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Selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide

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Science China Life Sciences 2025年

作者： Xiaonan Wang ning Zhou Xuejiao J.Gao Zijing Zhu Minmin sun Qian Wang Haolin Cao Xuetong Wu Caiyu Zhou Qingkang Zheng Ye Yuan Yuan Liu Lei Chen Jing Jiang Pengcheng Bu Lizeng Gao CAS Engineering Laboratory for nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences School of Life Sciences University of Chinese Academy of Sciences College of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Epigenetic Regulation and Intervention Institute of Biophysics Chinese Academy of Sciences nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science

Alternative treatment for the highly prevalent Helicobacter pylori infection is imperative due to rising antibiotic resistance. We unexpectedly discovered that the anti-H. pylori component in garlic is hydrogen polysulfide（H2S_n, n≥2）, not organic polysulfides. Studies on the mechanism of action（MoA） show that H2S_nspecifically inactivates H. pylori glucose-6-phosphate dehydrogenase（G6PDH） by interfering with electron transfer from glucose-6-phosphate（G6P） to nicotinamide adenine dinucleotide phosphate（nADP+）. However, low H2S_nyield makes garlic derivatives hard to be a reliable donor of H2S_nto treat H. pylori infection. To address this challenge, we established a polysulfide transformation process from garlic organosulfur compounds into Fe3S4that generates H2S_nwith a 25–58 times increase in *** chitosan encapsulation, we designed a gastric-adaptive H2S_nmicroreactor（GAPSR） that eradicates H. pylori with 250 times higher efficiency under gastric conditions. A single GAPSR achieves more rapid H. pylori eradication than combined antibiotics therapy without disturbing the gut microbiota. These findings indicate a distinct MoA transformation mediated by polysulfide as an alternative candidate to treat H. pylori infection.

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Effects of plasma actuation and hole configuration on film cooling performance

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Propulsion and Power Research 2023年第2期12卷 227-237页

作者： Jie sun Fuxing Zhang Jin Wang Gongnan Xie Bengt sundén School of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Key Laboratory of Thermo-Fluid Science and Engineering(Xi’an Jiaotong University) Ministry of EducationXi’an 710049China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072China Department of Energy Sciences Division of Heat TransferLund UniversityLund SE-22100Sweden

In this paper,plasma actuators are arranged asymmetrically downstream the wall to improve film cooling *** of blowing ratio,hole configuration and applied voltage on flow characteristics and film cooling effectiveness were investigated numerically on a flat *** show that highest film cooling effectiveness distribution is obtained both in the spanwise and streamwise directions under blowing ratio of *** wall film cooling effectiveness of cylindrical hole increases by 251.9%under blowing ratio of 0.5 compared to that under blowing ratio of *** scale of the counter rotating vortex pairs(CRVP)from fan shaped hole and sister hole are significantly reduced compared to that from cylindrical *** console hole has an anti-counter rotating vortex pair(Anti-CRVP),which weakens the entrainment of the CRVP to the coolant air near the *** with the cylindrical hole,average wall film cooling effectivenesses for fan shaped hole,sister hole and console hole increase by 73.1%,97.5%and 119.9%.The adherent performance of the coolant air is enhanced after applying plasma *** aerodynamic actuation of the plasma results in the rebound of the fluid close to the wall at 24 kV applied *** wall film cooling effectiveness of the console hole at 12 kV applied voltage is 10.6%higher than that without plasma.

关键词： Aerodynamic actuation Film cooling Flow control Hole configurat

Mechanism of defect evolution in H^(+)and He^(+)implanted InP

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Chinese Physics B 2021年第8期30卷 70-74页

作者： Ren-Jie Liu Jia-Jie Lin n Daghbouj Jia-Liang sun Tian-Gui You Peng Gao nie-Feng sun Min Liao Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education School of Materials Science and EngineeringXiangtan UniversityXiangtan 411105China Hunan Provincial Key Laboratory of Thin Film Materials and Devices School of Materials Science and EngineeringXiangtan UniversityXiangtan 411105China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China China nanhu Academy of Electronics and Information Technology Jiaxing 314000China Department of Control Engineering Faculty of Electrical EngineeringCzech Technical University in PragueTechnick´a 216000 Prague 6Czechia Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Science and Technology on Power Sources Laboratory Tianjin Institute of Power SourcesTianjin 300384China The 13th Research Institute CETCShijiazhuang 050051China

The defect evolution in InP with the 75 keV H^(+)and 115 keV He^(+)implantation at room temperature after subsequent annealing has been investigated in *** the same ion implantation fluence,the He^(+)implantation caused much broader damage distribution accompanied by much higher out-of-plane strain with respect to the H^(+)implanted *** annealing,the H^(+)implanted InP did not show any blistering or exfoliation on the surface even at the high fluence and the H2 molecules were stored in the heterogeneously oriented platelet ***,the He molecules were stored into the large bubbles which relaxed toward the free surface,creating blisters at the high fluence.

关键词： ion implantation defect evolution ion-slicing damaged band

Scaling laws of aquatic locomotion

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Science China(Physics,Mechanics & Astronomy) 2017年第10期60卷 27-33页

作者： BoHua sun Department of Mechanical Engineering Cape Peninsula University of Technology Cape Town 8000 South Africa

In recent years studies of aquatic locomotion have provided some remarkable insights into the many features of fish swimming performances. This paper derives a scaling relation of aquatic locomotion CD(Re)~2 =(Sw)~2 and its corresponding log law and power law. For power scaling law,(Sw)~2 = β_nRe^((2-1)/n), which is valid within the full spectrum of the Reynolds number Re=UL/v from low up to high, can simply be expressed as the power law of the Reynolds number Re and the swimming number Sw=ωAL/v as Re ∝ (Sw)~σ,with σ=2 for creeping flows,σ=4/3 for laminar flows, σ=10/9 and σ=14/13 for turbulent flows. For log law this paper has derived the scaling law as Sw ∝ Re=(lnRe+1.287), which is even valid for a much wider range of the Reynolds number Re. Both power and log scaling relationships link the locomotory input variables that describe the swimmer's gait A;ω via the swimming number Sw to the locomotory output velocity U via the longitudinal Reynolds number Re, and reveal the secret input-output relationship of aquatic locomotion at different scales of the Reynolds number.

关键词： aquatic locomotion scaling law Reynolds number swimming number creeping flows laminar flows turbulent flows

SpyStapler-mediated assembly of nanoparticle vaccines

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nano Research 2023年第2期16卷 2821-2828页

作者： Songzi Kou Weitao Chen Chenbo sun Fei sun Biomedical Research Institute Shenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Greater Bay Biomedical Innocenter Shenzhen Bay LaboratoryShenzhen 518132China Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has wreaked havoc around the globe,with no end in *** rapid emergence of viral mutants,marked by rapid transmission and effective immune evasion,has also posed unprecedented challenges for vaccine development,not least in its speed,mass production,and *** we report a versatile“plug-and-display”strategy for creating protein vaccines,including those against malaria parasites and SARS-CoV-2,through the combined use of the intrinsically disordered protein ligase SpyStapler and computationally designed viral-like *** resulting protein nanoparticles harboring multiple antigens induce potent neutralizing antibody responses in mice,substantially stronger than those induced by the corresponding free *** modular vaccine design enabled by SpyStapler furnishes us with a new weapon for combatting infectious diseases.

关键词： subunit vaccine SpyTag SARS-CoV-2 malaria

Synthesis of Aluminum nitride nanocrystalline

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Journal of Materials Science & Technology 1998年第5期14卷 470-472页

作者： sun, Xiangcheng sun, Xiukui Wei, Wenduo Acad Sinica Inst Met Res State Key Lab RSA Shenyang 110015 Peoples R China

nanocrystalline aluminum nitride (whisker and particle) has been synthesized by heating the mixed aluminum plus aluminum nitride ultrafine powders produced by nitrogen plasma-molten aluminum reaction, under n//2 atmosphere at lower temperature. Some bamboo like nano whiskers of aluminum nitride were observed in TEM, the possible formation mechanism of the whiskers was also discussed. (Edited author abstract) 7 Refs.

关键词： Aluminum compounds

nonlinear mechanics of a ring structure subjected to multi-pairs of evenly distributed equal radial forces

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Acta Mechanica Sinica 2017年第5期33卷 942-953页

作者： Q. Chen F. sun Z. Y. Li L. Taxis n. Pugno Biomechanics Laboratory School of Biological Science and Medical Engineering Southeast University State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics School of Chemistry Physics and Mechanical EngineeringQueensland University of Technology (QUT) Laboratory of Bio-Inspired and Graphene nanomechanics Department of Civil Environmental and Mechanical Engineering University of Trento School of Engineering and Materials Science Queen Mary University of London Ket Lab Italian Space Agency Via del Politecnico snc

Combining the elastica theory, finite element (FE) analysis, and a geometrical topological experiment, we studied the mechanical behavior of a ring subjected to multi-pairs of evenly distributed equal radial forces by looking at its seven distinct states. The results showed that the theoretical predictions of the ring deformation and strain energy matched the FE results very well, and that the ring deformations were comparable to the topological experiment. Moreover, no matter whether the ring was compressed or tensioned by n-pairs of forces, the ring always tended to be regular polygons with 2n sides as the force increased, and a proper compressive force deformed the ring into exquisite flower-like patterns. The present study solves a basic mechanical problem of a ring subjected to lateral forces, which can be useful for studying the relevant mechanical behavior of ring structures from the nano- to the macro-scale.

关键词： Ring structures Mechanical properties Shape Strain energy

Full privacy preserving electronic voting scheme

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The Journal of China Universities of Posts and Telecommunications 2012年第4期19卷 86-93页

作者： PAnG Lei sun Mao-hua LUO Shou-shan WAnG Bai X1n Yang School of Computer Science Beijing University of Posts and Telecommunications Beijing 100876 China national Engineering Laboratory for Disaster Backup and Recovery Beijing 100876 China Beijing Safe-Code Technology Company Limited Beijing 100082 China

Privacy is an important issue in electronic voting. The concept of ＇full privacy＇ in electronic voting was firstly proposed, not only the privacy of voters is concerned, but also the candidates＇. Privacy preserving electronic election architecture without any trusted third party is presented and a general technique for k-out-of-m election based on distributed E1Gamal encryption and mix-match is also provided. The voters can compute the result by themselves without disclosing their will and the vote of the losing candidates. Moreover, whether the vote of winner candidate is more than a half can be verified directly. This scheme satisfies ＇vote and go＇ pattern and achieves full privacy. The correctness and security are also analyzed.

关键词： electronic voting full privacy secure multi-party computation cryptography

高电压正极材料LiFe_(0.06)ni_(0.94)PO_(4)/C的制备及其性能研究

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现代化工 2025年第1期45卷 184-189页

作者：李志义孙赫孙海礼魏炜刘凤霞刘志军大连理工大学流体与粉体工程研究设计所辽宁大连116024

磷酸镍锂(LiniPO4)是一种具有5.1 V高电压平台的橄榄石类锂离子电池正极材料,由于较低的电导率和实际放电比容量限制了其实际应用。为了制备纯相LiniPO4,考察了不同摩尔比表面活性剂油胺对LiniPO4的影响,油胺添加摩尔比[n(油胺)∶n(金... 详细信息

磷酸镍锂(LiniPO4)是一种具有5.1 V高电压平台的橄榄石类锂离子电池正极材料,由于较低的电导率和实际放电比容量限制了其实际应用。为了制备纯相LiniPO4,考察了不同摩尔比表面活性剂油胺对LiniPO4的影响,油胺添加摩尔比[n(油胺)∶n(金属)]为10∶1制备的材料结晶度最佳,经过煅烧工艺参数优化成功获得纯相LiniPO4。为了改善LiniPO4的电化学性能,首次采用乙基纤维素为碳源制备的掺有Fe摩尔分数为6%的LiFe0.06ni0.94PO4/C并将其电化学性能与纯相LiniPO4进行比较,结果表明,采用乙基纤维素制备的LiFe0.06ni0.94PO4/C具有更大的初始放电比容量、更小的电荷转移电阻,其中10%乙基纤维素添加量的样品电化学性能最佳。

关键词：磷酸镍锂油胺乙基纤维素碳包覆电化学性能