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Classification of breast microcalcifications: radiological-pathological correlation

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Chinese Medical Journal 2005年第17期118卷 1429-1435页

作者： sun Zhe LIANG hong-wei XU Hui-mian Department of Oncological Surgery First Affiliated Hospital of China Medical University Shenyang 110001 China

Microcalcifications play a very important role in detection of breast cancer, especially early stage breast cancer. However, ambiguity still exists in understanding the relationship between radiological and pathological characteristics of microcalcifications. The definitive indication of a biopsy has not been established. The purpose of this study is to evaluate the relationship of classification of breast microcalcifications using full-field digital mammography to the pathological characteristics.

关键词： calcinosis breast neoplasms mammography

A single nucleotide substitution in the MATE transporter gene regulates plastochron and the many noded dwarf phenotype in barley(Hordeum vulgare L.)

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Journal of Integrative Agriculture 2023年第8期22卷 2295-2305页

作者： GUO Bao-jian sun hong-wei QI Jiang HUANG Xin-yu hong Yi HOU Jian Lü Chao WANG Yu-lin WANG Fei-fei ZHU Juan GUO Gang-gang XU Ru-gen Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Key Laboratory of Plant Functional Genomics Ministry of Education/Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Co-Innovation Center for Modern Production Technology of Grain CropsYangzhou UniversityYangzhou 225009P.R.China State Key Laboratory of Barley and Yak Germplasm Resources and Genetic Improvement/Tibet Academy of Agricultural and Animal Husbandry Sciences(TAAAS) Lhasa 850002P.R.China Key Laboratory of Crop Germplasm Resources and Utilization Ministry of Agriculture/National Key Facility for Crop Gene Resources and Genetic Improvement/Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081P.R.China

In higher plants,the shoot apical meristem produces lateral organs in a regular spacing(phyllotaxy)and timing(plastochron).The molecular analysis of mutants associated with phyllotaxy and plastochron would increase our understanding of the mechanism of shoot architecture *** this study,we identified mutant mnd8ynp5 that shows an increased rate of leaf emergence and a larger number of nodes in combination with a dwarfed growth habit from an EMS-treated population of the elite barley cultivar Yangnongpi *** a map-based cloning strategy,the mnd8 gene was narrowed down to a 6.7-kb genomic interval on the long arm of chromosome *** analysis revealed that a C to T single-nucleotide mutation occurred at the first exon(position 953)of HORVU5Hr1G118820,leading to an alanine(Ala)to valine(Val)substitution at the 318th amino acid ***,HORVU5Hr1G118820 was defined as the candidate gene of MND8 encoding 514 amino acids and containing two multidrug and toxic compound extrusion(MATE)*** is highly homologous to maize Bige1and has a conserved function in the regulation of plant development by controlling the leaf initiation *** of modern barely varieties showed that Hap-1 was the dominant haplotype and was selected in barley breeding around the ***,our results indicated that mnd8ynp5 is a novel allele of the HORVU5Hr1G118820 gene that is possibly responsible for the shortened plastochron and many noded dwarf phenotype in barley.

关键词： barley EMS plastochron many noded dwarf MATE transporter shoot architecture

Identification,evolution,expression and protein interaction analysis of genes encoding B-box zinc-finger proteins in maize

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Journal of Integrative Agriculture 2023年第2期22卷 371-388页

作者： XU Xiao-hui LI Wen-lan YANG Shu-ke ZHU Xiang-zhen sun hong-wei LI Fan LU Xing-bo CUI Jin-jie Shandong Key Laboratory of Plant Virology/Institute of Plant Protection Shandong Academy of Agricultural SciencesJinan 250100P.R.China State Key Laboratory of Cotton Biology/Institute of Cotton Research Chinese Academy of Agricultural SciencesAnyang 455000P.R.China Maize Research Institute Shandong Academy of Agricultural SciencesJinan 250100P.R.China

The B-box(BBX)family of proteins consists of zinc-finger transcription factors with one or two highly conserved B-box motifs at their *** proteins play crucial roles in various aspects of plant growth and development,including seedling photomorphogenesis,shade avoidance,flowering time,and biotic and abiotic stress *** studies have identified many different BBXs from several plant species,although the BBX family members in maize are largely ***-wide identification and comprehensive analysis of maize BBX(ZmBBX)expression and interaction networks would therefore provide valuable information for understanding their *** this study,36 maize BBXs in three major clades were *** ZmBBXs within a given clade were found to share similar domains,motifs,and genomic *** duplication analyses revealed that the expansion of BBX proteins in maize has mainly occurred by segmental *** expression levels of ZmBBXs were analyzed in various organs and tissues,and under different abiotic stress ***–protein interaction networks of ZmBBXs were established using bioinformatic tools and verified by bimolecular fluorescence complementation(BiFC)*** findings can facilitate a greater understanding of the complexity of the ZmBBX family and provide novel clues for unravelling ZmBBX protein functions.

关键词： maize B-box family protein evolution expression protein interaction

Classification of breast microcalcifications: radiological-pathological correlation

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中华医学杂志(英文版) 2005年第17期 23-29页

作者： sun Zhe,LIANG hong-wei and XU Hui-mianDepartment of Oncological Surgery, First Affiliated Hospital of China Medical University, Shenyang 110001, China

Background Microcalcifications play a very important role in detection of breast cancer, especially early stagebreast ***, ambiguity still exists in understanding the relationship between radiological andpathological characteristics of *** definitive indication of a biopsy has not been *** purpose of this study is to evaluate the relationship of classification of breast microcalcifications using full-field digital mammography to the pathological *** For all the women an open biopsy had been *** hundred and three mammographsshowing clustered microcalcifications from 98 consecutive patients were reviewed along with their *** investigate the value of each criterion for the detection of cancer, univariate and multivariate analyseswere performed on the entire sample and then on morphological *** Pathological examination showed 67 malignant lesions (65.05%) and 36 benign lesions (34.95%).In the univariate analysis, four radiological variables were significant: morphological type (P=0.001),complicated by a mass (P=0.002), number of microcalcifications per cluster (P=0.02) and linear ortriangular distribution of clusters (P=0.009).In the multivariate analysis, two criteria remained significant:morphological type (P<0.001) and complicated by a mass (P=0.001).The percentage of malignancy was37.0%, 60.0%, 78.8%, and 88.9%, respectively, for type 2 (regularly punctiform), type 3 (dusty), type4 ( irregularly punctiform) and type 5 ( vermicular) microcalcifications ( Le Gal’s classification).Themalignancy was78.6% for microcalcifications complicated by a mass and 48.9% without a *** differencewas significant (P<0.05).The relationship between morphological types of microcalcifications and thepathological characteristics was also *** subgroups, type 3 (dusty) microcalcifications complicated by amass (P=0.001) or with the number of microcalcifications more than 10 (P

关键词： calcinosis · breast neoplasms · mammography

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含酯基的二巯基噻二唑二聚物的摩擦学性能

石油学报（石油加工） 2007年第1期23卷 82-86页

作者：康茵孙洪伟中国石化石油化工科学研究院北京100083

合成了含酯基的二巯基噻二唑二聚物,采用四球试验机考察了其在12-羟基硬脂酸锂基脂中作为极压抗磨剂的摩擦学性能,并采用XPS、SEM和EDS分析了摩擦表面的特性。结果表明,添加了含酯基的二巯基噻二唑二聚物的12-羟基硬脂酸锂基脂的抗磨、... 详细信息

合成了含酯基的二巯基噻二唑二聚物,采用四球试验机考察了其在12-羟基硬脂酸锂基脂中作为极压抗磨剂的摩擦学性能,并采用XPS、SEM和EDS分析了摩擦表面的特性。结果表明,添加了含酯基的二巯基噻二唑二聚物的12-羟基硬脂酸锂基脂的抗磨、减摩和抗烧结性能都得到明显提高。这是由于添加剂在摩擦过程中发生了摩擦化学反应,反应产物在金属表面上形成了一层具有抗磨减摩性能的膜,与金属表面的吸附膜共同作用的结果。

关键词：酯基二巯基噻二唑二聚物 12-羟基硬脂酸锂基脂抗磨减摩抗烧结

Siderophore production from 27 filamentous fungal strains and a novel siderophore with potential biocontrol applications from Aspergillus niger An76

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Journal of Life Sciences 2008年第1期2卷 19-26,36页

作者： sun hong-qi ZHANG wei-can LU Xue-mei GAO Pei-ji State Key Laboratory of Microbial Technology Shandong University Jinan 250100 China

Among 27 filamentous fungi, a strain Aspergillus niger An76 gave the highest siderophore yield even when cultured on natural medium or minimal medium containing 1 mmol L^-1 Fe^3＋. Whereas for most other strains, the capacities of siderophore production was repressed as the concentrations of Fe^3＋ was higher than 20 ~tmol L^-1. Lower ferric iron concentrations were more conducive to siderophore synthesis for those strains. The An76 siderophore was partially purified through a series of chromatography steps using Sephadex LH20 and CM-Sepharose Fast Flow columns. Its structural characteristics differed from typical siderophores, such as catecholates or hydroxamates, and no amino acids or peptide bonds were detected. It may therefore represent a new type of siderophore structure. TBA assay and ESR trapping studies showed that An76 siderophore had remarkable scavenging activity of hydroxyl free radicals in vitro. The antibiotic activities of siderophores produced by An76 were tested against 29 bacterial strains, including plant, animal, and human pathogens. The growth of 14 bacterial strains could be completely inhibited at a siderophore concentration of 8 mg ml^-1 with an incubation time of 30 min. Evidence suggests that the An76 siderophore has potential value as an antioxidant and a biocontrol agent against pathogenic microorganisms.

关键词： antibiotic activity antioxidant ESR hydroxyl freeradicals sidcrophore

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润滑脂生物降解评定方法

石油学报（石油加工） 2009年第B9期25卷 86-88,106页

作者：宁少武孙洪伟中国石化石油化工科学研究院北京100083

参照ASTM D6139标准,将营养组分、菌液、润滑剂依次加入到带碱液收集器的锥形瓶中,通入无CO2的空气,密闭,在遮光条件下连续震荡28d。期间,定期取碱液收集器中的碱液,在无CO2空气的保护下,用标准盐酸进行滴定,再由消耗的盐酸量计算生成的... 详细信息

参照ASTM D6139标准,将营养组分、菌液、润滑剂依次加入到带碱液收集器的锥形瓶中,通入无CO2的空气,密闭,在遮光条件下连续震荡28d。期间,定期取碱液收集器中的碱液,在无CO2空气的保护下,用标准盐酸进行滴定,再由消耗的盐酸量计算生成的CO2的量,由此计算出生物降解率。实验得到的各种类润滑脂及基础油的生物降解率与事实相吻合,且重复性良好,相对标准偏差在5.0%以内。另外还考察了分散度对生物降解的影响。结果表明,分散度越大生物降解率越高。

关键词：润滑剂 ASTMD6139 生物降解率重复性分散度

基于多尺度多参量的硅MEMS陀螺仪漂移预测

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宇航学报 2009年第2期30卷 591-596页

作者：孙宏伟房建成北京航空航天大学仪器科学与光电工程学院新型惯性仪表与导航系统技术国防重点学科实验室北京100083

针对硅MEMS陀螺仪误差因素多,输出为非线性非平稳的特点,采用传统方法难以对其建立精确的误差模型。在对小波神经网络方法改进的基础上,提出了多尺度去噪的平稳化方法及多参量非线性预测方法并将其用于硅MEMS陀螺仪漂移预测。试验结果表... 详细信息

针对硅MEMS陀螺仪误差因素多,输出为非线性非平稳的特点,采用传统方法难以对其建立精确的误差模型。在对小波神经网络方法改进的基础上,提出了多尺度去噪的平稳化方法及多参量非线性预测方法并将其用于硅MEMS陀螺仪漂移预测。试验结果表明,采用多尺度多参量校准方法,硅MEMS陀螺仪精度由1°/s提高到0.02°/s。

关键词： MEMS陀螺仪漂移预测小波分析 RBF神经网络

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从定性到定量的信息安全模糊综合评估

系统工程理论与实践 2006年第12期26卷 93-98页

作者：孙卫红何德全四川大学数学学院成都610064

依据从定性到定量的综合集成思想,为电子政务信息安全评估提出了一种基于人-机结合数据采集的模糊综合评估方法,并提出了保障度的概念.在评估方法中,用人-机结合数据采集的方式,为Delphi方法中获取模糊矩阵时提供客观、科学的数据依据,... 详细信息

依据从定性到定量的综合集成思想,为电子政务信息安全评估提出了一种基于人-机结合数据采集的模糊综合评估方法,并提出了保障度的概念.在评估方法中,用人-机结合数据采集的方式,为Delphi方法中获取模糊矩阵时提供客观、科学的数据依据,减少了专家评判的主观性,解决了信息安全评估过程中数据采集困难、定性与定量评估不能很好结合的问题,并给出了应用实例,是一种兼具科学性、综合性和可操作性的综合评估方法.

关键词：从定性到定量的综合集成人-机结合模糊综合评估信息安全保障度