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Mechanism of cAMP-PKA Signaling Pathway Mediated by Shaoyao Gancao Decoction(芍药甘草汤)on Regulation of Aquaporin 5 and Muscarinic Receptor 3 Levels in Sjogren’s Syndrome

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Chinese Journal of Integrative Medicine 2020年第7期26卷 502-509页

作者： WANG Dan zhao Hao {1. Ben sun Yu WEI Dong-hui department of Rheumatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai(200437)China department of Emergency Shanghai Traditional Chinese and Western Medicine Integrated HospitalShanghai University of Traditional Chinese and Western MedicineShanghai(200082)China

Objective:To investigate the mechanism of c AMP-PKA signaling pathway mediated by Chinese medicine formula Shaoyao Gancao Decoction(芍药甘草汤,SGD)on the regulation of aquaporin 5(AQP5)and muscarinic receptor 3(M3 R)levels in Sjogren’s syndrome(SS).Methods:Of the 30 mice,5 were randomly selected as control,and others were used for creating SS *** successful modeling,mice were randomly divided into 5 groups(n=5 per group)and intragastrical y administered with saline(8 m L/kg),pilocarpine(1.4 mg/kg),or low,medium and high doses SGD(0.1.,0.2.,0.35 g/kg Radix paeoniae with 0.01.g/kg Radix glycyrrhizae,respectively)for 6 *** labial gland acinar cel s were treated with pilocarpine or varying doses of SGD with saline as the *** and eosin staining was used to observe the histopathological changes of the submandibular glands of *** serum levels of anti-SS antigen A(SS-A),anti-SS antigen B(SS-B),M3 R,andα-fodrin in submandibular glands of mice were measured by enzyme-linked immunosorbent *** staining was used to observe the spatial localization of AQP5 and M3 R in acinar *** transcriptase polymerase chain reaction and Western blot were used to detect the expressions of PKA,c AMP,Epac1.AQP5,M3 R,nuclear factor kappa-B(NF-κB),and tumor necrosis factor(TNF)-αin submandibular gland tissues and cel s of each ***:Compared to normal mice,body weight,5-min salivary secretion,30-min secretion of tears and breakup time of tear film of model mice decreased at 1.6 weeks after immunization(al P<0.05),whereas water intake increased(al P<0.05).In the model group,glands of the submandibular glands showed atrophy,accompanied by acini of different sizes,decreased numbers and loose arrangement,with catheter dilatation and different degrees of lymphocyte *** of mice in SGD groups were *** positive expression of AQP5 and M3 R were higher in the acinar cel s treated with al doses SGD compared to t

关键词： Shaoyao Gancao Decoction Chinese medicine cAMP-PKA Sjogren's syndrome mouse

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High-ionicity fluorophosphate lattice via aliovalent substitution as advanced cathode materials in sodium-ion batteries

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InfoMat 2021年第6期3卷 694-704页

作者： Zhen-Yi Gu Jin-Zhi Guo Xin-Xin zhao Xiao-Tong Wang Dan Xie Zhong-Hui {1. Chen-De zhao Hao-Jie liang Wen-Hao li Xing-Long Wu MOE Key Laboratory for UV light-Emitting Materials and Technology Northeast Normal UniversityChangchunJilinChina department of {1. Northeast Normal UniversityChangchunJilinChina Center for Advanced Analytical Science School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhouGuangdongChina

As a cathode for sodium-ion batteries(SIBs),Na3V2.PO4)2.3(NVPF)with 3D open framework is a promising candidate due to its high working voltage and large theoretical ***,the severe capacity degradation and poor rate capability hinder its practical *** present study demonstrated the optimization of Na-storage performance of NVPF via delicate lattice *** substitution of V^(3^(+))at Na^(+)in NVPF induces the generation of electronic defects and expansion of Na^(+)-migration channels,resulting in the enhancement in electronic conductivity and acceleration of Na^(+)-migration *** is disclosed that the formed stronger Na O bonds with high ionicity than V O bonds lead to the significant increase in structural stability and ionicity in the Na^(+)-substituted NVPF(NVPF-Nax).The aforementioned effects of Na^(+)substitution achieve the unprecedented electrochemical performance in the optimized Na_(3.1.)V1.93Na0.07(PO_(4))_(2.F_(3)(NVPF-Na_(0.07)).As a result,NVPF-Na0.07 delivers a high-rate capability(77.5 mAh g^(−1.at 2. C)and ultralong cycle life(only 0.02.%capacity decay per cycle over 1.00 cycles at 1. C).Sodium-ion full cells are designed using NVPF-Na0.07 as cathode and Se@reduced graphene oxide as *** full cells exhibit excellent wide-temperature electrochemical performance from−2. to 2.C with an outstanding rate capability(96.3 mAh g^(−1.at 2. C).Furthermore,it delivered an excellent cycling performance over 300 cycles with a capacity retention exceeding 90%at 0.5 C under different *** study demonstrates a feasible strategy for the development of advanced cathode materials with excellent electrochemical properties to achieve high-efficiency energy storage.

关键词： cathode full cell ionicity Na3V2.PO4)2.3 sodium-ion batteries

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沂山苔藓植物的区系研究

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山东科学 2000年第2期13卷 30-34,40页

作者：孙立彦赵遵田刘振亮山东师范大学生物系山东济南250014

沂山苔藓植物共有 34科 79属 1.48种 ,其苔藓植物区系泛北极成分占 83.5%。其中 ,欧、亚、北美区系成分占 35.0 % ,东亚特有成分占 34.2.% ,亚美成分占 2..7% ,中国特有成分占4.8%。本区系与欧、亚、北美在苔藓植物各方面有着广泛的联... 详细信息

沂山苔藓植物共有 34科 79属 1.48种 ,其苔藓植物区系泛北极成分占 83.5%。其中 ,欧、亚、北美区系成分占 35.0 % ,东亚特有成分占 34.2.% ,亚美成分占 2..7% ,中国特有成分占4.8%。本区系与欧、亚、北美在苔藓植物各方面有着广泛的联系 ,具明显东亚色彩。

关键词：沂山苔藓植物植物区系泛北极成分

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Mn3O4 nanoparticles@reduced graphene oxide composite:An efficient electrocatalyst for artificial N2.fixation to NH3 at ambient conditions

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Nano Research 2019年第5期12卷 1093-1098页

作者： Hong Huang Feng Gong Yuan Wang Huanbo Wang Xiufeng Wu Wenbo Lu Runbo zhao Hongyu Chen Xifeng Shi Abdullah M.Asiri Tingshuai {1. Qian {1.u Xuping sun Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China School of Environment and Resource Southwest University of Science and TechnologyMianyang 621010China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Key Laboratory of Magnetic Molecules and Magnetic Information Materials (Ministry of Education) School of Chemistry and Material ScienceShanxi Normal UniversityLinfen 041004China College of chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China chemistry {1. Faculty of Science & Center of Excellence for Advanced Materials ResearchKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia

Currently,industrial-scale NH3 production almost relies on energy-intensive Haber-Bosch process from atmospheric N{1.with large amount of CO{1.emission,while low-cost and high-efficient catalysts are demanded for the N{1.reduction reaction (NRR).In this study,Mn3O4 nanoparticles@reduced graphene oxide (Mn3O4@rGO) composite is reported as an efficient NRR electrocatalyst with excellent selectivity for NH3 *** 0.1.M Na{1.O4 solution,such catalyst obtains a NH3 yield of 1..4 μg·h^-1.mg^-*** a Faradaic efficiency of 3.5{1. at-0.85 V *** hydrogen ***,it also shows high electrochemical stability during electrolysis *** functional theory (DFT) calculations also demonstrate that the (1.{1. planes of Mn3O4 possess superior NRR activity.

关键词： Mn3O4@rGO composite electrocatalyst NH3synthesis N2.eduction reactionam bient conditions

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Engineering an enthesis-like graft for rotator cuff repair:An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers

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Bioactive Materials 2022年第10期7卷 451-471页

作者： Can Chen Qiang Shi Muzhi li Yang Chen Tao Zhang Yan Xu Yunjie liao Shulin Ding Zhanwen Wang Xing li Chunfeng zhao Lunquan sun Jianzhong Hu Hongbin Lu department of Orthopedics Xiangya HospitalCentral South UniversityChangsha410008China Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangsha410008China Hunan Engineering Research Center of Sports and Health Changsha410008China Xiangya Hospital-International Chinese Musculoskeletal Research Society Sports Medicine Research Centre Changsha410008China department of Sports Medicine Xiangya HospitalCentral South UniversityChangsha410008China department of Rehabi{1.tation The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China department of Radiology The Third Xiangya HospitalCentral South UniversityChangsha410013China department of Spine Surgery Xiangya HospitalCentral South UniversityChangshaHunan410008China Division of Orthopedic Research and department of Orthopedic Surgery Mayo ClinicRochesterMinnesota55905United States Center for Molecular Medicine Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan410008China

Rotator cuff(RC)attaches to humerus across a triphasic yet continuous tissue zones(bone-fibrocartilage-tendon),termed“enthesis”.Regrettably,rapid and functional enthesis regeneration is challenging after RC *** existing grafts bioengineered for RC repair are insufficient,as they were engineered by a scaffold that did not mimic normal enthesis in morphology,composition,and tensile property,meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon ***,an optimized decellularization approach based on a vacuum aspiration device(VAD)was developed to fabricate a book-shaped decellularized enthesis matrix(O-BDEM).Then,three recombinant growth factors(CBP-GFs)capable of binding collagen were synthesized by fusing a collagen-binding peptide(CBP)into the N-terminal of BMP-{1.TGF-β3,or GDF-7,and zone-specifically tethered to the collagen of O-BDEM to fabricate a novel scaffold(CBP-GFs/O-BDEM)satisfying the above-mentioned *** ensuring the low immunogenicity of CBP-GFs/O-BDEM by a novel single-cell mass cytometry in a mouse model,we interleaved urine-derived stem cell-sheets into this CBP-GFs/O-BDEM to bioengineer an enthesis-like *** high-performance on regenerating enthesis was determined in a canine *** findings indicate this CBP-GFs/O-BDEM may be an excellent scaffold for constructing enthesis-like graft to patch large/massive RC tears,and provide breakthroughs in fabricating graded interfacial tissue.

关键词： Acellular matrix Collagen-binding peptide Stem cell differentiation inducer Enthesis regeneration Rotator cuff

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Chemical characteristics of size-resolved aerosols in winter in beijing

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Journal of Environmental Sciences 2014年第8期26卷 1641-1650页

作者： Kang sun Yu Qu Qiong Wu Tingting Han Jianwei Gu Jingjing {1. Yele sun Qi Jiang Ziqi Gao Min Hu Yuanhang Zhang Keding Lu Stephan Nordmann Yafang Cheng li Hou Hui Ge Masami Furuuchi Mitsuhiko Hata Xingang liu State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal University College of Environmental Sciences and Engineering Peking University State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric chemistry Institute of Atmospheric PhysicsChinese Academy of Sciences Environmental Science Center University of Augsburg School of Foreign Languages China University of Political Science and Law School of chemistry Beijing Normal University Multiphase chemistry {1. Max Planck Institute for Chemistry Laboratory of Atmospheric Environment and Pollution Control Engineering Graduate School of Natural Science & TechnologyKanazawa University

Size-resolved aerosols were continuously collected by a Nano Sampler for 1. days at an urban site in beijing during winter {1.1.1.to measure the chemical composition of ambient aerosol particles. Data collected by the Nano Sampler and an ACSM（Aerodyne Aerosol Chemical Speciation Monitor） were compared. Between the data sets,similar trends and strong correlations were observed,demonstrating the validity of the Nano Sampler. PM1. and PM{1.5concentrations during the measurement were 1.0.5 ± 96.0 μg/m3（mean ± standard variation）and 1.6.9 ± 71.6 μg/m3,respectively. The PM{1.5/PM1. ratio was 0.70 ± 0.1.,indicating that PM{1.5dominated PM1.. The aerosol size distributions showed that three size bins of 0.5–1.1.{1.5 and {1.5–1. μm contributed {1..8%,{1..3% and {1..0% to the total mass concentration（TMC）,respectively. OM（organic matter） and SIA（secondary ionic aerosol,mainly SO4{1.,NO3-and NH4＋） were major components of PM{1.5. Secondary compounds（SIA and secondary organic carbon） accounted for half of TMC（about 49.8%） in PM{1.5,and suggested that secondary aerosols significantly contributed to the serious particulate matter pollution observed in winter. Coal burning,biomass combustion,vehicle emissions and SIA were found to be the main sources of PM{1.5. Mass concentrations of water-soluble ions and undetected materials,as well as their fractions in TMC,strikingly increased with deteriorating particle pollution conditions,while OM and EC（elemental carbon） exhibited different variations,with mass concentrations slightly increasing but fractions in TMC decreasing.

关键词： Aerosol Size distribution Chemical characteristics beijing

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Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion

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World Journal of Gastroenterology 2021年第32期27卷 5404-5423页

作者： Zi-Yi Wang Jian-Yu lin Yang-Rong Feng De-Shun liu Xu-Zi zhao Tong li Si-Yuan li Jing-Chao sun Shu-Feng li Wen-Yan Jia Hui-Rong Jing Emergent Intensive Care Unit The Second Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina department of Gastrointestinal Surgery Weihai Central HospitalWeihai 264200Shandong ProvinceChina Graduate College Shandong First Medical UniversityJinan 271000Shandong ProvinceChina department of General Surgery The Second Affiliated Hospital of Dalian Medical UniversityDalian 116027Liaoning ProvinceChina department of Pharmacology Dalian Medical UniversityDalian 116044Liaoning ProvinceChina department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100000China department of General Surgery Qingdao Municipal HospitalQingdao UniversityQingdao 266071Shandong ProvinceChina Physiological Examination Center The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Intestinal barrier breakdown,a frequent complication of intestinal ischemiareperfusion(I/R)including dysfunction and the structure changes of the intestine,is characterized by a loss of tight junction and enhanced permeability of the intestinal barrier and increased *** develop effective and novel therapeutics is important for the improvement of outcome of patients with intestinal barrier *** human angiopoietin-like protein 4(rhANGPTL4)is reported to protect the blood-brain barrier when administered exogenously,and endogenous ANGPTL4 deficiency deteriorates radiationinduced intestinal *** To identify whether rhANGPTL4 may protect intestinal barrier breakdown induced by I/*** Intestinal I/R injury was elicited through clamping the superior mesenteric artery for 60 min followed by 2.0 min *** epithelial(Caco-2.cells and human umbilical vein endothelial cells were challenged by hypoxia/reoxygenation to mimic I/R in *** Indicators including fluorescein isothiocyanate-conjugated dextran(4 kilodaltons;FD-4)clearance,ratio of phosphorylated myosin light chain/total myosin light chain,myosin light chain kinase and loss of zonula occludens-1,claudin-2.and VE-cadherin were significantly increased after intestinal I/R or cell hypoxia/***4 treatment significantly reversed these indicators,which were associated with inhibiting the inflammatory and oxidative cascade,excessive activation of cellular autophagy and apoptosis and improvement of survival *** results were observed in vitro when cells were challenged by hypoxia/reoxygenation,whereas rhANGPTL4 reversed the indicators close to normal level in Caco-2.cells and human umbilical vein endothelial cells *** rhANGPTL4 can function as a protective agent against intestinal injury induced by intestinal I/R and improve survival via maintenance of intestinal barrier structure and functions.

关键词： Angiopoietin-like protein 4 Intestinal ischemia/reperfusion COVID-1. Myosin light chain kinase Intestinal barrier breakdown

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High expression of BCL6 inhibits the differentiation and development of hematopoietic stem cells and affects the growth and development of chickens

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Journal of Animal Science and Biotechnology 2021年第3期12卷 904-916页

作者： hongmei {1. Bowen Hu Shang Hu Wen Luo Donglei sun Minmin Yang Zhiying {1.ao Haohui Wei Changbin {2. Dajian {1. Meiqing Shi Qingbin Luo Dexiang Zhang Qinghua Nie Xiquan Zhang department of Animal Genetics Breeding and ReproductionCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642Guangdong ProvinceChina Guangdong Provincial Key Lab of AgroAnimal Genomics and Molecular Breeding and Key Lab of Chicken Genetics Breeding and ReproductionMinistry of AgricultureGuangzhou 510642GuangdongChina State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources South China Agricultural UniversityGuangzhou 510642GuangdongChina Division of Immunology Virginia-Maryland College of Veterinary MedicineUniversity of MarylandCollege ParkMDUSA

Background:B-cell CLL/lymphoma 6(BCL6)is a transcriptional master regulator that represses more than 1.0}0 potential target *** previous study showed that a dec{1.ne in blood production in runting and stunting syndrome(RSS)affected sex-{1.nked dwarf(SLD)chickens compared to SLD ***,the association between BCL6 gene and hematopoietic function remains unknown in ***:In this study,we used RSS affected SLD(RSS-SLD)chickens,SLD chickens and normal chickens as research object and overexpression of BCL6 in hematopoietic stem cells(HSCs),to investigate the effect of the BCL6 on differentiation and development of ***:The results showed that comparison of RSS-SLD chickens with SLD chickens,the BCL6 was highly expressed in RSS-SLD chickens bone *** bone marrow of RSS-SLD chickens was exhausted and red bone marrow was largely replaced by yellow bone marrow,bone density was reduced,and the levels of immature erythrocytes in peripheral blood were *** the same time,the hematopoietic function of HSCs decreased in RSS-SLD chickens,which was manifested by a decrease in the hematopoietic growth factors(HGFs)EPO,SCF,TPO,and IL-3,as well as hemoglobinα1.and hemoglobinβ***,mitochondrial function in the HSCs of RSS-SLD chickens was damaged,including an increase in ROS production,decrease in ATP concentration,and decrease in mitochondrial membrane potential(ΔΨm).The same results were also observed in SLD chickens compared with normal chickens;however,the symptoms were more serious in RSS-SLD ***,after overexpression of the BCL6 in primary HSCs,the secretion of HGFs(EPO,SCF,TPO and IL-3)was inhibited and the expression of hemoglobinα1.and hemoglobinβwas ***,cell pro{1.feration was accelerated,apoptosis was inhibited,and the HSCs entered a cancerous *** function of mitochondria was also abnormal,ROS production was decreased,and ATP concentration andΔΨm were increased,which was related t

关键词： BCL6 Hematopoietic stem cells Mitochondrial function Runting and stunting syndrome Sex-linked dwarf chickens

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Vapor deposition of aluminium oxide into N-rich mesoporous carbon framework as a reversible sulfur host for lithium-sulfur battery cathode

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Nano Research 2021年第1期14卷 131-138页

作者： Fei sun Zhibin Qu Hua Wang Xiaoyan {1.u Tong Pei Rui Han Jihui Gao Guangbo zhao Yunfeng Lu School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China department of {1. Shanghai Normal UniversityShanghai 150001China department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesCA 90095USA

Restraining the shuttle effects of lithium polysulfides is the key to improve the cycling reversibility and stability of lithium-sulfur(li-S)batteries for which design of robust sulfur hosts has been regarded as the most effective *** this work,we report a new type of hybrid sulfur host which is composed of Al_(2.O_(3) homogenously decorated in nitrogen-rich mesoporous carbon framework(NMC-Al_(2.O_(3)).The NMC-Al_(2.O_(3) hybrid host features a poly-dispersed spherical morphology and a mesoporous configuration with high surface area and large pore volume that can accommodate a high sulfur content up to 73.5 wt.%.As a result,the fabricated NMC-Al_(2.O_(3)-S cathode exhibits all-round improvements in electrochemical properties in term of capacities(1.2.2.mAh·g^(-1.at 0.2.C;755 mAh·g^(-1.at 2.C),cycling charge-discharge reversibility(sustainably 1.0%efficiencies)and stability(1.000 cycles with only 0.02.%capacity decay per cycle at 0.5 C).By contrast,the Al_(2.O_(3)-free NMC-S cathode shows both decreased capacities and rapidly descending Coulombic efficiencies during *** functional theory(DFH")calculations further reveal that the implanted Al_(2.O_(3) can greatly enhance the chemical adsorption and catalytic conversion for various lithium polysulfides and thereby effectively prevent the polysulfide shuttling and significantly improve the utilizability,reversibility and stability of sulfur cathode.

关键词： lithium-sulfur battery aluminium oxide sulfur host nitrogen-rich carbon mesoporous structure

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Distinct functions of Trio GEF domains in axon outgrowth of cerebellar granule neurons

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Journal of Genetics and Genomics 2019年第2期46卷 87-96页

作者： Tao Tao Jie sun Yajing Peng Pei Wang Xin Chen Wei {1. Yeqiong li lisha Wei Wei Wang Yanyan Zheng Ye Wang Xuena Zhang Min-Sheng Zhu Model Animal Research Center State Key Laboratory of Pharmaceutical Biotechnology Department of Neurology of the Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Nanjing University

As a critical guanine nucleotide exchange factor(GEF) regulating neurite outgrowth, Trio coordinates multiple processes of cytoskeletal dynamics through activating Rac1. Cdc42.and RhoA small GTPases by two GEF domains... 详细信息

As a critical guanine nucleotide exchange factor(GEF) regulating neurite outgrowth, Trio coordinates multiple processes of cytoskeletal dynamics through activating Rac1, Cdc42.and RhoA small GTPases by two GEF domains, but the in vivo roles of these GEF domains and corresponding downstream effectors have not been determined yet. We established multiple lines of knockout mice and assessed the respective roles of Trio GEF domains and Rac1 in axon outgrowth. Knockout of total Trio in cerebellar granule neurons(CGNs) led to an impaired F-actin rearrangement of growth cone and hence a retarded neurite outgrowth. Such a retardation was reproduced by inhibition of GEF1 domain or knockdown of Cdc42.and restored apparently by introduction of active Cdc42. As Rac1 deficiency did not affect the neurite outgrowth of CGNs, we suggested that Trio GEF1-mediated Cdc42.activation was required for neurite outgrowth. We established a GEF2.knockout line with deletion of all Trio isoforms except a cerebella-specific Trio8, a short isoform of Trio without GEF2.domain, and used this line as a GEF2.deficient animal model. The GEF2.deficient CGNs had a normal neurite outgrowth but abolished Netrin-1-promoted growth, without affecting Netrin-1 induced Rac1 activation. We thus suggested that Trio GEF1-mediated Cdc42.activation rather than Rac1 activation drives the F-actin dynamics necessary for neurite outgrowth, while GEF2.functions in Netrin-1-promoted neurite elongation. Our results delineated the distinct roles of Trio GEF domains in neurite outgrowth, which is instructive to understand the pathogenesis of clinical Trio-related neurodevelopmental disorders.

关键词： Trio GEF Rho GTPases Axon outgrowth Cerebellar granule neuron

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