AIM:To investigate the clinical signs of blepharokeratoconjunctivitis(BKC)and evaluate the efficacy of penetrating keratoplasty(PKP)for the ***:Sixteen patients(16 eyes)with BKC complicated by corneal perforation hosp...
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AIM:To investigate the clinical signs of blepharokeratoconjunctivitis(BKC)and evaluate the efficacy of penetrating keratoplasty(PKP)for the ***:Sixteen patients(16 eyes)with BKC complicated by corneal perforation hospitalised at Shandong Eye Hospital were retrospectively *** patients received *** were assessed for symptoms,clinical manifestations,the activity and damage grading of BKC.A paired t-test was used to compare the uncorrected visual acuity(UCVA)before and after surgery for the perforated ***:The mean age of the patients was *** vision is the most common discomfort,followed by redness,and then *** duration of ocular discomfort lasted for 3.2y,on ***(18.8%)participants were associated with rosacea,while 11(68.8%)patients had recurrent chalazion or *** in eyelash follicles was positive in 11(68.8%)*** corneal perforations were≤3.0 mm in *** perforation was located mainly in the inferior cornea(68.8%).The mean area of corneal vascularisation was 3.0 *** patients manifested bilateral BKC,with the perforated eyes ranked as severely damaged and presenting with severe *** contralateral eyes manifested mild damage with no active ***(68.8%)of the perforated eyes were treated with PKP using a minimal *** UCVA increased significantly at the final follow-up(mean,21mo;P<0.001),with the manifestation of BKC alleviated *** of the patients developed immune rejection or other serious ***:BKC combined with corneal perforation occurs mainly among young people with a long history of ocular ***,especially using a minimal graft,is an effective and safe option for treating the disease.
The quest for efficient and durable catalysts using abundant resources has garnered significant interest in the field of bifunctional oxygen *** this contribution,we have designed a FeN4or CoN4embedded graphene-based ...
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The quest for efficient and durable catalysts using abundant resources has garnered significant interest in the field of bifunctional oxygen *** this contribution,we have designed a FeN4or CoN4embedded graphene-based bilayer as active layer and TMC3or TMN3doped graphene as supporting layer,named as FeN4/TMC3or FeN4/TMN3and CoN4/TMC3or CoN4/TMN3,wherein TM strands for transition *** on density functional theory calculations,our results demonstrate that the interaction formed between dual metal atoms in the bilayer interspace leads to the coordination environment altered from flat four-coordination to spatial five-coordination,further stabilizing the bilayer structure and impairing its affinity toward the O-containing *** to thermodynamic analysis,the bilayers of CoN4/CoN3,FeN4/FeC3,FeN4/CoC3,FeN4/NiC3,FeN4/ZnC3,FeN4/FeN3,FeN4/CrN3and FeN4/ZnN3are attractively promising for bifunctional oxygen electrocatalysis due to the small overpotential differenceΔη between oxygen reduction and oxygen evolution that are less than 1 *** functional theory calculations combined with machine learning analysis directly identify the key role played by the interbinding formed between bilayers,that boosts catalytic activity,which establishes a predictable framework for a fast screen for graphene-based bilayer vertical *** work opens up a new path for designing the efficient electrocatalysts via modification of coordination environment.
Polychlorinated naphthalenes(PCNs)are detrimental to human health and the *** the commercial production of PCNs banned,unintentional releases have emerged as a significant environmental ***,relevant information is sti...
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Polychlorinated naphthalenes(PCNs)are detrimental to human health and the *** the commercial production of PCNs banned,unintentional releases have emerged as a significant environmental ***,relevant information is still *** this study,provincial emissions for eight PCNs homologues from 37 sources in the Chinese mainland during the period of 1960-2019 were estimated based on a source-specific and time-varying emission factor *** results showed that the total PCNs emissions in 2019 reached 757.0 kg with Hebei ranked at the top among all the provinces and iron&steel industry as the biggest ***-chlorinated PCNs comprised 90%of emissions by mass,while highly chlorinated PCNs dominated in terms of toxicity,highlighting divergent priorities for mitigating emissions and safeguarding human *** emissions showed an overall upward trend from 1960 to 2019 driven by emission increase from iron&steel industry in terms of source,and from North China and East China in terms of geographic ***-capita emissions followed an inverted U-shaped environmental Kuznets curvewhile emission intensities decreased with increasing per-capita Gross Domestic Product(GDP)following a nearly linear pattern when log-transformed.
To improve the wettability of hypereutectic Al−60Si alloy and enhance the mechanical properties of the joints,Al−60Si alloy was joined by ultrasonic soldering with Sn-9Zn solder,and a sound joint with in-situ Si parti...
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To improve the wettability of hypereutectic Al−60Si alloy and enhance the mechanical properties of the joints,Al−60Si alloy was joined by ultrasonic soldering with Sn-9Zn solder,and a sound joint with in-situ Si particle reinforcement was *** oxide film of Al−60Si alloy at the interface was identified by transmission electron microscopy(TEM)analysis as amorphous Al_(2)O_(3).The oxide of Si particles in the base metal was also *** oxide film of Al−60Si alloy was observed to be removed by ultrasonic vibration instead of holding *** particle-reinforced joints(35.7 vol.%)were obtained by increasing the ultrasonication *** maximum shear strength peaked at 99.5 MPa for soldering at 330℃with an ultrasonic vibration time of 50 s.A model of forming of Si particles reinforced joint under the ultrasound was proposed,and ultrasonic vibration was considered to promote the dissolution of Al and migration of Si particles.
This study aimed to address the challenges of solid waste utilization,cost reduction,and carbon reduction in the treatment of deep-dredged soil at Xuwei Port in lianyungang city of *** research in this area was ***,a ...
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This study aimed to address the challenges of solid waste utilization,cost reduction,and carbon reduction in the treatment of deep-dredged soil at Xuwei Port in lianyungang city of *** research in this area was ***,a curing agent made from powdered shells was used to solidify the dredged soil in *** employed laboratory orthogonal tests to investigate the physical and mechanical properties of the powdered shell-based curing *** was collected by conducting experiments to assess the role of powdered shells in the curing process and to determine the optimal ratios of powdered shells to solidified soil for different *** development of strength in solidified soil was studied in both seawater and pure water *** study revealed that the strength of the solidified soil was influenced by the substitution rate of powdered shells and their interaction with *** cement content had a positive effect on *** high-strength solidified soil,the recommended ratio of wet soil:cement:lime:powdered shells were 100:16:4:4,while for low-strength solidified soil,the recommended ratio was 100:5.4:2.4:***,under appropriate conditions,improved short-term strength by promoting the formation of expansive ettringite minerals that contributed to cementation and *** findings suggest that the combination of cement and powdered shells is synergistic,positively affecting the strength of solidified *** recommended ratios provide practical guidance for achieving desired strength levels while considering factors such as cost and carbon *** role of seawater in enhancing short-term strength through crystal formation is noteworthy and can be advantageous for certain *** conclusion,this research demonstrates the potential of using a powdered shell-based curing agent for solidifying dredged soil in an environmentally friendly and cost-effective *** recommended ratios for different str
T cells play a critical and irreplaceable role in maintaining overall ***,their functions undergo alterations as individuals *** is of utmost importance to comprehend the specific characteristics of T-cell aging,as th...
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T cells play a critical and irreplaceable role in maintaining overall ***,their functions undergo alterations as individuals *** is of utmost importance to comprehend the specific characteristics of T-cell aging,as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic *** this review,we have thoroughly examined the existing studies on the characteristics of immune organ ***,we elucidated the changes and potential mechanisms that occur in T cells during the aging ***,we have discussed the latest research advancements pertaining to T-cell agingrelated *** findings provide a fresh perspective for the study of T cells in the context of aging.
High-resolution time-to-digital converter(TDC) finds major applications in light detection and ranging(lidar) systems as one of the high precision time measuring techniques. In this work, a high-resolution TDC is desi...
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High-resolution time-to-digital converter(TDC) finds major applications in light detection and ranging(lidar) systems as one of the high precision time measuring techniques. In this work, a high-resolution TDC is designed and implemented on a Xilinx field-programmable gate array(FPGA) board. For precision time measurements, the proposed TDC uses an internal tapped delay chain written in Verilog. The TDC circuit measurement errors are examined and calibrated following several principles of error reduction techniques to meet the specific demand for the high-precision lidar range. Experiments have shown that the suggested calibration TDC has higher performance, achieving sub-35 ps resolution. The design is fully customizable and implemented as a set of separate intellectual property cores. This allows for easy implementation and meets the requirements of the present-day pulse lidar systems.
BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding t...
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BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.
BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of color...
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BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.
A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pa...
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A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.
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