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Ruxolitinib improves the inflammatory microenvironment,restores glutamate homeostasis,and promotes functional recovery after spinal cord injury

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Neural Regeneration Research 2024年第11期19卷 2499-2512页

作者： Jiang Cao Xiao yu Jingcheng Liu Jiaju Fu Binyu Wang Chaoqin Wu Sheng Zhang Hongtao Chen Zi Wang Yinyang Xu Tao sui Jie Chang Xiaojian Cao Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Trauma Surgery Subei People’s Hospital of JiangsuClinical Medical College of Yangzhou UniversityYangzhouJiangsu ProvinceChina Department of Orthopedics Zhongda HospitalSoutheast UniversityNanjingJiangsu ProvinceChina Department of Orthopedic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina

The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord ***,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arthritis,and managing inflammatory cytokine *** studies have shown the neuroprotective potential of ruxolitinib in neurological trauma,the exact mechanism by which it enhances functional recovery after spinal cord injury,particularly its effect on astrocytes,remains *** address this gap,we established a mouse model of T10 spinal cord contusion and found that ruxolitinib effectively improved hindlimb motor function and reduced the area of spinal cord *** sequencing analysis showed that ruxolitinib alleviated inflammation and immune response after spinal cord injury,restored EAAT2 expression,reduced glutamate levels,and alleviated excitatory ***,ruxolitinib inhibited the phosphorylation of JAK2 and STAT3 in the injured spinal cord and decreased the phosphorylation level of nuclear factor kappa-B and the expression of inflammatory factors interleukin-1β,interleukin-6,and tumor necrosis factor-α.Additionally,in glutamate-induced excitotoxicity astrocytes,ruxolitinib restored EAAT2 expression and increased glutamate uptake by inhibiting the activation of STAT3,thereby reducing glutamate-induced neurotoxicity,calcium influx,oxidative stress,and cell apoptosis,and increasing the complexity of dendritic ***,these results indicate that ruxolitinib restores glutamate homeostasis by rescuing the expression of EAAT2 in astrocytes,reduces neurotoxicity,and effectively alleviates inflammatory and immune responses after spinal cord injury,thereby promoting functional recovery after spinal cord injury.

关键词： astrocytes EAAT2 excitotoxicity glutamate homeostasis JAK-STAT pathway locomotor function neurotoxicity ruxolitinib spinal cord injury transcriptome analysis

Effects of the initiation position on the damage and fracture characteristics of linear-charge blasting in rock

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 443-451页

作者： Chenxi Ding Renshu Yang Xiao Guo Zhe sui Chenglong Xiao Liyun Yang School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China State Key Lab of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

To study the effects of the initiation position on the damage and fracture characteristics of linear-charge blasting, blasting model experiments were conducted in this study using computed tomography scanning and three-dimensional reconstruction methods. The fractal damage theory was used to quantify the crack distribution and damage degree of sandstone specimens after blasting. The results showed that regardless of an inverse or top initiation, due to compression deformation and sliding frictional resistance, the plugging medium of the borehole is effective. The energy of the explosive gas near the top of the borehole is consumed. This affects the effective crushing of rocks near the top of the borehole, where the extent of damage to Sections Ⅰ and Ⅱ is less than that of Sections Ⅲ and Ⅳ. In addition, the analysis revealed that under conditions of top initiation, the reflected tensile damage of the rock at the free face of the top of the borehole and the compression deformation of the plug and friction consume more blasting energy, resulting in lower blasting energy efficiency for top initiation. As a result, the overall damage degree of the specimens in the top-initiation group was significantly smaller than that in the inverse-initiation group. Under conditions of inverse initiation, the blasting energy efficiency is greater, causing the specimen to experience greater damage. Therefore, in the engineering practice of rock tunnel cut blasting, to utilize blasting energy effectively and enhance the effects of rock fragmentation, using the inverse-initiation method is recommended. In addition, in three-dimensional(3D) rock blasting, the bottom of the borehole has obvious end effects under the conditions of inverse initiation, and the crack distribution at the bottom of the borehole is trumpet-shaped. The occurrence of an end effect in the 3D linear-charge blasting model experiment is related to the initiation position and the blocking condition.

关键词： blasting linear charge initiation position computed tomography three-dimensional reconstruction damage

黑土坡耕地土壤湿度时空演变及其与大豆产量空间相关性分析

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土壤 2006年第4期38卷 410-416页

作者：张兴义王其存隋跃宇于同艳中国科学院东北地理与农业生态研究所哈尔滨150040

利用经典统计学和地统计学方法对典型黑土坡耕地土壤湿度时空演变特征以及大豆产量与海拔高度和不同时期土壤湿度的空间关系进行了分析。结果表明：黑土坡耕地土壤含水量具有较强的空间异质性，有效空间相关距离为159．3—506．6m，而... 详细信息

利用经典统计学和地统计学方法对典型黑土坡耕地土壤湿度时空演变特征以及大豆产量与海拔高度和不同时期土壤湿度的空间关系进行了分析。结果表明：黑土坡耕地土壤含水量具有较强的空间异质性，有效空间相关距离为159．3—506．6m，而且它们随着降雨和农田管理措施作用而改变。干旱加剧，土壤水分空间异质性加强，农田管理可降低土壤含水量的空间异质性。大豆产量同播种前后的土壤含水量存在显著的空间相关关系。

关键词：黑土坡耕地土壤湿度大豆产量

不同施肥制度对小麦生育期土壤微生物量的影响

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中国土壤与肥料 2006年第3期 48-50页

作者：隋跃宇焦晓光张兴义东北地理与农业生态研究所黑龙江大学农学院哈尔滨150080

通过测定不同施肥制度下小麦土壤微生物量C、N的动态变化,探讨了不同施肥制度对小麦土壤的培肥效应。研究结果表明,与无肥、单施有机肥、单施化学肥料相比,有机肥与化学N、P、K配合施用能显著增加小麦各生育时期的土壤微生物量C、N,促... 详细信息

通过测定不同施肥制度下小麦土壤微生物量C、N的动态变化,探讨了不同施肥制度对小麦土壤的培肥效应。研究结果表明,与无肥、单施有机肥、单施化学肥料相比,有机肥与化学N、P、K配合施用能显著增加小麦各生育时期的土壤微生物量C、N,促进土壤微生物量显著增长,增强了土壤养分容量的供应强度,有利于培肥土壤。

关键词：小麦生育期土壤微生物施肥制度

Charge-asymmetry Fe_(1)Cu single-atom alloy catalyst for efficient oxygen reduction reaction

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Nano Research 2024年第6期17卷 4702-4710页

作者： Xudong Niu Jian Wei Dongyao Xu Jiajing Pei Rui sui School of Chemical&Environmental Engineering China University of Mining and TechnologyBeijing 100083China Institute of Water Ecology and Environment Chinese Research Academy of Environmental SciencesBeijing 100083China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084China

The development of high-efficient and low-cost oxygen reduction reaction(ORR)electrocatalysts is crucial for the practical applications of metal-air *** promising way is to develop Fe single-atom ***,the single active center and inherent electronic structure of Fe single-atom catalysts lead to the undesirable adsorption of multiple ORR ***,a charge-asymmetry single-atom alloy(SAA)catalyst with Fe-Cu dual sites supported on nitrogen-doped carbon nanosheet(Fe_(1)Cu SAA/NC)was *** characterizations manifest the existence of electron interaction between Fe and Cu in Fe_(1)Cu SAA/NC,which facilitates the adsorption of ORR intermediate for fast ***,the charge-asymmetry Fe_(1)Cu SAA/NC exhibits much faster ORR kinetics with a half-wave potential of 0.917 V *** hydrogen electrode(RHE),outperforming its counterparts in the ***,Fe_(1)Cu SAA/NC still maintains a high half-wave potential with only a drop of 5 mV after 5000 cycles,indicating excellent *** work provides a new strategy to design highly active and non-noble metal ORR electrocatalysts,which hold great potential for various catalytic applications.

关键词： Fe_(1)Cu single-atom alloy(SAA) electrocatalysis oxygen reduction reaction charge-asymmetry

黑土区域土地利用变化及其生态效应分析——以海伦市为例

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水土保持学报 2004年第5期18卷 138-141,145页

作者：赵军张玥孟凯隋跃宇中国科学院东北地理与农业生态研究所黑龙江哈尔滨150040 东北林业大学资源与环境学院哈尔滨150040

以1986年和2000年1:10万陆地卫星解译数据为基础,利用地理信息系统的空间分析功能结合景观生态学理论,分析了14年来海伦市土地利用变化及其景观生态效应。研究结果表明:14年来海伦市的林地、沼泽地和牧草地分别减少了3184.88,1625.8,399... 详细信息

以1986年和2000年1:10万陆地卫星解译数据为基础,利用地理信息系统的空间分析功能结合景观生态学理论,分析了14年来海伦市土地利用变化及其景观生态效应。研究结果表明:14年来海伦市的林地、沼泽地和牧草地分别减少了3184.88,1625.8,3994.85hm^2,而旱田、水田和城镇用地在明显地增加,分别增加了7786.39,3391.18,120.84hm^2。旱田是该区域的主要景观。景观生态效应主要表现在由于土地利用和覆被的变化产生了生境质量下降,土地退化、水土流失、气候变暖等后果。该研究对区域生态环境保护以及农业可持续发展和土地可持续利用具有十分重要的意义。

关键词：黑土区域土地利用生态效应海伦市

不同施肥制度对大豆生育期土壤微生物量的影响

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土壤通报 2006年第5期37卷 894-896页

作者：隋跃宇焦晓光张兴义赵军黑土生态黑龙江省重点实验室中国科学院东北地理与农业生态研究所黑龙江大学农学院黑龙江哈尔滨150081 中国科学院东北地理与农业生态研究所北京100039

通过测定不同施肥制度下大豆土壤微生物量C、N的动态变化,探讨了不同施肥制度对大豆土壤的培肥效应。研究结果表明,与无肥、单施有机肥、单施化肥相比,有机肥与N、P、K化肥配合施用能显著增加大豆各生育时期的土壤微生物量C、N,促进土... 详细信息

通过测定不同施肥制度下大豆土壤微生物量C、N的动态变化,探讨了不同施肥制度对大豆土壤的培肥效应。研究结果表明,与无肥、单施有机肥、单施化肥相比,有机肥与N、P、K化肥配合施用能显著增加大豆各生育时期的土壤微生物量C、N,促进土壤微生物量显著增长,增强了土壤养分容量的供应强度,有利于培肥土壤。

关键词：施肥制度大豆生育期土壤微生物量

基于玉米大豆轮作的黑土玉米农田酶活性对不同耕层厚度的响应

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玉米科学 2019年第6期27卷 95-103页

作者：赵月王春雨隋跃宇李彦生张兴义刘晓冰东北农业大学资源与环境学院哈尔滨150030 中国科学院东北地理与农业生态研究所/黑土区农业生态重点实验室哈尔滨150081

在重建不同厚度黑土层的定位模拟试验区开展免耕玉米大豆轮作试验,设置3个黑土耕层厚度,分别为10、20和30 cm,重点研究耕层厚度对玉米生育期内关键土壤酶活性的影响,分析乳熟期根际和非根际土壤的酶活性及其速效养分的差异。研究表明,... 详细信息

在重建不同厚度黑土层的定位模拟试验区开展免耕玉米大豆轮作试验,设置3个黑土耕层厚度,分别为10、20和30 cm,重点研究耕层厚度对玉米生育期内关键土壤酶活性的影响,分析乳熟期根际和非根际土壤的酶活性及其速效养分的差异。研究表明,不同生育期不同耕层厚度的玉米农田土壤脲酶活性变化差异不明显;土壤蔗糖酶活性变化差异显著;土壤磷酸酶活性在同一生长期不同耕层厚度差异明显,磷酸酶对耕层厚度的反应更为敏感。相同耕层厚度中不同土层深度间酶活性也有明显差异,0~10 cm土层的酶活性高于21~30 cm土层酶活性。乳熟期玉米根际土壤的脲酶、蔗糖酶、磷酸酶均在10 cm耕层厚度中活性最强。不同耕层厚度处理时,玉米农田土壤的根际土壤酶活性高于非根际土壤。30 cm耕层厚度速效氮含量根际土显著高于非根际土壤,有效磷含量无显著差异,根际土的速效钾含量均低于非根际土。

关键词：玉米耕层厚度酶活性速效养分根际

Determination of ice jam thickness—A new approach

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Journal of Hydrodynamics 2024年第3期36卷 570-581页

作者： Jun Wang Lian-sheng Sang Fei-hu Song Tie-jie Cheng Jueyi sui School of Civil and Water Engineering Hefei University of TechnologyHefei230009China School of Engineering University of Northern British ColumbiaPrince GeorgeCanada

In winter,rivers in cold regions often experience flood disasters resulted from ice jams or ice *** of the variation of ice jam thickness and water level during an ice jammed period are not only a practical need for ice prevention to avoid disaster and plan water resource,but also essential for the development of any mathematical model for predicting the evolution of ice *** far,some equations based on the energy equation have been proposed to describe the relationship between ice jam thickness and water ***,in the derivation of these equations,the local head loss coefficient at the ice jam head and the riverbed slope factor were ***,those reported equations cannot be used to preciously describe the flow energy equation with ice jams and accurately calculate the ice jam thickness and water *** the present study,a more comprehensive theoretical model for hydraulic calculation of ice jam thickness has been derived by considering important and essential factors including riverbed slope and local head loss coefficient at the ice jam ***,based on the data collected from laboratory experiments of ice jam accumulation,the local head loss coefficient at the ice jam head has been calculated,and the empirical equation for calculating the local head loss coefficient has been established by considering flow Froude number and the ratio of ice discharge to flow *** results of this study not only provide a new reference for calculating ice jam thickness and water level,but also present a theoretical basis for accurate CFD simulation of ice jams.

关键词： Energy equation ice jam thickness local head loss coefficient ice jam head riverbed slope