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Parkinson's Disease Risk Variant rs1109303 Regulates the Expression of INPP5K and CRK in Human Brain

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Neuroscience Bulletin 2019年第2期35卷 365-368页

作者： Guiyou Liu yi Zhao jing-yi sun Bao-liang sun Key Laboratory of Cerebral Microcirculation in Universities of Shandong Department of Neurology Affiliated Hospital of Taishan Medical College School of Life Science and Technology Harbin Institute of Technology Affiliated Hospital Taishan Medical University Wonju Severance Christian Hospital Wonju College of Medicine Yonsei University

Dear Editor,Parkinson’s disease (PD) is the second most common neurodegenerative disease in the elderly (1, 2)PD affects1%–2%of the world’s population older than 65 years(3–5)In recent years, large-scale genome-wide association studies (GWAS) have been widely conducted to identify the common genetic risk genes for PD. A number of PD susceptibility genes have been identified, including SNCA,MAPT, NUCKS1, the HLA region, GAK, BST1, GBA,WNT3, RIT2, and LRRK2 [3–5].

关键词： Parkinson’s Disease QTL SLC

Interfacial charge redistribution to promote the catalytic activity of Vs-CoP-CoS_(2)/C n-n heterojunction for oxygen evolution

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Chinese Chemical Letters 2024年第2期35卷 611-616页

作者： Jiawen sun Hui Xue jing sun Niankun Guo Tianshan Song yi-Ru Hao Qin Wang College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China

Modulating surface charge redistribution based on interface and defect engineering has been considered as a resultful means to boost electrocatalytic activity.However,the mechanism of synergistic regulation of heterojunction and vacancy defects remains unclear.Herein,a Vs-CoP-CoS_(2)/C n-n heterojunction with sulfur vacancies is successfully constructed,which manifests superior electrocatalytic activity for oxygen evolution,as demonstrated by a low overpotential of 170 mV to reach 10 mA/cm^(2).The experimental results and density functional theory calculations testify that the outstanding OER performance of Vs-CoP-CoS_(2)/C heterojunction is owed to the synergistic effect of sulfur vacancies and built-in electric field at n-n heterogeneous interface,which accelerates the electron transfer,induces the charge redistribution,and regulates the adsorption energy of active intermediates during the reaction.This study affords a promising means to regulate the electrocatalytic performance by the construction of heterogeneous interfaces and defects,and in-depth explores the synergistic mechanisms of n-n heterojunction and vacancies.

关键词： Charge redistribution n-n Heterojunction Built-in electric field Sulfur vacancy Oxygen evolution reaction

Effect of chemical composition on the element distribution,phase composition and calcification roasting process of vanadium slag

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International Journal of Minerals,Metallurgy and Materials 2022年第12期29卷 2144-2151页

作者： Tangxia Yu Tao Jiang jing Wen Hongyan sun Ming Li yi Peng State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization Panzhihua 617000China School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral of Ministry of Education Northeastern UniversityShenyang 110819China Liaoning Key Laboratory for Metallurgical Sensor and Technology Shenyang 110819China

The chemical composition of vanadium slag significantly affects its element distribution and phase composition,which affect the subsequent calcification roasting process and vanadium recovery.In this work,seven kinds of vanadium slags derived from different regions in China were used as the raw materials to study the effects of different components on the vanadium slag’s elements distribution,phase composition,calcification roasting,and leaching rate of major elements using scanning electron microscope,X-ray diffraction analysis,and inductively coupled plasma-optical emission spectroscopy.The results show that the spinel phase is wrapped with silicate phase in all vanadium slag samples.The main elements in the spinel phase are Cr,V,and Ti from the interior to the exterior.The size of spinel phase in low chromium vanadium slag is larger than the other vanadium slags with higher chromium contents.The spinel phase of high-calcium and high-phosphorus vanadium slag is more dispersed.The strongest diffraction peak of vanadium spinel phase in the vanadium slag migrates to a higher diffraction angle,and(Fe_(0.6)Cr_(0.4))_(2)O_(3)is formed after calcification roasting as the chromium content increased.A large amount of Ca_(2)SiO_(4)is produced because excess Ca reacts with Si in high-calcium and high-phosphorus vanadium slag.The vanadium leaching rate reaches 88%in some vanadium slags.The chromium leaching rate is less than 5%in all vanadium slags.The silicon leaching rate of high-calcium and high-phosphorus vanadium slag is much higher than that of the other slags.The leaching rate of manganese is higher than 10%,and the leaching rates of iron and titanium are negligible.

关键词： vanadium slag calcification roasting element distribution phase composition leaching rate

PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes

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Genes & Diseases 2023年第5期10卷 2151-2166页

作者： Huiwen Liu Yanting sun Hao Xu Bin Tan Qin yi Jie Tian jing Zhu Department of Pediatric Research Institute Children's Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Pediatrics Chongqing 400014China Department of Clinical Laboratory Children's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Cardiovascular(Internal Medicine) Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Human induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)have attracted attention in the field of regenerative medicine due to their potential ability to repair damaged hearts.However,the immature phenotype of these cells limits their clinical application.Cardiomyocyte maturation is accompanied by changes in mitochondrial quality.PTEN-induced putative kinase 1(PINK1)has been linked to mitochondrial quality control.However,whether the changes in mitochondrial quality in hiPSC-CMs are associated with PINK1,and the impact of PINK1 on hiPSC-CMs development are not clear.In this study,we found that knockdown of PINK1 in hiPSC-CMs resulted in mitochondrial fragmentation and impaired mitochondrial functions such as mitophagy and mitochondrial biogenesis.PINK1 deletion also inhibited the maturation of hiPSC-CMs,reverting them to a naive structural and functional state.We found that restoring the mitochondrial structure did not completely rescue the mitochondrial dysfunction caused by PINK1 deletion,while activation of PINK1 kinase activity using kinetin promoted mitochondrial fusion,increased the mitochondrial membrane potential and ATP production,and maintained the development and maturation of hiPSC-CMs.In conclusion,PINK1 regulates the mitochondrial structure and function of hiPSC-CMs,and is essential for the maturation of hiPSC-CMs.

关键词： hiPSC-CMs hiPSCs Maturation Mitochondrial quality PINK1

Atomistic study on the microscopic mechanism of grain boundary embrittlement induced by small dense helium bubbles in iron

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Nuclear Science and Techniques 2024年第3期35卷 84-95页

作者： Lei Peng Yong-Jie sun jing-yi Shi yi-Fei Liu Shang-Ming Chen Liu-Liu Li State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610213China

The helium bubbles induced by 14 MeV neutron irradiation can cause intergranular fractures in reduced activation ferritic martensitic steel,which is a candidate structural material for fusion reactors.In order to elucidate the susceptibility of different grain boundaries(GBs)to helium-induced embrittlement,the tensile fracture processes of 10 types of GBs with and without helium bubbles in body-centered cubic(bcc)iron at the relevant service temperature of 600 K were investigated via molecular dynamics methods.The results indicate that in the absence of helium bubbles,the GBs studied here can be classified into two distinct categories:brittle GBs and ductile GBs.The atomic scale analysis shows that the plastic deformation of ductile GB at high temperatures originates from complex plastic deformation mechanisms,including the Bain/Burgers path phase transition and deformation twinning,in which the Bain path phase transition is the most dominant plastic deformation mechanism.However,the presence of helium bubbles severely inhibits the plastic deformation channels of the GBs,resulting in a significant decrease in elongation at fractures.For bubble-decorated GBs,the ultimate tensile strength increases with the increase in the misorientation angle.Interestingly,the coherent twin boundary∑3{112}was found to maintain relatively high fracture strength and maximum failure strain under the influence of helium bubbles.

关键词： Helium bubble Grain boundary Embrittlement Reduced activation ferritic martensitic steel Molecular dynamics Bain path

Understanding nutritive need in Harmonia axyridis larvae:Insights from nutritional geometry

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Insect Science 2022年第5期29卷 1433-1444页

作者： Shao-Lei sun Nibijiang Abudisilimu Hao yi Sali Li Tong-Xian Liu Xiangfeng jing State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxiChina Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxiChina

The multicolored Asian lady beetle,Harmonia axyridis(Pallas)(Coleoptera:Coccinellidae),is an important natural enemy in agricultural ecosystems.In spite of being a carnivore consuming protein-rich preys,the lady beetles often consume carbohydrate-rich food like nectar or honeydew.However,most studies on nutrition regulation of carnivores mainly focus on protein and lipid,two major macronutrients in preys.In this study,nutrition regulation of protein and carbohydrate has been investigated in the 4th instar larvae of H.axyridis using Geometric Framework.We provided the insects two pairs of foods,one a protein-biased one and the second carbohydrate-biased,to determine the intake target.We then confined them to nutritionally imbalanced foods to examine how they regulated food intake to achieve maximal performance.The larvae performed well on the 2 foods that containing the closest P:C ratios to the intake target,but,surprisingly,the lipid content was much lower than that in the choice experiment.The lady beetles seemed to maintain the optimal lipid content by consuming carbohydrate-rich food.Moreover,consuming the carbohydrate-rich food was less metabolically expensive than the protein-rich food.Therefore,switching behavior between plant and animal foods actually reflects their nutritive needs.These findings extended our understanding of predator forage behavior and its influence on food web in ecosystems,and shed light on the role of agri-environment schemes in meeting the nutritional need of predators in field.

关键词： carbohydrate Harmonia axyridis nutritional geometry nutrition regulation protein

Synergy of phosphorus vacancies and build-in electric field into NiCo/NiCoP Mott-Schottky integrated electrode for enhanced water splitting performance

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Chinese Chemical Letters 2024年第2期35卷 604-610页

作者： Xiaochen Zhang Hui Xue jing sun Niankun Guo Tianshan Song Jiawen sun yi-Ru Hao Qin Wang College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China

Vacancy engineering and Mott-Schottky heterostructure can accelerate charge transfer,regulate adsorption energy of reaction intermediates,and provide additional active sites,which are regarded as valid means for improving catalytic activity.However,the underlying mechanism of synergistic regulation of interfacial charge transfer and optimization of electrocatalytic activity by combining vacancy and Mott-Schottky junction remains unclear.Herein,the growth of a bifunctional NiCo/NiCoP Mott-Schottky electrode with abundant phosphorus vacancies on foam nickel(NF)has been synthesized through continuous phosphating and reduction processes.The obtained NiCo/NiCoP heterojunctions show remarkable OER and HER activities,and the overpotentials for OER and HER are as low as 117 and 60 mV at 10 mA/cm^(2) in 1 mol/L KOH,respectively.Moreover,as both the cathode and anode of overall water splitting,the voltage of the bifunctional NiCo/NiCoP electrocatalyst is 1.44 V at 10 mA/cm^(2),which are far exceeding the benchmark commercial electrodes.DFT theoretical calculation results confirm that the phosphorus vacancies and build-in electric field can effectively accelerate ion and electron transfer between NiCo alloy and NiCoP semiconductor,tailor the electronic structure of the metal centers and lower the Gibbs free energy of the intermediates.Furthermore,the unique self-supported integrated structure is beneficial to facilitate the exposure of the active site,avoid catalyst shedding,thus improving the activity and structural stability of NiCo/NiCoP.This study provides an avenue for the controllable synthesis and performance optimization of Mott-Schottky electrocatalysts.

关键词： Mott-Schottky Build-in electric field Phosphorus vacancies Phosphides Overall water splitting

Lithographic printing inspired in-situ transfer of MXene-based films with localized topo-electro tunability for high-performance flexible pressure sensors

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Nano Research 2023年第11期16卷 12670-12679页

作者： Qiuyang Yan yi Zhou yin Cheng Liangjing Shi Ranran Wang Lian Gao jing sun State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of ScienceShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

MXene-based films have been intensively explored for construction of piezoresistive flexible pressure sensors owing to their excellent mechanical and electrical properties.High pressure sensitivity relies on pre-molding a flexible substrate,or regulating the micromorphology of MXene sheets,to obtain a micro-structured surface.However,the two avenues usually require complicated and time-consuming microfabrication or wet chemical processing,and are limited to non-adjustable topographicelectrical(topo-electro)properties.Herein,we propose a lithographic printing inspired in-situ transfer(LIPIT)strategy to fabricate MXene-ink films(MIFs).In LIPIT,MIFs not only inherit ridge-and-valley microstructure from paper substrate,but also achieve localized topo-electro tunability by programming ink-writing patterns and cycles.The MIF-based flexible pressure sensor with periodical topo-electro gradient exhibits remarkably boosted sensitivity in a wide sensing range(low detection limit of 0.29 Pa and working range of 100 kPa).The MIF sensor demonstrates versatile applicability in both subtle and vigorous pressuresensing fields,ranging from pulse wave extraction and machine learning-assisted surface texture recognition to piano-training glove(PT-glove)for piano learning.The LIPIT is quick,low-cost,and compatible with free ink/substrate combinations,which promises a versatile toolbox for designing functional MXene films with tailored morphological-mechanical-electrical properties for extended application scenarios.

关键词： MXene film transfer printing surface tunability flexible pressure sensor

Amine-functionalized mesoporous UiO-66 aerogel for CO_(2) adsorption

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Chinese Journal of Chemical Engineering 2023年第2期54卷 36-43页

作者： Mengge Shang jing Zhang Jinqiang sun Shimo Yu Feng Hua Xiaoxu Xuan Xun sun Serguei Filatov Xibin yi Shandong Key Laboratory for Special Silicon-containing Material Advanced Materials InstituteQilu University of Technology(Shandong Academy of Sciences)Jinan 250014China Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationNational Demonstration Center for Experimental Mechanical Engineering Education at Shandong UniversitySchool of Mechanical EngineeringShandong UniversityJinan 250061China Laboratory of Hydrogen Energy Institute of Heat and Mass Transfer of the National Academy of Sciences of BelarusMinsk 220072Belarus

A mesoporous UiO-66-NH_(2) aerogel is prepared via a straightforward sol-gel method without using any binders or mechanical pressures, in which the amine groups are directly introduced into the matrix by using 2-aminoterephthalic acid. The novel UiO-66-NH_(2) aerogel also exhibits high specific surface area and mesopore-dominated structure, implying its highly potential use in CO_(2) adsorption. For ulteriorly investigating the effect of amine loading on the CO_(2) adsorption ability, a series of UiO-66-NH_(2) aerogel with different amino content is fabricated by changing the ligand/metal molar ratio. When the molar ratio is 1.45, the CO_(2) adsorption capacity reaches the optimum value of 2.13 mmol·g^(-1) at 25 ℃ and 0.1 MPa, which is 12.2% higher than that of pure UiO-66 aerogel. Additionally, UiO-66-NH_(2)-1.45 aerogel also has noticeable CO_(2) selectivity against N_(2) and CH_(4) as well as good regeneration stability. Such results imply that it has good application prospect in the field of CO_(2) adsorption, and also contains the potential to be applied in catalysis, separation and other fields.

关键词： UiO-66-NH_(2)aerogel Sol–gel method Amine groups Nanostructure Carbon dioxide Adsorption