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Heat-killed Lactobacillus paracasei JY56 can relieve ovalbumin-induced food allergy via regulating immuno-inflammatory responses and gut microbiota

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Food Science and Human Wellness 2024年

作者： Miao Zheng Ming Ma Ruxue Fang Yilin sun Xinyan Yang Chaoxin man Qianyu Zhao Yujun Jiang Key Lab of Dairy Science， Ministry of Education， College of Food Science， Northeast Agricultural University

Food allergy (FA) is an aberrant immune response triggered by the ingestion of a food antigen. Ovalbumin (OVA)-sensitized and challenged BALB/c mice were orally administered heat-killed (HK)-L. paracasei JY56. In this work， HK-L. paracasei JY56 alleviated the FA-induced decrease in body weight and rectal temperature and reduced the allergy score. Serum analysis showed that HK-L. paracasei JY56 reduced the levels of specific antibodies (OVA-sIgE and OVA-sIgG) and allergic mediators (histamine and mast cell protease) in FA mice. In addition， HK-L. paracasei JY56 also could alleviate OVA-induced FA by suppressing Th2 and Th17-type immune responses， which was evidenced by the regulation of splenic lymphocyte subpopulations and associated cytokine secretion. Moreover， jejunal histological analysis and intestinal barrier function related gene expression measurement were performed to verify the intestinal barrier repair of HK-L. paracasei JY56. Meanwhile， the TLR4/NF-κB inflammatory pathway activation was inhibited by HK-L. paracasei JY56 at gene and protein levels. Finally， HK-L. paracasei JY56 was performed to modulate the gut microbiota structure and increase the levels of short-chain fatty acids. In conclusion， HK-L. paracasei JY56 could alleviate OVA-induced FA in multiple ways， and this study provides a theoretical basis for the application of inactivated probiotics in functional foods for FA.

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ONE-PARAMETER FINITE DIFFERENCE METHODS AND THEIR ACCELERATED SCHEMES FOR SPACE-FRACTIONAL SINE-GORDON EQUATIONS WITH DISTRIBUTED DELAY

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Journal of Computational Mathematics 2024年第3期42卷 705-734页

作者： Tao sun Chengjian Zhang Haiwei sun School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan 430074China Department of Mathematics University of MacaoMacaoChina

This paper deals with numerical methods for solving one-dimensional(1D)and twodimensional(2D)initial-boundary value problems(IBVPs)of space-fractional sine-Gordon equations(SGEs)with distributed *** 1D problems,we construct a kind of oneparameter finite difference(OPFD)*** is shown that,under a suitable condition,the proposed method is convergent with second order accuracy both in time and *** implementation,the preconditioned conjugate gradient(PCG)method with the Strang circulant preconditioner is carried out to improve the computational efficiency of the OPFD *** 2D problems,we develop another kind of OPFD *** such a method,two classes of accelerated schemes are suggested,one is alternative direction implicit(ADI)scheme and the other is ADI-PCG *** particular,we prove that ADI scheme can arrive at second-order accuracy in time and *** some numerical experiments,the computational effectiveness and accuracy of the methods are further ***,for the suggested methods,a numerical comparison in computational efficiency is presented.

关键词： Fractional sine-Gordon equation with distributed delay One-parameter finite difference methods Convergence analysis ADI scheme PCG method

Dominant woody plant species recognition with a hierarchical model based on multimodal geospatial data for subtropical forests

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Journal of Forestry Research 2024年第3期35卷 111-130页

作者： Xin Chen Yujun sun State Forestry&Grassland Administration Key Laboratory of Forest Resources&Environmental management Beijing Forestry UniversityBeijing 100083People's Republic of China

Since the launch of the Google Earth Engine(GEE)cloud platform in 2010,it has been widely used,leading to a wealth of valuable ***,the potential of GEE for forest resource management has not been fully *** extract dominant woody plant species,GEE combined Sen-tinel-1(S1)and Sentinel-2(S2)data with the addition of the National Forest Resources Inventory(NFRI)and topographic data,resulting in a 10 m resolution multimodal geospatial dataset for subtropical forests in southeast *** and texture features,red-edge bands,and vegetation indices of S1 and S2 data were computed.A hierarchical model obtained information on forest distribution and area and the dominant woody plant *** results suggest that combining data sources from the S1 winter and S2 yearly ranges enhances accuracy in forest distribution and area extraction compared to using either data source ***,for dominant woody species recognition,using S1 winter and S2 data across all four seasons was *** terrain factors and removing spatial correlation from NFRI sample points further improved the recognition *** optimal forest extraction achieved an overall accuracy(OA)of 97.4%and a maplevel image classification efficacy(MICE)of 96.7%.OA and MICE were 83.6%and 80.7%for dominant species extraction,*** high accuracy and efficacy values indicate that the hierarchical recognition model based on multimodal remote sensing data performed extremely well for extracting information about dominant woody plant *** the results using the GEE application allows for an intuitive display of forest and species distribution,offering significant convenience for forest resource monitoring.

关键词： Google Earth Engine Sentinel Forest resource inventory data Dominant woody plant species Subtropics Model performance

Complex adaptive system theory,agent-based modeling,and simulation in dominant technology formation

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Journal of Systems Engineering and Electronics 2024年第1期35卷 130-153页

作者： ZHANG Ruihan sun Bing Glorious sun School of Business and management Donghua UniversityShanghai 200051China School of Economics and management Harbin Engineering UniversityHarbin 150001China

Dominant technology formation is the key for the hightech industry to“cross the chasm”and gain an established foothold in the market(and hence disrupt the regime).Therefore,a stimulus-response model is proposed to investigate the dominant technology by exploring its formation process and ***,based on complex adaptive system theory and the basic stimulus-response model,we use a combination of agent-based modeling and system dynamics modeling to capture the interactions between dominant technology and the socio-technical *** results indicate the following:(i)The dynamic interaction is“stimulus-reaction-selection”,which promotes the dominant technology’s formation.(ii)The dominant technology’s formation can be described as a dynamic process in which the adaptation intensity of technology standards increases continuously until it becomes the leading technology under the dual action of internal and external mechanisms.(iii)The dominant technology’s formation in the high-tech industry is influenced by learning ability,the number of adopting users and ***,a“critical scale”of learning ability exists to promote the formation of leading technology:a large number of adopting users can promote the dominant technology’s formation by influencing the adaptive response of technology standards to the socio-technical landscape and the choice of technology standards by the socio-technical *** is a minimum threshold and a maximum threshold for the role of adaptability in the dominant technology’s formation.(iv)The socio-technical landscape can promote the leading technology’s shaping in the high-tech industry,and different elements have different *** study promotes research on the formation mechanism of dominant technology in the high-tech industry,presents new perspectives and methods for researchers,and provides essential enlightenment for managers to formulate technology strategies.

关键词： complex adaptive system theory agent-based modeling and simulation dominant technology socio-technical landscape adaptation-choice

The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： Di Wu Yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

Rational surface charge engineering of haloalkane dehalogenase for boosting the enzymatic performance in organic solvent solutions

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Chinese Journal of Chemical Engineering 2024年第1期65卷 276-285页

作者： Yin Wu Yan sun Department of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzymes in OSs often exhibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant E16R/E93R/E121R/E257R exhibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfoxide).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-type *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzyme molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzyme performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

Study on Coded Permutation Entropy of Finite Length Gaussian White Noise Time Series

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Chinese Journal of Electronics 2024年第1期33卷 185-194页

作者： Huihui sun Xiaofeng ZHANG School of Physics and Information Technology Shaanxi Normal University

As an extension of permutation entropy(PE), coded permutation entropy(CPE) improves the performance of PE by making a secondary division for ordinal patterns defined in PE. In this study, we provide an exploration of the statistical properties of CPE using a finite length Gaussian white noise time series theoretically. By means of the Taylor series expansion, the approximate expressions of the expected value and variance of CPE are deduced and the Cramér-Rao low bound(CRLB) is obtained to evaluate the performance of the CPE estimator. The results indicate that CPE is a biased estimator, but the bias only depends on relevant parameters of CPE and it can be easily corrected for an arbitrary time series. The variance of CPE is related to the encoding patterns distribution,and the value converges to the CRLB of the CPE estimator when the time series length is large enough. For a finitelength Gaussian white noise time series model, the predicted values can match well with the actual values, which further validates the statistic theory of CPE. Using the theoretical expressions of CPE, it is possible to better understand the behavior of CPE for most of the time series.

关键词： Time series analysis White noise Predictive models Taylor series Entropy Encoding Time measurement

Multi-Sensor Fusion Adaptive Estimation for Nonlinear Under-observed System with Multiplicative Noise

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Chinese Journal of Electronics 2024年第1期33卷 282-292页

作者： Yongpeng CUI Xiaojun sun School of Electronic Engineering Heilongjiang University Key Laboratory of Information Fusion Estimation and Detection

The adaptive fusion estimation problem was studied for the multi-sensor nonlinear under-observed systems with multiplicative noise. A one-step predictor with state update equations was designed for the virtual state with virtual noise first of all. An extended incremental Kalman filter(EIKF) was then proposed for the nonlinear under-observed systems. Furthermore, an adaptive filtering method was given for optimization. The fusion adaptive incremental Kalman filter weighted by scalar was finally proposed. The comparison analysis was made to verify the optimization of the state estimation using adaptive filtering method in the filtering process.

关键词： Adaptive systems Information filters Matrices Adaptive estimation Kalman filters State estimation Nonlinear systems

Turbulence Statistics of Thermo-Buoyancy Supercritical Fuel Flow in a Regenerative Cooling Channel

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Journal of Thermal Science 2024年第1期33卷 126-137页

作者： sun Feng XIE Gongnan School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China Department of Thermal Engineering Tsinghua UniversityBeijing 100084China

Active regenerative cooling with supercritical hydrocarbon fuel is considered as the most promising thermal protection *** existence of buoyancy force would lead to strongly anisotropic flow and thermal transport *** is closely related to the cooling performance of the *** elucidate the mechanisms of turbulent transport,the large eddy simulation(LES) was performed to assess turbulence statistics within different turbulence *** results indicated that the buoyancy and inertial force together dominated the change of turbulent ***,the spatial thermal buoyancy effect significantly suppressed the vertical velocity *** is due to the laminar motion caused by the buoyancy force,thereby weakening the thermal *** the statistics of velocity fluctuation,it was found that the buoyancy force and inertial force greatly weaken the vertical and streamwise velocity fluctuation,*** the statistics of thermal transport,the results pointed out that the near-wall heat transport characteristics need to be paid more *** thickness of the temperature mixing boundary layer led to the attenuation of vertical heat flux,which inhibited vertical temperature diffusion and predisposed to extreme conditions of heat transfer *** results can enhance the academic understanding of the heat transfer mechanism of supercritical fluids,and give guidance for further applications of thermal protection.

关键词： active regenerative cooling large eddy simulation(LES) buoyancy force turbulence statistics