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A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression

Science china(Life Sciences) 2024年第4期67卷 765-777页

作者： Hui Zhao Lin-Lin Liu jian sun Lian Jin Hai-Bing Xie jian-Bo Li Hui Xu Dong-Dong Wu Xiao-Lin Zhuang Min-Sheng Peng Ya-Jun Guo Wei-Zhu Qian Newton OOtecko Wei-Jie sun Liang-Hu Qu Jie He Zhao-Li Chen Rong Liu Ce-shi Chen Ya-Ping Zhang State Key Laboratory for Conservation and Utilization of Bio-resource School of Life SciencesSchool of Ecology and Environmental ScienceYunnan UniversityKunming 650091China school of Forensic Medicine Kunming Medical UniversityKunming 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China The Third Affiliated Hospital Kunming Medical UniversityKunming 650118China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China The Key Laboratory of Gene Engineering of the Ministry of Education State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China National Engineering Research Center for Antibody Medicine and Shanghai Key Laboratory of Cell Engineering and Antibody Shanghai 201203China Department of Thoracic Surgery Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Human-specific insertions play important roles in human phenotypes and *** we reported a 446-bp insertion(Insert-446)in intron 11 of the TBC1D8B gene,located on chromosome X,and traced its origin to a portion of intron 6 of the EBF1 gene on chromosome ***,Insert-446 was present in the human Neanderthal and Denisovans genomes,and was fixed in humans after human-chimpanzee *** have demonstrated that Insert-446 acts as an enhancer through binding transcript factors that promotes a higher expression of human TBC1D8B gene as compared with orthologs in *** addition,over-expression TBC1D8B promoted cell proliferation and migration through“a dual finger”catalytic mechanism(Arg538 and Gln573)in the TBC domain in vitro and knockdown of TBC1D8B attenuated tumorigenesis in *** of Insert-446 prevented cell proliferation and migration in cancer and normal *** results reveal that the human-specific Insert-446 promotes cell proliferation and migration by upregulating the expression of TBC1D8B *** findings provide a significant insight into the effects of human-specific insertions on evolution.

关键词： human-specific insertion enhancer gene expression cell proliferation and migration

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Healing the structural defects of spinel MnFe_(2.O_(4) to enhance the electrocatalytic activity for oxygen reduction reaction

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Journal of energy Chemistry 2024年第10期97卷 12-19,I0001页

作者： Manting Tang Yue Zou Zhiyong jiang Peiyu Ma Zhiyou Zhou Xiaodi Zhu Jun Bao shi-Gang {2. National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026AnhuiChina State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 36005 FujianChina iChEM(Collaborative Innovation Center of Chemistry for energy Materials) University of Science and Technology of ChinaHefei 230026AnhuiChina

Spinel metal oxides containing Mn,Co,or Fe(AB_(2.O_(4),A/B=Mn/Fe/Co)are one of the most promising nonPt electrocatalysts for oxygen reduction reaction(ORR)in alkaline ***,the low conductivity of metal oxides and the poor intrinsic activities of transition metal sites lead to unsatisfactory ORR *** this study,eutectic molten salt(EMS)treatment is employed to reconstruct the atomic arrangement of MnFe_(2.O_(4)electrocatalyst as a prototype for enhancing ORR *** analyses by using XAFS,soft XAS,XPS,and electrochemical methods reveal that the EMS treatment reduces the oxygen vacancies and spinel inverse in MnFe_(2.O_(4)effectively,which improves the electric conductivity and increases the population of more catalytically active Mn^(2.)sites with tetrahedral ***,the enhanced Mn-O interaction after EMS treatment is conducive to the adsorption and activation of O_(2.,which promotes the first electron transfer step(generally considered as the ratedetermining step)of the ORR *** a result,the EMS treated MnFe_(2.O_(4)catalyst delivers a positive shift of 40 mV in the ORR half-wave potential and a two-fold enhanced mass/specific *** work provides a convenient approach to manipulate the atomic architecture and local electronic structure of spinel oxides as ORR electrocatalysts and a comprehensive understanding of the structureperformance relationship from the molecular/atomic scale.

关键词： Spinel MnFe_(2.O_(4) Oxygen reduction reaction Spinel inverse Oxygen vacancies Eutectic molten salt

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A general synthetic strategy for N, P co-doped graphene supported metal-rich noble metal phosphides for hydrogen generation

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Green energy & environment 2024年第1期9卷 152-162页

作者： Jingwen Ma Xiang Li Guangyu Lei Jun Wang Juan Wang jian Liu Ming Ke Yang Li Chunwen sun school of Chemical and environmental Engineering China University of Mining and Technology(Beijing)Beijing100083China State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China Lab of Advanced Nano-structures&Transfer Processes Department of Chemical EngineeringTianjin UniversityTianjin300354China Petrochina Planning and Engineering Institute Beijing100083China

The exploitation of electrocatalysts with high activity and durability for HER is desirable for future energy systems,but it is still a *** have attracted increasing attentions,but the preparation process often needs toxic regents or dangerous reaction ***,we develop a general green method to fabricate metal-rich NMPs anchored on NPG through pyrolyzing DNA cross-linked *** obtained Ru_(2. P-NPG exhibits an ultrasmall overpotential of 7 mV at 10 mA cm^(2. and ultralow Tafel slope of 33 mV dec^(-1) in 1.0 mol L?1 KOH,even better than that of commercial Pt/*** addition,Ru 2.P-NPG also shows low overpotentials of 2. and 78 mV in 0.5 mol L^(-1) H_(2.SO_(4) and 1.0 mol L^(-1) PBS,*** superior activity can be attributed to the ultrafine dispersion of Ru 2.P nanoparticles for more accessible sites,more defects formed for abundant active sites,the two-dimensional plane structure for accelerated electron transfer and mass transport,as well as the regulation of electron distribution of the ***,the synthetic method can also be applied to prepare other metal-rich noble metal phosphides(Pd_(3)P-NPG and Rh_(2.P-NPG),which also exhibits high activity for *** work provides an effective strategy for designing NMP-based electrocatalysts.

关键词： Noble metal phosphides Electrocatalyst Deoxyribonucleic acid Hydrogen evolution pH universal

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Recent advances in vacancy engineering for reliable lithiumsulfur batteries

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Rare Metals 2024年第2期43卷 455-477页

作者： Wen-Dong Liu Xiao Tang Jun-An Feng Chao-Yue Zhang Hao Liu Chuan shi Xiao-Xian Zhao jian-Jun Song College of Physics School of Chemistry and Chemical EngineeringQingdao UniversityQingdao266071China Faculty of Science Centre for Clean Energy TechnologySchool of Mathematical and Physical SciencesUniversity of Technology SydneySydneyNSW2007Australia Department of Chemistry College of ScienceHebei Agricultural UniversityBaoding071001China

The high-energy-density and low-cost features endow lithium-sulfur batteries with broad application ***,many drawbacks,especially the detrimental shuttle effect,have hindered the further development of *** response,a lot of new structures have been applied to suppress the shuttle effect and promote the development of ***,vacancy engineering has gained the attention of researchers due to its unique electronic *** review aims to analyze the application of vacancy engineering in ***,the electrochemistry of LSBs has been systematically discussed and the existing challenges as well as improvement tactics of LSBs have also been ***,the preparation methods and characterization technologies of various vacancies are summarized,including oxygen vacancies,sulfur vacancies,selenium vacancies,other anion vacancies,cation vacancies,*** latest applications of vacancy engineering in LSBs are also summarized in this ***,some prospects and insights for further investigation and practical application of vacancy engineering in LSBs are put forward.

关键词： Lithium-sulfur batteries(LSBs) Defects Vacancy engineering Electronic structure Shuttle effect

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Polyimide covalent organic frameworks as efficient solid-state Li^(+) electrolytes

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Science china Chemistry 2024年第5期67卷 1647-1652页

作者： Xu Liu shi Wang Siqi Liu Chengfang Liu Xiangchun Li jian Wu Dazhi Li shihao Xu Chongyang Liu Wen-Yong Lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts&TelecommunicationsNanjing 210023China

Covalent organic frameworks(COFs) are attractive porous crystalline materials with extremely high stability, easy functionalization, and open channels, which are expected to be unique ion conductors/transporters in lithium ion batteries(LIBs). Despite recent advances, low ion conductivity and low transference number, resulting in low charging/discharging rate, low energy density, and short battery life, are the main issues that limit their direct application as solid electrolytes in LIBs. Here, we designed and synthesized a novel polyimide COF, namely, TAPA-PDI-COF, with abundant C=O groups, which has been successfully employed as high-performance solid electrolytes by doping TAPA-PDI-COF and succinonitrile(SN). Both the well-defined nanochannels of COFs and SN confined in the well-aligned channels restricted the free migration of anions, while C=O on COFs and CN groups of SN enhanced Li^(+) transport, thus achieving a high ion conductivity of 0.102.m S cm^(-1)at 80 °C and a high lithium-ion transference number of 0.855 at room temperature. According to density functional theory(DFT)calculations, Li-ion migration mainly adopted in-plane transport rather than the axial pathway, which may be due to the shorter hopping distances in the planar pathway. The results suggest an effective strategy for the design and development of all-solidstate ionic conductors for achieving high-performance LIBs.

关键词： lithium ion batteries(LIBs) covalent organic frameworks(COFs) solid-state ion conductors solid-state electrolytes ion conductivity

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Facile preparation of a SiC@SiO_(2.nanowire-toughened ZrB_(2.-SiC/SiC bilayer coating with good interfacial bonding,high toughness,and excellent cyclic ablation resistance on C/CA composites

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Journal of Advanced Ceramics 2024年第4期13卷 486-495页

作者： Meng Yan Chenglong Hu jian Li Shengyang Pang Bohui sun Rida Zhao Bin Liang Rui Luo Sufang Tang shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China school of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Preparing antioxidant coatings to address the inherent oxidation sensitivity of carbon fiber-reinforced carbon aerogel(C/CA)composites is a feasible way to promote their application in oxidizing environments as thermal insulation ***,preparing the coatings with excellent oxidation and ablation resistance while avoiding evident damage to the C/CA substrate still remains a ***,a SiC@SiO_(2.nanowire-toughened ZrB2.SiC/SiC bilayer coating with a large thickness of 500μm was prepared on C/CA using a one-step low-temperature reaction sintering method,which simultaneously formed a sintered outer layer with even-distributed nanowires and a siliconized gradient inner *** courtesy of the synergic thermal response of the layers and the crack deflection induced by the nanowires,the resulting coating has moderate residual compressive stress of 0.08–1.2. GPa in the interface,high interfacial bonding strength of 6.02.MPa,and good fracture toughness of 4.36 MPa·m^(1/2..Benefited from the optimum components and improved structure,the coating shows excellent cyclic ablation resistance with linear ablation rates of 0.1μm/s at 1650℃for 1500 s(300 s×5 cycles)and 0.4μm/s at 1850℃for 900 s(300 s×3 cycles).The one-step preparation strategy contributes to little damage to the substrate,thus showing the well-preserved mechanical and thermal insulation properties.

关键词： coating carbon fiber reinforced carbon aerogel(C/CA)composites toughness interface residual stress

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Microstructure and Properties of W-15Cu Alloys Prepared by Mechanical Alloying and Spark Plasma Sintering Process

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Journal of Wuhan university of Technology(Materials Science) 2008年第3期23卷 399-402页

作者：章桥新 school of Mechanical and Electronic Engineering Wuhan University of Technology State Key Laboratory of Advanced Technology for Materials Synthesis&Processing Wuhan University of TechnologyWuhan 430070China

W-15Cu composite powders prepared by mechanical alloying （MA） of raw powders were consolidated by spark plasma sintering （SPS） process at temperature ranged 1 2.0-1 300 ℃ for 10 min and under a pressure of 30 MPa. By using high energy milling, particles containing very fine tungsten grains embedded in copper, called composite particles, could be produced. The W grains were homogeneously dispersed in copper phase, which was very important to obtain W-Cu alloy with high mechanical properties, fine and homogeneous microstructure. The microstructure and properties of W-15Cu alloys prepared by SPS processes at different temperature were researched. The results show that W-15Cu alloys consolidated by SPS can reach 99.6 % relative density, and transverse rupture strength （TRS） is 1 400.9 MPa, Rockwell C hardness （HRC） is 45.2. the thermal conductivity is 196 W/m-K at room temperature, the average grain size is less than 2.μm, and W-15Cu alloy with excellent properties, homogeneous and fine microstructure is obtained.

关键词： W-15Cu mechanical alloying spark plasma sintering (SPS)

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First-principle study of interaction of H2.and H2. molecules with （ZnO）_n（n=3-6） ring clusters

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Progress in Natural Science:Materials International 2010年第1期20卷 30-37页

作者： Hua-peng CHEN~1,jian-ning DING~(2.3),Ning-yi YUAN~2.Xiu-qin WANG~2.Cheng-lung CHEN~4,Duan WENG~(1*) 1.Department of Materials Science and Engineering,Tsinghua Universtiy,Beijing 100084,china 2.Center for Low-dimensional Materials,Micro-nano Devices and System, jiangsu Polytechnic university,Changzhou 2.3164,china 3.Key Laboratory of New energy Source,Changzhou 2.3164,china 4.Department of Chemistry,National sun Yat-sen university,Kaohsiung 8042.,Taiwan,china [a] Department of Materials Science and Engineering Tsinghua Universtiy Beijing 100084 China [b] Center for Low-dimensional Materials Micro-nano Devices and System Jiangsu Polytechnic University Changzhou 213164 China [c] Key Laboratory of New energy Source Changzhou 213164 China [d] Department of Chemistry National Sun Yat-sen University Kaohsiung 80424 Taiwan China

A density functional calculation was performed to investigate the impact of hydrogen and water molecules on zinc oxide clusters（ZnO）n=3-6…X,where X=H2.nd *** calculated binding energies were corrected for the basis set superposition error （BSSE）.The structural parameters and chemical hardness were calculated for the complexes of zinc oxide clusters and guest *** strength values of the interaction between the clusters and the guest molecules were analyzed based on the topological properties of atoms in molecules（AIM）theory of *** stereo electronic interactions inside the ZnO clusters were analyzed in detail using the natural bond orbital（NBO）analysis.

关键词： density functional theory zinc oxide clusters atoms in molecules

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In situ regulating intimately connected heterostructure by decomposition of solid solution oxides toward high-efficient water oxidation

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Rare Metals 2024年第4期43卷 1557-1569页

作者： Shao-Fei Zhang Xiao-Lu Yin Jin Wang jian-Li Kang Tian-Tian Li Jin-Feng sun Yong-Qiang Meng jian-jiang Wang Dian-Long Wang Kai-Qiang Qin Hebei Key Laboratory of Flexible Functional Materials/Hebei Key Laboratory of Material Near-Net Forming Technology School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang050018China Key Laboratory of Advanced Ceramics and Machining Technology/Ministry of Education School of Materials Science and EngineeringTianjin UniversityTianjin300072China Electrochemical Engine Center Department of Mechanical EngineeringPennsylvania State UniversityUniversity ParkPA16802USA

Heterogeneous interfaces produced by interdomain interactions on a nanoscale performs a crucial role in boosting the properties of an electrocatalyst toward oxygen evolution reaction(OER)***,a series of dual-phase electrodes with intimately connected heterointerfaces are prepared by in situ decomposing solid solution oxide of Ni_(x)Co_(y)Fe_(100-x-y)O,which grew on Ni foam massively via an ultrafast combustion ***,with high-reaction kinetics caused by the reduction treatment at 450℃,the less electronegative Fe and Co are more oxyphilic than Ni,which facilitated their co-exsolution and formation of CoFe_2._4/NiO oxide with enriched oxygen *** from the nanoporous framework,heterojunction structure,and oxygen defects,the self-supporting electrodes present rapid charge/mass transmission and provide abundant active sites for *** optimized sample(R-SNCF4.5)shows low overpotentials of 2.6 and 32. mV at 10 and100 mA·cm^(-2.,a small Tafel slope(46.7 mV·dec^(-1)),and excellent *** assembled R-SNCF4.5//Pt/C/NF electrolyzer demonstrates continuous electrolysis over 50 h at a current density of 10 mA·cm^(-2.,under 1.51 *** functional theory(DFT)calculations verify that the strong electronic modulation plays a critical part in the CoFe_2._4/NiO hybrid by lowering the energy barriers for the ratedetermining steps,and Fe sites are the most active OER sites.

关键词： Rapid combustion Decomposition of solid solution oxide Dual-phase heterostructure Oxygen evolution reaction Theoretical calculation

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Enhancing Li-S battery performance via functional polymer binders for polysulfide inhibition

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Journal of energy Chemistry 2024年第10期97卷 228-236,I0005页

作者： Jinpeng jian Qian Chen Hao sun Rui Li Yaolin Hou Yulong Liu Jia Liu Haiming Xie Jiefang Zhu Nation&Local United Engineering Laboratory for Power Batteries Faculty of ChemistryNortheast Normal UniversityChangchun 130024JjilinChina Jilin Province Dongchi New energy Technology Co. Ltd.Changchun 13000oJilinChina Department of Chemistry-Angstrom Laboratory Uppsala UniversitySE-75121Sweden

The commercialization of lithium-sulfur(Li-S)batteries faces several challenges,including poor conductivity,unexpected volume expansion,and continuous sulfur loss from the cathode due to redox *** this study,we introduce a novel polymer via a simple cross-linking between poly(ether-thioureas)(PETU)and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)(PEDOT:PSS)as a bifunctio nal binder for Li-S batteries(devotes as"PPTU").Compared to polyvinylidene fluoride(PVDF),as-prepared PPTU exhibits significantly higher electrical conductivity,facilitating electrochemical ***,PPTU demonstrates effective adsorption of lithium polysulfides,leading to improved cycling stability by suppressing the shuttling *** investigate this behavior by monitoring morphological changes at the cell interface using synchrotron X-ray *** with PPTU binders exhibit remarkable rate performance,desired reversibility,and excellent cycling stability even under stringent bending and twisting *** work represents promising progress in functional polymer binder development for Li-S batteries.

关键词： Li-S batteries Bifunctional binders Electrode conductivity Shuttle effect

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