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不同质地土壤施用控释氮肥对小白菜生长发育的影响

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山东农业大学学报（自然科学版） 2024年第2期55卷 210-217页

作者：王其选于金晖王巍翰孙玲丽有限公司山东烟台264002

为了探究控释氮肥在不同质地土壤中的安全施用量,以“上海青”小白菜为供试作物,研究在砂土、壤土、粘壤土3种质地土壤上施用不同量控释氮肥对小白菜生长性状、产量的影响。试验设置氮肥空白CK(不施氮肥);普通氮肥处理F1(普通氮肥0.1 g... 详细信息

为了探究控释氮肥在不同质地土壤中的安全施用量,以“上海青”小白菜为供试作物,研究在砂土、壤土、粘壤土3种质地土壤上施用不同量控释氮肥对小白菜生长性状、产量的影响。试验设置氮肥空白CK(不施氮肥);普通氮肥处理F1(普通氮肥0.1 g/kg土)、F2(普通氮肥0.2 g/kg土)、F3(普通氮肥0.4 g/kg土)、F4(普通氮肥0.8 g/kg土);控释氮肥CF1(控释氮肥0.4 g/kg土)、CF2(控释氮肥0.8/kg土)、CF3(控释氮肥1.6 g/kg土)等8个施肥处理。结果表明,与同等施氮量的常规氮肥相比,控释氮肥处理的小白菜发芽成活率大幅度提高。控释氮肥处理下小白菜鲜、干重显著提高,粘壤土下0.8 g/kg的控释氮肥更有利于小白菜生物量的提高和干物质的积累。壤土和砂土下0.4g/kg的控释氮肥更有利于小白菜生物量的提高和干物质的积累。SPAD值、硝态氮含量、植株全氮含量均表现出控释氮肥优于普通氮肥的规律,且在粘壤土和砂土中表现更为明显。总之,较高施肥量下控释氮肥相对不易烧苗,相同适量的施氮量下,控释氮肥更有利于小白菜的生长发育和生物量的积累,具有更高的安全性、经济性和生态性。

关键词：控释氮肥土壤质地小白菜施肥量

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经皮冠状动脉介入术后患者氯吡格雷相关基因多态性的临床特点

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中国现代药物应用 2024年第1期18卷 37-40页

作者：胡涛刘子龙孙礼玲北京市昌平区医院心内科 102200

目的探讨经皮冠状动脉介入(PCI)术后患者的氯吡格雷相关基因多态性[细胞色素P4502C19(CYP2C19)、ATP结合盒亚家族B成员1(ABCB1)和对氧磷酶1(PON1)]的临床特点。方法 318例行PCI术后的患者,常规应用氯吡格雷联合阿司匹林抗栓治疗,采用... 详细信息

目的探讨经皮冠状动脉介入(PCI)术后患者的氯吡格雷相关基因多态性[细胞色素P4502C19(CYP2C19)、ATP结合盒亚家族B成员1(ABCB1)和对氧磷酶1(PON1)]的临床特点。方法 318例行PCI术后的患者,常规应用氯吡格雷联合阿司匹林抗栓治疗,采用荧光染色原位杂交技术检测其CYP2C19*2、CYP2C19*3、CYP2C19*17、ABCB1和PON1共5个基因位点。术后1个月用血栓弹力图筛选出氯吡格雷抵抗组和氯吡格雷正常组,比较CYP2C19相关基因发生的情况。所有患者随访6个月,记录患者的出血情况,并比较CYP2C19相关基因发生的情况。结果 318例PCI术后患者的氯吡格雷相关基因分型:CYP2C19*2基因的AA突变型10.06%, AG杂合型30.81%;CYP2C19*3基因无突变型, AG杂合型30.81%;CYP2C19*17基因无突变型, CT杂合型6.29%;ABCB1基因突变型约占9.74%, CT杂合型52.52%;PON1基因AA突变型10.06%, AG杂合型占65.41%。氯吡格雷抵抗组携带2个功能缺失(LOF)等位基因的发生率大于氯吡格雷正常组(P<0.05)。28例出血病例多为携带有功能增强(GOF)等位基因。结论从PCI术后患者的基因分型来看,氯吡格雷相关基因的杂合型和突变型较为多见,这部分患者氯吡格雷的吸收和代谢将受一定的影响,其冠状动脉血栓的风险性较高,而出血风险较低,特别对于急性冠状动脉综合征患者临床上应予重视。

关键词：经皮冠状动脉介入氯吡格雷基因多态性荧光染色原位杂交

达可替尼联合达卡瑞利珠单抗治疗EGFR突变局部晚期NSCLC的临床疗效及安全性研究

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海南医学 2024年第18期35卷 2595-2600页

作者：李秀林李明伟陈婷婷孙李凌濮阳市安阳地区医院药学部河南濮阳455000 河南省职工医院药学部河南郑州450000 濮阳市安阳地区医院肿瘤科河南濮阳455000

目的探究达可替尼联合卡瑞利珠单抗(Cam)治疗表皮生长因子受体(EGFR)突变局部晚期非小细胞肺癌(NSCLC)的临床疗效及安全性。方法选取2022年1月至2023年11月濮阳市安阳地区医院收治的98例EGFR突变局部晚期NSCLC患者纳入研究,采用简单随... 详细信息

目的探究达可替尼联合卡瑞利珠单抗(Cam)治疗表皮生长因子受体(EGFR)突变局部晚期非小细胞肺癌(NSCLC)的临床疗效及安全性。方法选取2022年1月至2023年11月濮阳市安阳地区医院收治的98例EGFR突变局部晚期NSCLC患者纳入研究,采用简单随机化法分为对照组和研究组各49例。对照组患者给予达可替尼治疗,研究组患者给予达可替尼联合Cam治疗,21 d为一个周期,均治疗4个周期。比较两组患者的治疗效果,以及治疗前、治疗2个周期、治疗4个周期后的T淋巴细胞亚群(CD3+、CD4+、CD4+/CD8+)、血管生长因子[血小板衍生生长因子(PDGF)、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)]、预后相关标志物[微小RNA(miRNA)-137-3p、miR-1255b-5p、miR-379-5p]、体能状态[卡氏功能状态(KPS)]和生存质量[肺癌患者生存质量评定量表(FACT-L)],并比较两组患者治疗期间的不良反应发生率。结果研究组患者的客观缓解率(ORR)为85.71%,明显高于对照组的67.35%,差异有统计学意义(P0.05)。结论达可替尼联合Cam治疗EGFR突变局部晚期NSCLC患者的疗效显著,其可改善患者免疫功能,抑制肿瘤血管生长因子,有助于改善患者预后,提高患者生存质量及体能状态,且安全性良好。

关键词：达可替尼卡瑞利珠单抗非小细胞肺癌 T淋巴细胞亚群生存质量表皮生长因子受体突变

HIV Vaccine-Challenges and Opportunities

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Virologica Sinica 2007年第6期22卷 486-492页

作者： Xin MA Cai-jun sun Feng li ling CHEN Guangzhou Institute of Biomedicine and Health Guangzhou International Business Incubator Science Park Guangzhou 510663 China

The need for an efficacious HIV/AIDS vaccine remains the highest priority of the world HIV/AIDS agenda. The generation of an efficacious HIV/AIDS vaccine proves an enormous scientific challenge. This article reviews the neutralizing antibody problem,elusive immune protection,im-munogen design,pre-existing anti-vector immunity and design of phase 3 vaccine trials and the challenges and opportunities in development of HIV/AIDS vaccine are discussed.

关键词： Neutralizing antibody Cellular immune Protective immunity Immunogen Efficacy studies

Relationship between linguistic functions and cognitive functions in a clinical study of Chinese patients with post-stroke aphasia

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Chinese Medical Journal 2013年第7期126卷 1252-1256页

作者： YU Zeng-zhi JIANG Shu-jun BI Sheng li Jun LEI Di sun li-ling Rehabilitation Medicine Center Chinese People's Liberation Army General Hospital Beijing 100853 China Very Important Person Neurology Ward Navy General Hospital Beijing 100048 China

Background There has been a long debate among scholars surrounding the relationship between language and cognition. The worldwide study of aphasia is actively exploring the function of language from cognitive point of view. This study aimed to investigate the relationship between linguistic functions and cognitive functions in a clinical study of Chinese patients with post-stroke aphasia. Methods Cognitive functions of 63 Chinese patients with aphasia following a stroke were assessed with the Chinese version of the second edition of Loewenstein Occupational Therapy Cognitive Assessment （LOTCA） battery and their linguistic functions were tested with the Western Aphasia Battery （WAB） Scale, respectively. The correlation between the results observed on the LOTCA battery and those on the WAB was analyzed. Aphasia quotient, performance quotient, cortical quotient, and linguistic function of the patients were compared. Then, each language function was analyzed by way of dependent adopt multiple regression analysis. Results The total score of 63 patients as shown on the LOTCA battery was significantly correlated with the aphasia quotient, performance quotient, and cortical quotient observed on the WAB Scale （P 〈0.05, P 〈0.01）. However, the correlation between visuomotor organization under LOTCA and repeat under WAB was not significant （P 〉0.05）. The attention of LOTCA and WAB＇s spontaneous speech, repeat, naming, and aphasia quotient was not relevant either （P 〉0.05）. In addition, correlations between the results observed on the LOTCA battery and the WAB were significant （P 〈0.05, P 〈0.01）. Among the significant variables finally entered into the standardized canonical discriminant functions, main factors affected the aphasia. Multiple regression analysis showed that orientation, spatial perception, and visual perception had a notable influence on aphasia quotient and naming. Orientation and thinking operation was found to have a notable influence on spontaneous speech. Sp

关键词： stroke Chinese aphasia language disorders cognitive impairments

“三进”工作背景下中华优秀传统文化融入高校外语课“432”教学模式研究

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青岛远洋船员职业学院学报 2024年第3期45卷 51-53,65页

作者：孙伶莉金鲁豪胡莲美青岛黄海学院山东青岛266555

新时代环境下,高校英语教学如何有效地融入中国优秀传统文化,解决英语教学过程中出现的母语文化缺失、思政教育缺位现象,是亟待解决的问题。鉴于此,本文基于“三进”工作背景,提出英语教学“432”教学模式,最大限度地发挥课程协同效应,... 详细信息

新时代环境下,高校英语教学如何有效地融入中国优秀传统文化,解决英语教学过程中出现的母语文化缺失、思政教育缺位现象,是亟待解决的问题。鉴于此,本文基于“三进”工作背景,提出英语教学“432”教学模式,最大限度地发挥课程协同效应,实现三全育人,推动课程教学改革,努力开创高校英语课程教学的新局面。

关键词： “三进”工作中华优秀传统文化高校英语 “432”教学模式

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light(Science & Applications) 2024年第2期13卷 333-346页

作者： Yifan sun Qian li ling-Jun Kong Xiangdong Zhang Key Laboratory of advanced optoelectronic quantum architecture and measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081BeijingChina

Compared with electrical neural networks,optical neural networks(ONNs)have the potentials to break the limit of the bandwidth and reduce the consumption of energy,and therefore draw much attention in recent *** far,several types of ONNs have been ***,the current ONNs cannot realize the acceleration as powerful as that indicated by the models like quantum neural *** to construct and realize an ONN with the quantum speedup is a huge ***,we propose theoretically and demonstrate experimentally a new type of optical convolutional neural network by introducing the optical *** is called the correlated optical convolutional neural network(COCNN).We show that the COCNN can exhibit“quantum speedup”in the training *** character is verified from the two *** is the direct illustration of the faster convergence by comparing the loss function curves of the COCNN with that of the traditional convolutional neural network(CNN).Such a result is compatible with the training performance of the recently proposed quantum convolutional neural network(QCNN).The other is the demonstration of the COCNN’s capability to perform the QCNN phase recognition circuit,validating the connection between the COCNN and the ***,we take the COCNN analog to the 3-qubit QCNN phase recognition circuit as an example and perform an experiment to show the soundness and the feasibility of *** results perfectly match the theoretical *** proposal opens up a new avenue for realizing the ONNs with the quantum speedup,which will benefit the information processing in the era of big data.

关键词： process quantum convolution

Isostructural Transition of MgB_(2) Under High Pressure

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Chinese Physics Letters 2001年第10期18卷 1401-1403页

作者： sun li-ling TKikegawa WU Qi ZHAN Zai-ji WANG Wen-Kui Laboratory of Extreme Condition Physics Institute of PhysicsChinese Academy of SciencesBeijing 100080 Photon Factory Institute for Materials Structure ScienceHigh Energy Accelerator OrganizationTsukuba355-0801Japan College of Material Science and Chemical Engineering Yanshan UniversityQinhuangdao 066004

The high-pressure behaviour of the superconductor MgB_(2) with a hexagonal structure has been investigated by the in situ synchrotron radiation x-ray diffraction method under pressures up to 42.2 GPa in a diamond anvil cell. An abrupt decrease of about 7% in the unit cell volume of this material occurs in the pressure range of 26.3-30.2 GPa. A split of the Raman spectrum was also observed. The jump of the compression curve and Raman spectrum are ascribed to an isostructural transition in MgB_(2 ) at a pressure of 30.2 GPa.

关键词： structural Transition hexagonal

Structural Relaxation of Pd_(39)Ni_(10)Cu_(30)P_(21) Bulk Metallic Glass Under High Pressure

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Chinese Physics Letters 2001年第4期18卷 567-569页

作者： WANG li-Min ZHAN Zai-Ji sun li-ling li Gong WANG Wen-Kui Center for Condensed Matter Physics Chinese Academy of SciencesBeijing 100080 College of Material Sciences and Chemical Engineering Yanshan UniversityQinhuangdao 066004

The Pd_(39)Ni_(10)Cu_(30)P_(21) bulk metallic glass is isothermally relaxed under various *** degree of the structural relaxation is evaluated in terms of the enthalpy recovery behaviours involved in the irreversible glass transition processes by using a temperature-modulated differential scanning calarimetry technique.A roughly linear increase of the recovery enthalpy is observed within the experimental pressure range from 2.67 to 4.45 GPa,which reflects the release of the frozen-in enthalpy in the as-quenched glass with increasing relaxation *** pressure dependence of the time scale of the enthalpy recovery processes is also exhibited.

关键词： technique. enthalpy relaxation