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NAD+associated genes as potential biomarkers for predicting the prognosis of gastric cancer

Oncology Research 2024年第2期32卷 283-296页

作者： XIANGDONG sun HUIJUAN WEN FAZHAN LI IHTISHAM BUKHARI feifei REN XIA XUE PENGYUAN ZHENG YANG MI Henan Key Laboratory for Helicobacter Pylori&Microbiota and GI Cancer Marshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Gastroenterology The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Nicotinamide adenine dinucleotide(NAD+)plays an essential role in cellular metabolism,mitochondrial homeostasis,inflammation,and ***,the role of NAD+-regulated genes,including coding and long non-coding genes in cancer development is poorly *** constructed a prediction model based on the expression level of NAD+metabolism-related genes(NMRGs).Furthermore,we validated the expression of NMRGs in gastric cancer(GC)tissues and cell lines;additionally,β-nicotinamide mononucleotide(NMN),a precursor of NAD+,was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation,cell cycle,apoptosis,and senescence-associated secretory phenotype(SASP).A total of 13 NMRGs-related lncRNAs were selected to construct prognostic risk signatures,and patients with high-risk scores had a poor *** immune checkpoint genes were upregulated in the high-risk *** addition,cell cycle,epigenetics,and senescence were significantly downregulated in the high-risk ***,we found that the levels of immune cell infiltration,including CD8 T cells,CD4 naïve T cells,CD4 memory-activated T cells,B memory cells,and naïve B cells,were significantly associated with risk ***,the treatment of NMN showed increased proliferation of AGS and MKN45 *** addition,the expression of SASP factors(IL6,IL8,IL10,TGF-β,and TNF-α)was significantly decreased after NMN *** conclude that the lncRNAs associated with NAD+metabolism can potentially be used as biomarkers for predicting clinical outcomes of GC patients.

关键词： NAD+ LncRNAs Cancer Cell infiltration Prognosis Tumor microenvironment

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Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling

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Protein & Cell 2024年第6期15卷 441-459页

作者： feifei Liu Yi Lu Xuebao Wang Shuhui sun Huize Pan Min Wang Zehua Wang Weiqi Zhang Shuai Ma Guoqiang sun Qun Chu Si Wang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Sports Medicine Department Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Division of Life Sciences and Medicine School of Life SciencesUniversity of Science and Technology of ChinaHefei 230001China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China The Fifth People’s Hospital of Chongqing Chongqing 400062China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China

The synovium,a thin layer of tissue that is adjacent to the joints and secretes synovial fluid,undergoes changes in aging that contribute to intense shoulder pain and other joint ***,the mechanism underlying human synovial aging remains poorly ***,we generated a comprehensive transcriptomic profile of synovial cells present in the subacromial synovium from young and aged *** delineating aging-related transcriptomic changes across different cell types and their associated regulatory networks,we identified two subsets of mesenchymal stromal cells(MSCs)in human synovium,which are lining and sublining MSCs,and found that angiogenesis and fibrosis-associated genes were upregulated whereas genes associated with cell adhesion and cartilage development were downregulated in aged ***,the specific cell-cell communications in aged synovium mirrors that of aging-related inflammation and tissue remodeling,including vascular hyperplasia and tissue *** particular,we identified forkhead box O1(FOXO1)as one of the major regulons for aging differentially expressed genes(DEGs)in synovial MSCs,and validated its downregulation in both lining and sublining MSC populations of the aged *** human FOXO1-depleted MSCs derived from human embryonic stem cells,we recapitulated the senescent phenotype observed in the subacromial synovium of aged *** data indicate an important role of FOXO1 in the regulation of human synovial ***,our study improves our understanding of synovial aging during joint degeneration,thereby informing the development of novel intervention strategies aimed at rejuvenating the aged joint.

关键词： FOXO1 degeneration inflammation

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论中国传统法律文化中的女性特质

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浙江大学学报（人文社会科学版） 2009年第2期39卷 191-200页

作者：孙菲菲浙江大学光华法学院浙江杭州310008

女性主义法学家认为男女两性具有性别气质差异,并通过对社会性别和关怀伦理学的研究,提出了女性化的价值取向和道德观,从而认为在司法实践中也具有独特的女性风格,而以上女性特质恰与中国古代法律文化中的某些传统相符。中国古代司法具... 详细信息

女性主义法学家认为男女两性具有性别气质差异,并通过对社会性别和关怀伦理学的研究,提出了女性化的价值取向和道德观,从而认为在司法实践中也具有独特的女性风格,而以上女性特质恰与中国古代法律文化中的某些传统相符。中国古代司法具有反形式化的特点,传统法官的思维是一种实质性的思维,这与女性主义法学家所提出的女性法律方法中实际推理方法所体现的注重实质正义的特征相吻合。传统法律文化以和谐为宗旨的特点也与女性注重维系关系、强调关怀的特质相符。而中国法律文化的儒家学说与女性的关怀伦理学更是有很多契合点。因此,从某种意义上可以认为,中国传统法律文化具有女性特质,而此一特质仍然具有现代性。

关键词：女性主义法学社会性别关怀伦理学中国传统法律文化

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组合钢板剪力墙的简化模型

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同济大学学报（自然科学版） 2010年第1期38卷 18-23页

作者：孙飞飞刘桂然同济大学土木工程防灾国家重点实验室上海200092 同济大学土木工程学院上海200092 上海建筑设计研究院有限公司上海200041

新型钢-混凝土组合钢板剪力墙在混凝土板与边缘构件之间留有缝隙,避免混凝土板参与抵抗剪力,从而可以避免其对钢板的约束作用发生退化.观察这种组合钢板剪力墙的受力机理和破坏模式,可以发现,缝隙的设置使得无约束区域的钢板产生与钢板... 详细信息

新型钢-混凝土组合钢板剪力墙在混凝土板与边缘构件之间留有缝隙,避免混凝土板参与抵抗剪力,从而可以避免其对钢板的约束作用发生退化.观察这种组合钢板剪力墙的受力机理和破坏模式,可以发现,缝隙的设置使得无约束区域的钢板产生与钢板墙类似的斜拉场效应.据此,在钢板墙的斜拉杆模型中引入斜压杆,提出了双向多斜杆简化分析模型.通过理论分析,给出了该模型中斜杆元件的截面特性、滞回模型.经验证,该模型能准确地模拟组合钢板剪力墙在单调加载和反复加载下的非线性性能.

关键词：组合钢板剪力墙简化模型双向多斜杆模型滞回模型

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Selective Oxidation of Isobutane to Methacrylic Acid over Supported V-Mo-P Based Composite Oxide Catalysts

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Journal of Energy Chemistry 2002年第Z2期 120-126页

作者： feifei sun, Yunfeng Geng, Shunhe ZhongCollege of Chemical Engineering and Technology, State Key Laboratory of Cl Chemistry and Technology,Tianjin University, Tianjin 300072, China

Heteropolyacid, the most popular catalyst for the direct oxidation of isobutane, exhibits high catalytic activity, poor thermal stability and a short lifetime. Therefore, the catalyst requires further research to improve its performance. Catalysts composed of mixed oxides (V2O5, P2O5, or MoO3) supported on silica were prepared by the sol-gel method to catalyze the reaction. Results of XRD, IR, and BET corroborated that the mixed oxides were dispersed homogeneously on the surface of support. The activity of lattice oxygen in the catalysts was studied by TPR, and the chemisorption property of isobutane on the surface of the catalysts was investigated by the TPD method. H2-TPR of the catalysts revealed that the lattice oxygen of the vanadium-based catalysts is more active than that of the molybdenum-based catalysts. The redox property of V or Mo species is slightly affected by other compositions of the series catalysts. The TPD curves illustrate that there are two kinds of adsorptive species of isobutane on

关键词： 

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Diagnosis,Treatment,and Associated Factors Among Patients with HCV Infection—Jiangsu Province,China,2004–2020

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China CDC weekly 2024年第1期6卷 1-5,I0001-I0003页

作者： Dandan Yang Jing Lu Zhi Zhang Chuanwu sun Zhuping Xu Yao Qi XiaoXia Liu Huan Ding feifei Chai Zhengdong Zhang Baoli Zhu Department of Genetic Toxicology The Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of Jiangsu ProvinceNanjing CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of XuzhouXuzhou CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of WuxiWuxi CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of YanchengYancheng CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of ZhenjiangZhenjiang CityJiangsu ProvinceChina.

What is already known on this topic?The global efforts to address the hepatitis C virus(HCV)are progressing,but there are still significant gaps in the diagnosis and treatment of HCV,leading to an increasing number of deaths related to *** is added by this report?An extensive investigation was conducted to assess HCV RNA diagnosis,treatment uptake,and associated factors among individuals infected with HCV within Jiangsu *** study encompassed a large geographical area and utilized a substantial sample *** are the implications for public health practice?Implementing focused interventions to improve the timely diagnosis of HCV RNA and increase the uptake of HCV treatment could effectively reduce the future burden of HCV-related health problems,deaths,and healthcare *** is essential for achieving the global target of eliminating hepatitis C.

关键词： diagnosis utilized Jiangsu

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周期性隔震基础的优化设计与试验验证

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振动与冲击 2020年第12期39卷 1-8页

作者：孙飞飞杨嘉琦肖蕾上海同济大学土木工程学院上海200092 上海同济大学土木工程防灾国家重点实验室上海200092

周期性隔震基础是利用周期性结构的衰减域特性,将地震动与上部结构自振频率接近的频率范围内的能量衰减,从而控制上部结构响应的新型隔震装置。周期性基础的隔震性能受到多方面因素的影响,包括局域共振子的调谐频率比、质量比、阻尼比... 详细信息

周期性隔震基础是利用周期性结构的衰减域特性,将地震动与上部结构自振频率接近的频率范围内的能量衰减,从而控制上部结构响应的新型隔震装置。周期性基础的隔震性能受到多方面因素的影响,包括局域共振子的调谐频率比、质量比、阻尼比、基体的刚度、上部结构与基础的相互作用以及地震动的频谱特性等。目前尚未有研究综合考虑上述因素的影响并提出周期性基础的设计方法。提出以一组地震动作用下上部结构峰值响应衰减率的平均值为目标函数,对周期性基础进行优化的设计方法。计算结果表明,按照该优化方法得到的周期性基础对上部结构在选取的44条地震动作用下,峰值响应的平均衰减率达30%。参数敏感性分析表明,优化设计得到的周期性基础对于自身参数的变化具有良好的鲁棒性。最后利用缩尺振动台试验验证了优化设计得到的周期性基础的隔震性能,证明了优化方法的有效性和优化结果的正确性。

关键词：周期性基础衰减域隔震优化

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点焊箱型铜构件轴压性能试验及有限元分析

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同济大学学报（自然科学版） 2019年第2期47卷 175-184页

作者：孙飞飞魏智锴黄杰同济大学土木工程学院上海200092

为研究振动台试验中常用的点焊箱型截面构件的轴向屈曲性能,设计了两种截面尺寸的点焊箱型紫铜构件,对其进行静力轴压试验.试验结果表明,两种构件发生屈曲时材料基本处于弹性状态,但两者存在差异,宽厚比的不同是造成结果差异的主要原因... 详细信息

为研究振动台试验中常用的点焊箱型截面构件的轴向屈曲性能,设计了两种截面尺寸的点焊箱型紫铜构件,对其进行静力轴压试验.试验结果表明,两种构件发生屈曲时材料基本处于弹性状态,但两者存在差异,宽厚比的不同是造成结果差异的主要原因.在此基础上,采用有限元分析软件ABAQUS建立点焊箱型铜构件的有限元模型,与试验对比验证了有限元模型的可靠性.同时,对点焊边界条件下的薄板屈曲进行研究,得到焊点间距与屈曲系数之间的关系.最后,针对宽厚比和焊点间距两个参数,进行数值分析,得到宽厚比和焊点间距对点焊箱型构件受力性能的影响规律.

关键词：振动台试验点焊构件试验研究有限元分析屈曲系数宽厚比焊点间距

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Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu Wei Liu Peng Zhao feifei Lv Jie sun Hongjun Li Zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

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波纹腹板H型钢组合梁抗弯性能

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土木工程学报 2014年第5期47卷 34-39页

作者：张哲李国强孙飞飞郑州大学河南郑州450002 同济大学上海200092

为研究波纹腹板H型钢组合梁的受弯性能,制作4根试件进行抗弯试验,并借助有限元软件进行辅助分析。试验结果表明,波纹腹板H型钢组合梁具有较好的塑性变形性能,截面上应力分布基本符合平截面假定,钢梁腹板基本不承受弯曲正应力,腹板上剪... 详细信息

为研究波纹腹板H型钢组合梁的受弯性能,制作4根试件进行抗弯试验,并借助有限元软件进行辅助分析。试验结果表明,波纹腹板H型钢组合梁具有较好的塑性变形性能,截面上应力分布基本符合平截面假定,钢梁腹板基本不承受弯曲正应力,腹板上剪应力均匀分布。试验得到的极限破坏弯矩可以达到理论塑性弯矩的150%以上,钢梁腹板局部承压强度高,加载点不需要设置加劲肋。结合试验结果,按照组合梁简化塑性理论,给出了多种情况下,波纹腹板H型钢组合梁抗弯承载力的设计表达式。

关键词：波纹腹板H型钢组合梁平截面假定延性系数设计弯矩

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