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Effects and mechanisms of L-glutamate microinjected into nucleus ambiguus on gastric motility in rats

Chinese Medical Journal 2010年第8期123卷 1052-1057页

作者： sun hong-zhao zhao Shu-zhen CUI Xi-yun AI hong-bin Key Laboratory of Animal Resistance College of Life Science Shandong Normal University Ji'nan Shandong 250014 China Department of Biological Science and Technology Shandong Institute of Education Ji'nan Shandong 250013 China

Background L-glutamate （L-GLU） is a major neurotransmitter in the nucleus ambiguus （NA）, which can modulate respiration, arterial pressure, heart rate, etc. This study investigated the effects and mechanisms of L-GLU microinjected into NA on gastric motility in rats. Methods A latex balloon connected with a pressure transducer was inserted into the pylorus through the forestomach for continuous recording of the gastric motility. The total amplitude, total duration, and motility index of gastric contraction waves within 5 minutes before microinjection and after microinjection were measured. Results L-GLU （5 nmol, 10 nmol and 20 nmol in 50 nl normal saline （PS） respectively） microinjected into the right NA significantly inhibited gastric motility, while microinjection of physiological saline at the same position and the same volume did not change the gastric motility. The inhibitory effect was blocked by D-2-amino-5-phophonovalerate （D-AP5, 5 nmol, in 50 nl PS）, the specific N-methyI-D-aspartic acid （NMDA） receptor antagonist, but was not influenced by 6-cyaon-7-nitroquinoxaline-2,3-（1H,4H）-dione （CNQX）（5 nmol, in 50 nl PS）, the non-NMDA ionotropic receptor antagonist. Bilateral subdiaphragmatic vagotomy abolished the inhibitory effect by microinjection of L-GLU into NA. Conclusions Microinjection of L-GLU into NA inhibits the gastric motility through specific NMDA receptor activity, not non-NMDA receptor activity, and the efferent pathway is the vagal nerves.

关键词： gastric motility L-glutamate nucleus ambiguus glutamate receptor vagotomy

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Improved Convolutional Neural Network for Traffic Scene Segmentation

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2691-2708页

作者： Fuliang Xu Yong Luo Chuanlong sun hong zhao College of Mechanical and Electrical Engineering Qingdao UniversityQingdao266071China

In actual traffic scenarios,precise recognition of traffic participants,such as vehicles and pedestrians,is crucial for intelligent transportation.This study proposes an improved algorithm built on Mask-RCNN to enhance the ability of autonomous driving systems to recognize traffic participants.The algorithmincorporates long and shortterm memory networks and the fused attention module(GSAM,GCT,and Spatial Attention Module)to enhance the algorithm’s capability to process both global and local information.Additionally,to increase the network’s initial operation stability,the original network activation function was replaced with Gaussian error linear unit.Experiments were conducted using the publicly available Cityscapes dataset.Comparing the test results,it was observed that the revised algorithmoutperformed the original algorithmin terms of AP_(50),AP_(75),and othermetrics by 8.7%and 9.6%for target detection and 12.5%and 13.3%for segmentation.

关键词： Instance segmentation deep learning convolutional neural network attention mechanism

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Engineering Strategies for Suppressing the Shuttle Effect in Lithium–Sulfur Batteries

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Nano-Micro Letters 2024年第1期16卷 187-221页

作者： Jiayi Li Li Gao Fengying Pan Cheng Gong Limeng sun hong Gao Jinqiang Zhang Yufei zhao Guoxiu Wang Hao Liu Joint International Laboratory On Environmental and Energy Frontier Materials School of Environmental and Chemical EngineeringShanghai UniversityShanghaiPeople’s Republic of China Centre for Clean Energy Technology University of Technology SydneyBroadwaySydneyNSW 2007Australia

Lithium–sulfur(Li–S)batteries are supposed to be one of the most potential next-generation batteries owing to their high theoretical capacity and low cost.Nevertheless,the shuttle effect of firm multi-step two-electron reaction between sulfur and lithium in liquid electrolyte makes the capacity much smaller than the theoretical value.Many methods were proposed for inhibiting the shuttle effect of polysulfide,improving corresponding redox kinetics and enhancing the integral performance of Li–S batteries.Here,we will comprehensively and systematically summarize the strategies for inhibiting the shuttle effect from all components of Li–S batteries.First,the electrochemical principles/mechanism and origin of the shuttle effect are described in detail.Moreover,the efficient strategies,including boosting the sulfur conversion rate of sulfur,confining sulfur or lithium polysulfides(LPS)within cathode host,confining LPS in the shield layer,and preventing LPS from contacting the anode,will be discussed to suppress the shuttle effect.Then,recent advances in inhibition of shuttle effect in cathode,electrolyte,separator,and anode with the aforementioned strategies have been summarized to direct the further design of efficient materials for Li–S batteries.Finally,we present prospects for inhibition of the LPS shuttle and potential development directions in Li–S batteries.

关键词： Shuttle effect Designed strategies Li-S battery Lithium polysulfides

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An Innovative Deep Architecture for Flight Safety Risk Assessment Based on Time Series Data

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2549-2569页

作者： hong sun Fangquan Yang Peiwen Zhang Yang Jiao Yunxiang zhao Civil Aviation Flight Technology and Flight Safety Research Base Civil Aviation Flight University of ChinaGuanghan618307China Airport Academy Civil Aviation Flight University of ChinaGuanghan618307China School of Economics and Management Civil Aviation Flight University of ChinaGuanghan618307China China Academy of Civil Aviation Science and Technology Beijing101300China Flight Training Standards Branch Civil Aviation Flight University of ChinaGuanghan618307China

With the development of the integration of aviation safety and artificial intelligence,research on the combination of risk assessment and artificial intelligence is particularly important in the field of risk management,but searching for an efficient and accurate risk assessment algorithm has become a challenge for the civil aviation industry.Therefore,an improved risk assessment algorithm(PS-AE-LSTM)based on long short-term memory network(LSTM)with autoencoder(AE)is proposed for the various supervised deep learning algorithms in flight safety that cannot adequately address the problem of the quality on risk level labels.Firstly,based on the normal distribution characteristics of flight data,a probability severity(PS)model is established to enhance the quality of risk assessment labels.Secondly,autoencoder is introduced to reconstruct the flight parameter data to improve the data quality.Finally,utilizing the time-series nature of flight data,a long and short-termmemory network is used to classify the risk level and improve the accuracy of risk assessment.Thus,a risk assessment experimentwas conducted to analyze a fleet landing phase dataset using the PS-AE-LSTMalgorithm to assess the risk level associated with aircraft hard landing events.The results show that the proposed algorithm achieves an accuracy of 86.45%compared with seven baseline models and has excellent risk assessment capability.

关键词： Safety engineering risk assessment time series data autoencoder LSTM

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Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions

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World Journal of Gastroenterology 2024年第14期30卷 1968-1981页

作者： hong-Ju sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang hong zhao Qing Xie Xiao-Hua Song Department of General Medicine Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Gastroenterology Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Medical Administration Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Qingdao Medical College Qingdao UniversityQingdao 266042Shandong ProvinceChina Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver disease.However,the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies.Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic options.Pyroptosis,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular characteristics.Considering the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the disease.The study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic approaches.Nevertheless,further studies are necessary.

关键词： Nonalcoholic fatty liver disease Apoptosis Necroptosis Cell death Diagnosis Treatment

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Studies of an event-building algorithm of the readout system for the twin TPCs in HFRS

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Nuclear Science and Techniques 2024年第4期35卷 82-95页

作者： Jing Tian Zhi-Peng sun Song-Bo Chang Yi Qian hong-Yun zhao Zheng-Guo Hu Xi-Meng Chen Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of LanzhouLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong LaboratoryHuizhou 516000China

The High-energy Fragment Separator(HFRS),which is currently under construction,is a leading international radioactive beam device.Multiple sets of position-sensitive twin time projection chamber(TPC)detectors are distributed on HFRS for particle identification and beam monitoring.The twin TPCs'readout electronics system operates in a trigger-less mode due to its high counting rate,leading to a challenge of handling large amounts of data.To address this problem,we introduced an event-building algorithm.This algorithm employs a hierarchical processing strategy to compress data during transmission and aggregation.In addition,it reconstructs twin TPCs'events online and stores only the reconstructed particle information,which significantly reduces the burden on data transmission and storage resources.Simulation studies demonstrated that the algorithm accurately matches twin TPCs'events and reduces more than 98%of the data volume at a counting rate of 500 kHz/channel.

关键词： High counting rate Twin TPCs Trigger-less Readout electronics Event building Hierarchical data processing

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Electrochemically recycling degraded superalloy and valorizing CO_(2)in the aff ordable borate-modified molten electrolyte

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Tungsten 2024年第2期6卷 382-393页

作者： Xiang Chen Yuan sun Long Wang Xin Qu Yan zhao hong-Wei Xie Di-Hua Wang Hua-Yi Yin Key Laboratory for Ecological Metallurgy of Multimetallic Mineral of Ministry of Education School of MetallurgyNortheastern UniversityShenyang 110819China Institute of Metal Research Chinese Academy of ScienceShenyang 110016China School of Resource and Environmental Science Wuhan UniversityWuhan 430072China

Integrating electrochemical reduction of CO_(2)and electrochemical oxidation to recycle degraded superalloys is a promising solution to ease resource scarcity and safeguard environmental sustainability.Herein,we propose an electrochemical technique for the conversion of bulk superalloy scraps and CO_(2)into oxide powder at the anode and solid carbon at the cathode,respectively.In particular,a borax-modifi ed CaCl_(2)-based molten salt electrolyte is used for enhancing the electrochemical oxidation of superalloy scraps.At a temperature of 700℃and a voltage of 2.8 V,90.55 wt.%of alloy scraps were oxidized in a molten CaCl_(2)–NaCl–CaCO_(3)–Na_(2)B_(4)O_(7)with an acid–base ratio(K_(a/b))of 1.The synergy of Cl−and B_(4)O_(7)2−of electrolyte prevents the passivation of the alloy anode and enables continuous oxidation.Furthermore,the Ni and Co in the anode products are recovered by sulfation roasting with recovery efficiencies of 85.58%and 95.27%for Ni and Co,respectively.Overall,modulating the alkalinity of the electrolyte for enhancing oxidation/pulverization of alloy scrap anode provides new insight into electrochemically recovering superalloy scraps.

关键词： Superalloy scraps Recycling Molten salt Alkalinity Electrochemical oxidation Cobalt

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Investigation of the cell composition and gene expression in the delayed-type hypersensitivity tuberculin skin test

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Military Medical Research 2024年第1期11卷 148-151页

作者： Hui-Juan Duan hong-Qian Chu Ting-Ming Cao Guang-Ming Dai Na Tian Gang Sheng zhao-Gang sun Beijing Key Laboratory in Drug Resistant Tuberculosis Research Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing Chest HospitalCapital Medical UniversityBeijing 101149China

Dear Editor,The tuberculin skin test(TST)reagents have continuously improved,with the ESAT6-CFP10(EC)test having recently been introduced,but are seldom based on the direction of the delayed-type hypersensitivity(DTH)mechanism.Previous studies only partially showed the infiltration and activation of immune cells and the production of cytokines of the skin induration[1,2],and lack the detailed measurements of cell proportions and gene expression in the DTH response.Therefore,in this study,we revealed the comprehensive characteristics of DTH by single-cell RNA sequencing(scRNA-seq)in the guinea pig tuberculosis(TB)model[Experimental Animal Welfare Ethics Committee,Beijing Tuberculosis and Thoracic Tumor Research Institute(2021-064)].

关键词： Tuberculin skin test Delayed-type hypersensitivity Single-cell RNA sequencing

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中国式现代化进程中的发展和安全——关系演进和经验总结

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湖北大学学报（哲学社会科学版） 2023年第4期50卷 19-27页

作者：孙照红首都师范大学马克思主义学院北京100089

发展与安全是关乎党和国家根本利益的“国之大者”。一百多年来,在探索现代化的过程中,中国共产党不断深化对发展和安全关系的认识。在为“站起来”而奋斗的新民主主义革命时期,中国共产党以安全主导发展,以“革命”为主进行反帝反封建... 详细信息

发展与安全是关乎党和国家根本利益的“国之大者”。一百多年来,在探索现代化的过程中,中国共产党不断深化对发展和安全关系的认识。在为“站起来”而奋斗的新民主主义革命时期,中国共产党以安全主导发展,以“革命”为主进行反帝反封建斗争;在为“站住脚”而奋斗的社会主义革命和建设时期,党采取的是安全优先于发展的战略策略,“建设”和“发展”让步于“革命”和“安全”;在为“富起来”而奋斗的改革开放和社会主义现代化建设新时期,党更强调发展之于安全的先决意义和主导作用,以“改革开放”和“现代化建设”促发展、保稳定;在为“强起来”而奋斗的中国特色社会主义新时代,党统筹发展和安全,把二者作为同等重要的两件大事协同推进。实现本世纪中叶建成社会主义现代化强国的目标,必须牢牢把握“六个坚持”的世界观和方法论,充分发挥党总揽全局、协调各方的领导核心作用,提升党统筹发展和安全、领导经济社会发展和从容应对各种风险挑战的能力,进一步挖掘中国特色社会主义制度在“统筹”方面的优势,将其转化为国家治理效能。

关键词：中国式现代化发展安全统筹发展和安全

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Hierarchical Spinning of Janus Textiles with Anisotropic Wettability for Wound Healing

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Research 2024年第1期2023卷 97-105页

作者： Han Zhang Lingyu sun Jiahui Guo Yuanjin zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China

Wound healing and tissue repair are recognized as basic human health problems worldwide.Attempts to accelerate the reparative process are focused on developing functional wound dressings.Herein,we present novel Janus textiles with anisotropic wettability from hierarchical microfluidic spinning for wound healing.The hydrophilic hydrogel microfibers from microfluidics are woven into textiles for freeze-drying treatment,followed by the deposition of electrostatic spinning nanofibers composed of hydrophobic polylactic acid(PLA)and silver nanoparticles.The electrospun nanofiber layer can be well coupled with the hydrogel microfiber layer to generate Janus textiles with anisotropic wettability due to the roughness of the hydrogel textile surface and the incomplete evaporation of PLA solution when reaching the surface.For wound treatment with the hydrophobic PLA side contacting the wound surface,the wound exudate can be pumped from the hydrophobic to the hydrophilic side based on the wettability differential derived drainage force.During this process,the hydrophobic side of the Janus textile can prevent excess fluid from infiltrating the wound again,preventing excessive moisture and preserving the breathability of the wound.In addition,the silver nanoparticles contained in the hydrophobic nanofibers could impart the textiles with good antibacterial effect,which further promote the wound healing efficiency.These features indicate that the described Janus fiber textile has great application potential in the field of wound treatment.

关键词： silver spinning healing

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