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Erzhi pills ameliorates cognitive dysfunction and alter proteomic profiles of hippocampus in ovariectomized Alzheimer disease model rats induced by D-galactose and Aβ1-40 injection

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中国药理学与毒理学杂志 2021年第9期35卷 658-659页

作者： XIE Yong-yan HOU Min ZHOU Mao-fu YAN Bo LIU Chao YAO Li-hua sun men-sheng HE Kun FANG Cong CHEN Yao-hui HUANG Li-ping LIU Bo School of Pharmacy Jiangxi University of Traditional Chinese MedicineNanchang 330004China College of traditional Chinese medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004China the Second People′s Hospital of Jingdezhen Jingdezhen 333099China Shandong Qidu Pharmaceutical Co. Ltd.Zibo 255400China Jiangxi Provincial People′s Hospital Affiliated to Nanchang University Nanchang 330006China China Pharmaceutical University Nanjing 211198China School of Life Science Jiangxi Science&Technology Normal UniversityNanchang 330096China 不详

OBJECTIVE Erzhi pills is a clas⁃sic prescription of Chinese medicine originated from Fu Shou Jing Fang in Ming dynasty,with the effects of nourishing kidney-Yin and hemosta⁃sis,black hair,strengthening muscles and *** a classical prescription for nourishing kidney-Yin,Erzhi pills has been used to treat senile dementia in China for many ***,our study aimed to investigate the protective effects of Erzhi pills in rat models of Alzheimer disease(AD)induced by ovariectomy as well as D-galactose and Aβ1-40 injection and to explore its potential *** The model of AD rats was established by ovariectomy com⁃bined with D-galactose and Aβ1-40 *** rats were randomly divided into four groups:model group,estradiol valerate(0.80 mg·kg-1)group,Erzhi pills high(1.50 mg·kg-1)and low(0.75 mg·kg-1)doses *** addition,rats of sham operation were selected as the sham operated *** for the sham oper⁃ated group,rats were injected intraperitoneally with D-galactose(100 mg·kg-1 per day,for 49 d)on the 8th day,then they were given intracerebro⁃ventricular injection of Aβ1-40(10μg per rat,1 g·L-1)on the 36th day,while the corresponding drugs were given by gastrointestinal administra⁃tion on the 22nd *** our study,Morris water maze test was used to evaluate the learning and memory abilities,while ELISA kit was used to an⁃alyze serum estrogen *** morphology of hippocampal neuron cells was observed by HE staining,and Nissl staining was utilized to ob⁃serve the Nissl body in ***,the ex⁃pression of ERβpositive cells and hippocampal Aβ1-40 and p-Tau404 proteins was determined by *** order to further explore the molecular mechanism of Erzhi pills preven⁃tion and treatment of AD,proteomics was used to find potential targets and related pathways,Western blotting was used to verify the expres⁃sion of candidate differential *** to the results of proteomics in our experiment,Western blotting w

关键词： Erzhi pills Alzheimer disease hip⁃pocampal neurons proteomics estrogen aging memory PI3K/Akt signaling pathway

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

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Substrate bias effects in p-channel GaN-on-Si transistors

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Science China(Information Sciences) 2025年第1期68卷 404-405页

作者： mengyao ZHAO Jie MA Lanlan YANG Chuanqi PAN Denggui WANG Jianjun ZHOU sheng LI Jiaxing WEI Long ZHANG Siyang LIU Weifeng sun National ASIC System Engineering Research Center School of Integrated Circuits Southeast University National Center of Technology Innovation for Electronic Design Automation Southeast University National Key Laboratory of Solid-State Microwave Devices and Circuits

The drain current （ID） of the n-channel GaN field-effecttransistor （n-FET） is influenced by the substrate-to-source bias voltage (VBS)（substrate bias effect）[1].Actually,nonzero VBSis also likely to occur in p-FET in real application,because the source electrode of p-FET is usually connected to high *** study reports the dependency between IDand VBSin p-FET for the first time,and analyzes the underlying mechanisms from the perspective of vertical electric field （EF） distribution.

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Optimal Dispatch of Electricity-gas-hydrogen Hybrid Integrated Energy System Considering Seasonal Hydrogen Storage

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Dianwang Jishu/Power System Technology 2025年第1期49卷 32-40页

作者： Chen, Mingjian Chen, sheng Wei, Zhinong sun, Guoqiang Zhou, Yizhou School of Electrical and Power Engineering Hohai University Jiangsu Province Nanjing 211100 China

Seasonal electricity imbalance in a renewable-dominant power system results in long-term and short-term coordinated scheduling challenges. Therefore, an optimal scheduling model of an electricity-gas-hydrogen hybrid integrated energy system considering seasonal hydrogen storage is proposed based on electricity-gas-hydrogen coupling. First, typical scenarios in high- and low-energy seasons are obtained based on time series decomposition and scene clustering method. Then, the operation model of the electricity-gas-hydrogen hybrid integrated energy system is developed based on the DC power flow model of the power system, and the quasi-dynamic natural-gas flow model considers green hydrogen injections. Moreover, sequential second-order cone programming is proposed to efficiently deal with nonlinear constraints in the gas flow model. Finally, numerical results verify the proposed model's economy and the solution method's feasibility. The multi-energy coupling relationship between electricity, gas, and hydrogen under seasonal hydrogen storage is also analyzed. Simulation results show that the operating cost of the proposed model is reduced by 6.43% compared with that obtained from traditional electricity-gas systems. © 2025 Power System Technology Press. All rights reserved.

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Composite Anti-Disturbance Control of Hidden Semi-Markov Jump Systems via Disturbance Observer

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Journal of Systems Science & Complexity 2023年第6期36卷 2255-2273页

作者： men Yunzhe sun Jian National Key Lab of Autonomous Intelligent Unmanned Systems School of AutomationBeijing Institute of TechnologyBeijing100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing401120China

This paper focuses on the disturbance suppression issue of hidden semi-Markov jump systems leveraging composite *** system consists of a semi-Markov layer and an observed mode sequence layer,and it is subject to a matched disturbance generated by an exogenous system and a mismatched disturbance that is norm *** proposal is to design a composite controller based on a disturbance observer to counteract and attenuate the disturbances *** constructing a special Lyapunov function comparison point,the exponential stability is analyzed with the stability criterion in the form of linear matrix inequality is *** simulation examples are provided to demonstrate the practical merits of the composite controller relative to the single H_(∞)control.

关键词： Composite control disturbance observer ε-error hidden semi-Markov jump systems

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Equilibrium and mechanism studies of gold(Ⅰ)extraction from alkaline aurocyanide solution by using fluorine-free ionic liquids

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Rare Metals 2021年第7期40卷 1987-1994页

作者： Ya-Ting Wang men Liu Nian Tang sheng-Jian Li Yan sun Shi-Xiong Wang Xiang-Jun Yang Key Laboratory of Medicinal Chemistry for Natural Resource(Yunnan University) Ministry EducationSchool of Chemical Science and TechnologyYunnan UniversityKunming 650091China

Solvent extraction based on ionic liquids is generally considered to be an environmentally benign and effective technology for gold(Ⅰ)*** aim of this work is to study gold(Ⅰ)extraction from aurocyanide solution using fluorine-free ionic liquids[A336][SCN],[A336][MTBA]and[A336][Mal].Various factors that affect gold(Ⅰ)extraction(including concentration of ionic liquids,equilibrium pH,concentration of the modifier tributyl phosphate(TBP),reaction time and initial concentration of gold in an aqueous solution)were studied and *** results indicate that the three Aliquat336-based ionic liquids all exhibit excellent behaviors for gold(Ⅰ)*** than 99.8%of gold(Ⅰ)can be extracted from the aqueous phase into the ionic liquid *** gold-loaded ionic liquids were characterized using infrared spectroscopy and mass spectrometry to study the extraction mechanism of gold(Ⅰ).The results revealed that extraction of gold(Ⅰ)into the ionic liquid phase was based on an exchange reaction between the anion Au(CN)2-in aqueous solution and the anion SCN-in ionic liquid[A336][SCN].The logarithmic relationship between distribution coefficient and TBP concentration indicates that two TBP molecules are involved in the formation of the extracted *** extracted complex was determined to be A336^(+)·Au(CN)_(2)^(-)·2 *** addition,the gold(Ⅰ)-loaded ionic liquids can be efficiently stripped using NH4 SCN,2-methylthiobenzoic acid and methyl *** results establish that Aliquat 336-based ionic liquids have potential application prospects in gold(Ⅰ)recovery from cyanide solutions.

关键词： Gold(Ⅰ) Solvent extraction Ionic liquid Alkaline aurocyanide solution

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Control of 2-D Semi-Markov Jump Systems:A View from Mode Generation Mechanism

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 258-260页

作者： Yunzhe men Jian sun Jie Chen the National Key Laboratory of Autonomous Intelligent Unmanned Systems the School of AutomationBeijing Institute of TechnologyBeijing 100081 the Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China the Department of Control Science and Engineering Tongji UniversityShanghai 201804 the National Key Laboratory of Autonomous Intelligent Unmanned Systems Beijing Institute of TechnologyBeijing 100081China

Dear Editor,Two-dimensional(2-D) systems have wide applications in image data processing,gas absorption and fluid dynamics analysis [1]-[3].When there exist abrupt changes in 2-D systems,they are usually modeled by 2-D Markov jump systems(MJSs) or 2-D semi-Markov jump systems(SMJSs).This letter investigates the control of 2-D SMJSs based on a novel mode generation mechanism,which could avoid mode ambiguousness phenomenon caused by the evolution of system mode in two different *** criterion that guarantees the almost surely exponential stability of the system is obtained.A thermal process is studied to demonstrate the availability of the proposed method.

关键词： Markov mode system

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Wavelet neural network based watermarking technology of 2D vector maps

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High Technology Letters 2011年第3期17卷 259-262页

作者： sun Jianguo men Chaoguang School of Computer Science and Technology Harbin Engineering University Harbin 150001 P. R. China

A novel lossless information hiding algorithm based on wavelet neural network for digital vector maps is introduced. Wavelet coefficients being manipulated are embedded into a vector map, which could be restored by adjusting the weights of neurons in the designed neural network. When extracting the watermark extraction, those coefficients would be extracted by wavelet decomposition. With the trained multilayer feed forward neural network, the watermark would be obtained finally by measuring the weights of neurons. Experimental results show that the average error coding rate is only 6% for the proposed scheme and compared with other classical algorithms on the same tests, it is indicated that the proposed algorithm hashigher robustness, better invisibility and less loss on precision.

关键词： information hiding digital watermarking vector map neural network

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非对称中空环形聚能装药成型与侵彻特性影响因素分析

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爆炸与冲击 2025年第1期45卷 41-50页

作者：李召婷王树有孙圣杰蒋建伟门建兵北京理工大学爆炸科学与安全防护全国重点实验室北京100081 北京理工大学唐山研究院河北唐山063000

为减弱中空环形聚能装药形成的中心侵彻体对后级结构的破坏作用,通过改变环锥罩的偏心距离和壁厚,调整了装药和药型罩的质量分布,使之形成准直环形射流,研究了炸高对环形射流侵彻威力的影响规律。数值模拟结果表明:内壳为铝合金时的中... 详细信息

为减弱中空环形聚能装药形成的中心侵彻体对后级结构的破坏作用,通过改变环锥罩的偏心距离和壁厚,调整了装药和药型罩的质量分布,使之形成准直环形射流,研究了炸高对环形射流侵彻威力的影响规律。数值模拟结果表明:内壳为铝合金时的中心孔平均侵彻深度较内壳为钢时的平均侵彻深度低36.13%;非偏心环锥罩形成的射流存在径向偏移,侵彻能力较弱。当环锥罩顶向外侧偏移0.05d(d为环形装药厚度)时,射流准直性较好,环形射流侵彻深度较大;随着药型罩壁厚的增加,射流头部速度不断减小,当壁厚为0.045d时,偏心环锥罩形成的环形射流侵彻能力较强;环形射流侵彻深度对炸高较为敏感,在炸高为1.12d时,环形射流侵彻深度较大。针对非偏心环锥罩和偏心环锥罩两种药型罩结构开展的静破甲试验表明,环形射流侵彻深度和扩孔直径的试验结果与数值模拟结果误差小于12%,验证了数值模拟模型的可靠性。

关键词：环形聚能装药偏心药型罩射流成型射流侵彻

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A combined evaluation of the characteristics and antibiotic resistance induction potential of antibiotic wastewater during the treatment process

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Journal of Environmental Sciences 2024年第4期138卷 626-636页

作者： sun Miao Yanyan Zhang Cong men Yiou Mao Jiane Zuo State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China School of Energy and Environmental Engineering Beijing Key Laboratory of Resource-Oriented Treatment of Industrial PollutantsUniversity of Science and Technology BeijingBeijing 100083China High School Affiliated to Renmin University of China Beijing 100080China Tsinghua Shenzhen International Graduate School Shenzhen 518055China

Antibiotic wastewater contains a variety of pollutant stressors that can induce and promote antibiotic resistance(AR)when released into the *** these substances are mostly in concentrations lower than those known to induce AR individually,it is possible that antibiotic wastewater discharge might still promote the AR transmission risk via additive or synergistic ***,the comprehensive effect of antibiotic wastewater on AR development has rarely been evaluated,and its treatment efficiency remains ***,samples were collected from different stages of a cephalosporin production wastewater treatment plant,and the potential AR induction effect of their chemical mixtures was explored through the exposure of the antibiotic-sensitive Escherichia coli K12 *** with raw cephalosporin production wastewater significantly promoted mutation rates(3.6×10^(3)-9.3×10^(3)-fold)and minimum inhibition concentrations(6.0-6.7-fold)of *** against ampicillin and *** may be attributed to the inhibition effect and oxidative stress of cephalosporin wastewater on *** AR induction effect of cephalosporin wastewater decreased after the coagulation sedimentation treatment and was completely removed after the full treatment process.A Pearson correlation analysis revealed that the reduction in the AR induction effect had a strong positive correlation with the removal of organics and biological *** indicates that the antibiotic wastewater treatment had a collaborative processing effect of conventional pollutants,toxicity,and the AR induction *** study illustrates the potential AR transmission risk of antibiotic wastewater and highlights the need for its adequate treatment.

关键词： Antibiotic wastewater treatment plant Antibiotic resistance Antibiotic resistance induction effect Correlation analysis Biological toxicity

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