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基于多参数MRI影像组学术前预测脑膜瘤Ki67表达的研究

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中国实验诊断学 2024年第4期28卷 416-421页

作者：温艳鲁莫展豪程斯文隋赫李涛吴帅范晓飞吕忠文吉林大学中日联谊医院放射线科吉林长春130033 吉林大学中日联谊医院超声科吉林长春130033 吉林大学中日联谊医院麻醉科吉林长春130033

目的探讨基于常规多参数MRI影像组学模型术前预测脑膜瘤的Ki67表达状态的价值。方法回顾性分析吉林大学中日联谊医院2013年3月至2021年11月305例经术后病理结果确诊为脑膜瘤患者的资料。获取所有患者术前轴位T1WI、T2WI、T2-FLAIR及T1W... 详细信息

目的探讨基于常规多参数MRI影像组学模型术前预测脑膜瘤的Ki67表达状态的价值。方法回顾性分析吉林大学中日联谊医院2013年3月至2021年11月305例经术后病理结果确诊为脑膜瘤患者的资料。获取所有患者术前轴位T1WI、T2WI、T2-FLAIR及T1WI增强(T1C)图像,手动标注肿瘤实质区作为感兴趣区(EnHROI),并将病灶边缘向周围膨胀3 mm、5 mm分别得到EnH3mmROI、EnH5mmROI。对图像进行灰度归一化后提取影像组学特征,并使用相关系数法与最小绝对收缩和选择算子(least absolute shrinkage and selection operator,LASSO)算法对影像组学特征进行筛选,依次使用二次判别分析和逻辑回归方法建立影像组学预测模型。通过绘制受试者工作特征曲线(ROC),计算曲线下面积(AUC)来评估各模型预测效能。结果二次判别分析和逻辑回归方法建立的模型均具有良好的预测效能,其中二次判别分析方法表现更佳,在EnH模型、EnH3mm模型、EnH5mm模型的训练集中的AUC分别为0.806、0.841、0.773,在测试集中的AUC分别为0.776、0.818、0.757。组学模型之间比较显示EnH3mm模型效能最佳,其在训练集和测试集中特异性分别为0.882、0.857,准确性分别为0.796、0.777。结论基于术前多序列MRI影像组学模型可有效预测脑膜瘤Ki67表达状态,其中病灶增强区并膨胀3 mm的区域构建模型的效能最佳。

关键词：脑膜瘤磁共振成像影像组学 Ki67

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农杆菌介导的ZmRLK基因转化玉米的分析

分子植物育种 2017年第1期15卷 150-154页

作者：李倩王帅隋颂扬单晓辉苏胜忠刘宏魁李世鹏吴颖原亚萍吉林大学植物科学学院长春130062

玉米是世界上非常重要的粮食作物,其产量受诸多生物胁迫及非生物胁迫的影响。转基因技术是玉米遗传改良的重要途径之一。利用转基因技术把抗逆基因导入玉米优良自交系,并使其后代具有抵抗逆境的能力,减少损害,从而实现高产稳产。本研究... 详细信息

玉米是世界上非常重要的粮食作物,其产量受诸多生物胁迫及非生物胁迫的影响。转基因技术是玉米遗传改良的重要途径之一。利用转基因技术把抗逆基因导入玉米优良自交系,并使其后代具有抵抗逆境的能力,减少损害,从而实现高产稳产。本研究通过将抗冷基因ZmRLK在玉米自交系Y423中遗传转化,得到过量表达ZmRLK基因的抗冷玉米新种质。结果表明,以玉米自交系Y423幼胚为受体,经检测获得ZmRLK过表达阳性植株89株;干扰载体获得121株阳性植株;空载体获得31株阳性植株。转基因阳性植株的获得为培育转基因玉米新品种提供帮助。

关键词：玉米 ZmRLK基因农杆菌介导转基因植株

基于多序列MRI影像组学模型预测脑膜瘤组织学分型的价值

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中国实验诊断学 2024年第3期28卷 278-286页

作者：孔春雨莫展豪程斯文隋赫宛迎春吴帅范晓飞吕忠文吉林大学中日联谊医院放射线科吉林长春130033 吉林大学中日联谊医院超声科吉林长春130033 吉林大学中日联谊医院内分泌科吉林长春130033

目的探究基于常规多序列MRI的影像组学模型在术前预测纤维型和非纤维型脑膜瘤的价值,以助于临床术前准备及预后评估。方法回顾性分析了自2013年3月至2022年12月经手术后病理证实的共317例脑膜瘤患者的临床及多序列MRI(包括T1WI、T2WI、T... 详细信息

目的探究基于常规多序列MRI的影像组学模型在术前预测纤维型和非纤维型脑膜瘤的价值,以助于临床术前准备及预后评估。方法回顾性分析了自2013年3月至2022年12月经手术后病理证实的共317例脑膜瘤患者的临床及多序列MRI(包括T1WI、T2WI、T2WIFLAIR、T1WI增强)资料。手动勾画获得脑膜瘤强化区作为感兴趣区域(EnHROI),并分别将勾画区域向外周各自膨胀3 mm、5 mm得到EnH3mmROI、EnH5mmROI,对每个MRI序列的三种ROI分别提取影像特征,分别采用5折交叉验证法和留一法交叉验证(LOOCV)分别进行特征筛选、模型验证及比较。使用相关系数法和最小绝对收缩和选择算子(least absolute shrinkage and selection operator,LASSO)算法进行特征选择,随后使用支持向量机的机器学习算法(AVM)构建模型,最后评估不同预测模型的效能。结果利用受试者工作特征曲线(receiver-operating characteristic curve,ROC)评估预测脑膜瘤分型的影像组学模型中,基于EnH3mmROI的预测模型均优于基于EnHROI的模型及EnH5mmROI的模型。基于EnHROI模型AUC值为0.801、准确率为0.842;基于EnH3mmROI模型AUC值为0.858、准确率为0.842;基于EnH5mmROI模型AUC值为0.841、准确率为0.868。结论(1)基于EnH3mmROI所建立的影像组学预测模型效能明显优于基于EnHROI及EnH5mmROI所建立的预测模型。(2)基于常规多序列MRI图像建立的术前预测脑膜瘤组织学分型的影像组学模型具有一定的临床价值,有助于临床判断预后以及为治疗计划提供依据。

关键词：脑膜瘤影像组学组织学分型磁共振成像

基于体力劳动能力的Heath-Carter体型的分析评价

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解剖学杂志 2016年第5期39卷 594-596,643页

作者：刘媛媛尹帅隋月林路兰红丁文锋王磊牟兆新沧州医学高等专科学校解剖学教研室沧州061001 沧州中西医结合医院沧州061001

目的：探讨高水平体力劳动能力（PWC170）的HeathCarter法体型分类。方法：对某全训部队418名男战士，按GJB1337—92规定，采用两级台阶运动负荷试验间接测定法，进行PWC170的测定；按国际通用的HeathCarter方法测量体型。结果：... 详细信息

目的：探讨高水平体力劳动能力（PWC170）的HeathCarter法体型分类。方法：对某全训部队418名男战士，按GJB1337—92规定，采用两级台阶运动负荷试验间接测定法，进行PWC170的测定；按国际通用的HeathCarter方法测量体型。结果：男战士 PWC170均值为（1355.8±331.1）kg·m·min^-1，总体评价为优秀；PWC170优秀者215人，占51.4%，均值为（1620.2±225.0）kg·m·min^-1，体型均值为2.3±0.7-5.1±3.8-2.4±0.9, SAM为1.7，优秀者中有193人体型集中于中胚层体型，占89.8%；优良（含优秀）者285人，占68.1%，PWC170均值为（1522.4±260.9）kg·m·min^-1，体型均值为2.3±0.7-5.0±3.3-2.4±0.9，SAM为17，优良者中有255人的体型集中于中胚层体型，占89.5%；内、中、外三因子是影响PWC170成绩的主要因素，PWC170成绩越好，内、外因子值越小，而中因子值越大。结论：高水平PWC170的体型分类高度集中于中胚层体型。PWC170与中因子值呈显著正相关。

关键词：体力劳动能力 Heath—Carter法体型分类

Geometrically Nonlinear Topology Optimization of Continuum Structures Based on an Independent Continuous Mapping Method

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Acta Mechanica Solida Sinica 2021年第5期34卷 658-672页

作者： Hong-ling Ye Bo-shuai Yuan Ji-cheng Li Xing Zhang Yun-kang sui Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing100124China

A geometrically nonlinear topology optimization method for continuum structures is proposed based on the independent continuous mapping *** stress constraint problem is studied due to the importance of structural strength in engineering ***,a topology optimization model is established for a lightweight structure with element stress as ***,the stress globalization method is adopted to convert local stress constraints into strain energy constraints,which overcomes the difficulties caused by local stress constraints,such as model establishment,sensitivity analysis,and massive solution ***,the sensitivity of the objective function and constraint function is analyzed,and the method of moving asymptotes is employed to solve the optimization *** addition,the additive hyperelasticity technique is utilized to solve the numerical instability induced by structures undergoing large *** examples are given to validate the feasibility of the proposed *** method provides a significant reference for geometrically nonlinear optimization design.

关键词： Topology optimization Geometric nonlinearity ICM method Stress constraints Stress globalization

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启航幼儿园,九寨沟,四川,中国

世界建筑 2024年第3期 96-97页

作者：无杨远景黄瑾郑泽旭何亚洁杨宗祥隋佳音唐帅马智超李凯璇广州市东意建筑设计咨询有限公司不详东意建筑南社·建筑

该项目为2017年九寨沟地震的灾后重建项目,由深圳壹基金公益基金会联合国家专项资金提供支持。新建的优质公办幼儿园承载着社区与地方发展的希望。风景、地形、城镇、社区与儿童是设计的核心议题。

关键词：公办幼儿园公益基金会壹基金九寨沟地震核心议题启航社区

1例早期HIV感染者外周血抗体变化和病毒基因序列分析

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军事医学科学院院刊 2008年第1期32卷 15-18,48页

作者：李林鲍作义苗文泉刘永健隋洪帅刘思扬庄道民李韩平李敬云军事医学科学院微生物流行病研究所全军艾滋病检测中心病原微生物生物安全国家重点实验室北京100071

目的:观察HIV早期感染者体内的抗体变化特征,为进一步研究HIV感染早期病毒与宿主的相互作用奠定基础。方法:对一名HIV感染者进行流行病学调查、外周血血清学检测、病毒载量和CD4细胞数检测、体外病毒分离,观察该感染者体内免疫学反应及... 详细信息

目的:观察HIV早期感染者体内的抗体变化特征,为进一步研究HIV感染早期病毒与宿主的相互作用奠定基础。方法:对一名HIV感染者进行流行病学调查、外周血血清学检测、病毒载量和CD4细胞数检测、体外病毒分离,观察该感染者体内免疫学反应及病毒复制特点。使用巢式PCR方法扩增病毒env区C2-V3区基因,通过测序及序列分析观察病毒部分膜区基因特点。结果:该感染者为早期感染,外周血抗体S/CO值呈逐渐增高趋势,外周血中针对HIV抗原的特异性条带呈逐渐增多趋势,感染183 d后出现针对所有HIV抗原的特异性抗体,病毒载量在感染后3个月时最高(18 000 cp/ml),随后下降,从该感染者外周血中分离的病毒毒力较强。基因序列分析显示该病毒为CRF01_AE亚型,与泰国93TH054毒株基因距离最近。结论:该感染者体内病毒可能起源于泰国毒株,对HIV早期感染的鉴定为研究我国HIV早期感染者体内病毒进化奠定了基础。

关键词：人免疫缺陷病毒早期感染血清学检测 CRF01_AE亚型 HIV抗体序列分析

Temperature variations along the Silk Road over the past 2000 years:Integration and perspectives

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Science China Earth Sciences 2023年第7期66卷 1468-1477页

作者： Jianhui CHEN Haipeng WANG Yan LIU shuai MA Wei HUANG MOE Key Laboratory of Western China’s Environmental Systems Lanzhou UniversityLanzhou 730000China State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Reconstructing temperature changes along the Silk Road(SR)over the last two millennia can provide insights into past global changes and their impact on the rise and fall of ancient civilizations in this *** high-quality single-site paleotemperature records have been produced for the eastern part of the SR(mainly for the Xinjiang region and its surrounding areas),which provide the data basis for a comprehensive *** this study,we used objective criteria to select 10 highquality ones from 30 temperature reconstructions derived from various geological archives including lacustrine sediments,ice cores,and tree rings in this *** aims are to summarize the pattern of temperature change over the past 2000 years,to provide a long-term viewpoint on the present warming,and to evaluate the impact of climate change on civilizations along the *** principal results are as follows:(1)The temperature variations over the last millennium are mutually consistent within these *** study area experienced typical climate anomalies during the Medieval Warm Period(MWP,AD 1000-1250),the Little Ice Age(LIA,AD 1450-1850),and the Current Warm Period(CWP,AD 1850 to present);however,contrary to previous knowledge,the amplitude of climatic warming during the CWP did not exceed that during the MWP.(2)Fewer temperature records were available for the interval AD 1–1000,and there were large differences between *** example,the reconstructed climate during both the Han Dynasty and the sui-Tang Dynasties was either warm or cold,without prevailing consensus.(3)The warming during the MWP favored the rapid development of the SR route along the northern slopes of the Tianshan Mountains,and the cooling during the LIA contributed to the decline of the SR marked by the closure of the Jiayuguan ***,the scarcity of temperature records and the discrepancies between them during AD 1-1000 in the eastern part of the SR have hindered our understanding of the hydroclim

关键词： Silk Road Medieval Warm Period Little Ice Age Current Warm Period Rise and fall of civilizations

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Gas-based reduction of vanadium titano-magnetite concentrate:behavior and mechanisms

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International Journal of Minerals,Metallurgy and Materials 2017年第1期24卷 10-17页

作者： Yu-lei sui Yu-feng Guo Tao Jiang Xiao-lin Xie shuai Wang Fu-qiang Zheng School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

The reduction of vanadium titano-magnetite pellets by H_2-CO at temperatures from 850 to 1050°C was investigated in this paper. The influences of pre-oxidation treatment, reduction temperature, and V_（H_2）/（V_（H_2）＋ VCO） on the metallization degree were studied. The results showed that pre-oxidation played a substantial role in the reduction of vanadium titano-magnetite pellets. During the reduction process, the metallization degree increased with increasing temperature and increasing V_（H_2） /（V_（H_2）＋ VCO）. The phase transformation of pre-oxidized vanadium titano-magnetite pellets during the reduction process under an H_2 atmosphere and a CO atmosphere was discussed, and the reduced samples were analyzed by scanning electron microscopy（SEM） in conjunction with back scatter electron（BSE） imaging. The results show that the difference in thermodynamic reducing ability between H_2 and CO is not the only factor that leads to differences in the reduction results obtained using different atmospheres. Some of Fe_（3-x）Ti_xO_4 cannot be reduced under a CO atmosphere because of the densification of particles＇ structure and because of the enrichment of Mg in unreacted cores. By contrast, a loose structure of particles was obtained when the pellets were reduced under an H_2 atmosphere and this structure decreased the resistance to gas diffusion. Moreover, the phenomenon of Mg enrichment in unreacted cores disappeared during H_2 reduction. Both the lower resistance to gas diffusion and the lack of Mg enrichment facilitated the reduction of vanadium titano-magnetite.

关键词： titano-magnetite ore reduction behavior mechanisms