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Experimental investigation of aerodynamics of turbine blade trailing edge cooling

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航空动力学报 2010年第5期25卷 1097-1102页

作者： sun da-wei QIAO wei-yang DONG Kang-tian XU Kai-fu School of Power and Energy Northwestern Polytechnical UniversityXi'an 710072China Xi'an Thermal Power Research Institute Xi'an 710032China

This paper presented an experimental investigation the effects of the trailing edge cooling on the aerodynamic performance. The experiments were conducted on the low-speed linear cascade tunnel at Northwestern Polytechnical University. The external aerodynamic characteristics in the 40 percent chord downstream of exit plane were measured using five-hole probe with the different ejection rates. The results showed that the total pressure loss coefficient at the middle spanwise plane increased at first and then it has a decreasing tendency with the increase of ejection ratio. The trailing edge cooling would influence the structure of the turbine cascade outlet flow field. When the ejection rate was 3%,the loss area near the blade endwall would become stronger,but it would become weaker with the 6% ejection ratio. On the whole,the trailing edge cooling had more influence on the profile loss than on the secondary loss.

关键词： turbine blade trailing edge cooling profile loss secondary loss

An increase in intracelluar free calcium ions modulated by cholinergic receptors in rat facial nucleus

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Chinese Medical Journal 2009年第9期122卷 1049-1055页

作者： sun da-wei ZHOU Rui LI Na ZHANG Qiu-gui ZHU Fu-gao Department of Otolaryngology Affiliated Hospital of MedicalCollege Qingdao University Qingdao Shandong 266003 China Qingdao Hiser Medical Center Qingdao Shandong 266033 China

Background Ca^2＋ in the central nervous system plays important roles in brain physiology, including neuronal survival and regeneration in rats with injured facial motoneurons. The present research was to study the modulations of intracellular free Ca^2＋ concentrations by cholinergic receptors in rat facial nucleus, and the mechanisms of the modulations. Methods The fluorescence intensity of facial nucleus in Fluo-3 AM loaded acute brainstem slices was detected by applying intracellular free Ca^2＋ measurement technique via confocal laser scanning microscope. The changes of fluorescence intensity of facial nucleus indicate the average changes of intracellular free Ca^2＋ levels of the neurons. Results Acetylcholine was effective at increasing the fluorescence intensity of facial nucleus. Muscarine chloride induced a marked increase of fluorescence intensity in a concentration dependent fashion. The enhancement of fluorescence intensity by muscarine chloride was significantly reduced by thapsigargin （depletor of intracellular Ca^2＋ store; P 〈0.01）, rather than Ca^2＋ free artifical cerebrospinal fluid or EGTA （free Ca^2＋ chelator; P〉0.05）. And the increase of fluorescence intensity was also significantly inhibited by pirenzepine （M1 subtype selective antagonist; P 〈0.01） and 4-daMP （M3 subtype selective antagonist; P 〈0.01）. In addition, fluorescence intensity was markedly increased by nicotine. The enhancement of fluorescence intensity by nicotine was significantly reduced by EGTA, nifedipine （L-type voltage-gated Ca^2＋ channel blocker）, dihydro-β-erythroidine （α4β2 subtype selective antagonist）, and in Ca^2＋ free artificial cerebrospinal fluid （P 〈0.01）, but not in the presence of mibefradil （M-type voltage-gated Ca^2＋ channel blocker） or thapsigargin （P〉0.05）. Conclusions The data provide the evidence that muscarinic receptors may induce the increase of intracellular free Ca^2＋ levels through the Ca^2＋ release of intracellular Ca^2＋ stores, in a manner related to M1 and M3 subtypes of muscarinic receptors in

关键词： calcium signaling receptors, cholinergic facial nerve

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压力管道施工焊接质量控制要点探讨

Study of brain-derived neurotrophic factor gene transgenic neural stem cells in the rat retina

建筑与装饰 2024年第11期 67-69页

作者：孙大伟海洋石油工程(青岛)有限公司山东青岛 266520

城市化进程的加快带动了我国各行业领域的进步.近年来,在"双碳"目标的驱使下,我国新能源材料产业迅速崛起,压力管道在新能源材料的制备生产中起到了极为重要的作用.在这种情况下,本文通过对压力管道施工焊接质量控制要点进行探索,分析... 详细信息

城市化进程的加快带动了我国各行业领域的进步.近年来,在"双碳"目标的驱使下,我国新能源材料产业迅速崛起,压力管道在新能源材料的制备生产中起到了极为重要的作用.在这种情况下,本文通过对压力管道施工焊接质量控制要点进行探索,分析焊接过程中的工艺以及检验步骤,来切实保障压力管道的焊接质量,并结合龙岩市上杭县蛟洋工业区的压力管道施工案例,来探讨焊接质量控制的要点.

关键词：压力管道施工焊接质量控制

来源：博看期刊评论

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Chinese Medical Journal 2009年第14期122卷 1642-1649页

作者： ZHOU Xue-mei YUAN Hui-ping WU Dong-lai ZHOU Xin-rong sun da-wei LI Hong-yi SHAO Zheng-bo Department of Ophthalmology Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150086 China Harbin Veterinary Research Institute China Agricultural Academy of Science Harbin Heilongjiang 150001 China

Background Neural stem cells （NSCs） transplantation and gene therapy have been widely investigated for treating the cerebullar and myelonic injuries, however, studies on the ophthalmology are rare. The aim of this study was to investigate the migration and differentJatJon of brain-derived neurotrophic factor （BDNF） gene transgenic NSCs transplanted into the normal rat retinas. Methods NSCs were cultured and purified in vitro and infected with recombinant retrovirus pLXSN-BDNF and pLXSN respectively, to obtain the BDNF overexpressed NSCs （BDNF-NSCs） and control cells （p-NSCs）. The expression of BDNF genes in two transgenic NSCs and untreated NSCs were measured by fluorescent quantitative polymerase chain reaction （FQ-PCR） and enzyme-linked Jmmunosorbent assay （ELISA）. BDNF-NSCs and NSCs were infected with adeno-associated viruses-enhanced green fluorescent protein （AAV-EGFP） to track them in vivo and served as donor cells for transplantation into the subretinal space of normal rat retinas, phosphated buffer solution （PBS） served as pseudo transplantation for a negative control. Survival, migration, and differentiation of donor cells in host retinas were observed and analyzed with Heidelberg retina angiograph （HRA） and immunohistochemistry, respectively. Results NSCs were purified successfully by limiting dilution assay. The expression of BDNF gene in BDNF-NSCs was the highest among three groups both at mRNA level tested by FQ-PCR （P 〈0.05） and at protein level measured by ELISA （P 〈0.05）, which showed that BDNF was overexpressed in BDNF-NSCs. The results of HRA demonstrated that graft cells could survive well and migrate into the host retinas, while the immunohistochemical analysis revealed that transplanted BDNF-NSCs differentiated into neuron more efficiently compared with the control NSCs 2 months after transplantation. Conclusions The seed cells of NSCs highly secreting BDNF were established. BDNF can promote NSCs to migrate and differentiate into neural cells in the normal host retinas.

关键词： neural stem cells brain-derived neurotrophic factor transplantation Heidelberg retina angiograph immunohistochemistry

Gene mapping of autosomal dominant retinitis pigmentosa in a Chinese family

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Chinese Medical Journal 2009年第9期122卷 1097-1101页

作者： daI Li-li sun da-wei WANG Zheng FU Song-bin HUANG Shang-zhi ZHANG Zhong-yu ZENG Guang PENG Shao-min Department of Ophthalmology Second Affiliated Hospital ofHarbin Medical University Harbin Heilongjiang 150081 China Genetic Laboratory Harbin Medical University HarbinHeilongjiang 150081 China Department of Medical Genetics Institute of Basic MedicalSciences Chinese Academy of Medical Sciences & Peking UnionMedical College Beijing 100005 China Departments of Surgery and Ophthalmology and Visual Sciences YaleUniversity School of Medicine New Haven CT USA

Background The autosomal dominant form of retinitis pigmentosa （ADRP） can be caused by mutations in 14 genes and further loci remains to be identified. This study was intended to identify mutations in a Chinese pedigree with ADRP. Methods A large Chinese family with retinitis pigmentosa was collected. The genetic analysis of the family suggested an autosomal dominant pattern. Microsatellite （STR） markers tightly linked to genes known to be responsible for ADRP were selected for linkage analysis. Exons along with adjacent splice junctions of PRPF31 were amplified by polymerase chain reaction （PCR） and screened by direct sequencing. Results The caused gene of ADRP was mapped to 19q13.4 between markers D19S572 and D19S877, with a maximum LOD score of 3.01 at marker D19S418 （recombination fraction=0）. Conclusion The affected gene linked to the 19q13.4 in a Chinese family with ADRP, which is different from other mutations at the same loci in other Chinese families.

关键词： retinitis pigmentosa, autosomal dominant genetic linkage Chinese

The Automorphism Group of U（4,Z）

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Chinese Quarterly Journal of Mathematics 2012年第1期27卷 98-103页

作者： WANG Yu-lei sun da-wei WANG Zhi-jun Department of Mathematics Henan University of TechnologyZhengzhou 450001China Department of Mathematics China University of Mining and TechnologyXuzhou 221116China

In this paper,the automorphism group of G is determined,where G is a 4 × 4 upper unitriangular matrix group over Z.Let K be the subgroup of AutG consisting of all elements of AutG which act trivially on G/G,G /ζG and ζG,then (i) InnG ■ K ■ AutG;(ii) AutG/K≌=G_1×D_8×Z_2,where G_1=(a,b,c|a^4=b^2=c^2=1,a^b=a^(-1),[a,c]= [b,c]=1 ;(iii) K/Inn G≌=Z×Z×Z.

关键词： upper unitriangular matrix groups general linear groups automorphism groups

艾司氯胺酮与舒芬太尼联合右美托咪定在经皮椎体成形术中的应用效果比较

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实用临床医学（江西） 2024年第1期25卷 29-33页

作者：李晓丽卜令标巩岩孙大为邹城市人民医院麻醉科山东邹城273500

目的比较艾司氯胺酮与舒芬太尼联合右美托咪定在老年患者经皮椎体成形术中的镇痛、镇静效果及安全性。方法采用前瞻性研究方法,将60例择期行椎体成形术患者随机分为SD组(舒芬太尼+右美托咪定组,n=30)和KD组(艾司氯胺酮+右美托咪定组,n=... 详细信息

目的比较艾司氯胺酮与舒芬太尼联合右美托咪定在老年患者经皮椎体成形术中的镇痛、镇静效果及安全性。方法采用前瞻性研究方法,将60例择期行椎体成形术患者随机分为SD组(舒芬太尼+右美托咪定组,n=30)和KD组(艾司氯胺酮+右美托咪定组,n=30)。SD组给予0.1μg·kg^(-1)舒芬太尼静脉注射,KD组给予艾司氯胺酮0.3 mg·kg^(-1)静脉注射,随后均给予右美托咪定0.5μg·kg^(-1)·h^(-1)持续泵注。比较2组T1(给药前)、T2(给予舒芬太尼或艾司氯胺酮后5 min)、T3(给予舒芬太尼或艾司氯胺酮后15 min)、T4(给予舒芬太尼或艾司氯胺酮后30 min)、T5(出手术室前)5个时间点的平均动脉压(MAP)、心率(HR)、血氧饱和度(SPO_(2))、疼痛程度VAS评分及Ramsay镇静评分;观察2组患者的不良反应,包括血压波动、心律失常、呼吸抑制、恶心呕吐及呓语躁动精神症状等。结果与SD组相比,KD组T3、T4时间点MAP及HR显著升高,T2、T3、T4时间点Ramsay镇静评分显著升高,T3、T4时间点VAS疼痛评分显著降低,差异均有统计学意义(P0.05)。结论在经皮椎体成形术中采用小剂量艾司氯胺酮与右美托咪定联合能够产生良好的镇痛镇静效果,生命体征更加平稳,是一种安全可行的麻醉用药组合。

关键词：艾司氯胺酮舒芬太尼右美托咪定经皮椎体成形术

基于业务要素的LNG接收站标准体系构建启示

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中国标准化 2024年第3期 79-83页

作者：祝悫智王凯濛孙大微薛鲁宁国家石油天然气管网集团有限公司科学技术研究总院分公司

近年我国LNG行业的市场竞争逐步放开,行业软科学和硬技术实现双突破,我国LNG行业标准已从直接采标国外LNG重点标准发展到自主制定适合国内LNG行业发展建设标准的阶段。通过综合标准化方法全面梳理我国LNG接收站全生命周期及其业务对象... 详细信息

近年我国LNG行业的市场竞争逐步放开,行业软科学和硬技术实现双突破,我国LNG行业标准已从直接采标国外LNG重点标准发展到自主制定适合国内LNG行业发展建设标准的阶段。通过综合标准化方法全面梳理我国LNG接收站全生命周期及其业务对象与要素,基于对现有LNG接收站关键核心标准的解读与适用性分析,通过LNG接收站全生命周期的业务需求及现阶段标准体系分析,梳理出LNG接收站标准体系中的薄弱环节,基于此,提出LNG接收站标准体系的规划建议。

关键词： LNG接收站标准体系标准化对象适用性分析

Malvidin Mitigates Sepsis-induced Cardiac Injury by Modulating the TLR4-iNOS-COX-2 Inflammatory Pathway and the Bax/Bcl-2/Cyto-C Mitochondrial Apoptosis Pathway in a p38 MAPK-dependent Manner

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Biomedical and Environmental Sciences 2024年第2期37卷 221-227页

作者： ZHANG wei YUAN Si Long QIANG Jing Chao HUANG He LI da sun Ying ZHANG Hong Gang Department of Vascular Surgery The First People’s Hospital of LianyungangLianyungang 222005JiangsuChina Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening College of PharmacyJiangsu Ocean UniversityLianyungang 222005JiangsuChina Jinzhou Medical University postgraduate training base(Lianyungang First People’s Hospital) Lianyungang 222005JiangsuChina

In critical care medicine,sepsis is a dangerous systemic condition that is highly prevalent and is associated with high morbidity and mortality rates^([1]).The high mortality rate associated with sepsis is closely related to multi-organ dysfunction,with heart injury being particularly critical and considered the starting point of multi-organ injury^([2]).

关键词： mortality Apoptosis TLR4