique for order preference by similarity to ideal solution （TOPSIS） method. This compensates for the lack of gut floras and gastrointestinal metabolism in network pharmacology. Firstly， four incubation models covering simulated gastric juice， simulated intestinal juice， gut floras of normal and transient middle cerebral artery occlusion （tMCAO） rat in vitro were applied to PRF. The 109 proto-components and 64 metabolites were elucidated by UPLC-QE-Orbitrap-MSn. Then， the key targets of MMP9， PTGS2， FYN， ESR1， APP， and EGFR， and gut floras of Enterococcus avium LY1 were selected. Moreover， the selected key proto-components were rosmarinic acid， daidzein， quercetin， luteolin， apigenin， methyl rosmarinate， kaempferol， luteoloside， and caffeic acid， and the key metabolites were isokaempferide， isorhamnetin， isoquercetin， and mangiferin. Binding of compounds to the key proteins was analyzed by molecular docking， and also verified though a AAPH induced oxidative stress zebrafish model and qRT-PCR assays. This study provides a new idea and a better understanding of PRF for its protective effects on CIRI and its underlying mechanisms.

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Role of chemokines in the hepatocellular carcinoma microenvironment and their translational value in immunotherapy

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Oncology and Translational Medicine 2022年第1期8卷 1-17页

作者： Yijun Wang mengyu sun Tongyue Zhang Yangyang Feng Xiangyuan Luo Meng Xie Xiaoyu Ji Danfei Liu Wenjie Huang Limin Xia Department of Gastroenterology Institute of Liver and Gastrointestinal DiseasesHubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hepatic Surgery Center Hubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The difficulty of early diagnosis,high tumor heterogeneity,and high recurrence and metastasis rates lead to an unsatisfactory treatment status for hepatocellular carcinoma(HCC).HCC is a typical inflammation-driven *** inflammation allows nascent tumors to escape *** are small,soluble,secreted proteins that can regulate the activation and trafficking of immune cells during *** studies have shown that various chemokines with overarching functions disrupt the immune microenvironment during the initiation and progression of *** dysregulated chemokine network in HCC contributes to multiple malignant processes,including angiogenesis,tumor proliferation,migration,invasion,tumor low response,and resistance to immune ***,we summarize the current studies focusing on the role of chemokines and their receptors in the HCC immune microenvironment,highlighting potential translational therapeutic uses for modulating the chemokine system in HCC.

关键词： hepatocellular carcinoma chemokine chemokine receptor tumor microenvironment immune therapy therapeutic target

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基于声发射频谱的次生胶结岩体加卸载损伤特性

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中南大学学报（自然科学版） 2024年第7期55卷 2763-2779页

作者：朱凌崔圣华裴向军孙平贺梁玉飞孙梦宇中南大学地球科学与信息物理学院湖南长沙410083 滑坡灾害风险预警与防控应急管理部重点实验室(成都理工大学) 四川成都610059 地质灾害防治与地质环境保护国家重点实验室(成都理工大学) 四川成都610059

斜坡岩体裂隙中广泛存在后期次生胶结物,地震过程中次生胶结岩体极易发育密集微裂纹。开展单轴静荷载和加卸载试验,通过声发射频谱演化特征研究荷载条件下次生胶结物对岩体微裂纹扩展过程的影响。研究结果表明:静荷载下小尺度裂纹、微... 详细信息

斜坡岩体裂隙中广泛存在后期次生胶结物,地震过程中次生胶结岩体极易发育密集微裂纹。开展单轴静荷载和加卸载试验,通过声发射频谱演化特征研究荷载条件下次生胶结物对岩体微裂纹扩展过程的影响。研究结果表明:静荷载下小尺度裂纹、微小裂纹、沿晶裂纹和穿晶裂纹贯穿整个试验过程,低频高频信号对应的大尺度裂纹主要产生在不稳定扩展阶段,加卸载条件下声发射主频演化类型受到次生胶结物面积的影响,次生胶结物对岩体损伤起主要控制作用,降低了造成岩体损伤的应力阈值,加卸载作用下次生胶结物与岩石性质差异造成的非协调变形是造成损伤的根本原因。

关键词：次生胶结岩体加卸载声发射频谱渐进损伤

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