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Engineering Microbiology 2024年第3期4卷 43-53页

作者： xin sun Haobin Zhang Yuping Jia Jingyi Li Meirong Jia State Key Laboratory of Bioactive Substance and Function of Natural Medicines NHC Key Laboratory of Biosynthesis of Natural ProductsCAMS Key Laboratory of Enzyme and Biocatalysis of Natural DrugsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Shandong Academy of Pharmaceutical Sciences Jinan 250101China

Terpenoids are widely used as medicines,flavors,and ***,the use of these natural products is largely restricted by their low abundance in native ***,heterologous biosynthesis of terpenoids in microorganisms offers an alternative and sustainable approach for efficient *** genome-editing technologies have been developed for microbial strain *** regularly interspaced short palin-dromic repeats(CRISPR)-CRISPR associated protein 9(Cas9)is the most commonly used system owing to its outstanding efficiency and convenience in genome *** this review,the basic principles of CRISPR-Cas9 systems are briefly introduced and their applications in engineering bacteria for the production of plant-derived terpenoids are *** aim of this review is to provide an overview of the current developments of CRISPR-Cas9-based genome-editing technologies in bacterial engineering,concluding with perspectives on the challenges and opportunities of these technologies.

关键词： CRISPR-Cas9 Genome editing Terpenoids Metabolic engineering Bacteria

No tillage increases soil microarthropod(Acari and Collembola)abundance at the global scale

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Soil Ecology Letters 2024年第2期6卷 5-19页

作者： Yulin Liu Lihong Song Donghui Wu Zihan Ai Qian Xu xin sun Liang Chang State Key Laboratory of Black Soil Conservation and Utilization Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun130102China University of Chinese Academy of Sciences Beijing100049China College of Agriculture Guizhou UniversityGuiyang550025China Key Laboratory of Urban Environment and Health Ningbo Observation and Research StationFujian Key Laboratory of Watershed EcologyInstitute of Urban EnvironmentChinese Academy of SciencesXiamen361021China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control CAS Haixi Industrial Technology Innovation Center in BeilunNingbo315830China

Conservation tillage increases soil microarthropod abundance at the global *** effect of conservative tillage on microarthropods is soil *** positive effect of conservation tillage is particularly evident in nutrient-poor soil *** temperate humid regions,however,this positive effect of conservation tillage is *** effect of conservative tillage on microarthropods varies with fauna group and climate regions.

关键词： no tillage soil microarthropod Acari Collembola meta-analysis

D-band center coordination modulated enzyme-like activity in Fe-Cu dual-metal single-atom nanozymes

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Nano Research 2024年第7期17卷 5872-5883页

作者： Ling Liu Shaofang Zhang Guo Li Yadong Zhe Jiamin Liu xinxu Zhang Jiahao Wei xin sun Yonghui Li Xiao-Dong Zhang Tianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational MedicineTianjin UniversityTianjin 300072China Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology School of SciencesTianjin UniversityTianjin 300350China

After explorations in a diversity of single-atom nanozymes(SAzymes),developing dual-centered SAzymes becomes a promising approach for superior catalytic *** confusing mechanisms including atomic coordination,spatial configuration,and metal–metal atom interaction hinder the development and design of ***,a dual-centered Fe-Cu-N_(x)SAzyme exhibits excellent peroxidase(POD)-and catalase(CAT)-like activities with d-band center(ε_(d))coordination of Fe and Cu in multiple reaction stages,which plays a critical role in the adsorption of H_(2)O_(2)molecule and H_(2)O and O_(2)***,the dband center coordination,which can be represented byε_(d)(Fe)–ε_(d)(Cu)shifts,leads to the competition between one-side and bilateral adsorption,which determines the favorable reaction path with lower energy *** on experimental statistics,simulated formation energies,and reaction barriers,3 configurations,Fe-Cu-N6-I,Fe-Cu-N_(8)-II,and Fe-Cu-N_(8)-III,are modeled and ***,configuration-dependent catalytic selectivity and the competition between one-side and bilateral adsorption can be unveiled by d-band center coordination paradigm *** simulations suggest that the unsymmetrical charge distribution over the three Fe-Cu configurations could tune the adsorption strength compared with the counterparts FeN_(4)and CuN_(4).The present work provides a potential route for optimizing enzyme-like catalysis by designing the dual-or even triple-metal SAzymes,which demonstrates the large space to modulate the metal atomic configuration and interaction.

关键词： single-atom catalysis Fe-Cu dual-metal d-band center coordination enzyme mimicking competitive adsorption mechanisms

Evolution of electron “zebra stripes” in the South Atlantic Anomaly: Initial observations from Macao Science Satellite-1

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Science China Technological Sciences 2024年第11期67卷 3344-3353页

作者： LIU Ying ZONG QiuGang ZOU Hong YE YuGuang sun Yi xin Institute of Space Physics and Applied Technology Peking University State Key Laboratory of Lunar and Planetary Science Macau University of Science and Technology

“Zebra stripes” denote banded structures characterized by periodic peaks and valleys in the spectrograms of energetic electrons in the Earth's inner radiation belt and slot region. In contrast to previous investigations primarily grounded in equatorial observations,this study presents two events exhibiting the evolution of electron zebra stripes within the South Atlantic Anomaly, as observed from the Macao Scientific Satellite-1 in low Earth orbit. Our findings affirm that the structural and evolutionary features of zebra stripes in both events accord with the drift echo hypothesis. The start time extrapolated from the electron spectrograms correlates with substorm onsets, consistent with prior conclusions. Notably, the duration of zebra stripe evolution during the event of June 5–6, 2023, reaches an impressive 34.7 h, a markedly longer interval than findings from the Van Allen Probes. This discrepancy suggests that the observed lifetime of electron zebra stripes may not inherently reflect natural limitations but could be constrained by instrumental capabilities. The results implicate that high-energy-resolution detectors have the potential to significantly enhance our capacity to scrutinize the dynamics of the radiation belt.

关键词： zebra stripe inner radiation belt energetic electron South Atlantic Anomaly Macao Science Satellite large-scale electric field

Terrestrial invertebrate hosts of human pathogens in urban ecosystems

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Eco-Environment & Health 2024年第3期3卷 369-380页

作者： An Xie Yiyue Zhang Martin F.Breed xinli An Haifeng Yao Qiansheng Huang Jianqiang Su xin sun Key Laboratory of Urban Environment and Health Ningbo Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control CAS Haixi Industrial Technology Innovation Center in BeilunNingbo 315830China College of Science&Engineering Flinders UniversitySA 5042Australia

Terrestrial invertebrates in urban ecosystems are extremely species-rich,have many important roles in material flow and energy circulation,and are host to many human pathogens that pose threats to human *** invertebrates are widely distributed in urban areas,including both out-and in-door ***,humans are frequently in contact with them,which provides many opportunities for them to pose human health ***,comprehensive knowledge on human pathogen transfer via invertebrates is lacking,with research to date primarily focused on dipterans(e.g.,mosquitoes,flies).Here,we take a broad taxonomic approach and review terrestrial invertebrate hosts(***,flies,termites,cockroaches,mites,ticks,earthworms,collembola,fleas,snails,and beetles)of human pathogens,with a focus on transmission *** also discuss how urbanization and global warming are likely to influence the communities of invertebrate hosts and have flow-on risks to human ***,we identify current research gaps and provide perspectives on future directions.

关键词： Human health Human pathogens Invertebrates Urbanization Zoonoses

Facile synthesis of magnetic covalent organic framework nanocomposites for the enrichment and quantification of trace organophosphorus pesticides in fruit juice

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Food Science and Human Wellness 2024年

作者： Quanbin Fu xin sun Lu Liu Hailong Jiang Geoffrey I.N.Waterhouse Shiyun Ai Rusong Zhao School of Chemical Sciences， The University of Auckland College of Chemistry and Material Science， Shandong Agricultural University Qilu University of Technology (Shandong Academy of Sciences)， Shandong Analysis and Test Center， Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province College of Food Science and Engineering， Shandong Agricultural University

Organophosphorus pesticides (OPPs) in foods pose a serious threat to human health， motivating the development of novel analytical methods for their rapid detection and quantification. A magnetic covalent organic framework (M-COF) adsorbent for the magnetic solid-phase extraction (MSPE) of OPPs from foods was reported. M-COF was synthesized by the Schiff base condensation reaction of 1，3，5-tris (4-aminophenyl)benzene and 4，4-biphenyldicarboxaldehyde on the surface of amino-functionalized magnetic nanoparticles. Density–functional theory (DFT) calculations showed that adsorption of OPPs onto the surface of M-COF involved hydrophobic effects， Van der Waals interactions， π–π interactions， halogen-N bonding， and hydrogen bonding. Combined with gas chromatography–mass spectrometry (GC–MS) technology， the MSPE method features low limits of detection for OPPs (0.002–0.015 μg/L)， good reproducibility (1.45%–6.14%)， wide linear detection range (0.01–1 μg/L， R≥ 0.9935)， and satisfactory recoveries (87.3%–110.4%). The method was successfully applied for the trace analysis of OPPs in spiked fruit juices.

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Research Progress on Purification Process, Content Determination and Pharmacological Action of Atractylodin

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Asian Agricultural Research 2024年第3期16卷 33-35,40页

作者： xin sun Jingwen WANG Yang XI Chenghao JIN College of Science Heilongjiang Bayi Agricultural UniversityDaqing 163319China College of Life Science and Biotechnology Heilongjiang Bayi Agricultural UniversityDaqing 163319China

Atractylodis Rhizoma comes from the dry rhizome of Atractylis lancea or Atractylodes chinensis in the Compositae family,and it is suitable for preventing and treating diseases such as cold,edema,night blindness and rheumatic *** is the main active component extracted and isolated from Atractylodis Rhizoma.A large number of studies have found that atractylodin has excellent drug activity in improving gastrointestinal emptying,anti-inflammation,inhibiting malignant tumor and reducing blood *** this paper,the purification process and pharmacological activity of Atractylodin were summarized to provide a theoretical basis for basic research,clinical application and further development and utilization of atractylodin.

关键词： Atractylodin Pharmacological action Purification process Content determination

Effect of inflammatory response on joint function after hip fracture in elderly patients:A clinical study

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World Journal of Orthopedics 2024年第4期15卷 337-345页

作者： Jia-Ming Wang Yu-Tao Pan Chen-Song Yang Ming-Chong Liu Sheng-Chao Ji Ning Han Fang Liu Gui-xin sun Department of Traumatic Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200092China

BACKGROUND Excellent hip joint function facilitates limb recovery and improves the quality of *** study aimed to investigate the potential risk factors affecting postoperative joint functional activity and outcomes in elderly hip fractures patients and to provide evidence for patient rehabilitation and clinical *** To explore the relationship between inflammatory factors and hip function and the interaction between inflammation and health after hip fracture in elderly *** The elderly patients who had hip fracture surgery at our hospital between January 1,2021,and December 31,2022 were chosen for this retrospective clinical *** with excellent and fair postoperative hip function had their clinical information and characteristics gathered and ***,gender,fracture site,surgical technique,laboratory indices,and other variables that could have an impact on postoperative joint function were all included in a univariate *** further identify independent risk factors affecting postoperative joint function in hip fractures,risk factors that showed statistical significance in the univariate analysis were then included in a multiple logistic regression *** addition to this,we also compared other outcome variables such as visual analogue scale and length of hospital stay between the two *** A total of 119 elderly patients with hip fractures were included in this study,of whom 37 were male and 82 were *** results of univariate logistic regression analysis after excluding the interaction of various factors showed that there was a statistically significant difference in interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP),and complement C1q(C1q)between the fair and excellent joint function groups(P20 pg/mL[Odds ratio(OR)3.070,95%CI:1.243-7.579],IL-8>21.4 pg/mL(OR 3.827,95%CI:1.498-9.773),CRP>10 mg/L(OR 2.142,95%CI:1.

关键词： Hip function Fracture Inflammatory factors Risk factors Prevention

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我国农村居民收入差距中的机会不平等

华南农业大学学报（社会科学版） 2024年第1期23卷 35-47页

作者：杨昭孙欣贵州财经大学大数据应用与经济学院贵州贵阳550025

基于“环境-努力”框架,结合对数偏差均值指数(MLD)以及不公平对数偏差均值指数(AMLD),使用CFPS2020数据研究了我国农民收入差距中的机会不平等问题。结果表明,我国农民收入差距MLD指数为0.488,机会不平等所致的份额在51.0%和58.4%之间... 详细信息

基于“环境-努力”框架,结合对数偏差均值指数(MLD)以及不公平对数偏差均值指数(AMLD),使用CFPS2020数据研究了我国农民收入差距中的机会不平等问题。结果表明,我国农民收入差距MLD指数为0.488,机会不平等所致的份额在51.0%和58.4%之间。分样本看,低年龄组、女性以及中西部农民收入分配中机会不平等成分更高。基于不同口径的测算结果表明,城镇迁移可为农民提供更公平的增收机会。另外,调节效应的回归结果表明,时代红利、性别歧视和区域分割都会影响个人努力的增收效应。为缩小农村居民收入差距中的机会不平等,需要持续提高生产效率,深入推进区域以及城乡基本公共服务均等化,合理引导农民流动以及持续规范劳动力市场。

关键词：农村居民收入差距机会不平等共同富裕

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基于蓝藻的氮磷共掺杂多孔碳的制备及在能源储存与转换中的应用

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化工新型材料 2024年第10期52卷 235-242页

作者：孙鑫秦勇常州大学石油化工学院常州213164

以蓝藻为原料,经水热活化和高温退火处理,制备了一系列氮磷共掺杂多孔碳(NPC)。通过X射线衍射(XRD)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和氮气吸脱附(BET)对NPC的形貌与结构进行表征;通过X射线光电子能谱和元素分析(XPS)确定氮... 详细信息

以蓝藻为原料,经水热活化和高温退火处理,制备了一系列氮磷共掺杂多孔碳(NPC)。通过X射线衍射(XRD)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和氮气吸脱附(BET)对NPC的形貌与结构进行表征;通过X射线光电子能谱和元素分析(XPS)确定氮和磷的原子百分数分别为5.47%和0.24%。将NPC用作超级电容器的电极材料时,其比容量在1A/g时达到568.7F/g。用作氧还原反应(ORR)的催化剂时,在KOH溶液中起始电位为0.92V,半波电位0.80V,循环48h电流保持率高达97%,因此无论是在能源存储(超级电容器),还是在能源转化(电催化ORR)方面均具有优异的性能。该制备工艺简单,并能将对环境有害的生物质转化为具有高附加值的催化剂,实现生物质的高值化利用,具有非常好的应用前景。

关键词：生物质炭超级电容器氧还原反应电催化剂蓝藻

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