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Elaborately engineering of lipid nanoparticle for targeting delivery of siRNA and suppressing acute liver injury

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Chinese chemical Letters 2024年第2期35卷 323-328页

作者： Qiu Wang Qikun Jiang Dan Li Zimeng Yang Lin Gao Fan liu Chang Li Yao feng Zhonggui He cong Luo Jin sun department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Kangya of Ningxia Pharmaceutical Co.Ltd. Yinchuan 750000China

Small interfering RNA(siRNA)-based gene silencing has been considered as a potential therapy modality against inflammatory ***,the effective delivery of siRNA to desired destination still remains challenging due to poor stability,high molecular weight and negative ***,ionizable lipid nanoparticle(LNP)has been extensively used as vector for effective delivery of ***,we report a mannose-modified LNP(M-MC_(3) LNP@TNFα)loading tumor necrosis factorα(TNFα)siRNA for targeting liver macrophages,achieving effectively inhibit acute liver *** M-MC_(3) LNP@TNFαnot only increases the internalization of LNP by macrophages,but also enhances the gene silencing efficiency of TNFαin ***,the M-MC_(3) LNP@TNFαexhibits higher accumulation in liver of healthy mice than that of MC_(3) LNP@TNFα(un-modified LNP)owing to the targeting effect of *** expected,the M-MC_(3) LNP@TNFαsignificantly suppresses the expression of TNFαand ameliorates liver damage in acute liver injury *** a LNP targeting siRNA delivery holds great potential for the treatment of diseases associated with liver in the future.

关键词： Lipid nanoparticle Targeting siRNA delivery Acute liver injury Gene silencing Tumor necrosis factorα

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Hydroxyl radical production by abiotic oxidation of pyrite under estuarine conditions:The effects of aging,seawater anions and illumination

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Journal of environmental Sciences 2024年第1期135卷 715-727页

作者： Ruixue liu Yinshun Dai Yucheng feng Shiwen sun Xiaodong Zhang Chunjiang An Shan Zhao Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityQingdao 266237China department of Building Civil and Environmental EngineeringConcordia UniversityMontrealQC H3G 1M8Canada

Pyrite is widely distributed in estuarine sediments as an inexpensive natural Fenton-like reagent,however,the mechanism on the hydroxyl radical(HO^(·))production by pyrite under estuarine environmental conditions is still poorly *** batch experiments were performed to investigate the effects of estuarine conditions including aging(in air,in water),seawater anions(Cl^(-),Br^(-)and HCO_(3)^(-))and light on the HO^(·)production by pyrite *** one-electron transfer dominated the process from O_(2) to HO^(·)induced by oxidation of *** Fe(oxyhydr)oxide coatings on the surface of pyrite aged in air and water consumed hydrogen peroxide while mediating the electron transfer,and the combined effect of the two resulted in a suppression of HO^(·)production in the early stage of aging and a promotion of HO^(·)production in the later stage of *** of the surface oxide layers by aggressive anions was the main reason for the inhibition of HO^(·)production by Cl^(-)and Br^(-),and the generation of Cl^(·)and Br^(·)may also play a role in the scavenging of HO^(·).HCO_(3)^(-)increased the average rate of HO^(·)production through surface-CO_(2) complexes formed by adsorption on the surface of *** significant enhancement of HO^(·)production under light was attributed to the formation of photoelectrons induced by photochemical reactions on pyrite and its surface oxide *** findings provide new insights into the environmental chemical behavior of pyrite in the estuary and enrich the understanding of natural remediation of estuarine environments.

关键词： Hydroxyl radical Pyrite oxidation Aging Anions Irradiation

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Fe-doped Co_(3)O_(4) nanowire strutted 3D pinewood-derived carbon: A highly selective electrocatalyst for ammonia production via nitrate reduction

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Nano Research 2024年第4期17卷 2276-2282页

作者： Xuwei liu Chaozhen liu Xun He Zhengwei Cai Kai Dong Jun Li Xiaoya Fan Ting Xie Xiya Yang Yonglan Luo Dongdong Zheng Shengjun sun Sulaiman Alfaifi feng Gong Xuping sun Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 211189China college of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Chemistry department Frontier of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Nitrate(NO_(3)^(-)),a nitrogen-containing pollutant,is prevalent in aqueous solutions,contributing to a range of environmental and health-related *** electrocatalytic reduction of NO_(3)^(-)holds promise as a sustainable approach to both eliminating NO_(3)^(-)and generating valuable ammonia(NH_(3)).Nevertheless,the reduction reaction of NO_(3)^(-)(NO_(3)^(-)RR),involving 8-electron transfer process,is intricate,necessitating highly efficient electrocatalysts to facilitate the conversion of NO_(3)^(-)to NH_(3).In this study,Fe-doped Co_(3)O_(4) nanowire strutted three-dimensional(3D)pinewood-derived carbon(Fe-Co_(3)O_(4)/PC)is proposed as a high-efficiency NO_(3)^(-)RR electrocatalyst for NH_(3) *** within 0.1 M NaOH containing NO_(3)^(-),Fe-Co_(3)O_(4)/PC demonstrates exceptional performance,obtain an impressively large NH_(3) yield of 0.55 mmol·h^(-1)·cm^(-2) and an exceptionally high Faradaic efficiency of 96.5%at-0.5 V,superior to its Co_(3)O_(4)/PC counterpart(0.2 mmol·h^(-1)·cm^(-2),73.3%).Furthermore,the study delves into the reaction mechanism of Fe-Co_(3)O_(4) for NO_(3)^(-)RR through theoretical calculations.

关键词： Fe-doped Co_(3)O_(4) nanowire pinewood-derived carbon electrocatalytic NO_(3)-reduction NH_(3) synthesis density functional theory

The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuotao Wang department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

Approach to predict partitioning of organic compounds from air into airborne particulate

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Chinese Science Bulletin 2005年第16期50卷 1696-1698页

作者： sun cong feng liu department of environmental engineering College of Chemical Engineering Beijing University of Chemical Technology Beijing 10029China

关键词：有机化合物空气传播微粒分割系数量子论

RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

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Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li Longqing cong Perry Ping Shum State Key Laboratory of Optical Fiber and Cable Manufacture technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China college of Optical and Electronic technology China Jiliang UniversityHangzhou 310018China department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China department of Ocean Science and engineering Southern University of Science and TechnologyShenzhen 518055China department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical Research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China department of Biomedical engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and *** is also an emerging omics technique for metabolic profiling to shape precision ***,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is *** Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information ***,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral *** can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human *** experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established *** this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint *** precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse *** scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

Numerical investigation of edge configurations on piston-modal resonance in a moonpool induced by heaving excitations

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Journal of Hydrodynamics 2019年第4期31卷 682-699页

作者： Sheng-chao Jiang Pei-wen cong Lei sun Chang-feng liu School of Naval Architecture State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of T/echnology Dalian 116024 China State Key Laboratory of Coastal and Offshore engineering Dalian University of Technology Dalian 116024 China department of Civil and environmental engineering National University of Singapore Singapore college of Ocean and Civil engineering Dalian Ocean University Dalian 116023 China

The renormalization group (RNG) turbulent model is used to investigate the fluid resonance in a moonpool formed by two identical rectangular hulls under synchronous heaving excitation (e.g., a catamaran or dual pontoon). The numerical model is validated against the available experimental data, and accurate numerical solutions are obtained. The present study focuses on the amplitude of the moving hulls and the edge configuration of the moonpool entrance, as well as their influences on the piston-modal resonant wave in the moonpool. The dependence of the resonant wave amplitude in the moonpool on the heaving amplitude, the characteristic moonpool dimensions and the local velocity magnitude is derived based on a theoretical analysis, and the results are in good agreement with the RNG turbulent solutions. Five different edge profiles are considered, including two convex edges, two concave edges (both with various dimensions), and a sharp edge. Numerical examinations show that the edge configuration has a significant influence on the piston-modal resonant responses, a larger opening size leading to a higher resonant frequency and a larger resonant wave amplitude in the moonpool. Various flow patterns of the piston-modal resonance in the vicinity of the moonpool entrance are also identified, mainly depending on the edge profile. More intensive turbulent and vortical flows give rise to more significant dissipation, accounting for the smaller relative wave amplitude in the moonpool. With the increase of the heaving amplitude, the relative piston-modal resonant amplitude is decreased in an approximate power function. Within the scope of this work, the numerical investigations show that the piston-modal resonant frequency is hardly affected by the heaving amplitude.

关键词： Moonpool wave resonance comer shape renormalization group (RNG) turbulent model heaving motion

Unveiling and Alleviating chemical“Crosstalk”of Succinonitrile Molecules in Hierarchical Electrolyte for High-Voltage Solid-State Lithium Metal Batteries

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Energy & environmental Materials 2023年第3期6卷 107-116页

作者： Fang Fu Ying liu Chen sun Lina cong Yulong liu Liqun sun Haiming Xie National&Local United engineering Laboratory for Power Battery Department of ChemistryNortheast Normal UniversityChangchun 130024China

Succinonitrile-based plastic crystal electrolytes have emerged for high-energy-density Li metal batteries in terms of their superior ambient ionic conductivity,low flammability,and benign compatibility with high voltage cathode,but are hampered by inherent instabilities toward Li *** hierarchical solid electrolytes structure is a fundamental approach to protect Li anode from succinonitrile attacks,with succinonitrile-based oxidation-resistance layer facing high voltage cathode and reduction-tolerant layer contacting Li ***,free succinonitrile molecules in succinonitrile-based electrolyte layer can diffuse across the electrolyte/electrolyte interface and further reach Li anode surface during the battery *** chemical“crosstalk”cause reduction-tolerant electrolyte layer to fail to protect the Li anode from the attacks of free succinonitrile *** Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)is introduced creatively into succinonitrile-based electrolyte *** taking advantage of the complexation between La atoms in Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)and N atoms in succinonitrile,the free succinonitrile molecules are successfully immobilized in succinonitrile-based electrolyte *** resulting low resistance and highly durable solid electrolyte interphase and cathode electrolyte interphase endow NCM622||Li batteries with remarkable cycle *** research provides a new idea for the real application of plastic crystal electrolytes in high voltage solid-state lithium metal batteries.

关键词： hierarchical solid electrolytes high voltage interface lithium metal plastic crystal

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Enhanced Peroxymonosulfate Activation by NixCo1-xOOH for Efficient Catalytic Oxidation of Organic Pollutants

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chemical Research in Chinese Universities 2019年第3期35卷 440-448页

作者： LYU cong LI Yicheng FANG Chen feng Wei sun Wentian ZHANG Qihui Key Laboratory of Groundwater Resources and Environment Ministry of Education Jilin UniversityChangchun 130021P.R.China Jilin Provincial Key Laboratory of Water Resources and Environment Jilin University Changchun 130021P.R.China department of Civil and environmental engineering Northeastern University BostonMassachusetts 02115USA

Peroxymonosulfate(PMS) has received increasing attention as viable technology for recalcitrant organics removal from polluted waters. Although promising, alternative heterogeneous catalysts with stable structure, strong hydrophilicity, environmental friendliness and excellent catalytic performance are highly desirable to facilitate the wide industrialization of PMS. In this work, Ni doped CoOOH catalyst was employed as PMS activator. Ni dopant had a significant influence on the morphology, structure and catalytic performance of CoOOH. *** exhibited the best catalytic performance. Reaction rate ofNio.2Coo.8OOH was 2, 4, and 4.4 times that of CoOOH, CoFe2O4 and CO3O4, respectively. Moreover, Ni。2C00.8OOH/PMS system had potential application to organic pollutants and displayed a great catalytic activity over a broader pH value(e.g., 4-10). More importantly, Ni doping accelerated the transfonnation of Co(Ⅲ) and Co(Ⅱ) and formed active species CoOH^+ and NiOH^+ which were responsible to the enhancement of PMS ***, SO4^-:O2^- and 1^O2 were detected, indicating both non-radical and radical processes in the Nio.2Coo.8OOH/PMS system. These findings provide a promising alternative to mixed-metal oxyhydroxides catalysts for PMS activation, demonstrating a great potential in environmental remediation and wastewater treatment.

关键词： Ni dopant Sulfate radical Superoxide radical Singlet oxygen Electron transfer