检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

一种残疾人触感头带装置的设计与实现

电脑知识与技术 2019年第1X期15卷 251-252,255页

作者：孙靖凡曹建峰赵阳梁茹薇无锡职业技术学院物联网学院江苏无锡214100

现实生活中视力受损的人在户外行走会遇到各种问题,这款头带旨在帮助视力受损的人,识别危险,能够在设备的帮助下能够自主的活动。近几年,我国残疾人口数量不断增加,据不完全统计,我国残疾人口数量截止到2010年已经突破了九千万,而盲人... 详细信息

现实生活中视力受损的人在户外行走会遇到各种问题,这款头带旨在帮助视力受损的人,识别危险,能够在设备的帮助下能够自主的活动。近几年,我国残疾人口数量不断增加,据不完全统计,我国残疾人口数量截止到2010年已经突破了九千万,而盲人残疾人的比例占总人数的比例居多,因为失去眼睛他们再也不能够像正常人一样生活。日常的外出等等或者在家里行走都遇到了不少的困难,正常的生活操作通过用手触摸,或者借助于一些拐杖等都不是很好而且有很大的危险性,这使得他们做一些其他的事更加困难,不能够很好体验生活,大大降低了他们的幸福感。在这样的背景下现设计一种残疾人触感头带装置实现辅助残疾人安全出行,判别危险物,使用方便,安全简单的功能。

关键词：残疾人智能安全头带

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan sun jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

同方期刊数据库

Single-cell technologies: current and near future

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第01期 1-4页

作者： Chenfei Wang Qi Liu Xiaohui fan Tieliu Shi Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration Ministry of EducationOrthopedics DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Key Laboratory of Advanced Theory and Application in Statistics and Data Science (MOE) School of StatisticsEast China Normal University

Single-cell technologies enable the indepth exploration of multiple biological hierarchies at the scale of individual cells,which have deepened our knowledge of cellular diversity, tissue organization, and overall organism function(sun et al.,2024). In 2009, single-cell RNA sequencing(sc RNA-seq) was first developed as a powerful tool to dissect gene expression and uncover transcriptional *** the rapid advancement of technology, single-cell approaches have expanded to encompass other omics, such as genomics, epigenomics, proteomics,and metabolomics.

关键词：

同方期刊数据库

Traditional Chinese medicine： potential approaches from modern dynamical complexity theories

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2016年第1期10卷 28-32页

作者： Yan Ma Kehua Zhou jing fan Shuchen sun Division of Interdisciplinary Medicine and Biotechnology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA Department of Health Care Studies Daemen College Amherst NY 14226 USA Daemen College Physical Therapy Wound Care Clinic Daemen College Amherst NY 14226 USA Department of Orthopedics Jiangsu Province Hospital of TCM Nanjing University of Chinese Medicine Nanjing 210029 China Department of Otolaryngology Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China

Despite the widespread use of traditional Chinese medicine （TCM） in clinical settings, proving its effectiveness via scientific trials is still a challenge. TCM views the human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. Such fundamental concepts require investigations using system-level quantification approaches, which are beyond conventional reductionism. Only methods that quantify dynamical complexity can bring new insights into the evaluation of TCM. In a previous article, we briefly introduced the potential value of Multiscale Entropy （MSE） analysis in TCM. This article aims to explain the existing challenges in TCM quantification, to introduce the consistency of dynamical complexity theories and TCM theories, and to inspire future system-level research on health and disease.

关键词： traditional Chinese medicine quantification dynamical complexity system level balance modem sciences

Prediction and interpretation of photocatalytic NO removal on g-C_(3)N_(4)-based catalysts using machine learning

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 477-483页

作者： jing Li Xinyan Liu Hong Wang Yanjuan sun fan Dong School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China Research Center for Carbon-Neutral Environmental & Energy Technology Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China

Predictive modeling of photocatalytic NO removal is highly desirable for efficient air pollution ***,great challenges remain in precisely predicting photocatalytic performance and understanding interactions of diverse features in the catalytic ***,a dataset of g-C_(3) N_(4)-based catalysts with 255 data points was collected from peer-reviewed publications and machine learning(ML)model was proposed to predict the NO removal *** result shows that the Gradient Boosting Decision Tree(GBDT)demonstrated the greatest prediction accuracy with R 2 of 0.999 and 0.907 on the training and test data,*** SHAP value and feature importance analysis revealed that the empirical categories for NO removal rate,in the order of importance,were catalyst characteristics>reaction process>preparation ***,the partial dependence plots broke the ML black box to further quantify the marginal contributions of the input features(e.g.,doping ratio,flow rate,and pore volume)to the model output *** ML approach presents a pure data-driven,interpretable framework,which provides new insights into the influence of catalyst characteristics,reaction process,and preparation conditions on NO removal.

关键词： Machine learning g-C_(3)N_(4)-based catalysts NO removal Interpretability Catalytic informatics

Cloning and RNA interference analysis of the salivary protein C002 gene in Schizaphis graminum

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2015年第4期14卷 698-705页

作者： ZHANG Yong fan Jia sun jing-rui CHEN Ju-lian State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural Sciences

The full-length c DNA of functionally-unknown salivary protein C002 in Schizaphis graminum was cloned using rapid amplification of c DNA ends（RACE） and designated as Sg C002（Gen Bank accession no. KC977563）. It is 767 bp long and encodes a protein of 190 amino acid residues with a predicted mass of 21.5 k Da and a predicted cleavage site of N-terminal signal peptide between the 24 th and the 25 th residues. Sg C002 is specifically expressed in salivary gland with the highest level at the 2nd instar. Introducing Sg C002-specific 476-si RNA, but not 546-si RNA to aphids through artificial diet significantly suppressed Sg C002 expression. Silencing Sg C002 gene led to lethality of the aphid on wheat plants, but not on pure artificial diet. Our study demonstrated that artificial diet-mediated RNAi can be a useful tool for research on the roles of genes in aphid salivary gland, and also provided new insights into the characteristics of C002 in wheat aphids.

关键词： Schizaphis graminum salivary protein C002 c DNA clone si RNA

Statistical analysis on the validity of the cold plasma approximation for chorus waves based on Van Allen Probe observations and their effects on radiation belt electrons

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2025年第1期9卷 159-170页

作者： AoJun Ren Jiang Yu jing Wang ZuZheng Chen XiaoMan Liu Planetary Environmental and Astrobiological Research Laboratory(PEARL) School of Atmospheric SciencesSun Yat-sen UniversityZhuhai Guangdong 519000China

Theoretical analysis has demonstrated that the dispersion relation of chorus waves plays an essential role in the resonant interaction and energy transformation between the waves and magnetospheric *** quantitative analyses often simplified the chorus dispersion relation by using the cold plasma ***,the applicability of the cold plasma assumption is doubtful,especially during geomagnetic *** here present a systematic statistical analysis on the validity of the cold plasma dispersion relation of chorus waves based on observations from the Van Allen Probes over the period from 2012 to *** statistical results show that the observed magnetic field intensities deviate substantially from those calculated from the cold plasma dispersion relation and that they become more pronounced with an increase in geomagnetic activity or a decrease in background plasma *** region with large deviations is mainly concentrated in the nightside and expands in both the radial and azimuthal directions as the geomagnetic activity increases or the background plasma density *** addition,the bounce-averaged electron scattering rates are computed by using the observed and cold plasma dispersion relation of chorus *** with usage of the cold plasma dispersion relation,usage of the observed dispersion relation considerably lowers the minimum resonant energy of electrons and lowers the scattering rates of electrons above tens of kiloelectronvolts but enhances those ***,these differences are more pronounced with the enhancement of geomagnetic activity or the decrease in background plasma density.

关键词： chorus waves cold plasma approximation dispersion relations scattering rates

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin sun fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

关键词：

同方期刊数据库

Calculation of left ventricular diastolic time constant(Tau) in dogs with aortic regurgitation using continuous-wave Doppler spectra

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第4期18卷 252-260页

作者： Chun-Zhi fan jing sun Hai-Ning ZHENG Chao-Yang WEN Department of Ultrasound Peking University International HospitalBeijingChina Department of Ultrasound Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Cardiovascular Department Shannxi Province Crops Hospital of Chinese People’s Armed Police ForcesXi’anChina

OBJECTIVE To investigate a new noninvasive method for calculating left ventricular diastolic time constant(Tau) through a continuous-wave aortic regurgitation Doppler *** According to ultrasound guidance, twenty-four animal models(beagles) of aortic regurgitation and acute ischemic left ventricular diastolic dysfunction were created. The left ventricular diastolic function was manipulated with dobutamine or esmolol and fifty-nine hemodynamic stages were achieved. Raw audio signals of the continuous-wave Doppler spectra were collected, and new aortic regurgitation Doppler spectra were built after reprocessing by a personal computer. The updating time of the spectral line was 0.3 ms. The new Doppler spectra contour line was automated using MATLAB(MATrix LABoratory, MathWorks, Natick, MA, USA), and two time intervals,(t2–t1) and(t3–t1) were measured on the ascending branch of the aortic regurgitation Doppler spectrum. Then, the two time intervals were substituted into Bai's equations, and Doppler-derived Tau(Tau-D)was resolved and compared with catheter-derived Tau(Tau-c).RESULTS There is no significant difference between Tau-D and Tau-c(45.95 ± 16.90 ms and 46.81 ± 17.31 ms, respectively;P >0.05). Correlation analysis between Tau-c and Tau-D suggested a strong positive relationship(r = 0.97, P = 0.000). A Bland-Altman plot of Tau-c and Tau-D revealed fair *** This new calculation method is simple, convenient, and shows a strong positive relationship and fair agreement with the catheter method.

关键词： Calculation of left ventricular diastolic time constant in dogs with aortic regurgitation using continuous-wave Doppler spectra Tau Doppler