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Mitochondrial Damage and Drp1 Overexpression in Rifampicin-and Isoniazid-induced Liver Injury Cell Model

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Journal of Clinical and Translational Hepatology 2019年第1期7卷 40-45页

作者： Fangfang Li Juan Zhou Yi Li kewei sun Jun Chen Department of Liver Diseases Third Hospital of ShenzhenShenzhenGuangdongChina Department of Digestive Diseases First Hospital of ChenzhouChenzhouHunanChina Department of Infectious Diseases The Affiliated Zhuzhou Hospital Xiangya Medical College CSUZhuzhouHunanChina Liver Diseases Center Department of Infectious DiseasesThe Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Infectious Diseases First Hospital of Hunan University of Chinese MedicineChangshaHunanChina

Background and Aims:Rifampicin(RFP)and isoniazid(INH)are widely used as anti-tuberculosis ***,the mechanisms underlying the involvement of reactive oxygen species and mitochondria in RFP-and INH-related hepatotoxicity have not been established *** study aimed to observe the intracellular mechanisms leading to mitochondrial dysfunction and morphological changes in RFP-and INH-induced hepatocyte ***:Cell injury,changes in mitochondrial function,and expression and activation of dynamin related protein 1(Drp1),known as the main protein for mitochondrial fission,were analyzed in cultured QSG7701 cells exposed to RFP and ***:INH and RFP treatment induced pronounced hepatocyte injury and increased cell *** the similar context of aspartate aminotransferase elevation and adenosine triphosphate synthesis decrease,changes in mitochondrial membrane permeability and reactive oxygen species in hepatocytes induced by RFP were significantly different from those induced by INH(p<0.05).Particularly,we observed the overactivation and mitochondrial translocation of Drp1 in RFP-induced cell injury,which was not occurred with exposure to ***:RFP-induced hepatotoxicity may be closely related to mitochondrial dysfunction and Drp1-mediated mitochondrial fission.

关键词： Anti-tuberculosis drug-induced liver injury Drp1 Mitochondrial dysfunction Mitochondrial fission

Oxygen-promoted synthesis of armchair graphene nanoribbons on Cu(111)

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Science China Chemistry 2021年第4期64卷 636-641页

作者： Penghui Ji Oliver MacLean Gianluca Galeotti Dominik Dettmann Giulia Berti kewei sun Haiming Zhang Federico Rosei Lifeng Chi Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft MaterialsSoochow UniversitySuzhou 215123China Centre Energie Matériaux et TélécommunicationsInstitut National de la Recherche Scientifique1650 Boulevard Lionel-BouletVarennesQCCanada Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Deutsches Museum Museumsinsel 180538 MunichGermany Research Center for Advanced Measurement and Characterization National Institute for Materials ScienceTsukubaIbaraki 305-0047Japan

We report the systematic investigation of the effects of oxygen on the synthesis of 3 p sub-family armchair graphene nanoribbons(3 p-AGNRs),which revealed a strong catalytic effect with a reduction in the reaction temperature by approximately 180 K without degradation of the ***(para-phenylene)(3-AGNR)was generated through Ullmann-type coupling of4,4’’-dibromo-p-terphenyl on Cu(111),which was then converted into wider 3 p-AGNRs via lateral *** tunneling microscopy(STM)and X-ray photoelectron spectroscopy demonstrated the formation of different ribbons up to 12-AGNR,which contained regions exhibiting increased STM contrast that we attribute to the intercalation of Br atoms during lateral fusion.

关键词： on-surface synthesis graphene nanoribbons C–H activation scanning tunneling microscopy X-ray photoelectron spectroscopy

EVALUATION OF SAND RECLAIMED BY DRY TYPE VIBRATION METHOD

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昆明理工大学学报（自然科学版） 1990年第3期31卷 8-17页

作者： Nobuhisa TSUTSUMI kewei sun Professor Dr.Eng.and Research Fellow Dispached Research Fellow(China Kun Ming Inst.of Technology)

It is customary to evaluate the sand reclamation efficiency by general standardmethod as sieve analysis *** the special method also can be used in the casewhere the weight of specimen sand is small and a more accurate result is ***’experiments,the grain-size analysis was carried out by an image analysingcomputer and the Na2O content analysis was done with a modified standard methodof acid *** the results of analyses,it might be recognized that theCO2-sodium silicate bonded sand can be reclaimed by dry type vibration methodeffectively after *** size and form of reclaimed sand grain are the sameas those of original new Sand and soda content in the remainder on the surface ofsand grain is about 0.I%.It is assumed that the sieve method may be replaced by theimage analysing computer in sand grain-size analysis in the *** is also pro-posed that the titration method for measuring Na2O content may be necessary tobe studied further.

关键词： pretreatment titration posed replaced assumed sieve specimen hydroxide silicate consumed

"Fish-Scale" Boy——Li Junwei in Beijing

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Women of China 1994年第4期 20-21页

作者： FENG kewei sun MAN

AFTER a long struggle with the rare disease, ichthy-erythroderma, 12-year-old Li Junwei was eventually able to go to school. This has been his desire for years. Li was born in Gaoxiong City in Taiwan. Since infancy he... 详细信息

关键词： Li Junwei in Beijing Boy Fish-Scale

Reclamation of Foundry Sand by Dry Type Vibration Method

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昆明理工大学学报（自然科学版） 1990年第3期31卷 2-7页

作者： Nobuhisa TSUTSUMI Dr.Eng sun kewei

Influences of frequency,amplitude,vibrating time,moisture in sand,thickness of sand layer and pretreatment of high frequency vibration and heating on sand reclamation were *** binder layers around sand grains are completely removed and original sand grains remain unbroken by vibration at a certain frequency and *** of sand reclamation by the vibration method is correlated to the vibration force which depends on the combination of frequency and amplitude to a great *** optimum vibration condition is limited by the capacity of *** of used sand is *** thickness of used sand is an important *** of used sand are also ***,preheating in a certain temperature range is preferable to preliminary vibration at high frequency.

关键词： vibrating heating grains pretreatment preliminary removed binder moisture 志石振幅比

Preparation of TiC/Ni_3Al Composites by Upward Melt Infiltration

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Journal of Materials Science & Technology 2000年第4期16卷 387-392页

作者： Yi PAN (Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China) kewei sun (National Engineering Research Center of Solid Waste Resources Recovery, Kunming University of Science and Technology,Kunming 650093, China) Department of Materials Science and Engineering Zhejiang University Hangzhou 310027 China National Engineering Research Center of Solid Waste Resources Recovery Kunming University of Science and Technology Kunming 650093 China

TiC/Ni_3Al composites have been prepared using upward infiltration method. The densification was performed by both Ni_3Al melt filling and TiC sintering during the infiltration. The dissolution of TiC in liquid Ni_3Al has been evidenced by finding Ni_3(Al,Ti)C after fast cooling in the TiC/Ni_3Al composites. The dissolution may be responsible for the infiltration and sintering. Compared with downward infiltration, the upward infiltration brought about higher strength and fracture toughness and shorter infiltration time. TiC/20 vol. pct Ni_3Al composite processed by upward infiltration had a flexural strength of 1476 MPa with a statistic Weibull modulus of 20.2 and a fracture toughness of 20.4 MPa . Better mechanical properties may be attributed to melt unidirectional movement in upward infiltration.

关键词： TiC Preparation of TiC/Ni3Al Composites by Upward Melt Infiltration Ni Al

Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration

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Acta Pharmaceutica Sinica B 2019年第3期9卷 648-658页

作者： Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu kewei sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An China Military Institute of Chinese Medicine Beijing302Hospital of ChinaBeijing100039China Center for Drug Evaluation China Food and Drug AdministrationBeijing100022China Renji Hospital of Shanghai Jiaotong University Shanghai200127China Beijing Youan Hospital of Capital Medical University Beijing100069China Shuguang Hospital of Shanghai University of Traditional Chinese Medicine Shanghai200127China First Affiliated Hospital of Hunan University of Traditional Chinese Medicine Changsha410007China Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine Beijing100700China Center for Non-infectious Liver Diseases Beijing302Hospital of ChinaBeijing100039China College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu610075China College of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai201203China Center for Infectious Liver Diseases Beijing302Hospital of ChinaBeijing100039China

1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and ... 详细信息

关键词： TCM PTA Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration China

孙克伟教授辨治慢性粒细胞白血病合并肝衰竭1例

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中医临床研究 2021年第15期13卷 7-8页

作者：胡雅琪孙克伟湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410007

重型肝炎即肝衰竭,目前主要临床方案包括内科综合治疗、人工肝及肝移植。中医药在治疗重型肝炎方面有独特之道,中西医结合治疗重型肝炎能有效降低病死率,改善黄疸指数,改善临床症状。

关键词：肝衰竭慢性粒细胞白血病中医辨治

孙克伟教授运用温法治疗慢加急性肝衰竭的经验

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湖南中医药大学学报 2024年第4期44卷 650-654页

作者：郑云杰张涛孙克伟湖南中医药大学第一附属医院湖南长沙410007

总结孙克伟教授治疗慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)的临床经验。孙克伟教授认为,ACLF以湿热瘀毒互结为标,脾阳虚损为本,脾虚可贯穿ACLF疾病全程,故治疗时多使用炮附子、白术、干姜等温药,全病程重视应用温法,并... 详细信息

总结孙克伟教授治疗慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)的临床经验。孙克伟教授认为,ACLF以湿热瘀毒互结为标,脾阳虚损为本,脾虚可贯穿ACLF疾病全程,故治疗时多使用炮附子、白术、干姜等温药,全病程重视应用温法,并创制自拟温阳解毒化瘀汤,攻补兼施,逆转肝功能急性失代偿,临床效果显著,为ACLF的临床治疗提供参考与借鉴。

关键词：慢加急性肝衰竭温法温阳解毒化瘀汤名医经验孙克伟

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