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流行性出血热患者血浆β—内啡肽的变化及其意义

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中华传染病杂志 1992年第2期10卷 76-79页

作者：孙志坚杨琪明江苏省人民医院江苏省丹阳市人民医院南京医学院生理教研室

对28例流行性出血热（EHF）患者作了血浆β－内啡肽样免疫活性物质（ir-β-EP）的动态研究。放免法检测正常值为33.78±20.62ng/L，而EHF患者低血压期明显升高（轻症与重症患者分别为133.33±57.74和130.58±48.58ng/L）。小剂量地塞米... 详细信息

对28例流行性出血热（EHF）患者作了血浆β－内啡肽样免疫活性物质（ir-β-EP）的动态研究。放免法检测正常值为33.78±20.62ng/L，而EHF患者低血压期明显升高（轻症与重症患者分别为133.33±57.74和130.58±48.58ng/L）。小剂量地塞米松试验见血浆ir-β-EP由104±45.96 ng/L降至58±24.88ng/L；注射TRH后血浆ir-β-EP轻微升高，且平均动脉压升高1.66±0.76kPa。上述结果提示EHF的循环紊乱与ir-β-EP升高有一定联系，小剂量地塞米松和TRH对改善血液循环有一定帮助。

关键词：流行性出血热 β-内啡肽皮质醇

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镍矿湿法冶金技术应用进展及研究展望

中国有色金属学报 2018年第2期28卷 356-364页

作者：孙建之陈勃伟温建康王淀佐北京有色金属研究总院生物冶金国家工程实验室北京100088

介绍了世界上镍资源的分布、开发利用现状,提出高镁是镍资源综合利用的一个瓶颈问题,阐述了还原焙烧-氨浸、高压酸浸、常压酸浸、堆浸等氧化镍矿湿法冶金处理工艺的基本流程、优缺点与应用前景,总结了氧化镍矿、硫化镍矿生物冶金技术的... 详细信息

介绍了世界上镍资源的分布、开发利用现状,提出高镁是镍资源综合利用的一个瓶颈问题,阐述了还原焙烧-氨浸、高压酸浸、常压酸浸、堆浸等氧化镍矿湿法冶金处理工艺的基本流程、优缺点与应用前景,总结了氧化镍矿、硫化镍矿生物冶金技术的研究应用情况,指出非常规体系生物浸出是解决高镁问题的一个方向。展望了高镁型镍矿处理工艺的发展方向,其中常压酸浸、生物浸出技术为研究热点。

关键词：高镁型镍矿硫化镍矿氧化镍矿湿法冶金生物冶金

Modeling and sliding mode control based on inverse compensation of piezo-positioning system

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中国光学(中英文) 2025年第1期18卷 170-185页

作者： LI zhi-bin XIN Yuan-ze ZHANG jian-qiang sun Chong-shang College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China Center for Advanced Control and Smart Operations Nanjing UniversitySuzhou 215163China

In order to enhance the control performance of piezo-positioning system,the influence of hysteresis characteristics and its compensation method are *** model is used to represent the dynamic hysteresis nonlinear characteristics of piezo-positioning *** static nonlinear part and dynamic linear part of the Hammerstein model are represented by models obtained through the Prandtl-Ishlinskii(PI)model and Hankel matrix system identification method,*** model demonstrates good generalization capability for typical input frequencies below 200 Hz.A sliding mode inverse compensation tracking control strategy based on P-I inverse model and integral augmentation is *** results show that compared with PID inverse compensation control and sliding mode control without inverse compensation,the sliding mode inverse compensation control has a more ideal step response and no overshoot,moreover,the settling time is only 6.2 *** the frequency domain,the system closed-loop tracking bandwidth reaches 119.9 Hz,and the disturbance rejection bandwidth reaches 86.2 *** proposed control strategy can effectively compensate the hysteresis nonlinearity,and improve the tracking accuracy and antidisturbance capability of piezo-positioning system.

关键词： piezo-positioning system hysteresis nonlinearity Hammerstein model Prandtl-Ishlinskii(P-I)model system identification sliding mode control

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Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease

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Science China(Life Sciences) 2025年第1期68卷 158-175页

作者： Wen-Tao sun jian-Yong Du Jia Wang Yi-Long Wang Er-Dan Dong Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)Schoolof Health and Life SciencesUniversityof Health and Rehabilitation SciencesQingdao 266071China Department of Cardiology and Instituteof Vascular Medicine Peking University Third HospitalTheInstituteofCardiovascular SciencesPeking UniversityState Key Laboratoryof Vascular Homeostasisand RemodelingPeking UniversityBeijing 100191China

Cardiac rehabilitation,a comprehensive exercise-based lifestyle and medical management,is effective in decreasing morbidity and improving life quality in patients with coronary heart *** function,an irreplaceable indicator in coronary heart disease progression,is measured by various methods in traditional cardiac rehabilitation pathways,including medicinal treatment,aerobic training,and smoking ***,studies on the effect of some emerging cardiac rehabilitation programs on endothelial function are *** article briefly reviewed the endothelium-beneficial effects of different cardiac rehabilitation pathways,including exercise training,lifestyle modification and psychological intervention in patients with coronary heart disease,and related experimental models,and summarized both uncovered and potential cellular and molecular mechanisms of the beneficial roles of various cardiac rehabilitation pathways on endothelial *** exercise training and some lifestyle interventions,the enhanced bioavailability of nitric oxide,increased circulating endothelial progenitor cells(EPCs),and decreased oxidative stress are major contributors to preventing endothelial dysfunction in coronary heart ***,the preservation of endothelial-dependent hyperpolarizing factors and inflammatory suppression play *** the one hand,to develop more endothelium-protective rehabilitation methods in coronary heart disease,adequately designed and sized randomized multicenter clinical trials should be advanced using standardized cardiac rehabilitation programs and existing assessment *** the other hand,additional studies using suitable experimental models are warranted to elucidate the relationship between some new interventions and endothelial protection in both macro-and microvasculature.

关键词： cardiac rehabilitation coronary heart disease endothelial function

Oxygen vacancies-rich molybdenum tungsten oxide nanowires as a highly active nitrogen fixation electrocatalyst

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Chinese Chemical Letters 2025年第1期36卷 545-548页

作者： Jincheng Zhang Mengjie sun Jiali Ren Rui Zhang Min Ma Qingzhong Xue jian Tian School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

Herein,vacancy engineering is utilized reasonably to explore molybdenum tungsten oxide nanowires(W_(4)MoO_(3)NWs)rich in O-vacancies as an advanced electrochemical nitrogen reduction reaction(eNRR)electrocatalyst,realizing further enhancement of NRR *** 0.1 mol/L Na_(2)SO_(4),W_(4)MoO_(3)NWs rich in O vacancies(CTAB-D-W_(4)MoO_(3))achieve a large NH3yield of 60.77μg h^(-1)mg^(-1)***-0.70 V *** and a high faradaic efficiency of 56.42%at-0.60 V,much superior to the W_(4)MoO_(3)NWs deficient in oxygen vacancies(20.26μg h^(-1)mg^(-1)*** 17.1%at-0.70 V ***).Meanwhile,W_(4)MoO_(3)NWs rich in O-vacancies also show high electrochemical *** functional theory(DFT)calculations present that O vacancies in CTAB-D-W_(4)MoO_(3)reduce the energy barrier formed by the intermediate of^(*)N-NH,facilitate the activation and further hydrogenation of^(*)N-N,promote the NRR process,and improve NRR activity.

关键词： Electrocatalytic N_(2) reduction reaction Molybdenum-tungsten oxide Nanowires Oxygen vacancies Non-noble metal

Hollow cerium nanoparticles synthesized by one-step method for multienzyme activity to reduce colitis in mice

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World Journal of Gastroenterology 2025年第5期31卷 94-104页

作者： Lin Mi Kai Zhang jian-Xia Ma jian-Feng Yao Yi-Li Tong zhi-Jun Bao Department of General Medicine Huadong HospitalFudan UniversityShanghai 200040China Department of Gastroenterology Huadong HospitalFudan UniversityShanghai 200040China

BACKGROUND Inflammatory bowel disease(IBD)is a common chronic intestinal inflammatory *** oxidative stress is a treatment target for *** oxide(CeO2)nanomaterials as nanozymes with antioxidant activity are potential drugs for the treatment of *** To synthesize hollow cerium(H-CeO2)nanoparticles by one-step method and to validate the therapeutic efficacy of H-CeO2 in *** H-CeO2 was synthesized by one-step method and examined its characterization and nanoenzymatic ***,we constructed dextran sulfate so-dium(DSS)-induced colitis in mice to observe the effects of H-CeO2 on colonic *** effects of H-CeO2 on colon inflammation and reactive oxygen species(ROS)levels in IBD mice were detected by hematoxylin and eosin staining and dichlorofluorescein diacetate staining,***,the biological sa-fety of H-CeO2 on mice was evaluated by hematoxylin and eosin staining,blood routine,and blood *** H-CeO2 nanoparticles prepared by the one-step method were uniform,monodi-sperse and hollow.H-CeO2 had a good ability to scavenge ROS,∙OH and∙OOH.H-CeO2 reduced DSS-induced decreases in body weight and colon length,colonic epithelial damage,inflammatory infiltration,and ROS accumulation.H-CeO2 administration reduced the disease activity index of DSS-induced animals from about 8 to 5.H-CeO2 had no significant effect on body weight,total platelet count,hemoglobin,white blood cell,and red blood cell counts in healthy *** significant damage to major organs was observed in healthy mice following H-CeO2 *** The one-step synthesis of H-CeO2 nanomaterials had good antioxidant activity,biosafety,and inhibited deve-lopment of DSS-induced IBD in mice by scavenging ROS.

关键词： Inflammatory bowel disease Nanozymes Hollow cerium nanoparticles One-step method Cerium oxide biosafety

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钒酸银光催化剂的研究型实验教学初探

实验室研究与探索 2014年第9期33卷 188-191页

作者：孙建之董岩德州学院化学化工学院山东德州253023

为了适应具有一定实验基础的大学生对科学实验能力培养的更高要求,在实验教学中,提出了基于课题型的研究型实验教学新模式。对于钒酸银光催化剂的研究型实验,学生在完成实验的过程中,通过文献查阅,尝试独立进行实验准备和设计,综合运用... 详细信息

为了适应具有一定实验基础的大学生对科学实验能力培养的更高要求,在实验教学中,提出了基于课题型的研究型实验教学新模式。对于钒酸银光催化剂的研究型实验,学生在完成实验的过程中,通过文献查阅,尝试独立进行实验准备和设计,综合运用多项实验技术和表征手段,得到不同性能的产品,并对实验数据进行分析,最后形成科研论文形式的实验报告,激发了学生的科学研究兴趣。本实验原理具有典型性、实验过程覆盖面较广、实验可操作性强,具有显著的研究性实验特征。教学实践表明,开展创新性实验是一项行之有效的教学途径,对培养学生的创新意识和实践能力具有很好的促进作用,符合高等教育人才培养的需要。

关键词：光催化剂钒酸银研究性实验教学改革

Positive effect of Mo on mechanical properties of a Ni-42W-10Co-xMo medium heavy alloy

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China Foundry 2025年第1期22卷 108-116页

作者： Guo-xin Cao jian-xin Dong Yong-sheng He He jiang Fang Hao zhi-hua Nie Teng-fei Ma Bao-quan Fu School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Xi'an Superalloy Technology Co. Ltd.Xi’an 710299China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina

In this study,a novel Ni-W-Co-Mo medium heavy alloy(MHA)was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-x Mo alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypo-eutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0 to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-x Mo alloys is Mo-induced solid solution strengthening and precipitation strengthening.

关键词： medium-heavy alloys Ni-based alloy mechanical properties solid solution strengthening precipitation strengthening

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CMOS direct conversion X-ray detector coupled with fluorinated liquid

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Nuclear Science and Techniques 2025年第1期36卷 59-68页

作者： Shi-Hua Liu Chao-Song Gao Xin Zhang Xiang-Ming sun Meng Wu zhi-Hui Han Tong Wan Yong-Shuai Ge Key Laboratory of Quark&Lepton Physics(MOE) Central China Normal UniversityWuhan 430079China Guizhou Education University Guiyang 550018China Research Center for Medical Artificial Intelligence Chinese Academy of SciencesShenzhen Institutes of Advanced TechnologyShenzhen 518055China

X-ray detectors show potential applications in medical imaging,materials science,and nuclear *** achieve high detection efficiency and spatial resolution,many conventional semiconductor materials,such as amorphous selenium,cadmium telluride zinc,and perovskites,have been utilized in direct conversion X-ray ***,these semiconductor materials are susceptible to temperature-induced performance degradation,crystallization,delamination,uneven lattice growth,radiation damage,and high dark *** study explores a new approach by coupling an FC40 electronic fluorinated liquid with a specialized high-resolution and high-readout-speed complementary metal-oxide-semiconductor(CMOS)pixel array,specifically the Topmetal II−chip,to fabricate a direct conversion X-ray *** fluorinated liquid FC40(molecular formula:C_(21)F_(48)N_(2))is an electronic medium that is minimally affected by temperature and displays no issues with uniform *** exhibits a low dark current and minimal radiation damage and enables customizable thickness in X-ray *** addresses the limitations inherent in conventional semiconductor-based *** this study,simple X-ray detector imaging tests were conducted,demonstrating the excellent coupling capability between FC40 electronic fluorinated liquid and CMOS chips by the X-ray detector.A spatial resolution of 4.0 lp/mm was measured using a striped line par card,and a relatively clear image of a cockroach was displayed in the digital radiography imaging *** test results indicated the feasibility of fabricating an X-ray detector by combining FC40 electronic fluorinated liquid and CMOS *** to the absence of issues related to chip-material coupling,a high spatial resolution could be achieved by reducing the chip pixel *** method presents a new avenue for studies on novel liquid-based direct conversion X-ray detectors.

关键词： FC40 electronic fluorinated liquid CMOS pixel chip X-ray detector Spatial resolution